To develop an effective process for titanium powders production, a calciothermic reduction process of pigment titanium dioxide （w（TiO2）〉98%）, based on the preform reduction process （PRP）, was investigated by me...To develop an effective process for titanium powders production, a calciothermic reduction process of pigment titanium dioxide （w（TiO2）〉98%）, based on the preform reduction process （PRP）, was investigated by means of XRD, SEM and EDS. In this process, the mixture of TiO2 powder and CaC12 was pressed into pieces as feed preform and was reduced by calcium vapor. Titanium powders was recovered after leaching from the reduced preform with hydrochloric acid and deionized water. The results indicate when the mass ratio of CaC12 to TiO2 is about 1：4 and at a constant temperature of 1 273 K for 6 h in vacuum furnace, titanium powders with 99.55% purity by EDS analysis and irregular shape （8-15 μm in particle size） are obtained.展开更多
Buckypapers(BPs)consist of carbon nanotube(CNT)membranes with good mechanical,thermal and elec-trical properties.We report the modification of CNT buckypapers by the surface deposition of a thin layer of ti-tanium dio...Buckypapers(BPs)consist of carbon nanotube(CNT)membranes with good mechanical,thermal and elec-trical properties.We report the modification of CNT buckypapers by the surface deposition of a thin layer of ti-tanium dioxide and their subsequent photocatalytic use for the removal of three wastewater pollutants:diclofenac(DF),carbofuran(CB)and methylene blue(MB).The results show the following decreases(RE)in the initial concentrations of these pollutants,REDF=99.5%,REMB=96%and RECB=90%after 90 min of exposure to UV-Vis radiation using~0.6 mg of photocatalyst.Experiments also showed that the degradation rate of diclofenac(k=0.1028 min^(−1))is respectively 3.5 and 6 times faster than the values for CB(k=0.0298 min^(−1))and MB(k=0.0174 min^(−1)),probably due to the easier bond cleavage in DF.UV-Vis irradiated solutions of these pollutants were then analyzed by mass spectrometry to identify the species formed during photocatalysis and suggest possible degradation paths for MB,DF,and CB.Data showed that the degradation of DF involves the formation of a photocyclization product through loss of HCl molecule,clearly consuming less energy than that needed for the opening of the central aromatic ring in MB,or the loss of the N-methyl amide functional group for CB.展开更多
In order to produce low-cost titanium(Ti)with high productivity,fundamental studies on producing metallic Ti from titanium dioxide(TiO_(2))in the cold pressed pellets were conducted by metallothermic reduction with an...In order to produce low-cost titanium(Ti)with high productivity,fundamental studies on producing metallic Ti from titanium dioxide(TiO_(2))in the cold pressed pellets were conducted by metallothermic reduction with an indirect contact method.This paper focuses on discussing the mechanism of the reduction process and the relationships of RM(a revised reduction index)with reduction temperature,reduction time,and mole ratio of TiO_(2) to CaCl_(2)(nTiO_(2)/nCaCl_(2))in the pellets.The results show that metallic Ti was obtained from the reduction of TiO_(2) in the pellets by calcium(Ca)vapor;pellets were reduced homogenously and Ca vapor diffused into the porous pellets by Knudsen diffusion or the mixing diffusion of molecular diffusion and Knudsen diffusion at 1273 K;RM increased with the increases of temperature and reduction time and was 96.34%when T_(Redu)=1273 K,t_(Redu)=6 h,and nTiO_(2)/nCaCl_(2)=4;the reasonable nTiO_(2)/nCaCl_(2) value is 3−5 for the pellets with enough strength and high RM.展开更多
