利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kr...利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.展开更多
It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be rea...It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.展开更多
目的应用网络药理学方法,研究中药西洋参治疗急性肝损伤的关键作用靶点以及主要信号通路。方法利用中药系统药理数据库和分析平台(Traditional Chinese Medicine Systems Pharmacology,TCMSP)查找获得西洋参的主要化学成分,在有机小分...目的应用网络药理学方法,研究中药西洋参治疗急性肝损伤的关键作用靶点以及主要信号通路。方法利用中药系统药理数据库和分析平台(Traditional Chinese Medicine Systems Pharmacology,TCMSP)查找获得西洋参的主要化学成分,在有机小分子生物活性数据库(Pubchem)中获取成分的分子式,在化合物靶标预测平台(SwissTarget Prediction)取得相关靶基因,在基因卡片数据库(GeneCards)采集急性肝损伤相关靶点。通过在线工具Venny2.1取得西洋参和急性肝损伤交集靶基因,在蛋白互作关系的数据库(STRING)构建交集靶蛋白相互作用网络并经Cytoscape 3.7.1软件可视化处理。交集靶基因的GO功能和KEGG通路富集分析均在David网站上进行。结果通过数据分析共获得西洋参的10个有效成分、330个药物相关靶点、急性肝损伤疾病相关靶点7795个、药物-疾病交集靶点291个。西洋参治疗急性肝损伤的作用机制涉及216个生物学进程、30个细胞组成、44个分子功能和116条信号通路。结论西洋参治疗急性肝损伤作用机制,主要与丝裂原活化蛋白激酶差异基因3(mitogen-activated protein kinase 3,MAPK3)、血管上皮生长因子A(vascular endothelial growth factor A,VEGFA)、热休克蛋白90AA1(heat shock protein 90AA1,HSP90AA1)、半胱氨酸天冬氨酸蛋白酶3(Caspase-3,CASP3)、信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)等关键蛋白及PI3K-Akt、Cancer、MAPK等信号通路相关。展开更多
文摘利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.
文摘It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.
文摘目的应用网络药理学方法,研究中药西洋参治疗急性肝损伤的关键作用靶点以及主要信号通路。方法利用中药系统药理数据库和分析平台(Traditional Chinese Medicine Systems Pharmacology,TCMSP)查找获得西洋参的主要化学成分,在有机小分子生物活性数据库(Pubchem)中获取成分的分子式,在化合物靶标预测平台(SwissTarget Prediction)取得相关靶基因,在基因卡片数据库(GeneCards)采集急性肝损伤相关靶点。通过在线工具Venny2.1取得西洋参和急性肝损伤交集靶基因,在蛋白互作关系的数据库(STRING)构建交集靶蛋白相互作用网络并经Cytoscape 3.7.1软件可视化处理。交集靶基因的GO功能和KEGG通路富集分析均在David网站上进行。结果通过数据分析共获得西洋参的10个有效成分、330个药物相关靶点、急性肝损伤疾病相关靶点7795个、药物-疾病交集靶点291个。西洋参治疗急性肝损伤的作用机制涉及216个生物学进程、30个细胞组成、44个分子功能和116条信号通路。结论西洋参治疗急性肝损伤作用机制,主要与丝裂原活化蛋白激酶差异基因3(mitogen-activated protein kinase 3,MAPK3)、血管上皮生长因子A(vascular endothelial growth factor A,VEGFA)、热休克蛋白90AA1(heat shock protein 90AA1,HSP90AA1)、半胱氨酸天冬氨酸蛋白酶3(Caspase-3,CASP3)、信号转导和转录激活因子3(signal transducer and activator of transcription 3,STAT3)等关键蛋白及PI3K-Akt、Cancer、MAPK等信号通路相关。
