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基于基因及蛋白组学技术探讨HIV/AIDS湿热证的作用机制 被引量:1
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作者 王娟 张淼 +3 位作者 刘飒 马素娜 张海燕 许前磊 《中华中医药学刊》 北大核心 2025年第2期72-75,I0028,共5页
目的探索艾滋病湿热证分子机制。方法通过Agilent基因表达谱芯片及iTRAQ-MS技术对艾滋病湿热证患者进行基因组学及蛋白组学检测,以比值改变≥1.15或≤0.87,P<0.05为标准共鉴定出人类免疫缺陷病毒(HIV)/艾滋病(AIDS)湿热证差异表达基... 目的探索艾滋病湿热证分子机制。方法通过Agilent基因表达谱芯片及iTRAQ-MS技术对艾滋病湿热证患者进行基因组学及蛋白组学检测,以比值改变≥1.15或≤0.87,P<0.05为标准共鉴定出人类免疫缺陷病毒(HIV)/艾滋病(AIDS)湿热证差异表达基因20个,差异表达蛋白22个。结果HIV/AIDS湿热证与健康对照组比较,趋化因子受体4(CXCR4)、核转录因子-κB抑制因子(NFκBIA)、Tribbles同源蛋白1(TRIB1)等基因表达增加,趋化因子受体1(CX3CR1)表达降低;血清中载脂蛋白A-Ⅱ(APOA-Ⅱ)、C反应蛋白(CPR)、血小板因子4(PF4)、AAT蛋白表达增多,补体因子B(CFB)、Gelsolin表达降低。结论HIV/AIDS湿热证与炎症反应密切相关,HIV/AIDS湿热证有其特定的分子生物学基础,为中医药客观化和标准化研究提供了方法和依据。 展开更多
关键词 艾滋病 湿热证 免疫基因
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Application of computer-aided engineering optimum design method in aluminum profile extrusion mould 被引量:8
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作者 帅词俊 肖刚 +1 位作者 倪正顺 钟掘 《Journal of Central South University of Technology》 2003年第1期64-68,共5页
The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtaine... The finite element analysis and the optimum design of aluminum profile extrusion mould were investigated using the ANSYS software and its parameterized modeling method. The optimum dimensions of the mould were obtained. It is found that the stress distribution is very uneven, and the stress convergence is rather severe in the bridge of the aluminum profile extrusion mould. The optimum height of the mould is 70.527 mm, and the optimum radius of dividing holes are 70.182 mm and 80.663 mm. Increasing the height of the mould in the range of 61.282 mm to 70.422 mm can prolong its longevity, but when the height is over 70.422 mm, its longevity reduces. 展开更多
关键词 EXTRUSION MOULD COMPUTER-aided ENGINEERING OPTIMUM design ANSYS
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一类信息干预下具有非线性感染率的HIV/AIDS模型
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作者 许志航 张太雷 +1 位作者 侯悦 乔霞 《高校应用数学学报(A辑)》 北大核心 2025年第2期193-208,共16页
根据艾滋病的传播机理,建立了一类受信息影响且具有非线性感染率的SEI1I2A传染病模型.首先,给出了模型的基本再生数R_(0)和两类平衡点:无病平衡点和地方病平衡点;通过构造Lyapunov函数和LaSalle不变集原理证明了R_(0)<1时无病平衡点... 根据艾滋病的传播机理,建立了一类受信息影响且具有非线性感染率的SEI1I2A传染病模型.首先,给出了模型的基本再生数R_(0)和两类平衡点:无病平衡点和地方病平衡点;通过构造Lyapunov函数和LaSalle不变集原理证明了R_(0)<1时无病平衡点的全局稳定性,借助第二加性复合矩阵的方法证明了R_(0)> 1时地方病平衡点的全局稳定性.其次,选取河南省2005年至2019年新发艾滋病病例数据进行了数值模拟.最后,对部分参数进行敏感性分析,研究结果表明易感者与无意识的感染者和潜伏者的有效接触率对基本再生数有着较大的影响.扩大艾滋病信息宣传的覆盖面、提高公众对艾滋病的检测意识可以有效地降低艾滋病的传播率,控制艾滋病的蔓延. 展开更多
关键词 信息影响 HIV/aidS模型 全局稳定性 第二加性复合矩阵
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The Computer Aided Integrated Design and Analysis of Oil Tank in Vehicle 被引量:1
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作者 CHEN Xu 1, CHEN Yong-guang 2 (1. Mechanical Engineering Institute, Chongqing University, Chongqing 400044, China 2. Logistical Engineering University, Chongqing 400016, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期269-,共1页
This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oi... This paper creates 3D solid model and assembly of U RJ 92-6 oil tank and analyses its strength by integrated CAD/CAE/CAM software I-D EAS. Through integrated simulation in computer, design efficiency and quality of oil tank is greatly improved. Adopting integrated CAD/CAE/CAM software to carry out integrated research to equ ipment and products, we will be able to take overall analysis in aspects of 3-D solid modeling, pre-assembly and strength, etc., to realize non-paper designi ng and parallel designing. Problems can be found and settled during designing, w hich will increase designing efficiency and one-time success rate and realize o ptimum designing for products. 展开更多