A large amount of coal gangue from coal mining and processing is regarded as waste and usually stockpiled directly. In order to recycle the valuable elements from the coal gangue, an integrated process is proposed. Th...A large amount of coal gangue from coal mining and processing is regarded as waste and usually stockpiled directly. In order to recycle the valuable elements from the coal gangue, an integrated process is proposed. The process consists of three steps: 1concentrating alumina from the coal gangue via activation roasting followed by alkali leaching of Si O2 which produces alumina concentrate for alumina extraction by the Bayer process; 2) synthesizing tobermorite whiskers from the filtrated alkali liquo containing silicate via a hydrothermal method and reusing excess caustic liquor; and 3) enriching titanium component from the Baye process residue by sulfuric acid leaching. Alumina concentrate with 69.5% Al_2O_3 and mass ratio of alumina to silica(A/S) of 5.9pure 1.1 nm tobermorite whisker and TiO_2-rich material containing 33% TiO_2 are produced, respectively, with the optimal parameters Besides, the actual alumina digestion ratio of alumina concentrate reaches 80.4% at 270 oC for 40 min in the Bayer process.展开更多
We reported the fabrication of highly porous graphene/TiO2 composite nanofibers in the form of a nonwoven mat by electrospinning followed by calcination in air at 450°C.The graphene can uniformly disperse in high...We reported the fabrication of highly porous graphene/TiO2 composite nanofibers in the form of a nonwoven mat by electrospinning followed by calcination in air at 450°C.The graphene can uniformly disperse in highly porous TiO2 nanofibers.The highly porous graphene/TiO2 composite nanofibers exhibited excellent catalytic activities.The new method for producing graphene/TiO2 composite nanofibers is versatile and can be extended to fabricate various types of metal oxide and graphene nanocomposites.展开更多
Based on the first-principles calculations of density functional theory,co-adsorption models of C or CO with Cl2 on rutile TiO2(100)surface were established.The adsorption structures and electronic properties during c...Based on the first-principles calculations of density functional theory,co-adsorption models of C or CO with Cl2 on rutile TiO2(100)surface were established.The adsorption structures and electronic properties during chlorination process were predicted.Then,the adsorption energy,charge density,electron density difference and density of state of the adsorption structures were calculated and analyzed.The stabilities of the adsorption structures and the charge distributions between atoms were studied.It was found that both C and CO could promote the adsorption reactions of Cl2 on TiO2(100)surface,and C was more favorable to the adsorption process.The results show that the adsorption process of Cl2 on TiO2(100)surface was physisorption,and the co-adsorption processes of C or CO with Cl2 on TiO2(100)surface were chemisorptions.展开更多
As a popular anode material for lithium-ion batteries,anatase TiO2 nanoparticles with exposed{001}facets usually exhibit exceptional lithium storage performance owing to more accessible sites and fast migration of lit...As a popular anode material for lithium-ion batteries,anatase TiO2 nanoparticles with exposed{001}facets usually exhibit exceptional lithium storage performance owing to more accessible sites and fast migration of lithium ions along the good crystalline channels.However,there are few researches on the lithium storage capability of TiO2 nanocrystals with other high-energy facets owing to lack of effective synthesis method for controlling crystal facets.Herein,anatase TiO2 nanocrystals with exposed{010}-and[111]-facets are successfully prepared by using the delaminated tetratitanate nanoribbons as precursors.The electrochemical properties of these TiO2 nanocrystals with high-energy surfaces and the comparison with commercial TiO2 nanoparticles(P25)are studied.It is found that the cycle and rate performance of TiO2 nanocrystals is highly improved by reducing the particle size of nanocrystals.Moreover,TiO2 nanocrystals with exposed{010}-and[111]-facets exhibit better lithium storage capacities in comparison with P25 without a specific facet though P25 has smaller particle size than these TiO2 nanocrystals,indicating that the exposed facets of TiO2 nanocrystals have an important impact on their lithium storage capacity.Therefore,the synthesis design of high-performance TiO2 materials applied in the next-generation secondary batteries should both consider the particle size and the exposed facets of nanocrystals.展开更多
