The stress gradient of surrounding rock and reasonable prestress of support are the keys to ensuring the stability of roadways.The elastic-plastic analytical solution for surrounding rock was derived based on unified ...The stress gradient of surrounding rock and reasonable prestress of support are the keys to ensuring the stability of roadways.The elastic-plastic analytical solution for surrounding rock was derived based on unified strength theory.A model for solving the stress gradient of the surrounding rock with the intermediate principal stress parameter b was established.The correctness and applicability of the solution for the stress gradient in the roadway surrounding rock was verified via multiple methods.Furthermore,the laws of stress,displacement,and the plastic zone of the surrounding rock with different b values and prestresses were revealed.As b increases,the stress gradient in the plastic zone increases,and the displacement and plastic zone radius decrease.As the prestress increases,the peak stress shifts toward the sidewalls,and the stress and stress gradient increments decrease.In addition,the displacement increment and plastic zone increment were proposed to characterize the support effect.The balance point of the plastic zone area appears before that of the displacement zone.The relationship between the stress gradient compensation coefficient and the prestress is obtained.This study provides a research method and idea for determining the reasonable prestress of support in roadways.展开更多
对珠子参中皂苷类成分进行定性鉴别分析,建立珠子参皂苷类多成分含量测定方法。采用超高效液相色谱-飞行时间质谱(UPLC-Q-TOF-MS/MS)技术对珠子参进行正、负离子模式扫描,使用UNIFI天然产物信息平台对珠子参所含的化学成分进行定性鉴别...对珠子参中皂苷类成分进行定性鉴别分析,建立珠子参皂苷类多成分含量测定方法。采用超高效液相色谱-飞行时间质谱(UPLC-Q-TOF-MS/MS)技术对珠子参进行正、负离子模式扫描,使用UNIFI天然产物信息平台对珠子参所含的化学成分进行定性鉴别分析;以0.1%磷酸水-乙腈溶液为流动相进行梯度洗脱,柱温30℃,流速0.3 mL/min,进行珠子参皂苷类多成分含量测定。珠子参中共鉴定出39个化学成分,包括37个皂苷类化合物和2个皂苷母核,并总结了皂苷类化合物的裂解规律,建立了UPLC同时测定珠子参中人参皂苷Rb1、人参皂苷Ro、人参皂苷Rb3、竹节参皂苷IV、竹节参皂苷IVa、人参皂苷Rd、姜状三七皂苷R1和金盏花苷E的多指标含量测定方法,该方法中8个待测成分在检测质量浓度范围内线性关系良好,精密度、重复性、稳定性的相对标准偏差(relative standard deviation,RSD)均小于3.0%,样品中人参皂苷Rb1、人参皂苷Ro、人参皂苷Rb3、竹节参皂苷IV、竹节参皂苷IVa、人参皂苷Rd、姜状三七皂苷R1和金盏花苷E的平均加样回收率分别为102.4%、103.1%、97.97%、99.42%、102.7%、102.1%、95.23%、100.5%,RSD分别为1.0%、0.98%、0.81%、2.3%、0.81%、1.9%、0.96%、1.8%。该研究建立的方法可快速、准确地对珠子参中的皂苷类成分进行定性及定量分析。展开更多
Aerocapture is one of the key technologies for low-cost transportation,with high demands of autonomy,accuracy,and robustness of guidance and control,due to its high reliability requirements for only one chance of tryi...Aerocapture is one of the key technologies for low-cost transportation,with high demands of autonomy,accuracy,and robustness of guidance and control,due to its high reliability requirements for only one chance of trying.A unified numerical predictor-corrector guidance method based on characteristic models for aerocapture is proposed.The numerical predictor-corrector guidance method is used to achieve autonomy and high accuracy,and the characteristic model control method is introduced to achieve robustness.At the same time,by transforming path constraints,characteristic model equations including apogee deviation and altitude differentiation are established.Based on the characteristic model equations,a unified guidance law which can satisfy path constraints and guidance objectives simultaneously is designed.In guidance problems,guidance deviation is not directly obtained from the output of the dynamics at present,but is calculated through integral and algebraic equations.Therefore,the method of directly discretizing differential equations cannot be used to establish characteristic models,which brings great difficulty to characteristic modeling.A method for characteristic modeling of guidance problems is proposed,and convergence analysis of the proposed guidance law is also provided.Finally,a joint numerical simulation of guidance and control considering navigation deviation and various uncertainties is conducted to verify the effectiveness of the proposed method.The proposed unified method can be extended to general aerodynamic entry guidance designs,providing theoretical and methodological support for them.展开更多
Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse,posing significant safety risks.However,previous theoretical studies on the range of blasting-in...Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse,posing significant safety risks.However,previous theoretical studies on the range of blasting-induced cracks often ignore the impact of the in-situ stress,especially that of the intermediate principal stress.The particle displacement−crack radius relationship was established in this paper by utilizing the blasthole cavity expansion equation,and theoretical analytical formulas of the stress−displacement relationship and the crack radius were derived with unified strength theory to accurately assess the range of cracks in deep surrounding rock under a blasting load.Parameter analysis showed that the crushing zone size was positively correlated with in-situ stress,intermediate principal stress,and detonation pressure,whereas negatively correlated with Poisson ratio and decoupling coefficient.The dilatancy angle-crushing zone size relationship exhibited nonmonotonic behavior.The relationships in the crushing zone and the fracture zone exhibited opposite trends under the influence of only in-situ stress or intermediate principal stress.As the in-situ stress increased from 0 to 70 MPa,the rate of change in the crack range and the attenuation rate of the peak vibration velocity gradually slowed.展开更多
