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Box-Behnken响应面法结合层次分析法优化萸仙茅炮制工艺
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作者 徐国伟 王巍 +3 位作者 刘思翰 洪艺丹 张立强 鞠成国 《中国中医药信息杂志》 CAS 2025年第1期134-139,共6页
目的优选萸仙茅炮制工艺。方法在单因素试验基础上,以料液比、炒制时间和炒制温度为影响因素,以仙茅苷、苔黑酚葡萄糖苷、苔黑酚龙胆二糖苷含量及外观性状的综合评分为评价指标,利用Box-Behnken响应面法结合层次分析法优化萸仙茅最佳炮... 目的优选萸仙茅炮制工艺。方法在单因素试验基础上,以料液比、炒制时间和炒制温度为影响因素,以仙茅苷、苔黑酚葡萄糖苷、苔黑酚龙胆二糖苷含量及外观性状的综合评分为评价指标,利用Box-Behnken响应面法结合层次分析法优化萸仙茅最佳炮制工艺,并进行工艺验证。结果萸仙茅最佳炮制工艺为:取生仙茅饮片,加入等量吴茱萸汁拌匀,置密闭容器内,闷润至药汁被完全吸尽,于130℃炒制6min,取出,60℃干燥。每100kg仙茅用吴茱萸10kg。吴茱萸汁制法:取吴茱萸10kg,加12倍量水浸泡60min,煎煮50min,提取3次,合并滤液,浓缩至100kg。结论本研究优化所得萸仙茅的炮制工艺可行、稳定。 展开更多
关键词 萸仙茅 box-behnken响应面法 层次分析法 炮制工艺
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基于Box-Behnken设计-响应面法优化败毒止泻提取物制备工艺研究 被引量:1
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作者 房思远 赵兵令 +2 位作者 郗艳菊 朱永明 李辰荃 《中兽医医药杂志》 2025年第1期73-79,共7页
为探索败毒止泻提取物的合理提取工艺,提高秦皮甲素和秦皮乙素总含量以及复方浸出物出膏率,选择影响试验指标的提取次数、提取时间、加水量等3个核心因素进行单因素试验,以最优单因素为影响因子,采用Box-Behnken中心组合设计建立数学模... 为探索败毒止泻提取物的合理提取工艺,提高秦皮甲素和秦皮乙素总含量以及复方浸出物出膏率,选择影响试验指标的提取次数、提取时间、加水量等3个核心因素进行单因素试验,以最优单因素为影响因子,采用Box-Behnken中心组合设计建立数学模型,考察相关参数对综合评分的影响程度。结果表明,败毒止泻提取物的最佳提取条件为提取3次,提取时间为1.5 h,加水量为12倍水;模型预测综合评分为96.932,验证值为96.757,理论值与验证值相对误差为0.18%。优化后的败毒止泻提取物标准工艺为中试生产转化以及临床使用的顺应性奠定了基础。 展开更多
关键词 败毒止泻提取物 box-behnken响应面法 综合评分
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基于AHP-EWM结合Box-Behnken设计响应面法优选丹参提取工艺
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作者 程深烨 徐国全 +3 位作者 陈翰文 张福明 高子涵 宋兆辉 《天津药学》 2025年第2期147-154,共8页
目的 优选丹参提取工艺,为后续放大生产提供实验依据。方法 采用层次分析法(AHP)-熵权法(EWM)结合的评价方法,以丹参中紫草酸、迷迭香酸、丹酚酸B综合评分为评价指标,使用超高效液相色谱仪(UPLC)作为检测工具,以上样温度、酸洗pH、醇洗... 目的 优选丹参提取工艺,为后续放大生产提供实验依据。方法 采用层次分析法(AHP)-熵权法(EWM)结合的评价方法,以丹参中紫草酸、迷迭香酸、丹酚酸B综合评分为评价指标,使用超高效液相色谱仪(UPLC)作为检测工具,以上样温度、酸洗pH、醇洗浓度、浓缩温度为影响因素进行单因素试验,利用单因素试验筛选关键工艺参数(CPP)。通过Box-Behnken响应面法设计试验,优选丹参提取工艺,并对提取工艺进行验证。结果 丹参最优提取工艺为上样温度35℃,酸洗pH 3.05,醇洗浓度80%,综合评分99.15。结论 采用Box-Behnken响应面法建立的模型相对准确,优选出的最佳工艺条件经验证,有效成分综合评分及出膏率均优于原工艺,可适用于丹参提取,为后续放大生产奠定基础。 展开更多
关键词 丹参 提取工艺 层次分析法 熵权法 综合评分 box-behnken响应面法
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一种基于Least Square Method算法的城轨车辆车门动作时间精准判断的研究
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作者 李宏菱 宋华杰 +3 位作者 马仲智 周辉 李晴 陈龙 《时代汽车》 2025年第3期190-192,共3页
为研究城市轨道交通车辆客室车门动作时间精准性,门的动作主要依靠直流无刷电机的驱动,所以门动作判断的根本,是对电机运动状态的判读,门运动过程中由于电机码盘线受杂波干扰,系统无法准确寻找计时点从而影响系统判断门运动时间;建立波... 为研究城市轨道交通车辆客室车门动作时间精准性,门的动作主要依靠直流无刷电机的驱动,所以门动作判断的根本,是对电机运动状态的判读,门运动过程中由于电机码盘线受杂波干扰,系统无法准确寻找计时点从而影响系统判断门运动时间;建立波形矫正模型,利用数学方法校准波形,让MCU找出最佳计时点并处理(误差不超过10ms),采用最小二乘法模型,通过最小化误差的平方和找到一组数据的最佳函数匹配,求得未知的数据,并使得这些求得的数据与实际数据之间误差的平方和为最小,可精准地得到门动作时间。模拟测试结果表明,门动作时间测算误差所示其误差为7.42ms,小于10ms。 展开更多
关键词 城轨车辆 客室车门 电机码盘 Least Square method算法 门动作时间精准
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Box-Behnken设计优化鸡腿堇菜总黄酮超声提取工艺及抗氧化活性研究
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作者 张桂娟 李大亮 +5 位作者 吕文博 徐丹鸿 李明涛 宋世杰 曹鑫桐 陈鑫 《食品与发酵科技》 2025年第1期80-87,共8页