关键词 oil tank solid modeling finite element analysis integrated design
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Combine Gearbox Aided Design Based on Artificial Neural Networks
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作者 WANGJin-wu 《Journal of Northeast Agricultural University(English Edition)》 CAS 2005年第1期83-86,共4页
In the optimum design of the self-propelled combine gearbox, the knowledge of ANN is applied to overcome slow calculation and low design efficiency. We did the normative approach of the charts information,then solved ... In the optimum design of the self-propelled combine gearbox, the knowledge of ANN is applied to overcome slow calculation and low design efficiency. We did the normative approach of the charts information,then solved the difficult problems in the design process and get satisfactory results. We also completed three-dimensional design of the gearbox in order to verify the rationality of the design visually. 展开更多
关键词 COMBINE neural networks aided design
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HIV感染者/AIDS患者创伤知情照护的研究进展
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作者 施敏敏 章蒙怜 +1 位作者 毛心淇 田力元 《护理学杂志》 北大核心 2025年第10期112-116,共5页
介绍创伤知情照护的概念以及目前在HIV感染者/AIDS患者中的应用情况,包括评估工具、水平、影响因素和干预策略,并从奉行创伤知情照护理念、构建多学科干预方案、开发本土化评估工具3个方面提出研究展望,旨在为相关研究和临床实践提供参考。
关键词 HIV感染者 aidS患者 创伤知情照护 创伤应对 创伤照护 创伤知情认知行为疗法 艾滋病护理 综述文献
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中老年HIV/AIDS患者合并慢性非传染性疾病情况与生命质量的关联研究
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作者 张瑶 张弛 +5 位作者 刘聪 钟海丹 杜佩珊 李全敏 李凌华 顾菁 《中山大学学报(医学科学版)》 北大核心 2025年第1期161-171,共11页
【目的】了解中老年HIV/AIDS患者合并慢性非传染性疾病(简称慢性病)的患病率及与生命质量的关联。【方法】采用横断面研究调查广州医科大学附属市八医院感染科门诊432名45岁及以上HIV/AIDS患者,经质量控制366名研究对象纳入分析。采用... 【目的】了解中老年HIV/AIDS患者合并慢性非传染性疾病(简称慢性病)的患病率及与生命质量的关联。【方法】采用横断面研究调查广州医科大学附属市八医院感染科门诊432名45岁及以上HIV/AIDS患者,经质量控制366名研究对象纳入分析。采用自制问卷和欧洲5维健康量表(EQ-5D-3L)调查慢性病和生命质量,采用Tobit回归分析慢性病与生命质量的关联。【结果】366名研究对象纳入分析,合并心血管疾病29人(7.9%),高血压45人(12.3%),高血糖122人(33.3%),高脂血症151人(41.3%),癌症7人(1.9%),慢性肾脏疾病17人(4.6%),慢性肝脏疾病38人(10.4%),肌肉骨骼疾病21人(5.7%),合并至少一类慢性病253人(69.1%)。EQ-5D效用指数的中位数(上下四分位数)为1.000(0.964~1.000)。多因素Tobit回归结果显示,合并癌症[b_(a)=-0.08,95%CI(-0.15,-0.01),P=0.036]、慢性肾脏疾病[b_(a)=-0.07,95%CI(-0.12,-0.02),P=0.006]、肌肉骨骼疾病[b_(a)=-0.09,95%CI(-0.13,-0.05),P<0.001]和≥3类慢性病[b_(a)=-0.05,95%CI(-0.08,-0.01),P=0.013]均与EQ-5D效用指数呈负向关联。不同CD4^(+)T细胞水平分层分析结果显示,CD4≤500个/μL组合并高血压[b_(a)=-0.07,95%CI(-0.12,-0.02),P=0.007]、慢性肾脏疾病[b_(a)=-0.10,95%CI(-0.18,-0.03),P=0.006]、肌肉骨骼疾病[b_(a)=-0.15,95%CI(-0.22,-0.07),P<0.001]和≥3类慢性病[b_(a)=-0.09,95%CI(-0.09,-0.01),P<0.001]与EQ-5D效用指数呈负向关联,CD4>500个/μL组合并癌症[b_(a)=-0.11,95%CI(-0.20,-0.01),P=0.031]与EQ-5D效用指数呈负向关联。【结论】中老年HIV/AIDS患者合并慢性非传染性疾病比例较高,合并癌症、慢性肾脏疾病等慢性病及慢性病类数与生命质量呈负向关联,但这种关联在不同CD4水平HIV/AIDS患者中存在差异,建议对HIV/AIDS患者的慢性病进行预防和早期识别,并加强艾滋病与慢性病卫生服务的联系与整合,对艾滋病和慢性病进行共同管理和控制,以提高目标人群的生命质量。 展开更多
关键词 HIV 艾滋病 中老年 慢性非传染性疾病 患病情况 生命质量
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Design of Underground Load Haul Dump Hybrid Power System Based on QFD and TRIZ