Objective:Multiple myeloma(MM)is a hematologically malignant clonal plasma cell disease.This study aims to explore the association between immunophenotypes and prognosis in patients with MM,to determine whether the ex...Objective:Multiple myeloma(MM)is a hematologically malignant clonal plasma cell disease.This study aims to explore the association between immunophenotypes and prognosis in patients with MM,to determine whether the expression of CD45 and CD200 is related to the prognosis of newly diagnosed MM(NDMM)patients,and to evaluate the significance of the combined expression of CD45 and CD200 in NDMM.Methods:A total of 123 NDMM patients admitted to Shengjing Hospital of China Medical University from July 2015 to August 2019 were enrolled.Five key immunophenotypic markers(including CD38,CD138,CD45,CD56,and CD200)were screened through flow cytometry and identified using random forest analysis and univariate Cox regression analysis.Patients were divided into 3 groups:Group A,CD45 and CD200 double-positive;Group B,CD45 or CD200 single-positive;Group C,CD45 and CD200 double-negative.Kaplan-Meier curves were used to analyze overall survival(OS)and progression-free survival(PFS)across groups.Multivariate Cox regression was performed to evaluate prognostic factors,and a nomogram was constructed based on these results.Results:The OS and PFS of single-positive groups for CD38,CD138,CD45,CD56,and CD200 were all shorter than those of their respective single-negative groups(all P<0.05).Significant differences were observed in OS(P<0.001)and PFS(P=0.001)among Groups A,B,and C.Group A had shorter OS and PFS(all P=0.001)compared to the Group B+C(cases from Group B and Group C were combined).CD45 and CD200 double-positive was an independent prognostic factor for NDMM[hazard ratio(HR)=2.178,95%confidence interval(CI)1.048 to 4.529;P=0.037].The nomogram and calibration curves constructed from multivariate Cox regression analysis demonstrated good concordance(concordance index=0.706;95%CI 0.661 to 0.751).Conclusion:NDMM patients with double-positive expression of CD45 and CD200 have significantly shorter OS and PFS.Compared with the use of either marker alone,the combined assessment of CD45 and CD200 may provide better prognostic stratification for MM patients.展开更多
The boundness and compactness of products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball are studied.We define the differentiation operator on the space of holomorphic fu...The boundness and compactness of products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball are studied.We define the differentiation operator on the space of holomorphic functions in the unit ball by radial derivative.Then we extend the Sharma's results.展开更多
Red mud is a solid waste discharged in the process of alumina production,and how to realize the efficient recovery of its iron is an urgent problem to be solved.In this study,the iron extraction test and mechanism stu...Red mud is a solid waste discharged in the process of alumina production,and how to realize the efficient recovery of its iron is an urgent problem to be solved.In this study,the iron extraction test and mechanism study of high iron red mud were carried out under the coupling conditions of multiple physical field(microwave field,gas-solid flow field and temperature field)with biomass as the reducing agent.The test results showed that under the optimal conditions,an iron concentrate with a yield of 78.4%,an iron grade of 59.23%,and a recovery rate of 86.65%was obtained.The analyses of XRD,XPS,TEM,and SEM-EDS showed that during the roasting process,the hematite in the high-iron red mud was completely converted to magnetite,and the biomass produced the reductant that provided the magnetization reaction;A large number of cracks and pores appeared in the surface of the hematite reduction product particles,which helped to induce iron minerals to undergo effective mineral phase transformation.The above study provides ideas for the phase transformation and efficient recovery of iron minerals in red mud.展开更多
As the performance of the box-type multiple launch rocket system(BMLRS)improves,its mechanical structures,particularly the plane clearance design between the slider on the rocket and the guide inside the launch canist...As the performance of the box-type multiple launch rocket system(BMLRS)improves,its mechanical structures,particularly the plane clearance design between the slider on the rocket and the guide inside the launch canister,have grown increasingly complex.However,deficiencies still exist in the current launch modeling theory for BMLRS.In this study,a multi-rigid-flexible-body launch dynamics model coupling the launch platform and rocket was established using the multibody system transfer matrix method and the Newton-Euler formulation.Furthermore,considering the bending of the launch canister,a detection algorithm for slider-guide plane clearance contact was proposed.To quantify the contact force and friction effect between the slider and guide,the contact force model and modified Coulomb model were introduced.Both the modal and launch tests were conducted.Additionally,the modal convergence was verified.By comparing the modal experiments and simulation results,the maximum relative error of the eigenfrequency is 3.29%.thereby verifying the accuracy of the developed BMLRS dynamics model.Furthermore,the launch test validated the proposed plane clearance contact model.Moreover,the study investigated the influence of various model parameters on the dynamic characteristics of BMLRS,including launch canister bending stiffness,slider and guide material,slider-guide clearance,slider length and layout.This analysis of influencing factors provides a foundation for future optimization in BMLRS design.展开更多