考察超声提取温度、乙醇浓度、超声提取功率、料液比、超声提取时间5个因素对鸡腿堇菜总黄酮得率的影响,采用Box-Behnken响应面分析法优化超声波提取鸡腿堇菜总黄酮工艺,并通过DPPH自由基清除能力考察鸡腿堇菜总黄酮提取物的抗氧化活性... 考察超声提取温度、乙醇浓度、超声提取功率、料液比、超声提取时间5个因素对鸡腿堇菜总黄酮得率的影响,采用Box-Behnken响应面分析法优化超声波提取鸡腿堇菜总黄酮工艺,并通过DPPH自由基清除能力考察鸡腿堇菜总黄酮提取物的抗氧化活性。结果表明,鸡腿堇菜总黄酮提取最优工艺为:超声提取温度56℃、乙醇浓度48%、超声提取功率300 W、料液比1∶26 g/mL、超声提取时间60 min,在此条件下鸡腿堇菜总黄酮得率为(2.83±0.02)%,鸡腿堇菜总黄酮提取量为28.35 mg/g;抗氧化试验结果表明鸡腿堇菜总黄酮提取物清除DPPH自由基的IC50值为0.32 mg/mL,清除作用随着质量浓度的增大而升高,当质量浓度为6 mg/mL时清除率可达92.08%,表明鸡腿堇菜总黄酮提取物具有良好的抗氧化活性。研究结果为系统研究及开发鸡腿堇菜植物资源提供理论依据及技术参考。 展开更多
关键词 响应面法 鸡腿堇菜 总黄酮 提取工艺 抗氧化活性
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An efficient and accurate numerical method for simulating close-range blast loads of cylindrical charges based on neural network
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作者 Ting Liu Changhai Chen +2 位作者 Han Li Yaowen Yu Yuansheng Cheng 《Defence Technology(防务技术)》 2025年第2期257-271,共15页
To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based sim... To address the problems of low accuracy by the CONWEP model and poor efficiency by the Coupled Eulerian-Lagrangian(CEL)method in predicting close-range air blast loads of cylindrical charges,a neural network-based simulation(NNS)method with higher accuracy and better efficiency was proposed.The NNS method consisted of three main steps.First,the parameters of blast loads,including the peak pressures and impulses of cylindrical charges with different aspect ratios(L/D)at different stand-off distances and incident angles were obtained by two-dimensional numerical simulations.Subsequently,incident shape factors of cylindrical charges with arbitrary aspect ratios were predicted by a neural network.Finally,reflected shape factors were derived and implemented into the subroutine of the ABAQUS code to modify the CONWEP model,including modifications of impulse and overpressure.The reliability of the proposed NNS method was verified by related experimental results.Remarkable accuracy improvement was acquired by the proposed NNS method compared with the unmodified CONWEP model.Moreover,huge efficiency superiority was obtained by the proposed NNS method compared with the CEL method.The proposed NNS method showed good accuracy when the scaled distance was greater than 0.2 m/kg^(1/3).It should be noted that there is no need to generate a new dataset again since the blast loads satisfy the similarity law,and the proposed NNS method can be directly used to simulate the blast loads generated by different cylindrical charges.The proposed NNS method with high efficiency and accuracy can be used as an effective method to analyze the dynamic response of structures under blast loads,and it has significant application prospects in designing protective structures. 展开更多
关键词 Close-range air blast load Cylindrical charge Numerical method Neural network CEL method CONWEP model
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基于Box-Behnken响应面法优化泽兰合剂制备工艺
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作者 肖娟 李江 +4 位作者 黄梅 王有福 李正芬 徐智 余晓玲 《中国医药导报》 2025年第5期36-41,共6页
目的优化泽兰合剂制备工艺。方法以芍药苷转移率和干膏得率的综合评分为评价指标,考察料液比、提取时间和提取次数对提取工艺的影响,利用Box-Behnken响应面法优化提取工艺。以芍药苷含量和干膏得率为评价指标,考察减压浓缩和常压浓缩两... 目的优化泽兰合剂制备工艺。方法以芍药苷转移率和干膏得率的综合评分为评价指标,考察料液比、提取时间和提取次数对提取工艺的影响,利用Box-Behnken响应面法优化提取工艺。以芍药苷含量和干膏得率为评价指标,考察减压浓缩和常压浓缩两种不同浓缩方式,并加以澄清度为评价指标,来筛选离心纯化方式。结果最佳工艺条件为提取时间1.5 h,料液比为1∶10,提取2次;浓缩工艺为减压浓缩(70℃,-0.06~-0.08 mPa);纯化工艺为10000 r/min离心20 min。结论该优化工艺方法简便,准确可靠,可为泽兰合剂及同类制剂提取工艺的优化提供参考和依据。 展开更多
