RISC-V作为一种新兴的开源精简指令集架构,是后摩尔时代处理器技术发展与创新的关键之一.浮点求和与点积运算是数值运算的基础组成部分,在众多领域应用广泛.目前RISC-V架构尚未适配兼具高精度和高效率的求和与点积运算算法,这是因为现...RISC-V作为一种新兴的开源精简指令集架构,是后摩尔时代处理器技术发展与创新的关键之一.浮点求和与点积运算是数值运算的基础组成部分,在众多领域应用广泛.目前RISC-V架构尚未适配兼具高精度和高效率的求和与点积运算算法,这是因为现有优化方案难以良好地平衡运算精度和效率,要么侧重于低精度算法效率,要么通过牺牲效率实现高精度运算.本文利用RVV(RISC-V Vector instruction set extension,RVV)矢量扩展指令,设计并实现了一种基于无误差变换技术的高效、高精度求和与点积算法.首先避免使用规约指令以防止运算精度降低,实现并优化两类运算基于RVV的向量化算法;其次根据算法中的数据依赖关系,对寄存器配置参数进行优化.最后针对算法核心步骤进行汇编优化,增加指令级并行度,提高流水线利用率.实验结果表明,与两类运算操作的原始算法相比,优化后的算法运算效率分别提高了4.4和4.2倍.优化后的算法与多精度库MPFR中的四精度算法有相同精度,但其运算效率明显优于后者,其计算速度与OpenBLAS的双精度计算速度相当.展开更多
OBJECTIVE To investigate the effect and the mechanisms of realgar transforming solution(RTS)on down-regulating over activated ras.METHODS we used the optimizing technical processes to obtain the RTS,and eval⁃uate the ...OBJECTIVE To investigate the effect and the mechanisms of realgar transforming solution(RTS)on down-regulating over activated ras.METHODS we used the optimizing technical processes to obtain the RTS,and eval⁃uate the mechanisms of RTS on down-regulating overactivated ras in Caenorhabditis elegans.RESULTS We found that the mRNA level of let60 and lin45 significantly decreased following exposure to RTS,but mRNA levels of mpk1 were not statistically significant in let60/ras(gf)mutant.RTS together with sorafenib(RAF inhibitors)significantly enhanced the activity of RTS on down-regulating overactivated ras more than RTS only,but 50μmol·L^-1 PD98059,a specific ERK inhibitor did not.Lin45 gene RNAi decreased the ability of RTS on down-regulating overactivated ras significantly,but mpk1 gene RNAi did not,indicating that the activity of RTS on down-regulating overactivated ras mainly through targeting to lin45/raf.In addition,RTS significantly increased mRNA level of pmk1/p38 and jnk1/jnk in let-60/ras(gf)mutant,50μmol·L^-1 SB203580(p38 inhibitor)and SP600125(JNK inhibitor)significantly attenuated the effects of RTS on down-regulating overactivated ras in some degree,and pmk1,jnk1 gene RNAi displayed the similar results,suggesting that P38 and JNK/MAPK pathways in some degree were involved in the effects of RTS on down-regulating overactivated ras in C.ele⁃gans.CONCLUSION Realgar transforming solution down-regulate the Ras/MAPK pathway through JNK and P38 MAPK pathways.展开更多
针对无边缘主动轮廓模型(Active contours without edges,C-V)难以分割灰度分布不均匀的甲状腺超声图像,本文提出结合局部信息改进的C-V超声图像分割模型。该方法根据局部信息具有不受灰度分布影响的拟合特性,利用图像局部拟合信息构造...针对无边缘主动轮廓模型(Active contours without edges,C-V)难以分割灰度分布不均匀的甲状腺超声图像,本文提出结合局部信息改进的C-V超声图像分割模型。该方法根据局部信息具有不受灰度分布影响的拟合特性,利用图像局部拟合信息构造一种新的速度函数,使速度函数依据图像局部灰度变化控制曲线的演化速率;然后将该速度函数引入到C-V模型中,具有全局分割能力。实验结果表明,本文方法可以实现对灰度分布不均匀的甲状腺肿瘤超声图像的准确分割,且分割效率也有所提高。展开更多
