Betel nut is the dry and mature seed of Areca catechu L.,which is originated in Malaysia and cultivated in Yunnan,Hainan and Taiwan and other tropical areas of China.It is also known as big belly,binmen,olive seed,gre...Betel nut is the dry and mature seed of Areca catechu L.,which is originated in Malaysia and cultivated in Yunnan,Hainan and Taiwan and other tropical areas of China.It is also known as big belly,binmen,olive seed,green seed and so on.Betel nut is a dual-use resource for medicine and food,which was first contained in LI Dang′s Pharmaceutical Record.Betel nut tastes bitter,pungent,warm in nature,and belongs to the stomach and large intestine meridian.It contains a variety of chemical components such as alkaloids,phenolic compounds,polysaccharides,fatty acids,amino acids, flavonoids, minerals, terpenoids, and steroids. It has the advantages of promoting digestion, lowering blood pres sure, anti-depression, anti-oxidation, anti-inflammatory, and anti-parasites, antibacterial and other activities. The content of total phenols in fresh fruits of areca nut was 31.1%, mainly including catechin, isorhamnetin, chrysopanthoxanthin, luteolin, tannin and other polyphenols. The commonly used methods for determination of polyphenols in areca are vanil lin titration potassium permanganate titration and potassium ferricyanide spectrophotometry. The main activities and mechanisms of areca polyphenols include: ① Antidepressant effect: polyphenols bind to monoamine oxidase type A (MAO-A) receptors that inhibit the production of neurotransmitters, thereby increasing the content of amine transmitters in the brain and playing a therapeutic effect on depression. ② Antioxidant effect: polyphenols contain multiple adjacent hydroxyl groups, which are easily oxidized and can effectively remove superoxide anion free radical, hydroxyl free radi cal, 1,1-diphenyl-2-picrylhydrazyl radical, showing good antioxidant activity. ③ Bacteriostatic effect: polyphenols can spe cifically bind to the surface of bacteria, thus achieving bacteriostatic effect. Studies have found that betel nut polyphenols have varying degrees of inhibitory effects on a variety of bacteria. ④ Inducing apoptosis of lymphocytes: polyphenols deplete the mercaptan in lymphocytes and make them unable to survive, thus inducing apoptosis of lymphocytes. ⑤ Anti-aging effect: polyphenols have the effect of anti-hyaluronidase and anti-elastase, so as to protect elastin fiber and pro mote collagen synthesis. ⑥ Anti-allergic effect: studies have found that polyphenols can reduce ovalbumin induced aller gic reactions. ⑦ Other functions: betel nut can freshen breath, eliminate bad breath, and resist the activity of cobra venom. At present, domestic and foreign scholars′ research on betel nut mainly focuses on arecoline and its carcinogenicity, mutagenicity, effects on reproductive function, addiction and toxicity to the nervous system, and there are few studies on the positive effects of betel nut, especially on it. There is less research on phenolic ingredients. Therefore, this article reviews the polyphenolic chemical constituents of betel nut, and fully excavates its pharmacological activity to provide a reasonable basis for the scientific use of betel nut.展开更多
Aiming to provide a theoretical basis for possible uses of flaxseed as a food supplement and functional ingredient, the heat treatment of flaxseed was carried out using steaming, roasting, and microwave methods to inv...Aiming to provide a theoretical basis for possible uses of flaxseed as a food supplement and functional ingredient, the heat treatment of flaxseed was carried out using steaming, roasting, and microwave methods to investigate the detoxification effects of these three pretreatment methods on flaxseed, as well as the impact of the three methods on the quality of flaxseed. The results showed that all three pretreatment methods had better detoxification effects on flaxseed, in which, microwave treatment was the most effective method. After 5 min of microwave treatment, the hydrogen cyanide(HCN) content in flaxseed decreased from(94.65±1.68) mg/kg to(7.80±0.57) mg/kg. All three pretreatment methods significantly reduced the water content in flaxseed but had a weaker effect on protein, fat, and ash contents. After pretreatment by the three methods, the polyphenol content, peroxide value(POV), and a*value of flaxseed increased significantly, thiobarbituric acid reactive substances(TBARS) increased, while polyunsaturated fatty acids(PUFA) content, amino acid content, and L*, W*, and b*values decreased, with varying degrees of wrinkles and cracks appearing on the surface of flaxseed, and the overall signal pattern of FTIR spectra did not change much. During the 40℃ accelerated storage process, the quality of flaxseed treated by all three preheating methods generally declined, and correlation analysis revealed that color change was a good indicator of quality changes in flaxseed. Notably, all three pretreatment methods extended the shelf-life of flaxseed. Compared with steaming(120℃ for 20 min) and roasting(100℃ for 40 min), microwave(560 W for 4 min) is recommended to remove cyanogenic glycosides and improve the stability and quality characteristics of flaxseed.展开更多
