Using 3-O-methyl-D-chiro-inosito as starting material,through acetalation and mesylation the intermediate 3,which was subjected to hydrolysis to afford 3-O-Methyl-4-[(methylsulfonyl)oxy]-D-chiro-inositol 4 was obtaine...Using 3-O-methyl-D-chiro-inosito as starting material,through acetalation and mesylation the intermediate 3,which was subjected to hydrolysis to afford 3-O-Methyl-4-[(methylsulfonyl)oxy]-D-chiro-inositol 4 was obtained.Subsequently,the key epoxide 5 was obtained in excellent yield via an epoxidation from the compound 4.Finally,the process of opening of epoxy ring by azole-bases resulted in the novel carbocyclic azole nucleoside compounds 6-10 in the presence of 1,8-diazabicycloundec-7-ene(DBU) as catalyst,which appeared strong regioselectivity.展开更多
从芒果属植物扁桃(Mangifera persiciformis C.Y.Wu et T.L.Ming)叶乙醇提取物乙酸乙酯萃取部位中分离得到7个化合物,经波谱鉴定为没食子酸甲酯(1),没食子酸(2),3,4-二羟基苯甲酸(3),槲皮素(4),山奈酚-3-O-β-D-葡萄糖苷(5),槲皮素-3-O-...从芒果属植物扁桃(Mangifera persiciformis C.Y.Wu et T.L.Ming)叶乙醇提取物乙酸乙酯萃取部位中分离得到7个化合物,经波谱鉴定为没食子酸甲酯(1),没食子酸(2),3,4-二羟基苯甲酸(3),槲皮素(4),山奈酚-3-O-β-D-葡萄糖苷(5),槲皮素-3-O-β-D-葡萄糖苷(6)和芒果苷(7)。其中化合物1、3、5、6为首次从该植物中分离得到。展开更多
文摘Using 3-O-methyl-D-chiro-inosito as starting material,through acetalation and mesylation the intermediate 3,which was subjected to hydrolysis to afford 3-O-Methyl-4-[(methylsulfonyl)oxy]-D-chiro-inositol 4 was obtained.Subsequently,the key epoxide 5 was obtained in excellent yield via an epoxidation from the compound 4.Finally,the process of opening of epoxy ring by azole-bases resulted in the novel carbocyclic azole nucleoside compounds 6-10 in the presence of 1,8-diazabicycloundec-7-ene(DBU) as catalyst,which appeared strong regioselectivity.
文摘从芒果属植物扁桃(Mangifera persiciformis C.Y.Wu et T.L.Ming)叶乙醇提取物乙酸乙酯萃取部位中分离得到7个化合物,经波谱鉴定为没食子酸甲酯(1),没食子酸(2),3,4-二羟基苯甲酸(3),槲皮素(4),山奈酚-3-O-β-D-葡萄糖苷(5),槲皮素-3-O-β-D-葡萄糖苷(6)和芒果苷(7)。其中化合物1、3、5、6为首次从该植物中分离得到。