A new unified analytical solution is presented for predicting the range of plastic zone and stress distributions around a deep circular tunnel in a homogeneous isotropic continuous medium. The rock mass, grouting zone...A new unified analytical solution is presented for predicting the range of plastic zone and stress distributions around a deep circular tunnel in a homogeneous isotropic continuous medium. The rock mass, grouting zone and lining are assumed as elastic-perfectly plastic and governed by the unified strength theory(UST). This new solution has made it possible to consider the interaction between seepage pressure, lining, grouting and rock mass, and the intermediate principal stress effect together. Moreover, parametric analysis is carried out to identify the influence of the related parameters on the plastic zone radius. Under the given conditions, the results show that the plastic zone radius decreases with an increasing cohesion, internal friction angle and hydraulic conductivity of lining and unified failure criterion parameter, respectively; whereas the plastic zone radius increases with the growth of elasticity modulus of lining. Comparison of results from the new solution and the other published one shows well agreement and provides confidence in the new solution proposed.展开更多
Fibre-reinforced polymer(FRP)has the advantages of high strength,light weight,corrosion resistance and convenient construction and is widely used in repairing and strengthening damaged concrete columns.Most of the exi...Fibre-reinforced polymer(FRP)has the advantages of high strength,light weight,corrosion resistance and convenient construction and is widely used in repairing and strengthening damaged concrete columns.Most of the existing strength models were built by regression analysis of experimental data;however,in this article,a new unified strength model is proposed using the Hoek-Brown failure criterion.To study the strength of FRP-confined damaged and undamaged concrete columns,900 test data were collected from the published literature and a large database that contains the cross-sectional shape of each specimen,the damage type,the damage level and the FRP-confined stiffness was established.A new strength model using the Hoek-Brown failure criterion was established and is suitable for both circular and square columns that are undamaged,load-damaged and fire-damaged.Based on the database,most of the existing strength models from the published literature and the model proposed in this paper were evaluated.The evaluation shows that the proposed model can predict the compressive strength for FRP-confined pre-damaged and undamaged concrete columns with good accuracy.展开更多
In order to study the mechanism of bearing behavior at the tip of a pile embedded in rock, the generalized nonlinear unified strength criterion and slip line principle for resolving the differential equation systems w...In order to study the mechanism of bearing behavior at the tip of a pile embedded in rock, the generalized nonlinear unified strength criterion and slip line principle for resolving the differential equation systems which govern the stress field were applied to derive the ultimate end beating capacity based on some reasonable hypothesis and failure plane model. Both numerical simulation and test results were compared with the theoretic solution. The results show good consistency with each other and verify the validity of the present approach. The depth effect with respective to embedment ratio and other influence factors like geological strength index, intermediate principal stress, overburden factor, and damage on end bearing capacity were discussed in the analytical solution. The results show that the proposed yield criterion can be much better for investigating the ultimate end bearing performance of rock-socketed pile. The end bearing capacity increases with embedment ratio and the increasing degree is influenced intensely by the above parameters. Furthermore, ignoring intermediate stress effect would underestimate the strength properties of the rock material and lead to a very conservative estimation value.展开更多
A unified semi-analytical solution is presented for elastic-plastic stress of a deep circular hydraulic tunnel with support yielding under plane strain conditions.The rock mass is assumed to be elastic-perfectly plast...A unified semi-analytical solution is presented for elastic-plastic stress of a deep circular hydraulic tunnel with support yielding under plane strain conditions.The rock mass is assumed to be elastic-perfectly plastic and governed by the unified strength theory (UST).Different major principal stresses in different engineering situations and different support yielding conditions are both considered.The unified solution obtained in this work is a series of results,rather than one specific solution,hence it is suitable for a wide range of rock masses.In addition,parametric study is conducted to investigate the effect of intermediate principal stress.The result shows the major principal stress should be rationally chosen according to different engineering conditions.Finally,the applicability of the unified solution is discussed according to the critical pressures.展开更多
Initiated three decades ago,integrated design of controllers and fault detectors has continuously attracted research attention.The recent development of the unified control and detection framework with an observer-bas...Initiated three decades ago,integrated design of controllers and fault detectors has continuously attracted research attention.The recent development of the unified control and detection framework with an observer-based residual generator in its core gives a more general form of the previous works.Its applications to residual centred modelling of uncertain control systems,fault detection in feedback control systems with uncertainties,fault-tolerant control(FTC)as well as control performance degradation monitoring,detection and recovery are introduced.In conclusion,some future perspectives are proposed.展开更多