Growing evidence indicates that cancer incidence across the world is not similar,and it is more prevalent in certain populations than others,suggesting the critical role for dietary and lifestyle factors.For instance ...Growing evidence indicates that cancer incidence across the world is not similar,and it is more prevalent in certain populations than others,suggesting the critical role for dietary and lifestyle factors.For instance cancer incidence among people from the Indian subcontinent,where most spices are consumed,is much lower than that in the Western World.Spices have been consumed for centuries for a variety of purposes e.g.as flavoring agents,colorants,and preservatives.However,there is increasing evidence for the importance of plant-based foods in regular diet to lowering the risk of most chronic diseases,so spices are now emerging as more than just flavor aids,but as agents that can not only prevent but may even treat disease.Besides suppressing inflammatory pathways,spice-derived nutraceuticals can suppress survival,proliferation,invasion,and angiogenesis of tumor cells.Increasing evidence indicates that genetic alterations are relatively rare,and epigenetic changes(DNA methylation,histone modifications and expression of noncoding RNAs)plays a bigger role in human cancer,and can be easily influenced by environmental,lifestyle and dietary factors,and some estimates suggest that over two-thirds of the cancer incidence can be accounted for by the environmental and dietary factors alone.Among all these factors,diet is probably the single most important factor which may influence carcinogenesis more comprehensively,because diet is readily modifiable and have the potential to modulate multiple epigenetic processes.Polyphenols in dietary botanicals represent a versatile group of phytochemicals with many potentially beneficial activities in terms of disease prevention.Dietary polyphenols(bioflavanoids)have antioxidant and anti-inflammatory properties that might explain their chemopreventive effects.However,the actual therapeutic potential of these compounds may not have been completely realized due to lack of understanding on the effects of these agents on epigenetic modifications.Recent,but limited evidence indicates that some of the polyphenols,including curcumin(from turmeric),genestein(from soy),EGCG(from green tea),diallyl disulfide(from garlic),sulforaphane(from broccoli)and resveratrol(from grapes)may induce epigenetic changes in various cancer cell lines.This presentation will describe some of the current scientific evidence for the role of epigenetic alterations induced by curcumin and boswellia,in support of their anti-cancer activities,which provides a strong scientific foundation for preclinical and human clinical intervention studies in future.展开更多
To understand the possible mechanism controlling the formation of silicon bodies in higher plants, we need to know the nature of organic compounds associated with silicon bodies and induces silicon precipitation in pl...To understand the possible mechanism controlling the formation of silicon bodies in higher plants, we need to know the nature of organic compounds associated with silicon bodies and induces silicon precipitation in plant cells. A new method was developed to isolate pure silicon body in fresh leaves of rice (Oryaa sativa L. Var. 297) at low temperature by grinding and centrifugation procedures, which avoided degradation of organic molecules induced by high temperature and strong oxidizing acids used in the traditional method. The energy dispersive X-ray spectrum under scanning electron microscope showed that there was a great amount of carbon in silicon bodies in addition to silicon and oxygen. Organic compounds intimately associated with silicon bodies were released by treatment with HF solution. Analysis of the organic compounds by micro-infrared spectroscopy revealed the presence of polyphenol and polysaccharide and a little protein.展开更多
Cotton is not only an important source of textilefibre and edible oil,but also a valuable source ofhigh-quality protein and fodder,because 45%～50% of the cotton seed powder is protein.However,the seeds of cultivated ...Cotton is not only an important source of textilefibre and edible oil,but also a valuable source ofhigh-quality protein and fodder,because 45%～50% of the cotton seed powder is protein.However,the seeds of cultivated cotton usuallycontain a special polyphenol compound calledgossypol,which is poisonous and hinders theutilization of the seeds.Therefore breeding展开更多
The burgeoning development of nanomedicine has provided state-of-the-art technologies and innovative methodologies for contemporary biomedical research,presenting unprecedented opportunities for resolving pivotal biom...The burgeoning development of nanomedicine has provided state-of-the-art technologies and innovative methodologies for contemporary biomedical research,presenting unprecedented opportunities for resolving pivotal biomedical challenges.Nanomaterials possess distinctive structures and properties.Through the exploration of the fabrication of emerging nanomedicines,multiple functions can be integrated to enable more precise diagnosis and treatment,thereby compensating for the limitations of traditional treatment modalities.Among various substances,polyphenols are natural organic compounds classified as