To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bisp...To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bispyridylanthrahydrazone(9,10‑PAH)were designed and synthesized.Utilizing 9‑PAH and 9,10‑PAH as promising anticancer ligands,their respective copper complexes,namely[Cu(L1)Cl_(2)]Cl(1)and{[Cu_(4)(μ_(2)‑Cl)_(3)Cl_(4)(9,10‑PAH)_(2)(DMSO)_(2)]Cl_(2)}_(n)(2),were subsequently synthesized,where the new ligand L1 is formed by coupling two 9‑PAH ligands in the coordination reaction.The chemical and crystal structures of 1 and 2 were elucidated by IR,MS,elemental analysis,and single‑crystal X‑ray diffraction.Complex 1 forms a mononuclear structure.L1 coordinates with Cu through its three N atoms,together with two Cl atoms,to form a five‑coordinated square pyramidal geometry.Complex 2 constitutes a polymeric structure,wherein each structural unit centrosymmetrically encompasses two five‑coordinated binuclear copper complexes(Cu1,Cu2)of 9,10‑PAH,with similar square pyramidal geometry.A chlorine atom(Cl_(2)),located at the symmetry center,bridges Cu1 and Cu1A to connect the two binuclear copper structures.Meanwhile,the two five‑coordinated Cu2 atoms symmetrically bridge the adjacent structural units via one coordinated Cl atom,respectively,thus forming a 1D chain‑like polymeric structure.In vitro anticancer activity assessments revealed that 1 and 2 showed significant cytotoxicity even higher than cisplatin.Specifically,the IC_(50)values of 2 against HeLa‑229 and SK‑OV‑3 cancer cell lines were determined to be(5.92±0.32)μmol·L^(-1)and(6.48±0.39)μmol·L^(-1),respectively.2 could also block the proliferation of HeLa‑229 cells in S phase and significantly induce cell apoptosis.In addition,fluorescence quenching competition experiments suggested that 2 might interact with DNA by an intercalative binding mode,offering insights into its underlying anticancer mechanism.CCDC:2388918,1;2388919,2.展开更多
Located in the northern margin of the Qinghai—Tibet Plateau, the Longshoushan Mt. is a small block between Qinghai—Tibet Landmass and Alashan Landmass.Traditional tectonic viewpoint does not consider that the Longsh...Located in the northern margin of the Qinghai—Tibet Plateau, the Longshoushan Mt. is a small block between Qinghai—Tibet Landmass and Alashan Landmass.Traditional tectonic viewpoint does not consider that the Longshoushan Mt. is a single tectonic block. It is quite evident that there is only a hazy idea about the Longshoushan block. Though there is a very complex tectonic region between Qinghai—Tibet Landmass and Alashan Landmass, the Longshoushan block in the region shows unique tectonic landforms, deep structures and uplift mechanisms. Researching into the relationship between the Longshoushan block and the Qinghai—Tibet and Alashan Landmasses will contribute to the realization of boundary and orogenic belt on the northern margin of the Qinghai—Tibet block. It is a very important scientific subject.The Longshoushan Mt., longer than 150km in NWW direction and wider than 10km, is located on the northern side of Hexi corridor(100 5°～102 5°E,38 5°～39 3°N). It extends from the northwest of Zhangye to Hexibu, and from the south of Chaoshui basin to the north of Minle basin. From west to east, there are the highest peak, Dongdashan Mt.(3616m), the second peak, Dufengding(2937m) and Qianshan peak(2827m), height of the mountains is getting lower and lower, mean height above sea level is over 2000m, and relative height difference is about 1000m. The Longshoushan Mt. provides a natural defence for stopping the southward migration of sandstorm in the Hexi corridor, and forms a topographic step zone from the Alashan Plateau to the Qinghai—Tibet Plateau. In the Longshoushan area, developed landforms, such as planation surface, table\|land, terrace land, are general characters of all geomorphic units. It is shown that the Longshoushan Mt. is a intermittently uplifted block. An astonishingly similar of geometric patterns of Taohualashan Mt. and Hongshihu basin is very interesting natural landscape in the area. It is suggested that Taohualashan Mt. broke away from Hongshihu Basin in secular tectonic movement. The viewpoint is supported by major formation, lithofacies, limitation and style of active faulting. The Longshoushan block consists of two major active fault zones (the northern Longshoushan fault zone and the southern Longshoushan fault zone), the active Pingshanhu—Hongshihu fault basin belt and Taohualashan—Xieposhan tectonic uplift belt. In addition, there are the NNW\|trending West Polamading fault, NWW\|trending Maohudong fault trough, NNE\|trending Daxiahe rift valley and others on the block. the activity and formation style of these structures indicate that the block is acted not only by compressive stress, but also by tensile stress. The northern Longshoushan and southern Longshoushan fault zones are closely related to formation and evolution of the Longshoushan block, the two zones are active fault zones since late Pleistocene and boundary fault zones of the block. The genesis and activity style of the Pingshanhu\|Hongshihu basin are similar to the continental rift, which may be due to the mantle uplift.展开更多