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作者 XU Jun QIAO Sha +3 位作者 MA Xiaowen YUAN Kun QI Wenbo LIU Keyi 《有色金属(中英文)》 北大核心 2025年第3期462-473,共12页
As the mining industry continues to expand and international oil prices increase,more rigorous demands are being placed on the design of mining equipment.Given this,there is an urgent need to develop new power-driven ... As the mining industry continues to expand and international oil prices increase,more rigorous demands are being placed on the design of mining equipment.Given this,there is an urgent need to develop new power-driven mining equipment to solve the problems of high energy consumption and insufficient power coupling of current equipment.This study proposed a design of a hybrid power system for underground Load Haul Dump(LHD).The proposed design integrated Quality Function Deployment(QFD)and Theory of Inventive Problem Solving(TRIZ).It identified 7 user requirements and 10 related technical features,formulated 11 innovative design solutions,and ultimately adopting an electric drive hybrid power scheme.This scheme effectively addressesd power transmission coupling problems and improve the efficiency of loaders.A 6 m³hybrid power loader prototype has been developed,which reduces operational energy consumption and advances the electrification and green,low-carbon evolution of mining equipment. 展开更多
关键词 quality function deployment TRIZ LHD design solution
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An optimal design of the liquid-cooling plate channel in a power battery based on response surface methodology
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作者 Jinbo Zheng Jibin Jiang +2 位作者 Xiwei Yu Bingjun Yan Guofu Lian 《中国科学技术大学学报》 北大核心 2025年第2期52-65,51,I0002,共16页
The work takes a new liquid-cooling plate in a power battery with pin fins inside the channel as the object.A mathematical model is established via the central composite design of the response surface to study the rel... The work takes a new liquid-cooling plate in a power battery with pin fins inside the channel as the object.A mathematical model is established via the central composite design of the response surface to study the relationships among the length,width,height,and spacing of pin fins;the maximum temperature and temperature difference of the battery module;and the pressure drop of the liquid-cooling plate.Model accuracy is verified via variance analysis.The new liquid-cooling plate enables the power battery to work within an optimal temperature range.Appropriately increasing the length,width,and height and reducing the spacing of pin fins could reduce the temperature of the power battery module and improve the temperature uniformity.However,the pressure drop of the liquid-cooling plate increases.The structural parameters of the pin fins are optimized to minimize the maximum temperature and the temperature difference of the battery module as well as the pressure drop of the liquid-cooling plate.The errors between the values predicted and actual by the simulation test are 0.58%,4%,and 0.48%,respectively,which further verifies the model accuracy.The results reveal the influence of the structural parameters of the pin fins inside the liquid-cooling plate on its heat dissipation performance and pressure drop characteristics.A theoretical basis is provided for the design of liquid-cooling plates in power batteries and the optimization of structural parameters. 展开更多