For the interaction relation between geological object and engineering object in some fields related to water conservancy and hydropower, a unified modeling idea was proposed. On the basis of summarizing both advantag...For the interaction relation between geological object and engineering object in some fields related to water conservancy and hydropower, a unified modeling idea was proposed. On the basis of summarizing both advantages and disadvantages of existing modeling methods, an automatic unified modeling method of both engineering and geological objects based on tri-prism(TP) model was presented. Through the lossless correction algorithm of deviated drill holes contained in this method, the real deviated drill holes could be corrected into the equivalent virtual vertical ones. And the correction accuracy fully meets the requirements of unified modeling. With the virtual vertical drilling data, TIN construction of both cover layer and other stratums would be built in order to obtain the 3D geological model. Then, the engineering design data would be introduced into the 3D geological model for achieving unified modeling. For this process, the volume subdividing and restructuring principles were introduced to deal with the spatial relationships between engineering object and geological object. In order to improve the efficiency of unified modeling, the reconstruction of TIN based on constraint information was also applied in this method. At last, the feasibility and validation of the unified modeling method as well as its relevant key algorithms were verified by specific experiments and analysis of results.展开更多
The yield behavior of metallic glasses was studied. Three yield criteria, including von Mises yield criterion, Mohr-Coulomb yield criterion and the unified yield criterion were used to describe the yield phenomena of ...The yield behavior of metallic glasses was studied. Three yield criteria, including von Mises yield criterion, Mohr-Coulomb yield criterion and the unified yield criterion were used to describe the yield phenomena of the metallic glasses. Two classes of the experimental data were chosen to draw the yield loci using the unified yield criterion. It is shown that the unified yield criterion can be used to describe the yield behavior of the metallic glasses no matter whether the metallic glasses show strength- different effect or non-strength-different effect. Almost all the widely accepted yield criteria are the subsets of the unified yield criterion if the intermediate principle stress and/or the intermediate principle shear stress are not considered at all.展开更多
1. IntroductionHumans have the ability (or competence) to think logically, and this is an undeniable fact. However,what this ability consists in is a difficult question. It might be said that logical ability consists ...1. IntroductionHumans have the ability (or competence) to think logically, and this is an undeniable fact. However,what this ability consists in is a difficult question. It might be said that logical ability consists in theknowledge of a set of logic rules. But what are those logic rules? For centuries logicians have devel-展开更多
This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the at...This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation countermeasures.Key evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment principles.The principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively deploying.Accordingly,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to space.Varied evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.展开更多
How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS consi...How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%.展开更多
基金Project(52274130)supported by the National Natural Science Foundation of ChinaProject(ZR2024ZD22)supported by the Major Basic Research Project of the Shandong Provincial Natural Science Foundation,China+2 种基金Project(2023375)supported by the Guizhou University Research and Innovation Team,ChinaProject(Leading Fund(2023)09)supported by the Natural Science Research Fund of Guizhou University,ChinaProject(JYBSYS2021101)supported by the Open Fund of Key Laboratory of Safe and Effective Coal Mining,Ministry of Education,China。
文摘The stress gradient of surrounding rock and reasonable prestress of support are the keys to ensuring the stability of roadways.The elastic-plastic analytical solution for surrounding rock was derived based on unified strength theory.A model for solving the stress gradient of the surrounding rock with the intermediate principal stress parameter b was established.The correctness and applicability of the solution for the stress gradient in the roadway surrounding rock was verified via multiple methods.Furthermore,the laws of stress,displacement,and the plastic zone of the surrounding rock with different b values and prestresses were revealed.As b increases,the stress gradient in the plastic zone increases,and the displacement and plastic zone radius decrease.As the prestress increases,the peak stress shifts toward the sidewalls,and the stress and stress gradient increments decrease.In addition,the displacement increment and plastic zone increment were proposed to characterize the support effect.The balance point of the plastic zone area appears before that of the displacement zone.The relationship between the stress gradient compensation coefficient and the prestress is obtained.This study provides a research method and idea for determining the reasonable prestress of support in roadways.
