目的探讨阿托伐他汀对超老年去卵巢大鼠骨密度(bone mineral density,BMD)、骨微结构及骨生物力学性能的影响。方法7月龄SD雌性大鼠12只,行双侧卵巢切除术后继续饲养至22月龄,制作超老年去卵巢大鼠模型,随机分为对照组(A组,6只)和他汀...目的探讨阿托伐他汀对超老年去卵巢大鼠骨密度(bone mineral density,BMD)、骨微结构及骨生物力学性能的影响。方法7月龄SD雌性大鼠12只,行双侧卵巢切除术后继续饲养至22月龄,制作超老年去卵巢大鼠模型,随机分为对照组(A组,6只)和他汀组(B组,6只)。B组予阿托伐他汀以20 mg/(kg·d)的剂量行腹腔注射,A组予DMSO溶剂作为对照,干预4周。双能X线吸收测量仪(dual energy X-ray absorptiometry,DXA)测定超老年去卵巢大鼠活体面积BMD(area bone mineral density,aB MD)。微计算机断层扫描技术(micro-computed tomography,micro-CT)检测第5腰椎松质骨微结构参数:体积BMD(volume bone mineral density,vB MD),骨体积百分比(BV/TV)、骨小梁厚度(trabecular thickness,Tb.Th)、骨小梁数量(trabecular number,Tb.N)、骨小梁分离度(trabecular separating capacity,Tb.Sp)、骨小梁结构模式指数(structure model index,SMI);以及左股骨皮质骨微结构参数:骨体积百分比(bone volume/total volume,BV/TV)、皮质骨厚度(cortical bone thickness,Cor.Th),总分析孔隙率[porosity(Po),Po(tot)%]。骨生物力学指标:压缩试验检测第4腰椎压缩强度及最大载荷,三点弯曲试验检测右股骨最大弯曲强度、弹性模量及刚性系数。结果A组与B组腰椎离体a BMD未见统计学差异(P>0.05);骨微结构参数:B组第5腰椎Tb.Th较A组减低(0.117±0.004和0.128±0.006 mm,P<0.01),vB MD、BV/TV、Tb.N、Tb.Sp、SMI指数(P>0.05)及左股骨的vB MD、Cor.Th、BV/TV、Po(tot)%未见显著差异(P>0.05);生物力学性能:B组第4腰椎压缩强度及最大载荷、右股骨的最大载荷及最大弯曲强度、弹性模量及刚性系数较A组差异无统计学(P>0.05)。结论阿托伐他汀干预后,超老年去卵巢大鼠宏观上BMD及骨生物力学性能未发生改变,但微观结构骨小梁厚度明显减低,存在潜在的骨质量下降风险。展开更多
Reactions of CuBr with equimolar PyHBr orγMePyHBr afforded two novel one dimensional bromocuprate?polymers{(PyH)_(3)[Cu_(3)Br_(6)]}_(∞)(1)and{(γMePyH)_(2)[Cu_(2)Br_(4)]}_(∞)(2),respectively.Both 1 and 2 were chara...Reactions of CuBr with equimolar PyHBr orγMePyHBr afforded two novel one dimensional bromocuprate?polymers{(PyH)_(3)[Cu_(3)Br_(6)]}_(∞)(1)and{(γMePyH)_(2)[Cu_(2)Br_(4)]}_(∞)(2),respectively.Both 1 and 2 were characterized by IR,elemental analysis,and X ray crystallography.Crystal data for 1:monoclinic,space group P2_(1)/n,a=0.93262(12)nm,b=1.3497(2)nm,c=1.9149(2)nm,β=93.465(7)°,V=2.4060(5)nm^(3),Z=4.Crystal data for 2:orthorhombic,space group Pbcm,a=0.8659(4)nm,b=1.5669(6)nm,c=1.2849(5)nm,V=1.7432(2)nm^(3),Z=4.The structure of 1 has a unique helical chain composed of units andμbromide anions while that of 2 shows a linear chain consisted of[Cu_(2)(μBr)_(2)]units bridged by pairs ofμBr atoms.CCDC:1,208412;2,208413.展开更多
文摘目的探讨阿托伐他汀对超老年去卵巢大鼠骨密度(bone mineral density,BMD)、骨微结构及骨生物力学性能的影响。方法7月龄SD雌性大鼠12只,行双侧卵巢切除术后继续饲养至22月龄,制作超老年去卵巢大鼠模型,随机分为对照组(A组,6只)和他汀组(B组,6只)。B组予阿托伐他汀以20 mg/(kg·d)的剂量行腹腔注射,A组予DMSO溶剂作为对照,干预4周。双能X线吸收测量仪(dual energy X-ray absorptiometry,DXA)测定超老年去卵巢大鼠活体面积BMD(area bone mineral density,aB MD)。微计算机断层扫描技术(micro-computed tomography,micro-CT)检测第5腰椎松质骨微结构参数:体积BMD(volume bone mineral density,vB MD),骨体积百分比(BV/TV)、骨小梁厚度(trabecular thickness,Tb.Th)、骨小梁数量(trabecular number,Tb.N)、骨小梁分离度(trabecular separating capacity,Tb.Sp)、骨小梁结构模式指数(structure model index,SMI);以及左股骨皮质骨微结构参数:骨体积百分比(bone volume/total volume,BV/TV)、皮质骨厚度(cortical bone thickness,Cor.Th),总分析孔隙率[porosity(Po),Po(tot)%]。骨生物力学指标:压缩试验检测第4腰椎压缩强度及最大载荷,三点弯曲试验检测右股骨最大弯曲强度、弹性模量及刚性系数。结果A组与B组腰椎离体a BMD未见统计学差异(P>0.05);骨微结构参数:B组第5腰椎Tb.Th较A组减低(0.117±0.004和0.128±0.006 mm,P<0.01),vB MD、BV/TV、Tb.N、Tb.Sp、SMI指数(P>0.05)及左股骨的vB MD、Cor.Th、BV/TV、Po(tot)%未见显著差异(P>0.05);生物力学性能:B组第4腰椎压缩强度及最大载荷、右股骨的最大载荷及最大弯曲强度、弹性模量及刚性系数较A组差异无统计学(P>0.05)。结论阿托伐他汀干预后,超老年去卵巢大鼠宏观上BMD及骨生物力学性能未发生改变,但微观结构骨小梁厚度明显减低,存在潜在的骨质量下降风险。
文摘Reactions of CuBr with equimolar PyHBr orγMePyHBr afforded two novel one dimensional bromocuprate?polymers{(PyH)_(3)[Cu_(3)Br_(6)]}_(∞)(1)and{(γMePyH)_(2)[Cu_(2)Br_(4)]}_(∞)(2),respectively.Both 1 and 2 were characterized by IR,elemental analysis,and X ray crystallography.Crystal data for 1:monoclinic,space group P2_(1)/n,a=0.93262(12)nm,b=1.3497(2)nm,c=1.9149(2)nm,β=93.465(7)°,V=2.4060(5)nm^(3),Z=4.Crystal data for 2:orthorhombic,space group Pbcm,a=0.8659(4)nm,b=1.5669(6)nm,c=1.2849(5)nm,V=1.7432(2)nm^(3),Z=4.The structure of 1 has a unique helical chain composed of units andμbromide anions while that of 2 shows a linear chain consisted of[Cu_(2)(μBr)_(2)]units bridged by pairs ofμBr atoms.CCDC:1,208412;2,208413.