关键词 response surface methodology power battery cooling channel optimal design
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Energy Efficiency Operating Indicator Forecasting and Speed Design Optimization for Polar Ice Class Merchant Vessels
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作者 LU Yu LI Chen−ran +3 位作者 ZHU Xiang−hang LI Shi−an GU Zhu−hao LIU She−wen 《船舶力学》 北大核心 2025年第6期901-911,共11页
In order to accurately forecast the main engine fuel consumption and reduce the Energy Efficiency Operational Indicator(EEOI)of merchant ships in polar ice areas,the energy transfer relationship between ship-machine-p... In order to accurately forecast the main engine fuel consumption and reduce the Energy Efficiency Operational Indicator(EEOI)of merchant ships in polar ice areas,the energy transfer relationship between ship-machine-propeller is studied by analyzing the complex force situation during ship navigation and building a MATLAB/Simulink simulation platform based on multi-environmental resistance,propeller efficiency,main engine power,fuel consumption,fuel consumption rate and EEOI calculation module.Considering the environmental factors of wind,wave and ice,the route is divided into sections,the calculation of main engine power,main engine fuel consumption and EEOI for each section is completed,and the speed design is optimized based on the simulation model for each section.Under the requirements of the voyage plan,the optimization results show that the energy efficiency operation index of the whole route is reduced by 3.114%and the fuel consumption is reduced by 9.17 t. 展开更多
关键词 Energy Efficiency Operational Indicator ice-class ships segment division design optimization
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Study on Approach for Computer-Aided Design and Machining of General Cylindrical Cam Using Relative Velocity and Inverse Kinematics
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作者 Se-Hwan Park Byong-Kook Gu +1 位作者 Joong-Ho Shin Geun-Jong Yoo 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期205-,共1页
Cylindrical Cam Mechanism which is one of the best eq uipments to accomplish an accurate motion transmission is widely used in the fie lds of industries, such as machine tool exchangers, textile machinery and automa t... Cylindrical Cam Mechanism which is one of the best eq uipments to accomplish an accurate motion transmission is widely used in the fie lds of industries, such as machine tool exchangers, textile machinery and automa tic transfer equipments. This paper proposes a new approach for the shape design and manufacturing of the cylindrical cam. The design approach uses the relative velocity concept and the manufacturing approach uses the inverse kinematics concept. For the shape desig n, the contact points between the cam and the follower roller are calculated bas ed on relative velocity of which the direction is on the common tangential line, and then the whole shape of cam is determined from transformation of the coordi nate system. For the manufacturing procedures, the location and the orientation of cutter path can be allocated corresponding to the designed shape data. The in tegral NC code for