Degenerative diseases significantly reduce the quality of human life.Non-invasive treatments are used in the initial stages of osteoarthritis(OA).Total knee arthroplasty is used in the late stages of osteoarthritis of...Degenerative diseases significantly reduce the quality of human life.Non-invasive treatments are used in the initial stages of osteoarthritis(OA).Total knee arthroplasty is used in the late stages of osteoarthritis of the knee joint.Non-invasive methods based on mechanical action are also used for the rehabilitation of a patient after arthroplasty.This paper presents numerical models of the knee joint with degenerative OA changes and arthroplasty.Using these models,a computational study was made of the influence of the intensity of shock-wave exposure on the conditioning for the regeneration of bone and cartilage tissues.Based on the modeling results,it was found that in the knee joint with degenerative OA changes,conditions for the regeneration of cartilage and meniscus tissues were fulfilled under medium and highintensity loading.Under high-intensity loading(up to 0.9 m J/mm^(2)),the stress level was significantly below the ultimate value required for fracture.At knee arthroplasty,the conditions for bone tissue regeneration around the tibia component are fulfilled only under high-intensity loading.展开更多
Objective To observe IL-1B,IL-6 and TNF-a level change of the joint fluid in the experimental knee joint degeneration and the effect of the local loosening therapy.Methods Thirty rabbits were divided into 3 groups at ...Objective To observe IL-1B,IL-6 and TNF-a level change of the joint fluid in the experimental knee joint degeneration and the effect of the local loosening therapy.Methods Thirty rabbits were divided into 3 groups at random:ten in the normal contrast group,ten in the blank model group and ten in the loosening therapy group to observe the IL-1B,IL-6 and TNF-a change of the joint fluid before and after the treatment in each group.Result IL-1B,IL-6 and TNF-a level in the blank model group was obviously higher than that in the normal group.(P<0.05).IL-1B,IL-6 and TNF-a level in the treatment group was obviously lower than that in the normal group.(P<0.05).Conclusions 1)IL-1B,IL-6 and TNF-a level of the joint fluid in the blank model group was obviously higher than that in the normal group.2)Loosening soft tissues of the knees can improve IL-1B,IL-6 and TNF-a level of the joint fluid.展开更多
目的观察培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效。方法纳入肾阳不足型膝关节退行性病变患者80例,采取随机数字表法分为对照组40例与观察组40例,对照组接受膝关节置换术治疗,观察组在对照组治疗基础上结合培元养心...目的观察培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效。方法纳入肾阳不足型膝关节退行性病变患者80例,采取随机数字表法分为对照组40例与观察组40例,对照组接受膝关节置换术治疗,观察组在对照组治疗基础上结合培元养心法(背俞穴温针灸)治疗,观察各组数据情况:疗效优良率、治疗前后中医证候积分变化、术后3 d及术后6 d、术后9 d患者的疼痛评分[视觉模拟疼痛评分法(Visual analogue scale,VAS)],治疗前后患者C反应蛋白(C-reactive protein,CRP)及肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)和白介素-6(Interleukin-6,IL-6)指标变化、治疗前后患者Lysholm膝关节量表评分变化、并发症发生率、治疗前、治疗2周及治疗4周身体健康评分(the MOS item short from health survey,SF-36)。结果观察组患者治疗效果优良率(95.00%,38/40)高于对照组(80.00%,32/40),差异有统计学意义(P<0.05);各组患者治疗后中医证候积分下降,炎症因子(CRP、TNF-α、IL-6)均显著下降,Lysholm膝关节量表总评分显著上升,观察组治疗后中医证候积分及炎症因子(CRP、TNF-α、IL-6)均低于对照组,Lysholm膝关节量表总评分高于对照组,差异有统计学意义(P<0.05);观察组患者术后3、6、9 d的VAS评分均比对照组更低,差异有统计学意义(P<0.05);对照组并发症率为20.00%(8/40),比观察组的5.00%(2/40)更低,差异有统计学意义(P<0.05);治疗2周及治疗4周后观察组患者的SF-36评分均高于对照组患者,差异有统计学意义(P<0.05)。结论培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效良好,患者症状改善,膝关节功能改善,并发症少,治疗安全可靠,且患者治疗后身体健康好转,值得应用。展开更多