文摘对珠子参中皂苷类成分进行定性鉴别分析,建立珠子参皂苷类多成分含量测定方法。采用超高效液相色谱-飞行时间质谱(UPLC-Q-TOF-MS/MS)技术对珠子参进行正、负离子模式扫描,使用UNIFI天然产物信息平台对珠子参所含的化学成分进行定性鉴别分析;以0.1%磷酸水-乙腈溶液为流动相进行梯度洗脱,柱温30℃,流速0.3 mL/min,进行珠子参皂苷类多成分含量测定。珠子参中共鉴定出39个化学成分,包括37个皂苷类化合物和2个皂苷母核,并总结了皂苷类化合物的裂解规律,建立了UPLC同时测定珠子参中人参皂苷Rb1、人参皂苷Ro、人参皂苷Rb3、竹节参皂苷IV、竹节参皂苷IVa、人参皂苷Rd、姜状三七皂苷R1和金盏花苷E的多指标含量测定方法,该方法中8个待测成分在检测质量浓度范围内线性关系良好,精密度、重复性、稳定性的相对标准偏差(relative standard deviation,RSD)均小于3.0%,样品中人参皂苷Rb1、人参皂苷Ro、人参皂苷Rb3、竹节参皂苷IV、竹节参皂苷IVa、人参皂苷Rd、姜状三七皂苷R1和金盏花苷E的平均加样回收率分别为102.4%、103.1%、97.97%、99.42%、102.7%、102.1%、95.23%、100.5%,RSD分别为1.0%、0.98%、0.81%、2.3%、0.81%、1.9%、0.96%、1.8%。该研究建立的方法可快速、准确地对珠子参中的皂苷类成分进行定性及定量分析。
基金The National Key R&D Program of China(2018YFA0703800)。
文摘Aerocapture is one of the key technologies for low-cost transportation,with high demands of autonomy,accuracy,and robustness of guidance and control,due to its high reliability requirements for only one chance of trying.A unified numerical predictor-corrector guidance method based on characteristic models for aerocapture is proposed.The numerical predictor-corrector guidance method is used to achieve autonomy and high accuracy,and the characteristic model control method is introduced to achieve robustness.At the same time,by transforming path constraints,characteristic model equations including apogee deviation and altitude differentiation are established.Based on the characteristic model equations,a unified guidance law which can satisfy path constraints and guidance objectives simultaneously is designed.In guidance problems,guidance deviation is not directly obtained from the output of the dynamics at present,but is calculated through integral and algebraic equations.Therefore,the method of directly discretizing differential equations cannot be used to establish characteristic models,which brings great difficulty to characteristic modeling.A method for characteristic modeling of guidance problems is proposed,and convergence analysis of the proposed guidance law is also provided.Finally,a joint numerical simulation of guidance and control considering navigation deviation and various uncertainties is conducted to verify the effectiveness of the proposed method.The proposed unified method can be extended to general aerodynamic entry guidance designs,providing theoretical and methodological support for them.