multi-axis CNC machining center is created using the inverse kinematics concept from the data of the location and the orientation of cutter path. As the advantages of the proposed approach, the machine tool is designed t o having an alternative size in fabricating the general cam, while the tool must be fitted to diameter size of the follower in the conventional approach. Finally, CAD/CAM program, "Cylindrical DAM", is developed on C++ lan guage. This program can perform shape design, manufacturing and kinematics simul ation, which can make integral NC code for multi-axis CNC machining center. The proposed method can be applied easily on fields of industries. 展开更多
关键词 Cylindrical Cam Mechanism(CCM) shape design rel ative velocity method NC Code Multi-axis CNC machining center inverse kinema tics
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Simulation of light environment in a serrated photovoltaic greenhouse and optimization of daylighting roofs based on Design Builder
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作者 LIU Jian WU Xuyong +2 位作者 WANG Baolong WU Qingsen TIAN Libo 《农业工程学报》 北大核心 2025年第7期211-221,共11页
In the tropical regions represented by Hainan,there are abundant solar and thermal resources,and it is relatively suitable for the construction of photovoltaic greenhouse(PVG).However,the construction of PVG still rel... In the tropical regions represented by Hainan,there are abundant solar and thermal resources,and it is relatively suitable for the construction of photovoltaic greenhouse(PVG).However,the construction of PVG still relies mainly on experience and is incapable of quantifying the balance between the photovoltaic(PV)generation and the light requirements for agricultural production.As a result,actual PVGs are primarily PV-based,without carefully considering the needs of agricultural daylighting.To quantify the influence of the design parameters of PVGs and the layout of PV panels on the internal daylighting of serrated PVGs,and to optimize the daylighting design of the roof,this paper utilizes the Design Builder software to establish gradient models for a multi-span serrated-type PVG in tropical regions.Gradient models were established in terms of aspects,namely span,width of longitudinal/transverse daylighting strip,height,roof angle,and photovoltaic panel coverage rate(PCR).Daylighting in the greenhouse of each gradient model was simulated,and with the annual average daily light integral(A_(DLI))and distribution uniformity(DU)as evaluation indicators,the influence of various design parameters on the daylighting inside the greenhouse was quantified.The result reveals that:(1)PCR is the decisive indicator for daylighting in the PVG,and a function between PCR and the A_(DLI) is derived as A_(DLI)=-15.5 PCR+16.841;(2)Increasing the width of longitudinal daylighting strip significantly improves the A_(DLI) and enhances DU while increasing the span has a noticeable effect on improving A_(DLI) but does not significantly enhance DU;(3)Increasing the eave height without changing PCR does not enhance A_(DLI) but effectively improves DU;increasing the transverse daylighting strip and adjusting the roof angle hardly improves A_(DLI).In summary,it is recommended that the optimal span for PVGs in tropical regions be set within the range of 6.5-8.0m,and the eave height be set within the range of 2.5-3.5m.Preferably,the longitudinal daylighting strip with a width ranging from 0.5-0.8m should be installed.Based on the above relationship function,the PCR can be calculated according to the appropriate light demand for the cultivated crops.The daylighting design theory proposed in this paper can provide a theoretical basis and reference for the healthy development of the PV industry in tropical regions. 展开更多
