Objective Several previous studies have shown androgens deficiency in men with CHF, and 2 studies on the prognostic significance of serum levels of androgens in CHF patients have yielded conflicting results. The aim o...Objective Several previous studies have shown androgens deficiency in men with CHF, and 2 studies on the prognostic significance of serum levels of androgens in CHF patients have yielded conflicting results. The aim of this study was to examine the relationship between serum concentration of testosterone and mortality in men with systolic CHE Methods A total of 175 elderly （age ≥ 60 years） men with CHF were recruited. Total testosterone fiT） and sex hormone binding globulin （SHBG） were measured, and free serum testosterone （eFT） was calculated. The median follow-up time was 1262 days. Results During follow-up 54 （30.9%） patients died. TT and eFF deficiency was found in 21.7% （38/175） and 27.4% （48/175） patients, respectively. Both TT and eFT were inversely associated with LVEF and NT-proBNP （all P〈0.01）. Kaplan-Meier curves for patients in low, medium and high tertiles according to TF and eFT level showed significantly different cumulative survival rate （both P〈0.01 by log-rank test）. However, after adjustment for clinical variables, there were no significant associations between either Tr or eFT levels or survival time （OR=0.97, 95% CI, 0.84-1.12, P--0.28; and OR=0.92, 95% CI, 0.82-1.06,/＇=0.14, respectively）. Conclusion Our study showed that although levels of TT and eFT are commonly decreased in elderly patients with systolic CHF and related to disease severity, they are not independent predictors for mortality展开更多
The observed high over-luminous type-Ia supernovae imply the existence of super-Chandrasekhar limit white dwarfs, which raises a challenge to the classical white dwarf theories. By employing the Eddington-inspired Bor...The observed high over-luminous type-Ia supernovae imply the existence of super-Chandrasekhar limit white dwarfs, which raises a challenge to the classical white dwarf theories. By employing the Eddington-inspired Born-Infeld （EiBI） gravity, we reinvestigate the structures and properties of white dwarfs, and find out that the EiBI gravity provides a new way to understand the observations. It is shown that by choosing an appropriate positive Eddington parameter k, a massive white dwarf with mass up to 2.8M can be supported by the equation of state of free electron gas. Unlike the classical white dwarf theory, the maximum mass of the white dwarf sequence in the EiBI gravity is not decided by the mass radius relations, but is decided by the central density, pc = 4.3 × 1014 kg/ms, above which neutronization cannot be avoided and the white dwarf will transform into a neutron star. On the other hand, if the gravity in the massive white dwarf really behaves as the EiBI gravity predicts, then one can obtain a constraint on the Eddington parameter in the EiBI gravity, that is, 87rpokG/c2 ≥ 80 （where po =- 10^18 kg/m3） to support a massive white dwarf with mass up to 2.8M. Moreover, we find out that the fast Keplarian frequency of the massive white dwarf raises a degeneration between the two kinds of compact stars, that is, one cannot distinguish whether the observed massive pulsar is a massive neutron star or a massive white dwarf only through the observed pulse frequency and mass.展开更多
Objective There is little population-based data on the prevalence and the environmental or genetic determinants of left ventricular hypertrophy （LVH） in China. The purpose of this paper is to study LVH in relation t...Objective There is little population-based data on the prevalence and the environmental or genetic determinants of left ventricular hypertrophy （LVH） in China. The purpose of this paper is to study LVH in relation to systolic blood pressure and the angiotensin converting enzyme （ACE） insertion/deletion（I/D） polymorphism in Chinese. Methods We recorded 12- lead ECG （CardioSoft, v4.2） in 1365 residents in the Jingning County, Zhejiang Province, China. LVH was defined according to the gender-specific Sokolow-Lyon and Cornell product ECG criteria. Results Regardless of whether the Sokolow-Lyon or Cornell product ECG criteria was used, the prevalence of LVH （20.7% and 4.8%, respectively） significantly （P〈0.0001） increased with male gender （odds ratio [OR] 2.33 and 7.15） and systolic blood pressure （per 10 mm Hg increase, OR 1.46 and 1.33）. If the Sokolow-Lyon criteria was used, the prevalence of LVH was also influenced by alcohol intake （OR 1.44, P=-0.03） and body mass index （OR 0.83, P=0.0005）. The association between the Sokolow-Lyon voltage amplitude and the ACE I/D polymorphism was dependent on antihypertensive therapy （P=0.01）. In 1262 untreated subjects, but not 103 patients on antihypertensive medication, the ACE DD compared with II subjects had significantly higher Sokolow-Lyon voltage amplitudes （29.8：-0.6 vs. 28.0-3：0.5 mV, P=-0.02） and higher risk of LVH （OR 1.74, 95% CI： 1.12-2.69, P=-0.01）. Conclusion LVH is prevalent in Chinese, and is associated with systolic blood pressure and the ACE D allele. The genetic association might be modulated by antihypertensive therapy（J Geriatr Cardio12009; 6：131-136）.展开更多
