The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(OPBE) catalyzed by Saccharomyces cerevisiae in aqueous phase to synthesize chiral ethyl-2-hydroxy-4-phenylbutyrate(HPBE) was investigated in detail.The enantiom...The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(OPBE) catalyzed by Saccharomyces cerevisiae in aqueous phase to synthesize chiral ethyl-2-hydroxy-4-phenylbutyrate(HPBE) was investigated in detail.The enantiomeric excess value(ee%) of product(S)-HPBE reached up to 80% determined by using chiral GC.The byproduct of the above reaction was characterized as 3-phenylpropanol(PPN) by means of GC-MS.The reaction process and mechanism of the byproduct PPN was also discussed.展开更多
文摘The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(OPBE) catalyzed by Saccharomyces cerevisiae in aqueous phase to synthesize chiral ethyl-2-hydroxy-4-phenylbutyrate(HPBE) was investigated in detail.The enantiomeric excess value(ee%) of product(S)-HPBE reached up to 80% determined by using chiral GC.The byproduct of the above reaction was characterized as 3-phenylpropanol(PPN) by means of GC-MS.The reaction process and mechanism of the byproduct PPN was also discussed.