目的探讨关节熏洗仪结合独活寄生汤对膝关节骨关节炎(Knee osteoarthritis,KOA)患者膝关节功能、疼痛及血清炎症因子的影响。方法选取60例KOA患者,随机分为对照组与观察组,每组30例,对照组关节腔内注射玻璃酸钠治疗,观察组在对照组用药...目的探讨关节熏洗仪结合独活寄生汤对膝关节骨关节炎(Knee osteoarthritis,KOA)患者膝关节功能、疼痛及血清炎症因子的影响。方法选取60例KOA患者,随机分为对照组与观察组,每组30例,对照组关节腔内注射玻璃酸钠治疗,观察组在对照组用药基础上给予关节熏洗仪结合独活寄生汤治疗,疗程4周,观察治疗前后中医证候积分、膝关节功能、疼痛及血清炎症因子水平变化。结果两组患者治疗前中医症候积分比较差异无统计学意义(P>0.05),治疗后症候积分下降,观察组下降程度大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前Lysholm评分、西安大略大学和麦克马斯特大学(The Western Ontario and McMaster Universities,WOMAC)骨关节炎指数评分、美国纽约特种外科医院(Hospital for Special Surgery,HSS)膝关节评分差异无统计学意义(P>0.05),Lysholm评分、HSS评分治疗后较治疗前升高,观察组升高幅度大于对照组,WOMAC评分治疗后较治疗前下降,观察组下降程度大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前VAS评分及血清P物质(substanceP,SP)、5-羟色胺(5-hydrox-ytryptamine,5-HT)及前列腺素E2(prostaglandin E 2,PGE 2)水平比较差异无统计学意义(P>0.05),治疗后均下降,观察组下降程度大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前血清肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素(interleukin,IL)-6、IL-10、胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)、转化生长因子β(transforming growth factor-β,TGF-β)水平比较差异无统计学意义(P>0.05),治疗后均下降,观察组下降程度大于对照组,比较差异有统计学意义(P<0.05);观察组治疗疗效明显优于对照组,比较差异有统计学意义(P<0.05)。结论关节熏洗仪结合独活寄生汤治疗KOA的效果显著,可有效缓解疼痛等不适症状,抑制疼痛因子、炎症因子水平,改善膝关节功能,提高治疗疗效。展开更多
基金financial support of the Russian Foundation for Basic Research,grant No.20-08-00818(simulation results)the Government research assignment for ISPMS SB RAS,project FWRW-2021-009(in-house software development)。
文摘Degenerative diseases significantly reduce the quality of human life.Non-invasive treatments are used in the initial stages of osteoarthritis(OA).Total knee arthroplasty is used in the late stages of osteoarthritis of the knee joint.Non-invasive methods based on mechanical action are also used for the rehabilitation of a patient after arthroplasty.This paper presents numerical models of the knee joint with degenerative OA changes and arthroplasty.Using these models,a computational study was made of the influence of the intensity of shock-wave exposure on the conditioning for the regeneration of bone and cartilage tissues.Based on the modeling results,it was found that in the knee joint with degenerative OA changes,conditions for the regeneration of cartilage and meniscus tissues were fulfilled under medium and highintensity loading.Under high-intensity loading(up to 0.9 m J/mm^(2)),the stress level was significantly below the ultimate value required for fracture.At knee arthroplasty,the conditions for bone tissue regeneration around the tibia component are fulfilled only under high-intensity loading.
基金Project(99JJy2081)supported by the Natural Science Foundation of Hunan Province
文摘Objective To observe IL-1B,IL-6 and TNF-a level change of the joint fluid in the experimental knee joint degeneration and the effect of the local loosening therapy.Methods Thirty rabbits were divided into 3 groups at random:ten in the normal contrast group,ten in the blank model group and ten in the loosening therapy group to observe the IL-1B,IL-6 and TNF-a change of the joint fluid before and after the treatment in each group.Result IL-1B,IL-6 and TNF-a level in the blank model group was obviously higher than that in the normal group.(P<0.05).IL-1B,IL-6 and TNF-a level in the treatment group was obviously lower than that in the normal group.(P<0.05).Conclusions 1)IL-1B,IL-6 and TNF-a level of the joint fluid in the blank model group was obviously higher than that in the normal group.2)Loosening soft tissues of the knees can improve IL-1B,IL-6 and TNF-a level of the joint fluid.