plant secondary metabolites and are ubiquitously present in vegetables,teas,and other plants.Polyphenols are rich in active groups,including hydroxyl,carboxyl,amino,and conjugated double bonds.They exhibit robust adhesion,antioxidant,anti-inflammatory,and antibacterial biological activities and are extensively applied in pharmaceutical formulations.Additionally,polyphenols are characterized by their low cost,ready availability,and do not necessitate intricate chemical synthesis processes.Nevertheless,when natural polyphenol-based nanomedicines are utilized in isolation,they encounter several issues.These include poor water solubility,feeble stability,low bioavailability,the requirement for high dosages,and difficulties in precisely reaching the site of action.To address these concerns,researchers have developed nanomedicines by combining metal ions and functional ligands through metal coordination strategies.Nanomaterials,owing to their unique electronic and optical properties,have been successfully introduced into the realm of medical biology.Nano preparations not only enhance the stability of natural products but also endow them with targeting capabilities,thus enabling precise drug delivery.Polyphenols can further synergize with metal ions,anti-cancer drugs,or photosensitizers via supramolecular interactions to achieve multifunctional synergistic therapies,such as targeted drug delivery,efficacy enhancement,and the construction of engineering scaffolds.Metal-Polyphenol Coordination Polymers(MPCPs),composed of metal ions and phenolic ligands,are regarded as ideal nanoplatforms for disease diagnosis and treatment.In recent years,MPCPs have attracted extensive research in the biomedical field on account of their advantages,including facile synthesis,adjustable structure,excellent biocompatibility,and pH responsiveness.In this review,the classification and preparation strategies of MPCPs were systematically presented.Subsequently,their remarkable achievements in biomedical domains,such as bioimaging,biosensing,drug delivery,tumor therapy,and antimicrobial applications were highlighted.Finally,the principal limitations and prospects of MPCPs were comprehensi vely discussed.展开更多
基金Fund of Dean of Huachuang Institute of Areca Research-Hainan(HCBL2020YZ-012)。
文摘Betel nut is the dry and mature seed of Areca catechu L.,which is originated in Malaysia and cultivated in Yunnan,Hainan and Taiwan and other tropical areas of China.It is also known as big belly,binmen,olive seed,green seed and so on.Betel nut is a dual-use resource for medicine and food,which was first contained in LI Dang′s Pharmaceutical Record.Betel nut tastes bitter,pungent,warm in nature,and belongs to the stomach and large intestine meridian.It contains a variety of chemical components such as alkaloids,phenolic compounds,polysaccharides,fatty acids,amino acids, flavonoids, minerals, terpenoids, and steroids. It has the advantages of promoting digestion, lowering blood pres sure, anti-depression, anti-oxidation, anti-inflammatory, and anti-parasites, antibacterial and other activities. The content of total phenols in fresh fruits of areca nut was 31.1%, mainly including catechin, isorhamnetin, chrysopanthoxanthin, luteolin, tannin and other polyphenols. The commonly used methods for determination of polyphenols in areca are vanil lin titration potassium permanganate titration and potassium ferricyanide spectrophotometry. The main activities and mechanisms of areca polyphenols include: ① Antidepressant effect: polyphenols bind to monoamine oxidase type A (MAO-A) receptors that inhibit the production of neurotransmitters, thereby increasing the content of amine transmitters in the brain and playing a therapeutic effect on depression. ② Antioxidant effect: polyphenols contain multiple adjacent hydroxyl groups, which are easily oxidized and can effectively remove superoxide anion free radical, hydroxyl free radi cal, 1,1-diphenyl-2-picrylhydrazyl radical, showing good antioxidant activity. ③ Bacteriostatic effect: polyphenols can spe cifically bind to the surface of bacteria, thus achieving bacteriostatic effect. Studies have found that betel nut polyphenols have varying degrees of inhibitory effects on a variety of bacteria. ④ Inducing apoptosis of lymphocytes: polyphenols deplete the mercaptan in lymphocytes and make them unable to survive, thus inducing apoptosis of lymphocytes. ⑤ Anti-aging effect: polyphenols have the effect of anti-hyaluronidase and anti-elastase, so as to protect elastin fiber and pro mote collagen synthesis. ⑥ Anti-allergic effect: studies have found that polyphenols can reduce ovalbumin induced aller gic reactions. ⑦ Other functions: betel nut can freshen breath, eliminate bad breath, and resist the activity of cobra venom. At present, domestic and foreign scholars′ research on betel nut mainly focuses on arecoline and its carcinogenicity, mutagenicity, effects on reproductive function, addiction and toxicity to the nervous system, and there are few studies on the positive effects of betel nut, especially on it. There is less research on phenolic ingredients. Therefore, this article reviews the polyphenolic chemical constituents of betel nut, and fully excavates its pharmacological activity to provide a reasonable basis for the scientific use of betel nut.