关键词 photovoltaic greenhouse annual average daily light integral greenhouse design parameters DAYLIGHTING tropical regions
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LPI radar sequence design against cyclostationary analysis
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作者 Qiang Liu Fucheng Guo +3 位作者 Kunlai Xiong Xi Li Guizhou Wu Weidong Hu 《Defence Technology(防务技术)》 2025年第3期227-237,共11页
In this paper,we present a novel unimodular sequence design algorithm based on the coordinate descent(CD)algorithm,aimed at countering electronic surveillance(ES)systems based on cyclostationary analysis.Our algorithm... In this paper,we present a novel unimodular sequence design algorithm based on the coordinate descent(CD)algorithm,aimed at countering electronic surveillance(ES)systems based on cyclostationary analysis.Our algorithm not only provides resistance against cyclostationary analysis(CSA)but also maintains low integrated sidelobe(ISL)characteristics.Initially,we derive the expression of the cyclostationary feature(CSF)detector and simplify it into an iterative quadratic form.Additionally,we derive a quadratic form to ensure the similarity of the autocorrelation sidelobes.To balance the minimization of the detection probability and the ISL values,we introduce a Pareto scalar that transforms the multiobjective optimization problem into a convex combination of objective functions.This approach allows us to find an optimal trade-off between the two objectives.Finally,we propose a monotonic algorithm based on the CD algorithm to counter CSA analysis.This algorithm efficiently solves the optimization problem mentioned earlier.Numerical experiments are conducted to validate the correctness and effectiveness of our proposed algorithm. 展开更多
关键词 ISL Waveform design Low probability of intercept(LPI) CSA CD algorithm
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Radar pulse waveform design method based on complementary amplitude coding
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作者 XIE Ailun LIU Xiaobin +3 位作者 WU Qihua ZHAO Feng QIAO Zhenyu XIAO Shunping 《Journal of Systems Engineering and Electronics》 2025年第3期671-680,共10页
Low sidelobe waveform can reduce mutual masking between targets and increase the detection probability of weak targets.A low sidelobe waveform design method based on complementary amplitude coding(CAC)is proposed in t... Low sidelobe waveform can reduce mutual masking between targets and increase the detection probability of weak targets.A low sidelobe waveform design method based on complementary amplitude coding(CAC)is proposed in this paper,which can be used to reduce the sidelobe level of multiple waveforms.First,the CAC model is constructed.Then,the waveform design problem is transformed into a nonlinear optimization problem by constructing an objective function using the two indicators of peak-to-sidelobe ratio(PSLR)and integrated sidelobe ratio(ISLR).Finally,genetic algorithm(GA)is used to solve the optimization problem to get the best CAC waveforms.Simulations and experiments are conducted to verify the effectiveness of the proposed method. 展开更多