文摘RISC-V作为一种新兴的开源精简指令集架构,是后摩尔时代处理器技术发展与创新的关键之一.浮点求和与点积运算是数值运算的基础组成部分,在众多领域应用广泛.目前RISC-V架构尚未适配兼具高精度和高效率的求和与点积运算算法,这是因为现有优化方案难以良好地平衡运算精度和效率,要么侧重于低精度算法效率,要么通过牺牲效率实现高精度运算.本文利用RVV(RISC-V Vector instruction set extension,RVV)矢量扩展指令,设计并实现了一种基于无误差变换技术的高效、高精度求和与点积算法.首先避免使用规约指令以防止运算精度降低,实现并优化两类运算基于RVV的向量化算法;其次根据算法中的数据依赖关系,对寄存器配置参数进行优化.最后针对算法核心步骤进行汇编优化,增加指令级并行度,提高流水线利用率.实验结果表明,与两类运算操作的原始算法相比,优化后的算法运算效率分别提高了4.4和4.2倍.优化后的算法与多精度库MPFR中的四精度算法有相同精度,但其运算效率明显优于后者,其计算速度与OpenBLAS的双精度计算速度相当.
文摘OBJECTIVE To investigate the effect and the mechanisms of realgar transforming solution(RTS)on down-regulating over activated ras.METHODS we used the optimizing technical processes to obtain the RTS,and eval⁃uate the mechanisms of RTS on down-regulating overactivated ras in Caenorhabditis elegans.RESULTS We found that the mRNA level of let60 and lin45 significantly decreased following exposure to RTS,but mRNA levels of mpk1 were not statistically significant in let60/ras(gf)mutant.RTS together with sorafenib(RAF inhibitors)significantly enhanced the activity of RTS on down-regulating overactivated ras more than RTS only,but 50μmol·L^-1 PD98059,a specific ERK inhibitor did not.Lin45 gene RNAi decreased the ability of RTS on down-regulating overactivated ras significantly,but mpk1 gene RNAi did not,indicating that the activity of RTS on down-regulating overactivated ras mainly through targeting to lin45/raf.In addition,RTS significantly increased mRNA level of pmk1/p38 and jnk1/jnk in let-60/ras(gf)mutant,50μmol·L^-1 SB203580(p38 inhibitor)and SP600125(JNK inhibitor)significantly attenuated the effects of RTS on down-regulating overactivated ras in some degree,and pmk1,jnk1 gene RNAi displayed the similar results,suggesting that P38 and JNK/MAPK pathways in some degree were involved in the effects of RTS on down-regulating overactivated ras in C.ele⁃gans.CONCLUSION Realgar transforming solution down-regulate the Ras/MAPK pathway through JNK and P38 MAPK pathways.
文摘针对无边缘主动轮廓模型(Active contours without edges,C-V)难以分割灰度分布不均匀的甲状腺超声图像,本文提出结合局部信息改进的C-V超声图像分割模型。该方法根据局部信息具有不受灰度分布影响的拟合特性,利用图像局部拟合信息构造一种新的速度函数,使速度函数依据图像局部灰度变化控制曲线的演化速率;然后将该速度函数引入到C-V模型中,具有全局分割能力。实验结果表明,本文方法可以实现对灰度分布不均匀的甲状腺肿瘤超声图像的准确分割,且分割效率也有所提高。
基金国家自然科学基金(the National Natural Science Foundation of China under Grant No.60773172)香港特区政府研究资助局研究项目(No.CUHK/4185/00E)+2 种基金香港中文大学研究基金(No.2050345)江苏省青蓝工程南京信息工程大学科研基金