Taking the selection of coal-tar pitch as precursor and KOH as activated agent, the activated carbon electrode material was fabricated for supercapacitor.The surface area and the pore structure of activated carbon wer...Taking the selection of coal-tar pitch as precursor and KOH as activated agent, the activated carbon electrode material was fabricated for supercapacitor.The surface area and the pore structure of activated carbon were analyzed by Nitro adsorption method. The electrochemical properties of the activated carbons were determined using two-electrode capacitors in 6 mol/L KOH aqueous electrolytes. The influences of activated temperature and mass ratio of KOH to C on the pore structure and electrochemical property of porous activated carbon were investigated in detail. The reasons for the changes of pore structure and electrochemical performance of activated carbon prepared under different conditions were also discussed theoretically. The results indicate that the maximum specific capacitance of 240 F/g can be obtained in alkaline medium, and the surface area, the pore structure and the specific capacitance of activated carbon depend on the treatment methods; the capacitance variation of activated carbon cannot be interpreted only by the change of surface area and pore structure, the lattice order and the electrolyte wetting effect of the activated carbon should also be taken into account.展开更多
The influences of molar ratio of KOH to C and activated temperature on the pore structure and electrochemical property of porous activated carbon from mesophase pitch activated by KOH were investigated. The surface ar...The influences of molar ratio of KOH to C and activated temperature on the pore structure and electrochemical property of porous activated carbon from mesophase pitch activated by KOH were investigated. The surface areas and the pore structures of activated carbons were analyzed by nitrogen adsorption, and the electrochemical properties of the activated carbons were studied using two-electrode capacitors in organic electrolyte. The results indicate that the maximum surface area of 3 190 m2/g is obtained at molar ratio of KOH to C of 5:1, the maximum specific capacitance of 122 F/g is attained at molar ratio of KOH to C of 4:1, and 800 ℃ is the proper temperature to obtain the maximum surface area and capacitance.展开更多
文摘To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bispyridylanthrahydrazone(9,10‑PAH)were designed and synthesized.Utilizing 9‑PAH and 9,10‑PAH as promising anticancer ligands,their respective copper complexes,namely[Cu(L1)Cl_(2)]Cl(1)and{[Cu_(4)(μ_(2)‑Cl)_(3)Cl_(4)(9,10‑PAH)_(2)(DMSO)_(2)]Cl_(2)}_(n)(2),were subsequently synthesized,where the new ligand L1 is formed by coupling two 9‑PAH ligands in the coordination reaction.The chemical and crystal structures of 1 and 2 were elucidated by IR,MS,elemental analysis,and single‑crystal X‑ray diffraction.Complex 1 forms a mononuclear structure.L1 coordinates with Cu through its three N atoms,together with two Cl atoms,to form a five‑coordinated square pyramidal geometry.Complex 2 constitutes a polymeric structure,wherein each structural unit centrosymmetrically encompasses two five‑coordinated binuclear copper complexes(Cu1,Cu2)of 9,10‑PAH,with similar square pyramidal geometry.A chlorine atom(Cl_(2)),located at the symmetry center,bridges Cu1 and Cu1A to connect the two binuclear copper structures.Meanwhile,the two five‑coordinated Cu2 atoms symmetrically bridge the adjacent structural units via one coordinated Cl atom,respectively,thus forming a 1D chain‑like polymeric structure.In vitro anticancer activity assessments revealed that 1 and 2 showed significant cytotoxicity even higher than cisplatin.Specifically,the IC_(50)values of 2 against HeLa‑229 and SK‑OV‑3 cancer cell lines were determined to be(5.92±0.32)μmol·L^(-1)and(6.48±0.39)μmol·L^(-1),respectively.2 could also block the proliferation of HeLa‑229 cells in S phase and significantly induce cell apoptosis.In addition,fluorescence quenching competition experiments suggested that 2 might interact with DNA by an intercalative binding mode,offering insights into its underlying anticancer mechanism.CCDC:2388918,1;2388919,2.