Unveiling the active site of an electrocatalyst is fundamental for the development of efficient electrode material.For the two-electron water oxidation to produce H_(2)O_(2),competitive reactions,including four-and on...Unveiling the active site of an electrocatalyst is fundamental for the development of efficient electrode material.For the two-electron water oxidation to produce H_(2)O_(2),competitive reactions,including four-and one-electron water oxidation and surface reconstruction derived from the high-oxidative environment co-existed,leading to great challenges to identify the real active sites on the electrode.In this work,Ti/TiO_(2)-based electrodes calcined under air,nitrogen,or urea atmospheres were selected as electrocatalysts for two-electron water oxidation.Electrochemical analyses were applied to evaluate the catalytic activity and selectivity.The morphological and current change on the electrode surface were determined by scanning electrochemical microscopy,while the chemical and valence evolutions with depth distributions were tested by XPS combined with cluster argon ion sputtering.The results demonstrated that Ti/TiO_(2) nanotube arrays served as the support,while the functional groups of carbonyl groups and pyrrolic nitrogen derived from the co-pyrolysis with urea were the active sites for the H_(2)O_(2) production.This finding provided a new horizon to design efficient catalysts for H_(2)O_(2) production.展开更多
Nanocrystalline Fe-doped TiO2 with size of 6070 nm was prepared by a sol-gel technique, followed by freeze-drying treatment for 2 h. Thermogravimetric and differential thermal analyses, X-ray diffraction, scanning （e...Nanocrystalline Fe-doped TiO2 with size of 6070 nm was prepared by a sol-gel technique, followed by freeze-drying treatment for 2 h. Thermogravimetric and differential thermal analyses, X-ray diffraction, scanning （electron） microscope, laser diffraction particle size analyzer and UV-Vis spectrophotometer technologies were used to characterize the product. The photocatalytic activities of the samples were evaluated by the degradation of wastewater of paper-making. The effects of Fe ion implantation on the photocatalytic activity of TiO2 were also discussed. The results show that the iron content plays an essential role in affecting the photocatalytic activity of the Fe-doped TiO2 and the optimum content of Fe-doped is 0.05% （mass fraction）. The photocatalytic activity of samples with lower content of Fe-doped is higher than that of pure TiO2 in the treatment of paper-making wastewater. The photo-degradation effect of paper-making effluent is the best by means of Fe-doped TiO2 with 0.05% Fe.展开更多
OBJECTIVE Nanotechnology provides a novel strategy for the delivery of anticancer drugs.METHODS Titanium dioxide coated gold nanostructures(Au/TiO2)was used as the drug carrier for the natural anticancer drug gambogic...OBJECTIVE Nanotechnology provides a novel strategy for the delivery of anticancer drugs.METHODS Titanium dioxide coated gold nanostructures(Au/TiO2)was used as the drug carrier for the natural anticancer drug gambogic acid in order to improve its anticancer effect.Biocompatibility and cellular uptake of Au/TiO2 was studied in human glio⁃blastoma U-87 MG cells.Cell viability was evaluated by ATP assay and calcein AM staining.LysoSensor Green DND-189 and Hoechst 33342 were used to analyze the intracellular location of Au/TiO2.The anticancer effect of gambogic acid loaded nanoparticles was compared with free drug.RESULTS Au/TiO2 was biocompatible,and they were localized at the intracellular acidic compartments of endosomes and lysosomes.The intracellular drug content delivered via Au/TiO2 was 6-fold higher than the free form,thus dramatically enhancing the anticancer effect of gambogic acid.Furthermore,mild photothermal therapy also showed synergistic effect with the drug.CONCLUSION Au/TiO2 is a promising anticancer drug carrier.展开更多
