The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly effi...The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly efficient photothermal conversion gold nanorods and a temperature-responsive probe((E)-4-(4-(diethylamino)styryl)-1-methylpyridin-1-ium,PyS)within MOF-199,an intelligent nanoplatform(AMPP)was fabricated for simultaneous chemodynamic therapy and NIR light-induced temperature-feedback PTT.The fluorescence intensity and temperature of the PyS probe are linearly related due to the restriction of the rotation of the characteristic monomethine bridge.Moreover,the copper ions resulting from the degradation of MOF-199 in an acidic microenvironment can convert H_(2)O_(2)into•OH,resulting in tumor ablation through a Fenton-like reaction,and this process can be accelerated by increasing the temperature.This study establishes a feasible platform for fabricating highly sensitive temperature sensors for efficient temperature-feedback PTT.展开更多
本文基于Web of Science数据库,借助CiteSpace软件,对1996—2024年国外发表的二语写作反馈研究的趋势、特点与热点话题进行分析。结果显示,国外二语写作反馈研究在数量上整体呈现增长趋势,多发表于语言学和教育学期刊,并明显具有与心理...本文基于Web of Science数据库,借助CiteSpace软件,对1996—2024年国外发表的二语写作反馈研究的趋势、特点与热点话题进行分析。结果显示,国外二语写作反馈研究在数量上整体呈现增长趋势,多发表于语言学和教育学期刊,并明显具有与心理学、计算机科学跨学科融合的特点。研究以反馈有效性争论为起点,经历了从外部因素到学习者内在心理因素、从反馈效果到反馈过程、从微观视角到宏观视域、从师生反馈到数智赋能反馈的4次转向。未来国内二语写作反馈研究可以采用动态、宏观的视角,基于技术接受与使用整合理论等探究写作自动评估系统和大语言模型反馈对二语写作表现的影响,重视学习者认知和情感个体差异因素及反馈投入,考察学习者和教师的反馈素养,改进数据收集方法,合理运用眼动、键盘记录和脑成像等技术进行深入研究。展开更多
基金supported by the National Natural Science Foundation of China(22171001,22305001,51972001,52372073)the Natural Science Foundation of Anhui Province of China(2108085MB49).
文摘The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly efficient photothermal conversion gold nanorods and a temperature-responsive probe((E)-4-(4-(diethylamino)styryl)-1-methylpyridin-1-ium,PyS)within MOF-199,an intelligent nanoplatform(AMPP)was fabricated for simultaneous chemodynamic therapy and NIR light-induced temperature-feedback PTT.The fluorescence intensity and temperature of the PyS probe are linearly related due to the restriction of the rotation of the characteristic monomethine bridge.Moreover,the copper ions resulting from the degradation of MOF-199 in an acidic microenvironment can convert H_(2)O_(2)into•OH,resulting in tumor ablation through a Fenton-like reaction,and this process can be accelerated by increasing the temperature.This study establishes a feasible platform for fabricating highly sensitive temperature sensors for efficient temperature-feedback PTT.
文摘本文基于Web of Science数据库,借助CiteSpace软件,对1996—2024年国外发表的二语写作反馈研究的趋势、特点与热点话题进行分析。结果显示,国外二语写作反馈研究在数量上整体呈现增长趋势,多发表于语言学和教育学期刊,并明显具有与心理学、计算机科学跨学科融合的特点。研究以反馈有效性争论为起点,经历了从外部因素到学习者内在心理因素、从反馈效果到反馈过程、从微观视角到宏观视域、从师生反馈到数智赋能反馈的4次转向。未来国内二语写作反馈研究可以采用动态、宏观的视角,基于技术接受与使用整合理论等探究写作自动评估系统和大语言模型反馈对二语写作表现的影响,重视学习者认知和情感个体差异因素及反馈投入,考察学习者和教师的反馈素养,改进数据收集方法,合理运用眼动、键盘记录和脑成像等技术进行深入研究。