文摘Objective Several previous studies have shown androgens deficiency in men with CHF, and 2 studies on the prognostic significance of serum levels of androgens in CHF patients have yielded conflicting results. The aim of this study was to examine the relationship between serum concentration of testosterone and mortality in men with systolic CHE Methods A total of 175 elderly （age ≥ 60 years） men with CHF were recruited. Total testosterone fiT） and sex hormone binding globulin （SHBG） were measured, and free serum testosterone （eFT） was calculated. The median follow-up time was 1262 days. Results During follow-up 54 （30.9%） patients died. TT and eFF deficiency was found in 21.7% （38/175） and 27.4% （48/175） patients, respectively. Both TT and eFT were inversely associated with LVEF and NT-proBNP （all P〈0.01）. Kaplan-Meier curves for patients in low, medium and high tertiles according to TF and eFT level showed significantly different cumulative survival rate （both P〈0.01 by log-rank test）. However, after adjustment for clinical variables, there were no significant associations between either Tr or eFT levels or survival time （OR=0.97, 95% CI, 0.84-1.12, P--0.28; and OR=0.92, 95% CI, 0.82-1.06,/＇=0.14, respectively）. Conclusion Our study showed that although levels of TT and eFT are commonly decreased in elderly patients with systolic CHF and related to disease severity, they are not independent predictors for mortality
基金Supported by the National Natural Science Foundation of China under Grant Nos 11275073 and 11305063the Fundamental Research Funds for the Central Universities under Grant No 2014ZG0036
文摘The observed high over-luminous type-Ia supernovae imply the existence of super-Chandrasekhar limit white dwarfs, which raises a challenge to the classical white dwarf theories. By employing the Eddington-inspired Born-Infeld （EiBI） gravity, we reinvestigate the structures and properties of white dwarfs, and find out that the EiBI gravity provides a new way to understand the observations. It is shown that by choosing an appropriate positive Eddington parameter k, a massive white dwarf with mass up to 2.8M can be supported by the equation of state of free electron gas. Unlike the classical white dwarf theory, the maximum mass of the white dwarf sequence in the EiBI gravity is not decided by the mass radius relations, but is decided by the central density, pc = 4.3 × 1014 kg/ms, above which neutronization cannot be avoided and the white dwarf will transform into a neutron star. On the other hand, if the gravity in the massive white dwarf really behaves as the EiBI gravity predicts, then one can obtain a constraint on the Eddington parameter in the EiBI gravity, that is, 87rpokG/c2 ≥ 80 （where po =- 10^18 kg/m3） to support a massive white dwarf with mass up to 2.8M. Moreover, we find out that the fast Keplarian frequency of the massive white dwarf raises a degeneration between the two kinds of compact stars, that is, one cannot distinguish whether the observed massive pulsar is a massive neutron star or a massive white dwarf only through the observed pulse frequency and mass.
基金The authors gratefully acknowledge the voluntary collaboration of the study participants and the support of the local public health authorities of Jingning County, Zhejiang Province, China. This study was financially supported by grants from the National Natural Science Foundation of China （grants 30871360 and 30871081）, Beij＇ing, China, and the Shanghai Commissions of Science and Technology （grant 07JC14047 and the ＂Rising Star＂ program 06QA14043） and Education （grant 07ZZ32 and the ＂Dawn＂ program 08SG20）, and the European Union （InGenious HyperCare LSHM-CT-2006-037093 and HYPERGENES FP7-HEALTH-2007-201550）. Dr Alexander Headley was supported by the AusAID Australian Youth Ambassadors for Development scheme and the George Foundation of the George Institute for International Health, Sydney, Australia.
文摘Objective There is little population-based data on the prevalence and the environmental or genetic determinants of left ventricular hypertrophy （LVH） in China. The purpose of this paper is to study LVH in relation to systolic blood pressure and the angiotensin converting enzyme （ACE） insertion/deletion（I/D） polymorphism in Chinese. Methods We recorded 12- lead ECG （CardioSoft, v4.2） in 1365 residents in the Jingning County, Zhejiang Province, China. LVH was defined according to the gender-specific Sokolow-Lyon and Cornell product ECG criteria. Results Regardless of whether the Sokolow-Lyon or Cornell product ECG criteria was used, the prevalence of LVH （20.7% and 4.8%, respectively） significantly （P〈0.0001） increased with male gender （odds ratio [OR] 2.33 and 7.15） and systolic blood pressure （per 10 mm Hg increase, OR 1.46 and 1.33）. If the Sokolow-Lyon criteria was used, the prevalence of LVH was also influenced by alcohol intake （OR 1.44, P=-0.03） and body mass index （OR 0.83, P=0.0005）. The association between the Sokolow-Lyon voltage amplitude and the ACE I/D polymorphism was dependent on antihypertensive therapy （P=0.01）. In 1262 untreated subjects, but not 103 patients on antihypertensive medication, the ACE DD compared with II subjects had significantly higher Sokolow-Lyon voltage amplitudes （29.8：-0.6 vs. 28.0-3：0.5 mV, P=-0.02） and higher risk of LVH （OR 1.74, 95% CI： 1.12-2.69, P=-0.01）. Conclusion LVH is prevalent in Chinese, and is associated with systolic blood pressure and the ACE D allele. The genetic association might be modulated by antihypertensive therapy（J Geriatr Cardio12009; 6：131-136）.