关键词 泽兰合剂 提取工艺 box-behnken响应面法 芍药苷 干膏得率
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Stability Analysis of a Floating Multirobot Coordinated Towing System Based on the Stability Cone Method
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作者 Xiangtang Zhao Zhigang Zhao +1 位作者 Cheng Su Jiadong Meng 《哈尔滨工程大学学报(英文版)》 2025年第2期449-457,共9页
Currently,the cranes used at sea do not have enough flexibility,efficiency,and safety.Thus,this study proposed a floating multirobot coordinated towing system to meet the demands for offshore towing.Because of the fle... Currently,the cranes used at sea do not have enough flexibility,efficiency,and safety.Thus,this study proposed a floating multirobot coordinated towing system to meet the demands for offshore towing.Because of the flexibility of rope-driven robots,the one-way pulling characteristics of the rope,and the floating characteristics of the base,towing robots are easily overturned.First,the spatial configuration of the towing system was established according to the towing task,and the kinematic model of the towing system was established using the coordinate transformation.Then,the dynamic model of the towing system was established according to the rigid-body dynamics and hydrodynamic theory.Finally,the stability of the towing system was analyzed using the stability cone method.The simulation experiments provide a reference for the practical application of the floating multirobot coordinated towing system,which can improve the stability of towing systems by changing the configuration of the towing robot. 展开更多
关键词 Offshore towing Kinematic model Dynamic model Stability cone method STABILITY
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A Review of the Hydrodynamic Damping Characteristics of Blade-like Structures:Focus on the Quantitative Identification Methods and Key Influencing Parameters
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作者 Yongshun Zeng Zhaohui Qian +1 位作者 Jiayun Zhang Zhifeng Yao 《哈尔滨工程大学学报(英文版)》 2025年第1期21-34,共14页
Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.Howev... Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.However,the widened hydraulic excitation frequency may satisfy the blade resonance due to the time variation in the velocity and angle of attack of the ocean current,even resulting in blade fatigue and destructively interfering with grid stability.A key parameter that determines the resonance amplitude of the blade is the hydrodynamic damping ratio(HDR).However,HDR is difficult to obtain due to the complex fluid-structure interaction(FSI).Therefore,a literature review was conducted on the hydrodynamic damping characteristics of blade-like structures.The experimental and simulation methods used to identify and obtain the HDR quantitatively were described,placing emphasis on the experimental processes and simulation setups.Moreover,the accuracy and efficiency of different simulation methods were compared,and the modal work approach