基金Project(2021JJ10063)supported by the Natural Science Foundation of Hunan Province,ChinaProject(202115)supported by the Science and Technology Progress and Innovation Project of Hunan Provincial Department of Transportation,ChinaProject(2021K094-Z)supported by the Science and Technology Research and Development Program of China Railway Guangzhou Group Co.,Ltd。
文摘Blasting-induced cracks in the rock surrounding deeply buried tunnels can result in water gushing and rock mass collapse,posing significant safety risks.However,previous theoretical studies on the range of blasting-induced cracks often ignore the impact of the in-situ stress,especially that of the intermediate principal stress.The particle displacement−crack radius relationship was established in this paper by utilizing the blasthole cavity expansion equation,and theoretical analytical formulas of the stress−displacement relationship and the crack radius were derived with unified strength theory to accurately assess the range of cracks in deep surrounding rock under a blasting load.Parameter analysis showed that the crushing zone size was positively correlated with in-situ stress,intermediate principal stress,and detonation pressure,whereas negatively correlated with Poisson ratio and decoupling coefficient.The dilatancy angle-crushing zone size relationship exhibited nonmonotonic behavior.The relationships in the crushing zone and the fracture zone exhibited opposite trends under the influence of only in-situ stress or intermediate principal stress.As the in-situ stress increased from 0 to 70 MPa,the rate of change in the crack range and the attenuation rate of the peak vibration velocity gradually slowed.
基金supported by the National Natural Science Foundation,China(81870166).
文摘Objective:Multiple myeloma(MM)is a hematologically malignant clonal plasma cell disease.This study aims to explore the association between immunophenotypes and prognosis in patients with MM,to determine whether the expression of CD45 and CD200 is related to the prognosis of newly diagnosed MM(NDMM)patients,and to evaluate the significance of the combined expression of CD45 and CD200 in NDMM.Methods:A total of 123 NDMM patients admitted to Shengjing Hospital of China Medical University from July 2015 to August 2019 were enrolled.Five key immunophenotypic markers(including CD38,CD138,CD45,CD56,and CD200)were screened through flow cytometry and identified using random forest analysis and univariate Cox regression analysis.Patients were divided into 3 groups:Group A,CD45 and CD200 double-positive;Group B,CD45 or CD200 single-positive;Group C,CD45 and CD200 double-negative.Kaplan-Meier curves were used to analyze overall survival(OS)and progression-free survival(PFS)across groups.Multivariate Cox regression was performed to evaluate prognostic factors,and a nomogram was constructed based on these results.Results:The OS and PFS of single-positive groups for CD38,CD138,CD45,CD56,and CD200 were all shorter than those of their respective single-negative groups(all P<0.05).Significant differences were observed in OS(P<0.001)and PFS(P=0.001)among Groups A,B,and C.Group A had shorter OS and PFS(all P=0.001)compared to the Group B+C(cases from Group B and Group C were combined).CD45 and CD200 double-positive was an independent prognostic factor for NDMM[hazard ratio(HR)=2.178,95%confidence interval(CI)1.048 to 4.529;P=0.037].The nomogram and calibration curves constructed from multivariate Cox regression analysis demonstrated good concordance(concordance index=0.706;95%CI 0.661 to 0.751).Conclusion:NDMM patients with double-positive expression of CD45 and CD200 have significantly shorter OS and PFS.Compared with the use of either marker alone,the combined assessment of CD45 and CD200 may provide better prognostic stratification for MM patients.
基金Supported by Natural Science Foundation of Guangdong Province in China(2018KTSCX161)。
文摘The boundness and compactness of products of multiplication,composition and differentiation on weighted Bergman spaces in the unit ball are studied.We define the differentiation operator on the space of holomorphic functions in the unit ball by radial derivative.Then we extend the Sharma's results.
基金Project(MMCS2023OF02)supported by the Open Foundation of State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures,ChinaProject(AA23073018)supported by the Guangxi Science and Technology,ChinaProject(2024M751861)supported by the China Postdoctoral Science Foundation。
文摘Red mud is a solid waste discharged in the process of alumina production,and how to realize the efficient recovery of its iron is an urgent problem to be solved.In this study,the iron extraction test and mechanism study of high iron red mud were carried out under the coupling conditions of multiple physical field(microwave field,gas-solid flow field and temperature field)with biomass as the reducing agent.The test results showed that under the optimal conditions,an iron concentrate with a yield of 78.4%,an iron grade of 59.23%,and a recovery rate of 86.65%was obtained.The analyses of XRD,XPS,TEM,and SEM-EDS showed that during the roasting process,the hematite in the high-iron red mud was completely converted to magnetite,and the biomass produced the reductant that provided the magnetization reaction;A large number of cracks and pores appeared in the surface of the hematite reduction product particles,which helped to induce iron minerals to undergo effective mineral phase transformation.The above study provides ideas for the phase transformation and efficient recovery of iron minerals in red mud.