OBJECTIVE To improve the anticancer drug gambogic acid’s effect by using titanium dioxide coated gold nanorods(GNR/Ti O2)as a drug carrier.METHODS Biocompatibility and cellular uptake of GNR/Ti O2was studied in human...OBJECTIVE To improve the anticancer drug gambogic acid’s effect by using titanium dioxide coated gold nanorods(GNR/Ti O2)as a drug carrier.METHODS Biocompatibility and cellular uptake of GNR/Ti O2was studied in human glioblastoma U-87 MG cells.Cel viability was evaluated by ATP assay and calcein AM staining.Lyso SensorTMGreen DND-189 and Hoechst 33342 were used to analyze the intracellular location of GNR/Ti O2.The in vitro anticancer effect of gambogic acid loaded nanoparticles was compared with free drug.RESULTS The results showed that GNR/Ti O2is biocompatible,andthey are localized at the intracellular acidic compartments of endosomes and lysosomes.The intracellular drug content delivered via GNR/Ti O2was 6 fold higher than the free form,thus dramatically enhancing the anticancer effect of gambogic acid.Furthermore,mild photothermal therapy also showed synergistic effect with the drug.CONCLUSION Our study suggested that GNR/Ti O2is a promising anticancer drug carrier。展开更多
OBJECTIVE Nanotechnology provides a novel strategy for the delivery of anticancer drugs.In this study,titanium dioxide coated gold nanorod(GNR/TiO_2) nanostructures were used as the drug carrier for gambogic acid in o...OBJECTIVE Nanotechnology provides a novel strategy for the delivery of anticancer drugs.In this study,titanium dioxide coated gold nanorod(GNR/TiO_2) nanostructures were used as the drug carrier for gambogic acid in order to improve its anticancer effect.METHODS Biocompatibility and cellular uptake of GNR/TiO_2 nanostructures were studied in human glioblastoma U-87 MG cells.Cell viability was evaluated by ATP assay and calcein AM staining.Lyso Sensor Green DND-189 and Hoechst 33342 were used to analyze the intracellular location of GNR/TiO_2 nanostructures.The in vitro anti-cancer effect of gambogic acid loaded nanoparticles was compared with free drug.RESULTS The results showed that GNR/TiO_2 nanostructures are biocompatible,and they are localized at the intracellular acidic compartments of endosomes and lysosomes.The intracellular drug content delivered via GNR/TiO_2 nanostructures was 6 fold higher than the free form,thus dramatically enhancing the anticancer effect of gambogic acid.Furthermore,mild photothermal therapy also showed synergistic effect with the drug.CONCLUSION Our study suggested that GNR/TiO_2 nanostructures can be considered as a promising anticancer drug carrier.展开更多
基金Project(51004058) supported by the National Natural Science Foundation of ChinaProject(2011FB039) supported by the Natural Science Foundation of Yunnan Province,China
文摘To develop an effective process for titanium powders production, a calciothermic reduction process of pigment titanium dioxide （w（TiO2）〉98%）, based on the preform reduction process （PRP）, was investigated by means of XRD, SEM and EDS. In this process, the mixture of TiO2 powder and CaC12 was pressed into pieces as feed preform and was reduced by calcium vapor. Titanium powders was recovered after leaching from the reduced preform with hydrochloric acid and deionized water. The results indicate when the mass ratio of CaC12 to TiO2 is about 1：4 and at a constant temperature of 1 273 K for 6 h in vacuum furnace, titanium powders with 99.55% purity by EDS analysis and irregular shape （8-15 μm in particle size） are obtained.
基金MIUR,Italian Ministry for University and Research(EX-60%/2024)。
文摘Buckypapers(BPs)consist of carbon nanotube(CNT)membranes with good mechanical,thermal and elec-trical properties.We report the modification of CNT buckypapers by the surface deposition of a thin layer of ti-tanium dioxide and their subsequent photocatalytic use for the removal of three wastewater pollutants:diclofenac(DF),carbofuran(CB)and methylene blue(MB).The results show the following decreases(RE)in the initial concentrations of these pollutants,REDF=99.5%,REMB=96%and RECB=90%after 90 min of exposure to UV-Vis radiation using~0.6 mg of photocatalyst.Experiments also showed that the degradation rate of diclofenac(k=0.1028 min^(−1))is respectively 3.5 and 6 times faster than the values for CB(k=0.0298 min^(−1))and MB(k=0.0174 min^(−1)),probably due to the easier bond cleavage in DF.UV-Vis irradiated solutions of these pollutants were then analyzed by mass spectrometry to identify the species formed during photocatalysis and suggest possible degradation paths for MB,DF,and CB.Data showed that the degradation of DF involves the formation of a photocyclization product through loss of HCl molecule,clearly consuming less energy than that needed for the opening of the central aromatic ring in MB,or the loss of the N-methyl amide functional group for CB.