was recommended.The effects of key typical parameters,including flow velocity,angle of attack,gap,rotational speed,and cavitation,on the HDR were then summarized,and the suggestions on operating conditions were presented from the perspective of increasing the HDR.Subsequently,considering multiple flow parameters,several theoretical derivations and semi-empirical prediction formulas for HDR were introduced,and the accuracy and application were discussed.Based on the shortcomings of the existing research,the direction of future research was finally determined.The current work offers a clear understanding of the HDR of blade-like structures,which could improve the evaluation accuracy of flow-induced vibration in the design stage. 展开更多
关键词 Blade fatigue Hydrodynamic damping ratio Identification method Affecting factors Prediction formula
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Interfacial modulation of nano Li_(7)La_(3)Zr_(2)O_(12) composite electrolytes prepared by solvent-free method
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作者 Qigao Han Yaqing Guo +9 位作者 Fuhe Wang Xuechun Lou Fengqian Wang Jun Zhong Jinqiao Du Jie Tian Weixin Zhang Shun Tang Shijie Cheng Yuancheng Cao 《Green Energy & Environment》 2025年第3期528-536,共9页
Solid-state batteries(SSBs) with high safety are promising for the energy fields,but the development has long been limited by machinability and interfacial problems.Hence,self-supporting,flexible Nano LLZO CSEs are pr... Solid-state batteries(SSBs) with high safety are promising for the energy fields,but the development has long been limited by machinability and interfacial problems.Hence,self-supporting,flexible Nano LLZO CSEs are prepared with a solvent-free method at 25℃.The 99.8 wt% contents of Nano LLZO particles enable the Nano LLZO CSEs to maintain good thermal stability while exhibiting a wide electrochemical window of 5.0 V and a high Li~+ transfer number of 0.8.The mean modulus reaches 4376 MPa.Benefiting from the interfacial modulation,the Li|Li symmetric batteries based on the Nano LLZO CSEs show benign stability with lithium at the current densities of 0.1 mA cm^(-2),0.2 mA cm^(-2),and 0.5 mA cm^(-2).In addition,the Li|LiFePO_(4)(LFP) SSBs achieve favorable cycling performance:the specific capacity reaches128.1 mAh g^(-1) at 0.5 C rate,with a capacity retention of about 80% after 600 cycles.In the further tests of the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) cathodes with higher energy density,the Nano LLZO CSEs also demonstrate good compatibility:the specific capacities of NCM811-based SSBs reach 177.9 mAh g^(-1) at 0.5 C rate,while the capacity retention is over 96% after 150 cycles.Furthermore,the Li|LFP soft-pack SSBs verify the safety characteristics and the potential for application,which have a desirable prospect. 展开更多
关键词 Solvent-free method Nano LLZO CSEs Interfacial modulation Cycling performance Safety characteristics
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Investigation into enhancing the sensitivity method for monitoring trace erosion product concentration in the ceramic channel of a Hall thruster