文摘目的观察培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效。方法纳入肾阳不足型膝关节退行性病变患者80例,采取随机数字表法分为对照组40例与观察组40例,对照组接受膝关节置换术治疗,观察组在对照组治疗基础上结合培元养心法(背俞穴温针灸)治疗,观察各组数据情况:疗效优良率、治疗前后中医证候积分变化、术后3 d及术后6 d、术后9 d患者的疼痛评分[视觉模拟疼痛评分法(Visual analogue scale,VAS)],治疗前后患者C反应蛋白(C-reactive protein,CRP)及肿瘤坏死因子α(Tumor necrosis factor-α,TNF-α)和白介素-6(Interleukin-6,IL-6)指标变化、治疗前后患者Lysholm膝关节量表评分变化、并发症发生率、治疗前、治疗2周及治疗4周身体健康评分(the MOS item short from health survey,SF-36)。结果观察组患者治疗效果优良率(95.00%,38/40)高于对照组(80.00%,32/40),差异有统计学意义(P<0.05);各组患者治疗后中医证候积分下降,炎症因子(CRP、TNF-α、IL-6)均显著下降,Lysholm膝关节量表总评分显著上升,观察组治疗后中医证候积分及炎症因子(CRP、TNF-α、IL-6)均低于对照组,Lysholm膝关节量表总评分高于对照组,差异有统计学意义(P<0.05);观察组患者术后3、6、9 d的VAS评分均比对照组更低,差异有统计学意义(P<0.05);对照组并发症率为20.00%(8/40),比观察组的5.00%(2/40)更低,差异有统计学意义(P<0.05);治疗2周及治疗4周后观察组患者的SF-36评分均高于对照组患者,差异有统计学意义(P<0.05)。结论培元养心法(背俞穴温针灸)治疗肾阳不足型膝关节退行性病变疗效良好,患者症状改善,膝关节功能改善,并发症少,治疗安全可靠,且患者治疗后身体健康好转,值得应用。
文摘目的探讨关节熏洗仪结合独活寄生汤对膝关节骨关节炎(Knee osteoarthritis,KOA)患者膝关节功能、疼痛及血清炎症因子的影响。方法选取60例KOA患者,随机分为对照组与观察组,每组30例,对照组关节腔内注射玻璃酸钠治疗,观察组在对照组用药基础上给予关节熏洗仪结合独活寄生汤治疗,疗程4周,观察治疗前后中医证候积分、膝关节功能、疼痛及血清炎症因子水平变化。结果两组患者治疗前中医症候积分比较差异无统计学意义(P>0.05),治疗后症候积分下降,观察组下降程度大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前Lysholm评分、西安大略大学和麦克马斯特大学(The Western Ontario and McMaster Universities,WOMAC)骨关节炎指数评分、美国纽约特种外科医院(Hospital for Special Surgery,HSS)膝关节评分差异无统计学意义(P>0.05),Lysholm评分、HSS评分治疗后较治疗前升高,观察组升高幅度大于对照组,WOMAC评分治疗后较治疗前下降,观察组下降程度大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前VAS评分及血清P物质(substanceP,SP)、5-羟色胺(5-hydrox-ytryptamine,5-HT)及前列腺素E2(prostaglandin E 2,PGE 2)水平比较差异无统计学意义(P>0.05),治疗后均下降,观察组下降程度大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前血清肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素(interleukin,IL)-6、IL-10、胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)、转化生长因子β(transforming growth factor-β,TGF-β)水平比较差异无统计学意义(P>0.05),治疗后均下降,观察组下降程度大于对照组,比较差异有统计学意义(P<0.05);观察组治疗疗效明显优于对照组,比较差异有统计学意义(P<0.05)。结论关节熏洗仪结合独活寄生汤治疗KOA的效果显著,可有效缓解疼痛等不适症状,抑制疼痛因子、炎症因子水平,改善膝关节功能,提高治疗疗效。