基金Projects(51774071,50804007,51974073)supported by the National Natural Science Foundation of China。
文摘In order to produce low-cost titanium(Ti)with high productivity,fundamental studies on producing metallic Ti from titanium dioxide(TiO_(2))in the cold pressed pellets were conducted by metallothermic reduction with an indirect contact method.This paper focuses on discussing the mechanism of the reduction process and the relationships of RM(a revised reduction index)with reduction temperature,reduction time,and mole ratio of TiO_(2) to CaCl_(2)(nTiO_(2)/nCaCl_(2))in the pellets.The results show that metallic Ti was obtained from the reduction of TiO_(2) in the pellets by calcium(Ca)vapor;pellets were reduced homogenously and Ca vapor diffused into the porous pellets by Knudsen diffusion or the mixing diffusion of molecular diffusion and Knudsen diffusion at 1273 K;RM increased with the increases of temperature and reduction time and was 96.34%when T_(Redu)=1273 K,t_(Redu)=6 h,and nTiO_(2)/nCaCl_(2)=4;the reasonable nTiO_(2)/nCaCl_(2) value is 3−5 for the pellets with enough strength and high RM.
基金Projects(51234008,51174230)supported by the National Natural Science Foundation of ChinaProject(NCET-11-0515)supported by the Program for New Century Excellent Talents in University,ChinaProject supported by Co-Innovation Center for Clean and Efficient Utilization of Strategic Metal Mineral Resources,China
文摘A large amount of coal gangue from coal mining and processing is regarded as waste and usually stockpiled directly. In order to recycle the valuable elements from the coal gangue, an integrated process is proposed. The process consists of three steps: 1concentrating alumina from the coal gangue via activation roasting followed by alkali leaching of Si O2 which produces alumina concentrate for alumina extraction by the Bayer process; 2) synthesizing tobermorite whiskers from the filtrated alkali liquo containing silicate via a hydrothermal method and reusing excess caustic liquor; and 3) enriching titanium component from the Baye process residue by sulfuric acid leaching. Alumina concentrate with 69.5% Al_2O_3 and mass ratio of alumina to silica(A/S) of 5.9pure 1.1 nm tobermorite whisker and TiO_2-rich material containing 33% TiO_2 are produced, respectively, with the optimal parameters Besides, the actual alumina digestion ratio of alumina concentrate reaches 80.4% at 270 oC for 40 min in the Bayer process.
基金Project(41271332)supported by the National Natural Science Foundation of China
文摘We reported the fabrication of highly porous graphene/TiO2 composite nanofibers in the form of a nonwoven mat by electrospinning followed by calcination in air at 450°C.The graphene can uniformly disperse in highly porous TiO2 nanofibers.The highly porous graphene/TiO2 composite nanofibers exhibited excellent catalytic activities.The new method for producing graphene/TiO2 composite nanofibers is versatile and can be extended to fabricate various types of metal oxide and graphene nanocomposites.