基金Dalian Science and Technology Innovation Fund Project (2022JJ11CG008)。
文摘Aiming to provide a theoretical basis for possible uses of flaxseed as a food supplement and functional ingredient, the heat treatment of flaxseed was carried out using steaming, roasting, and microwave methods to investigate the detoxification effects of these three pretreatment methods on flaxseed, as well as the impact of the three methods on the quality of flaxseed. The results showed that all three pretreatment methods had better detoxification effects on flaxseed, in which, microwave treatment was the most effective method. After 5 min of microwave treatment, the hydrogen cyanide(HCN) content in flaxseed decreased from(94.65±1.68) mg/kg to(7.80±0.57) mg/kg. All three pretreatment methods significantly reduced the water content in flaxseed but had a weaker effect on protein, fat, and ash contents. After pretreatment by the three methods, the polyphenol content, peroxide value(POV), and a*value of flaxseed increased significantly, thiobarbituric acid reactive substances(TBARS) increased, while polyunsaturated fatty acids(PUFA) content, amino acid content, and L*, W*, and b*values decreased, with varying degrees of wrinkles and cracks appearing on the surface of flaxseed, and the overall signal pattern of FTIR spectra did not change much. During the 40℃ accelerated storage process, the quality of flaxseed treated by all three preheating methods generally declined, and correlation analysis revealed that color change was a good indicator of quality changes in flaxseed. Notably, all three pretreatment methods extended the shelf-life of flaxseed. Compared with steaming(120℃ for 20 min) and roasting(100℃ for 40 min), microwave(560 W for 4 min) is recommended to remove cyanogenic glycosides and improve the stability and quality characteristics of flaxseed.
文摘Growing evidence indicates that cancer incidence across the world is not similar,and it is more prevalent in certain populations than others,suggesting the critical role for dietary and lifestyle factors.For instance cancer incidence among people from the Indian subcontinent,where most spices are consumed,is much lower than that in the Western World.Spices have been consumed for centuries for a variety of purposes e.g.as flavoring agents,colorants,and preservatives.However,there is increasing evidence for the importance of plant-based foods in regular diet to lowering the risk of most chronic diseases,so spices are now emerging as more than just flavor aids,but as agents that can not only prevent but may even treat disease.Besides suppressing inflammatory pathways,spice-derived nutraceuticals can suppress survival,proliferation,invasion,and angiogenesis of tumor cells.Increasing evidence indicates that genetic alterations are relatively rare,and epigenetic changes(DNA methylation,histone modifications and expression of noncoding RNAs)plays a bigger role in human cancer,and can be easily influenced by environmental,lifestyle and dietary factors,and some estimates suggest that over two-thirds of the cancer incidence can be accounted for by the environmental and dietary factors alone.Among all these factors,diet is probably the single most important factor which may influence carcinogenesis more comprehensively,because diet is readily modifiable and have the potential to modulate multiple epigenetic processes.Polyphenols in dietary botanicals represent a versatile group of phytochemicals with many potentially beneficial activities in terms of disease prevention.Dietary polyphenols(bioflavanoids)have antioxidant and anti-inflammatory properties that might explain their chemopreventive effects.However,the actual therapeutic potential of these compounds may not have been completely realized due to lack of understanding on the effects of these agents on epigenetic modifications.Recent,but limited evidence indicates that some of the polyphenols,including curcumin(from turmeric),genestein(from soy),EGCG(from green tea),diallyl disulfide(from garlic),sulforaphane(from broccoli)and resveratrol(from grapes)may induce epigenetic changes in various cancer cell lines.This presentation will describe some of the current scientific evidence for the role of epigenetic alterations induced by curcumin and boswellia,in support of their anti-cancer activities,which provides a strong scientific foundation for preclinical and human clinical intervention studies in future.