基金supported by National Natural Science Foundation of China(Grant No.92266201).
文摘As the performance of the box-type multiple launch rocket system(BMLRS)improves,its mechanical structures,particularly the plane clearance design between the slider on the rocket and the guide inside the launch canister,have grown increasingly complex.However,deficiencies still exist in the current launch modeling theory for BMLRS.In this study,a multi-rigid-flexible-body launch dynamics model coupling the launch platform and rocket was established using the multibody system transfer matrix method and the Newton-Euler formulation.Furthermore,considering the bending of the launch canister,a detection algorithm for slider-guide plane clearance contact was proposed.To quantify the contact force and friction effect between the slider and guide,the contact force model and modified Coulomb model were introduced.Both the modal and launch tests were conducted.Additionally,the modal convergence was verified.By comparing the modal experiments and simulation results,the maximum relative error of the eigenfrequency is 3.29%.thereby verifying the accuracy of the developed BMLRS dynamics model.Furthermore,the launch test validated the proposed plane clearance contact model.Moreover,the study investigated the influence of various model parameters on the dynamic characteristics of BMLRS,including launch canister bending stiffness,slider and guide material,slider-guide clearance,slider length and layout.This analysis of influencing factors provides a foundation for future optimization in BMLRS design.
基金Project(51378309)supported by National Natural Science Foundation of China
文摘A new unified analytical solution is presented for predicting the range of plastic zone and stress distributions around a deep circular tunnel in a homogeneous isotropic continuous medium. The rock mass, grouting zone and lining are assumed as elastic-perfectly plastic and governed by the unified strength theory(UST). This new solution has made it possible to consider the interaction between seepage pressure, lining, grouting and rock mass, and the intermediate principal stress effect together. Moreover, parametric analysis is carried out to identify the influence of the related parameters on the plastic zone radius. Under the given conditions, the results show that the plastic zone radius decreases with an increasing cohesion, internal friction angle and hydraulic conductivity of lining and unified failure criterion parameter, respectively; whereas the plastic zone radius increases with the growth of elasticity modulus of lining. Comparison of results from the new solution and the other published one shows well agreement and provides confidence in the new solution proposed.
基金Project(2017M622540)supported by the China Postdoctoral Science FoundationProject(51808419)supported by the National Natural Science Foundation of China+1 种基金Project(2019CFB217)supported by the National Natural Science Foundation of Hubei Province,ChinaProject(201623)supported by the Science and Technology Project of Wuhan Urban and Rural Construction Committee,China。
文摘Fibre-reinforced polymer(FRP)has the advantages of high strength,light weight,corrosion resistance and convenient construction and is widely used in repairing and strengthening damaged concrete columns.Most of the existing strength models were built by regression analysis of experimental data;however,in this article,a new unified strength model is proposed using the Hoek-Brown failure criterion.To study the strength of FRP-confined damaged and undamaged concrete columns,900 test data were collected from the published literature and a large database that contains the cross-sectional shape of each specimen,the damage type,the damage level and the FRP-confined stiffness was established.A new strength model using the Hoek-Brown failure criterion was established and is suitable for both circular and square columns that are undamaged,load-damaged and fire-damaged.Based on the database,most of the existing strength models from the published literature and the model proposed in this paper were evaluated.The evaluation shows that the proposed model can predict the compressive strength for FRP-confined pre-damaged and undamaged concrete columns with good accuracy.
基金Project(2007AA11Z134) supported by the National High-tech Research and Development Program of ChinaProject(10JJ4035) supported by Hunan Provincial Natural Science Foundation of ChinaProject(04SK2008) supported by Hunan Provincial Science and Technology Department,China
文摘In order to study the mechanism of bearing behavior at the tip of a pile embedded in rock, the generalized nonlinear unified strength criterion and slip line principle for resolving the differential equation systems which govern the stress field were applied to derive the ultimate end beating capacity based on some reasonable hypothesis and failure plane model. Both numerical simulation and test results were compared with the theoretic solution. The results show good consistency with each other and verify the validity of the present approach. The depth effect with respective to embedment ratio and other influence factors like geological strength index, intermediate principal stress, overburden factor, and damage on end bearing capacity were discussed in the analytical solution. The results show that the proposed yield criterion can be much better for investigating the ultimate end bearing performance of rock-socketed pile. The end bearing capacity increases with embedment ratio and the increasing degree is influenced intensely by the above parameters. Furthermore, ignoring intermediate stress effect would underestimate the strength properties of the rock material and lead to a very conservative estimation value.