基金Projects(51674052,51974046)supported by the National Natural Science Foundation of ChinaProject(cstc2018jcyjAX0003)supported by the Chongqing Research Program of Basic Research and Frontier Technology,China。
文摘Based on the first-principles calculations of density functional theory,co-adsorption models of C or CO with Cl2 on rutile TiO2(100)surface were established.The adsorption structures and electronic properties during chlorination process were predicted.Then,the adsorption energy,charge density,electron density difference and density of state of the adsorption structures were calculated and analyzed.The stabilities of the adsorption structures and the charge distributions between atoms were studied.It was found that both C and CO could promote the adsorption reactions of Cl2 on TiO2(100)surface,and C was more favorable to the adsorption process.The results show that the adsorption process of Cl2 on TiO2(100)surface was physisorption,and the co-adsorption processes of C or CO with Cl2 on TiO2(100)surface were chemisorptions.
基金Projects(21573023,51572031)supported by the National Natural Science Foundation of ChinaProject supported by the Grants-in-Acid for Doctor Research Funds+1 种基金Project supported by “1331 Project” for Innovation Team Construction Plan Funds of Jinzhong University,ChinaProject supported by “1331 Project” for 2018 Key Innovation Team Construction Plan Funds of Shanxi Province,China
文摘As a popular anode material for lithium-ion batteries,anatase TiO2 nanoparticles with exposed{001}facets usually exhibit exceptional lithium storage performance owing to more accessible sites and fast migration of lithium ions along the good crystalline channels.However,there are few researches on the lithium storage capability of TiO2 nanocrystals with other high-energy facets owing to lack of effective synthesis method for controlling crystal facets.Herein,anatase TiO2 nanocrystals with exposed{010}-and[111]-facets are successfully prepared by using the delaminated tetratitanate nanoribbons as precursors.The electrochemical properties of these TiO2 nanocrystals with high-energy surfaces and the comparison with commercial TiO2 nanoparticles(P25)are studied.It is found that the cycle and rate performance of TiO2 nanocrystals is highly improved by reducing the particle size of nanocrystals.Moreover,TiO2 nanocrystals with exposed{010}-and[111]-facets exhibit better lithium storage capacities in comparison with P25 without a specific facet though P25 has smaller particle size than these TiO2 nanocrystals,indicating that the exposed facets of TiO2 nanocrystals have an important impact on their lithium storage capacity.Therefore,the synthesis design of high-performance TiO2 materials applied in the next-generation secondary batteries should both consider the particle size and the exposed facets of nanocrystals.
基金Project(2021JJ30792) supported by the Natural Science Foundation of Hunan Province,ChinaProject(52170031) supported by the National Natural Science Foundation of ChinaProject supported by the Fundamental Research Funds for the Central Universities,China。
文摘Unveiling the active site of an electrocatalyst is fundamental for the development of efficient electrode material.For the two-electron water oxidation to produce H_(2)O_(2),competitive reactions,including four-and one-electron water oxidation and surface reconstruction derived from the high-oxidative environment co-existed,leading to great challenges to identify the real active sites on the electrode.In this work,Ti/TiO_(2)-based electrodes calcined under air,nitrogen,or urea atmospheres were selected as electrocatalysts for two-electron water oxidation.Electrochemical analyses were applied to evaluate the catalytic activity and selectivity.The morphological and current change on the electrode surface were determined by scanning electrochemical microscopy,while the chemical and valence evolutions with depth distributions were tested by XPS combined with cluster argon ion sputtering.The results demonstrated that Ti/TiO_(2) nanotube arrays served as the support,while the functional groups of carbonyl groups and pyrrolic nitrogen derived from the co-pyrolysis with urea were the active sites for the H_(2)O_(2) production.This finding provided a new horizon to design efficient catalysts for H_(2)O_(2) production.
文摘Nanocrystalline Fe-doped TiO2 with size of 6070 nm was prepared by a sol-gel technique, followed by freeze-drying treatment for 2 h. Thermogravimetric and differential thermal analyses, X-ray diffraction, scanning （electron） microscope, laser diffraction particle size analyzer and UV-Vis spectrophotometer technologies were used to characterize the product. The photocatalytic activities of the samples were evaluated by the degradation of wastewater of paper-making. The effects of Fe ion implantation on the photocatalytic activity of TiO2 were also discussed. The results show that the iron content plays an essential role in affecting the photocatalytic activity of the Fe-doped TiO2 and the optimum content of Fe-doped is 0.05% （mass fraction）. The photocatalytic activity of samples with lower content of Fe-doped is higher than that of pure TiO2 in the treatment of paper-making wastewater. The photo-degradation effect of paper-making effluent is the best by means of Fe-doped TiO2 with 0.05% Fe.
