Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)G...Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)Ga,and^(89)Zr.Among the radiotracers,the radioactive^(18)F-labelled chemical agent as PET probes plays a predominant role in monitoring,detecting,treating,and predicting tumours due to its perfect half-life.In this paper,the^(18)F-labelled chemical materials as PET probes are systematically summarized.First,we introduce various radionuclides of PET and elaborate on the mechanism of PET imaging.It highlights the^(18)F-labelled chemical agents used as PET probes,including[^(18)F]-2-deoxy-2-[^(18)F]fluoro-D-glucose([^(18)F]-FDG),^(18)F-labelled amino acids,^(18)F-labelled nucleic acids,^(18)F-labelled receptors,^(18)F-labelled reporter genes,and^(18)F-labelled hypoxia agents.In addition,some PET probes with metal as a supplementary element are introduced briefly.Meanwhile,the^(18)F-labelled nanoparticles for the PET probe and the multi-modality imaging probe are summarized in detail.The approach and strategies for the fabrication of^(18)F-labelled PET probes are also described briefly.The future development of the PET probe is also prospected.The development and application of^(18)F-labelled PET probes will expand our knowledge and shed light on the diagnosis and theranostics of tumours.展开更多
文摘目的探究胸部正电子发射断层/磁共振(positron emission tomography/magnetic resonance,PET/MR)检查中^(18)F-氟代脱氧葡萄糖(^(18)F-fluorodeoxyglucose,^(18)F-FDG)使用剂量降低对正电子发射断层(positron emission tomography,PET)图像质量及病变可检测性的影响。材料与方法回顾性分析2022年3月至2023年8月于东部战区总医院放射诊断科使用SIGNA PET/MR行^(18)F-FDG胸部PET/MR检查(注射剂量3.70 MBq/kg)的患者图像118例,所有图像中均有异常放射性核素浓聚病灶。用5个不同PET采集时间(20、10、5、2、1 min)对列表(list-mode,list)数据回顾性重建,分别模拟100%、50%、25%、10%、5%^(18)F-FDG注射剂量,记作G100、G50、G25、G10、G5。用李克特5分法对5组图像整体质量进行主观评分,采用Friedman检验比较各组间差异。客观分析指标包括病变标准化摄取值(standardized uptake value,SUV)的最大值(maximum SUV of lesion,L-SUVmax)、平均值(mean SUV of lesion,L-SUVmean)、标准差(standard deviation of lesion SUV,L-SUVsd)、背景SUV标准差(standard deviation of background SUV,B-SUVsd)、病变信噪比(signal-to-noise ratio of lesion,L-SNR)、图像噪声比(image noise ratio,IN)和L-SUVmax相对背景噪声比(lesion-to-background ratio,LBR),采用单因素重复测量方差分析比较各指标组间整体差异,组间两两比较采用Bonferroni校正。以G100为参考,评估其他组病变可检测性。结果5组^(18)F-FDG模拟剂量越高图像整体质量的主观评分也越高(P<0.05)。G25、G50、G100图像质量可满足临床诊断需求,均评分>4分。各组L-SUVmax、L-SUVmean、L-SUVsd、IN和LBR随^(18)F-FDG模拟剂量增加而降低,差异有统计学意义(均P<0.05),L-SNR随^(18)F-FDG模拟剂量增加而增加,差异亦有统计学意义(P<0.05)。组间比较结果:在L-SUVmax和L-SUVsd上G25、G50、G100任意两组相比差异均无统计学意义(均P>0.05),其余任意两组相比差异均有统计学意义(均P<0.05);L-SUVmean和L-SNR上,G5、G10两组之间或G25、G50、G100三组之间对比差异均无统计学意义(均P>0.05),其余任意两组相比差异均有统计学意义(均P<0.05);IN上,5组之间任意两组对比差异均有统计学意义(均P<0.05);LBR上,G5和G10、G25和G100、G50和G100对比差异均无统计学意义(均P>0.05),余任意两组相比差异均有统计学意义(均P<0.05)。以G100为参考,G50、G25、G10、G5漏检率分别为1.4%、2.4%、4.4%、6.8%。结论使用SIGNA PET/MR,若胸部^(18)F-FDG PET/MR检查PET时间为20 min,^(18)F-FDG剂量可由3.70 MBq/kg减少至0.93 MBq/kg,用量减少了75%,这不会改变PET图像质量及定量评估结果。
文摘Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)Ga,and^(89)Zr.Among the radiotracers,the radioactive^(18)F-labelled chemical agent as PET probes plays a predominant role in monitoring,detecting,treating,and predicting tumours due to its perfect half-life.In this paper,the^(18)F-labelled chemical materials as PET probes are systematically summarized.First,we introduce various radionuclides of PET and elaborate on the mechanism of PET imaging.It highlights the^(18)F-labelled chemical agents used as PET probes,including[^(18)F]-2-deoxy-2-[^(18)F]fluoro-D-glucose([^(18)F]-FDG),^(18)F-labelled amino acids,^(18)F-labelled nucleic acids,^(18)F-labelled receptors,^(18)F-labelled reporter genes,and^(18)F-labelled hypoxia agents.In addition,some PET probes with metal as a supplementary element are introduced briefly.Meanwhile,the^(18)F-labelled nanoparticles for the PET probe and the multi-modality imaging probe are summarized in detail.The approach and strategies for the fabrication of^(18)F-labelled PET probes are also described briefly.The future development of the PET probe is also prospected.The development and application of^(18)F-labelled PET probes will expand our knowledge and shed light on the diagnosis and theranostics of tumours.
