The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(OPBE) catalyzed by Saccharomyces cerevisiae in aqueous phase to synthesize chiral ethyl-2-hydroxy-4-phenylbutyrate(HPBE) was investigated in detail.The enantiom...The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(OPBE) catalyzed by Saccharomyces cerevisiae in aqueous phase to synthesize chiral ethyl-2-hydroxy-4-phenylbutyrate(HPBE) was investigated in detail.The enantiomeric excess value(ee%) of product(S)-HPBE reached up to 80% determined by using chiral GC.The byproduct of the above reaction was characterized as 3-phenylpropanol(PPN) by means of GC-MS.The reaction process and mechanism of the byproduct PPN was also discussed.展开更多
A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)...A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)-3-[(1R)-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none(4AA)upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.展开更多
1,2-Bis(4-hydroxy-3-methoxyphenyl)ethane,a by-product formed from synthesis reaction of vanillyl nonanoate,is separated by silica-gel column chromatography and characterized by 1HNMR,13CNMR and MS.
文摘The asymmetric reduction of ethyl-2-oxo-4-phenylbutyrate(OPBE) catalyzed by Saccharomyces cerevisiae in aqueous phase to synthesize chiral ethyl-2-hydroxy-4-phenylbutyrate(HPBE) was investigated in detail.The enantiomeric excess value(ee%) of product(S)-HPBE reached up to 80% determined by using chiral GC.The byproduct of the above reaction was characterized as 3-phenylpropanol(PPN) by means of GC-MS.The reaction process and mechanism of the byproduct PPN was also discussed.
文摘A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)-3-[(1R)-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none(4AA)upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.
文摘1,2-Bis(4-hydroxy-3-methoxyphenyl)ethane,a by-product formed from synthesis reaction of vanillyl nonanoate,is separated by silica-gel column chromatography and characterized by 1HNMR,13CNMR and MS.