基金Macao Science and Technology Development Fund(FDCT)(014/2014/A1)
文摘OBJECTIVE Nanotechnology provides a novel strategy for the delivery of anticancer drugs.METHODS Titanium dioxide coated gold nanostructures(Au/TiO2)was used as the drug carrier for the natural anticancer drug gambogic acid in order to improve its anticancer effect.Biocompatibility and cellular uptake of Au/TiO2 was studied in human glio⁃blastoma U-87 MG cells.Cell viability was evaluated by ATP assay and calcein AM staining.LysoSensor Green DND-189 and Hoechst 33342 were used to analyze the intracellular location of Au/TiO2.The anticancer effect of gambogic acid loaded nanoparticles was compared with free drug.RESULTS Au/TiO2 was biocompatible,and they were localized at the intracellular acidic compartments of endosomes and lysosomes.The intracellular drug content delivered via Au/TiO2 was 6-fold higher than the free form,thus dramatically enhancing the anticancer effect of gambogic acid.Furthermore,mild photothermal therapy also showed synergistic effect with the drug.CONCLUSION Au/TiO2 is a promising anticancer drug carrier.
基金The project supported by Macao Science and Technology Development Fund(014/2014/A1)
文摘OBJECTIVE To improve the anticancer drug gambogic acid’s effect by using titanium dioxide coated gold nanorods(GNR/Ti O2)as a drug carrier.METHODS Biocompatibility and cellular uptake of GNR/Ti O2was studied in human glioblastoma U-87 MG cells.Cel viability was evaluated by ATP assay and calcein AM staining.Lyso SensorTMGreen DND-189 and Hoechst 33342 were used to analyze the intracellular location of GNR/Ti O2.The in vitro anticancer effect of gambogic acid loaded nanoparticles was compared with free drug.RESULTS The results showed that GNR/Ti O2is biocompatible,andthey are localized at the intracellular acidic compartments of endosomes and lysosomes.The intracellular drug content delivered via GNR/Ti O2was 6 fold higher than the free form,thus dramatically enhancing the anticancer effect of gambogic acid.Furthermore,mild photothermal therapy also showed synergistic effect with the drug.CONCLUSION Our study suggested that GNR/Ti O2is a promising anticancer drug carrier。
基金supported by Macao Science and Technology Development Fund(FDCT)(014/2014/A1)
文摘OBJECTIVE Nanotechnology provides a novel strategy for the delivery of anticancer drugs.In this study,titanium dioxide coated gold nanorod(GNR/TiO_2) nanostructures were used as the drug carrier for gambogic acid in order to improve its anticancer effect.METHODS Biocompatibility and cellular uptake of GNR/TiO_2 nanostructures were studied in human glioblastoma U-87 MG cells.Cell viability was evaluated by ATP assay and calcein AM staining.Lyso Sensor Green DND-189 and Hoechst 33342 were used to analyze the intracellular location of GNR/TiO_2 nanostructures.The in vitro anti-cancer effect of gambogic acid loaded nanoparticles was compared with free drug.RESULTS The results showed that GNR/TiO_2 nanostructures are biocompatible,and they are localized at the intracellular acidic compartments of endosomes and lysosomes.The intracellular drug content delivered via GNR/TiO_2 nanostructures was 6 fold higher than the free form,thus dramatically enhancing the anticancer effect of gambogic acid.Furthermore,mild photothermal therapy also showed synergistic effect with the drug.CONCLUSION Our study suggested that GNR/TiO_2 nanostructures can be considered as a promising anticancer drug carrier.