关键词 waveform design low sidelobe complementary amplitude coding(CAC) genetic algorithm(GA)
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Design method of high prestressed support for shallow-buried large-span caverns
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作者 JIANG Bei WEI Hua-yong +3 位作者 WANG Qi WANG Ming-zi YIN Chen ZHANG Yan-bo 《Journal of Central South University》 2025年第3期1099-1116,共18页
The surrounding rock is prone to large-scale loosening and failure after the excavation of shallow large-span caverns because of the thin overlying strata and large cross-section span.The rational design of bolt suppo... The surrounding rock is prone to large-scale loosening and failure after the excavation of shallow large-span caverns because of the thin overlying strata and large cross-section span.The rational design of bolt support is very important to the safety control of surrounding rock as a common support means.The control mechanism and design method of bolt support for shallow-buried large-span caverns is carried out.The calculation method of bolt prestress and length based on arched failure and collapsed failure mode is established.The influence mechanism of different influencing factors on the bolt prestress and length is clarified.At the same time,the constant resistance energy-absorbing bolt with high strength and high toughness is developed,and the comparative test of mechanical properties is carried out.On this basis,the design method of high prestressed bolt support for shallow-buried large-span caverns is put forward,and the field test is carried out in Qingdao metro station in China.The monitoring results show that the maximum roof settlement is 6.8 mm after the new design method is adopted,and the effective control of the shallow-buried large-span caverns is realized.The research results can provide theoretical and technical support for the safety control of shallow-buried large-span caverns. 展开更多
关键词 Hoek-Brown strength criterion shallow-buried large-span caverns limit analysis upper bound method high prestress bolt support design method
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HIV/AIDS患者疲乏管理的最佳证据总结
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作者 高会英 钱湘云 +3 位作者 夏兰婷 葛春杏 王美兰 邹美银 《护理学杂志》 北大核心 2025年第12期34-38,共5页
目的总结HIV/AIDS患者疲乏管理相关的最佳证据,为医护人员开展疲乏管理实践提供参考。方法系统检索国内外数据库、专业网站中关于HIV/AIDS患者疲乏管理的相关文献,检索时限为建库至2024年8月1日。由2名研究者对文献质量进行评价,并提取... 目的总结HIV/AIDS患者疲乏管理相关的最佳证据,为医护人员开展疲乏管理实践提供参考。方法系统检索国内外数据库、专业网站中关于HIV/AIDS患者疲乏管理的相关文献,检索时限为建库至2024年8月1日。由2名研究者对文献质量进行评价,并提取相关证据。结果最终纳入14篇文献,包括5篇指南、1篇证据总结、4篇系统评价、4篇随机对照试验。总结了25条最佳证据,归为8个主题:HIV/AIDS患者疲乏筛查及评估、运动干预、心理社会疗法、补充和替代疗法、睡眠管理、药物管理、随访管理、共同决策及多学科协作。结论医护人员应重视HIV/AIDS患者的疲乏管理,结合临床实际情况和患者偏好,实施有效安全的疲乏管理方案,改善患者预后及生活质量。 展开更多
关键词 艾滋病 疲乏 症状管理 证据总结 运动干预 心理社会疗法 循证护理
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HIV/AIDS青少年医疗过渡准备管理的最佳证据总结
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作者 钟汶汐 张曦 +4 位作者 唐建 马李 程静 任建兰 陈燕华 《护理学杂志》 北大核心 2025年第10期40-45,共6页
