IC 50 values of 13 flavonoids to lipid peroxidation induced by OH · in liver microsomer from rat were evaluated and the relationship between structure and activity was studied. The flavonoids with catechol group,...IC 50 values of 13 flavonoids to lipid peroxidation induced by OH · in liver microsomer from rat were evaluated and the relationship between structure and activity was studied. The flavonoids with catechol group, which usually have a higher energy in the highest occupied molecular orbital and lower ΔHOF values, have higher inhibitory activities than those without catechol group. The flavonoids without catechol group in B ring not being suitable structure to chelate with Fe 2+ have little inhibitory activities. The results suggest the anti-lipid peroxidation activity of flavonoids is related with the structure of flavonoids.展开更多
文摘IC 50 values of 13 flavonoids to lipid peroxidation induced by OH · in liver microsomer from rat were evaluated and the relationship between structure and activity was studied. The flavonoids with catechol group, which usually have a higher energy in the highest occupied molecular orbital and lower ΔHOF values, have higher inhibitory activities than those without catechol group. The flavonoids without catechol group in B ring not being suitable structure to chelate with Fe 2+ have little inhibitory activities. The results suggest the anti-lipid peroxidation activity of flavonoids is related with the structure of flavonoids.