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作者 Wei XI Ximing ZHU +2 位作者 Bowen ZHENG Zhongxi NING Daren YU 《Plasma Science and Technology》 2025年第4期95-104,共10页
An optical emission spectroscopy(OES)method with a non-invasive measurement capability,without inducing disturbance to the discharge,represents an effective method for material monitoring.However,when the OES method i... An optical emission spectroscopy(OES)method with a non-invasive measurement capability,without inducing disturbance to the discharge,represents an effective method for material monitoring.However,when the OES method is employed to monitor the trace erosion product within the ceramic channel of a Hall thruster,it becomes challenging to distinguish between signal and noise.In this study,we propose a model filtering method based on the signal characteristics of the Hall thruster plume spectrometer.This method integrates the slit imaging and spectral resolution features of the spectrometer.Employing this method,we extract the spectral signals of the erosion product and working gas from the Hall thruster under different operating conditions.The results indicate that our new method performs comparably to the traditional method without model filtering when extracting atom signals from strong xenon working gas.However,for trace amounts of the erosion product,our approach significantly enhances the signal-to-noise ratio(SNR),enabling the identification of extremely weak spectral signals even under low mass flow rate and low-voltage conditions.We obtain boron atom concentration of 3.91×10^(-3) kg/m^(3) at a mass flow rate of 4×10^(-7) kg/s and voltage of 200 V while monitoring a wider range of thruster operating conditions.The new method proposed in this study is suitable for monitoring other low-concentration elements,making it valuable for materials processing,environmental monitoring and space propulsion applications. 展开更多
关键词 model filtering method optical emission spectroscopy Hall thruster advanced actinometry method trace erosion product concentration(Some figures may appear in colour only in the online journal)
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A program for modeling the RF wave propagation of ICRF antennas utilizing the finite element method
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作者 Lei-Yu Zhang Yi-Xuan Li +1 位作者 Ming-Yue Han Quan-Zhi Zhang 《Chinese Physics B》 2025年第4期154-160,共7页
Controlled nuclear fusion represents a significant solution for future clean energy,with ion cyclotron range of frequency(ICRF)heating emerging as one of the most promising technologies for heating the fusion plasma.T... Controlled nuclear fusion represents a significant solution for future clean energy,with ion cyclotron range of frequency(ICRF)heating emerging as one of the most promising technologies for heating the fusion plasma.This study primarily presents a self-developed 2D ion cyclotron resonance antenna electromagnetic field solver(ICRAEMS)code implemented on the MATLAB platform,which solves the electric