Phosphodiesterase Ⅴ inhibitor Sildenafil was synthesized by a new synthetic route.The hydrazine hydrate was used as deoxidizer in synthesizing of intermediate 4 amino 1 methyl 3 n propylpyrazole 5 carboxamide,the yie...Phosphodiesterase Ⅴ inhibitor Sildenafil was synthesized by a new synthetic route.The hydrazine hydrate was used as deoxidizer in synthesizing of intermediate 4 amino 1 methyl 3 n propylpyrazole 5 carboxamide,the yield being 91 5%.Surfactants was used in the process of the cycliztion.The yield was 8% higher than the original technology.This route is unique in that only common reagents are required.rection conditions are mild,and the process is simple,being with out use of silicon colum chromatography treatment.It is therefore suitable for industrial production.展开更多
We designed and synthesized 5 new compounds. Their chemical structures were confirmed by means of MS, HNMR andelemental analysis. FPA was tested for positive inotropic activity. The results showed that FPA could incre...We designed and synthesized 5 new compounds. Their chemical structures were confirmed by means of MS, HNMR andelemental analysis. FPA was tested for positive inotropic activity. The results showed that FPA could increase the contrastive amplitudeof isolated atrium of guinea pigs and had no influence upon rhythm of the hearts.展开更多
A series of benzofurocoumarin derivatives have been synthesized. Three of them and a simple coumarin have beendatermined for their Ca2+ atagonizing activity. Preliminary results show that all of them possesses potent ...A series of benzofurocoumarin derivatives have been synthesized. Three of them and a simple coumarin have beendatermined for their Ca2+ atagonizing activity. Preliminary results show that all of them possesses potent activity.展开更多
文摘Phosphodiesterase Ⅴ inhibitor Sildenafil was synthesized by a new synthetic route.The hydrazine hydrate was used as deoxidizer in synthesizing of intermediate 4 amino 1 methyl 3 n propylpyrazole 5 carboxamide,the yield being 91 5%.Surfactants was used in the process of the cycliztion.The yield was 8% higher than the original technology.This route is unique in that only common reagents are required.rection conditions are mild,and the process is simple,being with out use of silicon colum chromatography treatment.It is therefore suitable for industrial production.
文摘We designed and synthesized 5 new compounds. Their chemical structures were confirmed by means of MS, HNMR andelemental analysis. FPA was tested for positive inotropic activity. The results showed that FPA could increase the contrastive amplitudeof isolated atrium of guinea pigs and had no influence upon rhythm of the hearts.
文摘A series of benzofurocoumarin derivatives have been synthesized. Three of them and a simple coumarin have beendatermined for their Ca2+ atagonizing activity. Preliminary results show that all of them possesses potent activity.