文摘Located in the northern margin of the Qinghai—Tibet Plateau, the Longshoushan Mt. is a small block between Qinghai—Tibet Landmass and Alashan Landmass.Traditional tectonic viewpoint does not consider that the Longshoushan Mt. is a single tectonic block. It is quite evident that there is only a hazy idea about the Longshoushan block. Though there is a very complex tectonic region between Qinghai—Tibet Landmass and Alashan Landmass, the Longshoushan block in the region shows unique tectonic landforms, deep structures and uplift mechanisms. Researching into the relationship between the Longshoushan block and the Qinghai—Tibet and Alashan Landmasses will contribute to the realization of boundary and orogenic belt on the northern margin of the Qinghai—Tibet block. It is a very important scientific subject.The Longshoushan Mt., longer than 150km in NWW direction and wider than 10km, is located on the northern side of Hexi corridor(100 5°～102 5°E,38 5°～39 3°N). It extends from the northwest of Zhangye to Hexibu, and from the south of Chaoshui basin to the north of Minle basin. From west to east, there are the highest peak, Dongdashan Mt.(3616m), the second peak, Dufengding(2937m) and Qianshan peak(2827m), height of the mountains is getting lower and lower, mean height above sea level is over 2000m, and relative height difference is about 1000m. The Longshoushan Mt. provides a natural defence for stopping the southward migration of sandstorm in the Hexi corridor, and forms a topographic step zone from the Alashan Plateau to the Qinghai—Tibet Plateau. In the Longshoushan area, developed landforms, such as planation surface, table\|land, terrace land, are general characters of all geomorphic units. It is shown that the Longshoushan Mt. is a intermittently uplifted block. An astonishingly similar of geometric patterns of Taohualashan Mt. and Hongshihu basin is very interesting natural landscape in the area. It is suggested that Taohualashan Mt. broke away from Hongshihu Basin in secular tectonic movement. The viewpoint is supported by major formation, lithofacies, limitation and style of active faulting. The Longshoushan block consists of two major active fault zones (the northern Longshoushan fault zone and the southern Longshoushan fault zone), the active Pingshanhu—Hongshihu fault basin belt and Taohualashan—Xieposhan tectonic uplift belt. In addition, there are the NNW\|trending West Polamading fault, NWW\|trending Maohudong fault trough, NNE\|trending Daxiahe rift valley and others on the block. the activity and formation style of these structures indicate that the block is acted not only by compressive stress, but also by tensile stress. The northern Longshoushan and southern Longshoushan fault zones are closely related to formation and evolution of the Longshoushan block, the two zones are active fault zones since late Pleistocene and boundary fault zones of the block. The genesis and activity style of the Pingshanhu\|Hongshihu basin are similar to the continental rift, which may be due to the mantle uplift.
基金Project(2005CB623703) supported by the National Basic Research Program of China project(5JJ30103) supported bythe Natural Science Foundation of Hunan Province
文摘Taking the selection of coal-tar pitch as precursor and KOH as activated agent, the activated carbon electrode material was fabricated for supercapacitor.The surface area and the pore structure of activated carbon were analyzed by Nitro adsorption method. The electrochemical properties of the activated carbons were determined using two-electrode capacitors in 6 mol/L KOH aqueous electrolytes. The influences of activated temperature and mass ratio of KOH to C on the pore structure and electrochemical property of porous activated carbon were investigated in detail. The reasons for the changes of pore structure and electrochemical performance of activated carbon prepared under different conditions were also discussed theoretically. The results indicate that the maximum specific capacitance of 240 F/g can be obtained in alkaline medium, and the surface area, the pore structure and the specific capacitance of activated carbon depend on the treatment methods; the capacitance variation of activated carbon cannot be interpreted only by the change of surface area and pore structure, the lattice order and the electrolyte wetting effect of the activated carbon should also be taken into account.
基金Project(06FJ4059) supported by Hunan Provincial Academician Foundation
文摘The influences of molar ratio of KOH to C and activated temperature on the pore structure and electrochemical property of porous activated carbon from mesophase pitch activated by KOH were investigated. The surface areas and the pore structures of activated carbons were analyzed by nitrogen adsorption, and the electrochemical properties of the activated carbons were studied using two-electrode capacitors in organic electrolyte. The results indicate that the maximum surface area of 3 190 m2/g is obtained at molar ratio of KOH to C of 5:1, the maximum specific capacitance of 122 F/g is attained at molar ratio of KOH to C of 4:1, and 800 ℃ is the proper temperature to obtain the maximum surface area and capacitance.