field wave equation by using the finite element method,establishing perfectly matched layer(PML)boundary conditions,and post-processing the electromagnetic field data.This code can be utilized to facilitate the design and optimization processes of antennas for ICRF heating technology.Furthermore,this study examines the electric field distribution and power spectrum associated with various antenna phases to investigate how different antenna configurations affect the electromagnetic field propagation and coupling characteristics. 展开更多
关键词 ion cyclotron range of frequency(ICRF)antennas finite element method perfect matching layer
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A MIXED FINITE ELEMENT AND UPWIND MIXED FINITE ELEMENT MULTI-STEP METHOD FOR THE THREE-DIMENSIONAL POSITIVE SEMI-DEFINITE DARCY-FORCHHEIMER MISCIBLE DISPLACEMENT PROBLEM
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作者 Yirang YUAN Changfeng LI +1 位作者 Huailing SONG Tongjun SUN 《Acta Mathematica Scientia》 2025年第2期715-736,共22页
In this paper,a composite numerical scheme is proposed to solve the threedimensional Darcy-Forchheimer miscible displacement problem with positive semi-definite assumptions.A mixed finite element is used for the fow e... In this paper,a composite numerical scheme is proposed to solve the threedimensional Darcy-Forchheimer miscible displacement problem with positive semi-definite assumptions.A mixed finite element is used for the fow equation.The velocity and pressure are computed simultaneously.The accuracy of velocity is improved one order.The concentration equation is solved by using mixed finite element,multi-step difference and upwind approximation.A multi-step method is used to approximate time derivative for improving the accuracy.The upwind approximation and an expanded mixed finite element are adopted to solve the convection and diffusion,respectively.The composite method could compute the diffusion flux and its gradient.It possibly becomes an eficient tool for solving convection-dominated diffusion problems.Firstly,the conservation of mass holds.Secondly,the multi-step method has high accuracy.Thirdly,the upwind approximation could avoid numerical dispersion.Using numerical analysis of a priori estimates and special techniques of differential equations,we give an error estimates for a positive definite problem.Numerical experiments illustrate its computational efficiency and feasibility of application. 展开更多
关键词 Darcy-Forchheimer fow three-dimensional positive semi-definite problem upwind mixed finite element multi-step method conservation of mass convergence analysis
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A novel method for simultaneous measurement of^(222)Rn and^(220)Rn progeny concentrations measured by an alpha spectrometer
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作者 Zhong-Kai Fan Jia-Le Sun +5 位作者 Hao-Xuan Li Xiang-Ming Cai Hui Yang Shou-Kang Qiu Yan-Liang Tan Jian Shan 《Nuclear Science and Techniques》 2025年第1期127-139,共13页
