The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly effi...The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly efficient photothermal conversion gold nanorods and a temperature-responsive probe((E)-4-(4-(diethylamino)styryl)-1-methylpyridin-1-ium,PyS)within MOF-199,an intelligent nanoplatform(AMPP)was fabricated for simultaneous chemodynamic therapy and NIR light-induced temperature-feedback PTT.The fluorescence intensity and temperature of the PyS probe are linearly related due to the restriction of the rotation of the characteristic monomethine bridge.Moreover,the copper ions resulting from the degradation of MOF-199 in an acidic microenvironment can convert H_(2)O_(2)into•OH,resulting in tumor ablation through a Fenton-like reaction,and this process can be accelerated by increasing the temperature.This study establishes a feasible platform for fabricating highly sensitive temperature sensors for efficient temperature-feedback PTT.展开更多
本文基于Web of Science数据库,借助CiteSpace软件,对1996—2024年国外发表的二语写作反馈研究的趋势、特点与热点话题进行分析。结果显示,国外二语写作反馈研究在数量上整体呈现增长趋势,多发表于语言学和教育学期刊,并明显具有与心理...本文基于Web of Science数据库,借助CiteSpace软件,对1996—2024年国外发表的二语写作反馈研究的趋势、特点与热点话题进行分析。结果显示,国外二语写作反馈研究在数量上整体呈现增长趋势,多发表于语言学和教育学期刊,并明显具有与心理学、计算机科学跨学科融合的特点。研究以反馈有效性争论为起点,经历了从外部因素到学习者内在心理因素、从反馈效果到反馈过程、从微观视角到宏观视域、从师生反馈到数智赋能反馈的4次转向。未来国内二语写作反馈研究可以采用动态、宏观的视角,基于技术接受与使用整合理论等探究写作自动评估系统和大语言模型反馈对二语写作表现的影响,重视学习者认知和情感个体差异因素及反馈投入,考察学习者和教师的反馈素养,改进数据收集方法,合理运用眼动、键盘记录和脑成像等技术进行深入研究。展开更多
基金supported by the National Natural Science Foundation of China(22171001,22305001,51972001,52372073)the Natural Science Foundation of Anhui Province of China(2108085MB49).
文摘The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly efficient photothermal conversion gold nanorods and a temperature-responsive probe((E)-4-(4-(diethylamino)styryl)-1-methylpyridin-1-ium,PyS)within MOF-199,an intelligent nanoplatform(AMPP)was fabricated for simultaneous chemodynamic therapy and NIR light-induced temperature-feedback PTT.The fluorescence intensity and temperature of the PyS probe are linearly related due to the restriction of the rotation of the characteristic monomethine bridge.Moreover,the copper ions resulting from the degradation of MOF-199 in an acidic microenvironment can convert H_(2)O_(2)into•OH,resulting in tumor ablation through a Fenton-like reaction,and this process can be accelerated by increasing the temperature.This study establishes a feasible platform for fabricating highly sensitive temperature sensors for efficient temperature-feedback PTT.
文摘本文基于Web of Science数据库,借助CiteSpace软件,对1996—2024年国外发表的二语写作反馈研究的趋势、特点与热点话题进行分析。结果显示,国外二语写作反馈研究在数量上整体呈现增长趋势,多发表于语言学和教育学期刊,并明显具有与心理学、计算机科学跨学科融合的特点。研究以反馈有效性争论为起点,经历了从外部因素到学习者内在心理因素、从反馈效果到反馈过程、从微观视角到宏观视域、从师生反馈到数智赋能反馈的4次转向。未来国内二语写作反馈研究可以采用动态、宏观的视角,基于技术接受与使用整合理论等探究写作自动评估系统和大语言模型反馈对二语写作表现的影响,重视学习者认知和情感个体差异因素及反馈投入,考察学习者和教师的反馈素养,改进数据收集方法,合理运用眼动、键盘记录和脑成像等技术进行深入研究。
文摘水声网络(underwater acoustic network,UAN)具有长传播时延、高误码率、半双工通信等特性,这些特性严重影响了UAN中数据的可靠传输。而在线喷泉码具有在线控制、编解码复杂度低、码率自适应等诸多优势,在线喷泉码适合于保障UAN中数据的可靠传输。针对递归与限制反馈的在线喷泉码(recursive OFC with limited feedback,ROFC-LF)存在不理想覆盖和4元环问题导致略高的开销和频繁的反馈,提出适用于UAN的基于优先级与可Zigzag解码的ROFC-LF(priority-based and zigzag-decodable ROFC-LF,P-ZROFC-LF)。P-ZROFC-LF在建立阶段选取具有最高优先级的原始包进行编码直至所有原始包均参与编码。同时,引入可Zigzag解码编码,将无用编码包进行移位异或转换为有用编码包来提高解码性能。通过随机图理论,分析P-ZROFC-LF所需编码包数与原始包数之间的关系。理论分析与仿真结果表明,与大部分在线喷泉码相比,P-ZROFC-LF显著提高了反馈和开销性能。其中P-ZROFC-LF相比于ROFC-LF的反馈和开销分别减少了18%和0.0176,更适用于UAN。