目的总结10~24岁HIV/AIDS青少年从儿童至成人医疗过渡准备期管理的最佳证据,为政策制定者、临床医护人员及照护者提供参考。方法采用PIPOST模式构建循证问题,依据“6S”金字塔证据模型检索关于HIV/AIDS青少年过渡准备管理的文献,检索时... 目的总结10~24岁HIV/AIDS青少年从儿童至成人医疗过渡准备期管理的最佳证据,为政策制定者、临床医护人员及照护者提供参考。方法采用PIPOST模式构建循证问题,依据“6S”金字塔证据模型检索关于HIV/AIDS青少年过渡准备管理的文献,检索时限为建库至2024年4月。对选定的文献进行质量评价,整合证据条目,评定证据等级。结果共纳入17篇文献。从过渡准备原则(以患者为中心、家庭参与、跨学科支持)、社区资源融合(友好服务、医疗保险、职业发展)、医疗系统协同(信息共享、连贯服务、过渡框架)、个体发展支持(自我管理、心理关怀)和过渡执行动态(共同决策、持续评估)5个维度13个类别汇总出36条证据。结论本研究汇总的HIV/AIDS青少年过渡准备管理的证据具有全面性、科学性和适用性,有助于提升HIV/AIDS青少年过渡准备期的医疗服务质量和健康结果。 展开更多
关键词 艾滋病 获得性免疫缺陷综合征 青少年 过渡准备 医疗过渡 过渡期护理 证据总结 循证护理
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HIV/AIDS肺脾气虚证相关心脑血管疾病风险因素探析 被引量:1
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作者 潘万旗 张淼 +1 位作者 许前磊 郭会军 《中华中医药学刊》 CAS 北大核心 2024年第7期108-111,共4页
目的通过检测血脂四项、血管内皮损伤因子、炎症相关因子,并结合前期的基因芯片结果,初步探讨人类免疫缺陷病毒(HIV)/艾滋病(AIDS)肺脾气虚证相关心脑血管疾病风险因素及机制,为中医药早期干预心脑血管疾病提供依据。方法2020年9月—202... 目的通过检测血脂四项、血管内皮损伤因子、炎症相关因子,并结合前期的基因芯片结果,初步探讨人类免疫缺陷病毒(HIV)/艾滋病(AIDS)肺脾气虚证相关心脑血管疾病风险因素及机制,为中医药早期干预心脑血管疾病提供依据。方法2020年9月—2020年11月选取河南省某地区确诊的20例HIV/AIDS肺脾气虚证患者作为研究对象,同地区20例HIV抗体阴性作为健康对照组。检测CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)计数,并计算CD_(4)^(+)/CD_(8)^(+)比值;检测血脂四项甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C);检测氧化低密度脂蛋白(Ox-LDL)、载脂蛋白A-I(ApoAⅠ)、载脂蛋白A-Ⅱ(ApoAⅡ)、载脂蛋白B(ApoB)、锌-α2-糖蛋白1(AZGP1)、可溶性血栓调节蛋白(sTM)、血管性血友病因子(vWF)、脂联素、瘦素(LEP)、超敏C反应蛋白(Hs-CRP)、单核细胞趋化因子1(MCP-1)、肿瘤坏死因子α(TNF-α)。结果HIV/AIDS肺脾气虚证患者与健康对照组比较CD_(4)^(+)降低,CD_(4)^(+)/CD_(8)^(+)比值倒置,TC降低,sTM、AZGP1、Ox-LDL、Hs-CRP升高。结论HIV/AIDS肺脾气虚证患者存在炎性反应、血脂异常的表现,罹患心脑血管疾病风险增加。为中医药早期干预心脑血管疾病的发生提供新思路。 展开更多
关键词 HIV/aidS 肺脾气虚证 心脑血管疾病 风险因素
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武汉市1994~2022年HIV感染者/AIDS患者的生存时间及其影响因素 被引量:2
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作者 谢年华 闫晗 +3 位作者 马红飞 翁秀芳 王夏 刘毅俊 《华中科技大学学报(医学版)》 CAS CSCD 北大核心 2024年第5期641-646,共6页
目的分析武汉市1994~2022年HIV感染者/AIDS患者(HIV/AIDS)生存时间及其影响因素,为进一步制定防治策略提供依据。方法收集国家艾滋病综合防治信息系统中武汉市1994~2022年直报的常住HIV/AIDS流行病学调查和抗病毒治疗数据,采用寿命表法... 目的分析武汉市1994~2022年HIV感染者/AIDS患者(HIV/AIDS)生存时间及其影响因素,为进一步制定防治策略提供依据。方法收集国家艾滋病综合防治信息系统中武汉市1994~2022年直报的常住HIV/AIDS流行病学调查和抗病毒治疗数据,采用寿命表法、Cox比例风险回归模型对生存时间及其影响因素进行分析。结果纳入研究的8954例HIV/AIDS共随访47245.4人年,全死因死亡1078例,中位生存时间22.3年;第1、5、10、15、20年生存率分别为92.9%、88.5%、83.5%、78.7%、73.8%;Cox比例风险回归模型分析结果显示,未治疗、男性、较大年龄、无职业、低文化程度、本地户籍、异性性行为传播及注射吸毒传播、医疗机构检测发现及较低CD4基线水平是影响HIV/AIDS生存时间的危险因素,未治疗患者死亡风险为已治疗患者的13.979倍(95%CI:11.883~16.446),无职业患者死亡风险为有职业患者的1.140倍(95%CI:1.004~1.295),本地患者死亡风险是流动人口1.682倍(95%CI:1.415~2.000),医疗机构检测发现的患者死亡风险是自愿咨询检测患者的1.823倍(95%CI:1.421~2.339)。结论应针对50岁及以上、无职业、低文化程度、医疗机构检测发现及低CD4基线水平等危险因素,开展宣传教育提升大众对艾滋病的科学认识,并通过医防协同、社会组织参与等方式促进早检测、早治疗;充分利用HIV/AIDS人群健康大数据,形成多维度全生命周期健康档案,针对不同个体提供包括心理干预在内的精准医疗,延长生存时间和提高生活质量是今后努力的方向。 展开更多
关键词 艾滋病 生存分析 影响因素
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水田动力底盘逆向建模与质心验证——基于Geomagic Design X
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作者 何剑飞 曾志浩 +5 位作者 郭梓游 李贵蓉 钟文能 钟顺 王在满 李庆 《农机化研究》 北大核心 2024年第10期248-253,共6页
针对目前农业机械仿真和优化模型精度不高的问题,提出了一种构建精确模型的逆向建模方法。应用光学扫描仪采集点云数据,基于Geomagic Design X处理点云数据并重构零部件模型,在SolidWorks中完成水田动力底盘的装配。以VP6D-CQ型水田动... 针对目前农业机械仿真和优化模型精度不高的问题,提出了一种构建精确模型的逆向建模方法。应用光学扫描仪采集点云数据,基于Geomagic Design X处理点云数据并重构零部件模型,在SolidWorks中完成水田动力底盘的装配。以VP6D-CQ型水田动力底盘为例,将测得的实际质心位置与所建的模型质心位置进行比较,并对提出的逆向建模方法进行了试验验证以及误差分析。结果表明:总质量、x坐标、y坐标、z坐标的误差值分别为4.55%、3.62%、2.23%、4.81%,误差值均在5%内。此方法可构建准确的三维模型,为后续仿真优化数据精确性奠定了基础,与传统的研发相比较,可缩短农业机械研发周期、降低设计成本。 展开更多
关键词 水田 动力底盘 逆向建模 质心验证 Geomagic design X 数字样机
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