The accumulation of^(222)Rn and^(220)Rn progeny in poorly ventilated environments poses the risk of natural radiation exposure to the public.A previous study indicated that satisfactory results in determining the^(222... The accumulation of^(222)Rn and^(220)Rn progeny in poorly ventilated environments poses the risk of natural radiation exposure to the public.A previous study indicated that satisfactory results in determining the^(222)Rn and^(220)Rn progeny concentrations by measuring the total alpha counts at five time intervals within 560 min should be expected only in the case of high progeny concentrations in air.To complete the measurement within a relatively short period and adapt it for simultaneous measurements at comparatively lower^(222)Rn and^(220)Rn progeny concentrations,a novel mathematical model was proposed based on the radioactive decay law.This model employs a nonlinear fitting method to distinguish nuclides with overlapping spectra by utilizing the alpha particle counts of non-overlapping spectra within consecutive measurement cycles to obtain the concentrations of^(222)Rn and^(220)Rn progeny in air.Several verification experiments were conducted using an alpha spectrometer.The experimental results demonstrate that the concentrations of^(222)Rn and^(220)Rn progeny calculated by the new method align more closely with the actual circumstances than those calculated by the total count method,and their relative uncertainties are all within±16%.Furthermore,the measurement time was reduced to 90 min,representing an acceleration of 84%.The improved capability of the new method in distinguishing alpha particles with similar energies emitted from ^(218)Po and^(212)Bi,both approximately 6 MeV,contributed to realizing more accurate results.The proposed method has the potential advantage of measuring relatively low concentrations of^(222)Rn and^(220)Rn progeny in air more quickly via air filtration. 展开更多
关键词 ^(222)Rn ^(220)Rn Progeny concentration Nonlinear fitting method Alpha spectrometer
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基于Box-Behnken响应面法优化膝痛康β-蜕皮甾酮的提取工艺
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作者 高建辉 张舜华 +5 位作者 张宇 范元赫 闵冬雨 叶恒 赵龙山 关雪峰 《沈阳药科大学学报》 CAS CSCD 2024年第4期451-456,共6页
目的优化膝痛康方剂中β-蜕皮甾酮的提取工艺。方法采用Box-Behnken响应面法和单因素试验,对提取过程中的浸泡时间、提取次数、提取时间和甲醇倍量等进行优化,通过响应面模型分析与预测,得到最佳的提取工艺条件,并对最优条件进行验证。... 目的优化膝痛康方剂中β-蜕皮甾酮的提取工艺。方法采用Box-Behnken响应面法和单因素试验,对提取过程中的浸泡时间、提取次数、提取时间和甲醇倍量等进行优化,通过响应面模型分析与预测,得到最佳的提取工艺条件,并对最优条件进行验证。结果饮片浸泡96 min,提取100 min,反复2次,甲醇倍数为16倍,此时牛膝的提取工艺达到最佳,在此提取工艺下β-蜕皮甾酮的提取量达到最大。结论该提取方法具有设备简单、成本低、提取工艺稳定等特点,此外,该提取工艺具有较好的应用价值,以其为膝痛康的应用提供实验依据。 展开更多
关键词 牛膝 β-蜕皮甾酮 box-behnken响应面法 提取工艺
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AHP-熵权法结合Box-Behnken设计-响应面法优选党参精准煮散工艺 被引量:2
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作者 周晶晶 周洁 +1 位作者 窦霞 靳子明 《中国中医药信息杂志》 CAS CSCD 2024年第1期135-141,共7页
目的优选党参煮散的最佳粒度及煎煮工艺。方法以加水量、浸泡时间及煎煮时间为考察因素,以总黄酮、总多糖、干膏率为考察指标,运用AHP-熵权法结合Box-Behnken设计-响应面法确定党参煮散饮片的最佳粒度及煎煮工艺参数。结果党参煮散饮片... 目的优选党参煮散的最佳粒度及煎煮工艺。方法以加水量、浸泡时间及煎煮时间为考察因素,以总黄酮、总多糖、干膏率为考察指标,运用AHP-熵权法结合Box-Behnken设计-响应面法确定党参煮散饮片的最佳粒度及煎煮工艺参数。结果党参煮散饮片的最佳粒度为4.00~4.75 mm(4~5目),最优煎煮工艺为加水量13倍,浸泡时间15 min,煎煮时间10 min。结论本研究优选出的党参煮散粒度科学合理,切合实际生产;确定的煎煮工艺方便快捷,合理可行,可为煮散的工业化生产提供依据。 展开更多