基金Natural Science Foundation of the Education Department of Anhui Province (2005kj398zc)
文摘To understand the possible mechanism controlling the formation of silicon bodies in higher plants, we need to know the nature of organic compounds associated with silicon bodies and induces silicon precipitation in plant cells. A new method was developed to isolate pure silicon body in fresh leaves of rice (Oryaa sativa L. Var. 297) at low temperature by grinding and centrifugation procedures, which avoided degradation of organic molecules induced by high temperature and strong oxidizing acids used in the traditional method. The energy dispersive X-ray spectrum under scanning electron microscope showed that there was a great amount of carbon in silicon bodies in addition to silicon and oxygen. Organic compounds intimately associated with silicon bodies were released by treatment with HF solution. Analysis of the organic compounds by micro-infrared spectroscopy revealed the presence of polyphenol and polysaccharide and a little protein.
文摘Cotton is not only an important source of textilefibre and edible oil,but also a valuable source ofhigh-quality protein and fodder,because 45%～50% of the cotton seed powder is protein.However,the seeds of cultivated cotton usuallycontain a special polyphenol compound calledgossypol,which is poisonous and hinders theutilization of the seeds.Therefore breeding
文摘The burgeoning development of nanomedicine has provided state-of-the-art technologies and innovative methodologies for contemporary biomedical research,presenting unprecedented opportunities for resolving pivotal biomedical challenges.Nanomaterials possess distinctive structures and properties.Through the exploration of the fabrication of emerging nanomedicines,multiple functions can be integrated to enable more precise diagnosis and treatment,thereby compensating for the limitations of traditional treatment modalities.Among various substances,polyphenols are natural organic compounds classified as plant secondary metabolites and are ubiquitously present in vegetables,teas,and other plants.Polyphenols are rich in active groups,including hydroxyl,carboxyl,amino,and conjugated double bonds.They exhibit robust adhesion,antioxidant,anti-inflammatory,and antibacterial biological activities and are extensively applied in pharmaceutical formulations.Additionally,polyphenols are characterized by their low cost,ready availability,and do not necessitate intricate chemical synthesis processes.Nevertheless,when natural polyphenol-based nanomedicines are utilized in isolation,they encounter several issues.These include poor water solubility,feeble stability,low bioavailability,the requirement for high dosages,and difficulties in precisely reaching the site of action.To address these concerns,researchers have developed nanomedicines by combining metal ions and functional ligands through metal coordination strategies.Nanomaterials,owing to their unique electronic and optical properties,have been successfully introduced into the realm of medical biology.Nano preparations not only enhance the stability of natural products but also endow them with targeting capabilities,thus enabling precise drug delivery.Polyphenols can further synergize with metal ions,anti-cancer drugs,or photosensitizers via supramolecular interactions to achieve multifunctional synergistic therapies,such as targeted drug delivery,efficacy enhancement,and the construction of engineering scaffolds.Metal-Polyphenol Coordination Polymers(MPCPs),composed of metal ions and phenolic ligands,are regarded as ideal nanoplatforms for disease diagnosis and treatment.In recent years,MPCPs have attracted extensive research in the biomedical field on account of their advantages,including facile synthesis,adjustable structure,excellent biocompatibility,and pH responsiveness.In this review,the classification and preparation strategies of MPCPs were systematically presented.Subsequently,their remarkable achievements in biomedical domains,such as bioimaging,biosensing,drug delivery,tumor therapy,and antimicrobial applications were highlighted.Finally,the principal limitations and prospects of MPCPs were comprehensi vely discussed.