基金Project(50969007)supported by National Natural Science Foundation of ChinaProject(GJJ13753)supported by the Scientific and Technological Research Fund,Department of Education,Jiangxi Province,China
文摘A unified semi-analytical solution is presented for elastic-plastic stress of a deep circular hydraulic tunnel with support yielding under plane strain conditions.The rock mass is assumed to be elastic-perfectly plastic and governed by the unified strength theory (UST).Different major principal stresses in different engineering situations and different support yielding conditions are both considered.The unified solution obtained in this work is a series of results,rather than one specific solution,hence it is suitable for a wide range of rock masses.In addition,parametric study is conducted to investigate the effect of intermediate principal stress.The result shows the major principal stress should be rationally chosen according to different engineering conditions.Finally,the applicability of the unified solution is discussed according to the critical pressures.
基金This work was supported by the National Natural Science Foundation of China(62020106003,62073029)the Beijing Natural Science Foundation(4202045)the Fundamental Research Funds for the Central Universities(FRF-TP-20-012A3).
文摘Initiated three decades ago,integrated design of controllers and fault detectors has continuously attracted research attention.The recent development of the unified control and detection framework with an observer-based residual generator in its core gives a more general form of the previous works.Its applications to residual centred modelling of uncertain control systems,fault detection in feedback control systems with uncertainties,fault-tolerant control(FTC)as well as control performance degradation monitoring,detection and recovery are introduced.In conclusion,some future perspectives are proposed.
基金Project(BK2012812)supported by the Natural Science Foundation of Jiangsu Province,ChinaProject(51079053)supported by the National Natural Science Foundation of China+2 种基金Project(KYLX_0493)supported by the Scientific Research and Innovation Program for College Graduates of Jiangsu Province,ChinaProject(2014B38814)supported by the Fundamental Research Funds for Central Universities,ChinaProject(2014.1526)supported by the Open Research Fund Program of Key Laboratory of Geological Information of Ministry of Land and Resources,China
文摘For the interaction relation between geological object and engineering object in some fields related to water conservancy and hydropower, a unified modeling idea was proposed. On the basis of summarizing both advantages and disadvantages of existing modeling methods, an automatic unified modeling method of both engineering and geological objects based on tri-prism(TP) model was presented. Through the lossless correction algorithm of deviated drill holes contained in this method, the real deviated drill holes could be corrected into the equivalent virtual vertical ones. And the correction accuracy fully meets the requirements of unified modeling. With the virtual vertical drilling data, TIN construction of both cover layer and other stratums would be built in order to obtain the 3D geological model. Then, the engineering design data would be introduced into the 3D geological model for achieving unified modeling. For this process, the volume subdividing and restructuring principles were introduced to deal with the spatial relationships between engineering object and geological object. In order to improve the efficiency of unified modeling, the reconstruction of TIN based on constraint information was also applied in this method. At last, the feasibility and validation of the unified modeling method as well as its relevant key algorithms were verified by specific experiments and analysis of results.
基金Projects(51011120053, 50823006, 50825102) supported by the National Natural Science Foundation of China
文摘The yield behavior of metallic glasses was studied. Three yield criteria, including von Mises yield criterion, Mohr-Coulomb yield criterion and the unified yield criterion were used to describe the yield phenomena of the metallic glasses. Two classes of the experimental data were chosen to draw the yield loci using the unified yield criterion. It is shown that the unified yield criterion can be used to describe the yield behavior of the metallic glasses no matter whether the metallic glasses show strength- different effect or non-strength-different effect. Almost all the widely accepted yield criteria are the subsets of the unified yield criterion if the intermediate principle stress and/or the intermediate principle shear stress are not considered at all.
文摘1. IntroductionHumans have the ability (or competence) to think logically, and this is an undeniable fact. However,what this ability consists in is a difficult question. It might be said that logical ability consists in theknowledge of a set of logic rules. But what are those logic rules? For centuries logicians have devel-
基金the National Natural Science Foundation of China(Grant No.42174047 and No.42174036)the National Science Foundation Project for Outstanding Youth(No.42104034).
文摘This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation countermeasures.Key evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment principles.The principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively deploying.Accordingly,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to space.Varied evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.
基金National Natural Science Foundation of China(Grant Nos.11972193 and 92266201)。
文摘How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%.