关键词 党参 精准煮散 AHP-熵权法 box-behnken设计-响应面法 最佳粒度 煎煮工艺
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基于AHP-EWM结合Box-Behnken响应面法优化黄芩多指标成分的微波提取工艺 被引量:1
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作者 蒋佳丽 刘婷 +2 位作者 李宇浩 韩伟 薛东升 《华东理工大学学报(自然科学版)》 CAS CSCD 北大核心 2024年第5期678-686,共9页
结合层次分析法(AHP)-熵权法(EWM),通过单因素实验考察功率、液固比、提取时间、提取次数和粒度对黄芩苷、汉黄芩苷、黄芩素和汉黄芩素得率及出膏率的影响。以综合评分为响应值,利用四因素三水平Box-Behnken(BBD)响应面法优化黄芩的微... 结合层次分析法(AHP)-熵权法(EWM),通过单因素实验考察功率、液固比、提取时间、提取次数和粒度对黄芩苷、汉黄芩苷、黄芩素和汉黄芩素得率及出膏率的影响。以综合评分为响应值,利用四因素三水平Box-Behnken(BBD)响应面法优化黄芩的微波提取工艺,并通过扫描电子显微镜(SEM)观察提取前后药材粉末的微观形态变化。BBD响应面法得到的最优提取工艺条件为:微波功率390 W、液固比56 mL/g、提取时间472 s、粒度80目(180μm),此时黄芩苷、汉黄芩苷、黄芩素、汉黄芩素得率分别为16.82%、3.46%、0.30%、0.31%,出膏率73.73%,综合评分10.75。该工艺提取效果优于常见的回流提取方法,实现评价结果主客观的内在统一。 展开更多
关键词 黄芩 微波提取 层次分析法 熵权法 box-behnken响应面法
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Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方研究 被引量:2
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作者 程索婷 黄莉 +3 位作者 邹纯才 鄢海燕 任佩 王紫彤 《安徽中医药大学学报》 CAS 2024年第3期93-99,共7页
目的采用Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方。方法在前期预试验的基础上,以载药量、促渗剂用量、聚乙二醇(polyethylene glycol,PEG)6000与微粉硅胶的比例为影响因素,进行单因素试验。结合体外透皮试验,利用高效液... 目的采用Box-Behnken响应面法结合BP神经网络优化黑胡椒脐贴处方。方法在前期预试验的基础上,以载药量、促渗剂用量、聚乙二醇(polyethylene glycol,PEG)6000与微粉硅胶的比例为影响因素,进行单因素试验。结合体外透皮试验,利用高效液相色谱法测定胡椒碱的含量,对胡椒碱峰面积、指纹图谱的总峰面积和脐贴的成型性、剥离残留度和基质填充情况赋以权重,所得结果为综合评价指标。在单因素试验的基础上利用Box-Behnken响应面法结合BP神经网络优化脐贴处方。结果黑胡椒脐贴的最佳处方为载药量7%、氮酮4.5%、PEG6000与微粉硅胶的质量比为43∶1。结论黑胡椒脐贴的处方合理,可为后续贴剂的药效学研究提供基础。 展开更多
关键词 黑胡椒 脐贴 box-behnken响应面法 BP神经网络
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基于Box-Behnken响应面法优化鹿角蛋白的提取工艺
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作者 高建辉 李旭欣 +6 位作者 范元赫 张舜华 叶恒 张宇 赵龙山 关雪峰 《沈阳药科大学学报》 CAS CSCD 2024年第6期742-747,774,共7页
目的 通过Box-Behnken响应面法优化鹿角蛋白的提取工艺。方法 在单因素考察基础上进行响应面法设计,寻找最佳提取条件。以鹿角中蛋白含量为考察指标,使用考马斯亮蓝染色法测量样品溶液吸光度,再通过回归方程计算出样品溶液的鹿角蛋白含... 目的 通过Box-Behnken响应面法优化鹿角蛋白的提取工艺。方法 在单因素考察基础上进行响应面法设计,寻找最佳提取条件。以鹿角中蛋白含量为考察指标,使用考马斯亮蓝染色法测量样品溶液吸光度,再通过回归方程计算出样品溶液的鹿角蛋白含量。结果 最优提取工艺条件为NaOH浓度0.35 mol·L^(-1),液料比6:1,提取时间114 min。结论 经验证通过Box-Behnken响应面法所得到的预测值与测定的实际值偏差均在±1%以内,可以为膝痛康中鹿角蛋白的提取工艺提供参考。 展开更多
关键词 鹿角 box-behnken响应面 提取工艺 蛋白含量
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Box-Behnken响应面分析法优化葫芦素B-PLGA纳米粒的制备工艺 被引量:1
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作者 王梦颜 姚鹏利 +2 位作者 任娅博 常金花 刘喜纲 《天津药学》 2024年第6期5-10,共6页
目的:优化以聚乳酸-羟基乙酸共聚物(PLGA)作为纳米制剂载体材料,将葫芦素B制备成纳米粒的制备工艺。方法:采用纳米沉淀法制备葫芦素B-聚乳酸-羟基乙酸共聚物纳米粒(CuB-PLGA/NPs),以粒径、PDI和ζ电位为评价指标,对CuB-PLGA/NPs的处方... 目的:优化以聚乳酸-羟基乙酸共聚物(PLGA)作为纳米制剂载体材料,将葫芦素B制备成纳米粒的制备工艺。方法:采用纳米沉淀法制备葫芦素B-聚乳酸-羟基乙酸共聚物纳米粒(CuB-PLGA/NPs),以粒径、PDI和ζ电位为评价指标,对CuB-PLGA/NPs的处方和制备工艺进行单因素考查,再以包封率和载药量为评价指标,利用星点设计-响应面法(Box-Behnken响应面分析法)优化处方,并对CuB-PLGA/NPs的形态、粒径等进行表征。结果:筛选的最优处方与工艺为:CuB用量为10.31 mg、PLGA用量为13.56 mg、F68用量为0.75%、有机相体积为5 ml、有机相与水相体积比为1∶4、超声功率195 W、超声8 min。制备的CuB-PLGA/NPs的粒径为(122.9±3.14)nm,ζ电位为(-15.67±0.69)mV,包封率为99.86%,载药量为12.63%。结论:制备的CuB-PLGA/NPs粒径小,有较高的包封率和载药量,为葫芦素B的进一步开发提供新思路。 展开更多
关键词 葫芦素B 聚乳酸-羟基乙酸共聚物 纳米粒 box-behnken设计
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