Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal tract.Traditional Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrhea...Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal tract.Traditional Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrheal therapy.The aims of this study were to investigate the protective effect of PR using the dextran sulfate sodium salt(DSS)-induced UC model in mice and identify molecular mechanisms of PR action.The chemical constituents of PR via ultra-performance liquid chromatography/tandem mass spectrometry and identified potential PR and UC targets using a network pharmacology(NP)approach were obtained to guide mouse experiments.A total of 180 peaks were identified from PR including 48 flavonoids,46 organic acids,14 amino acids,8 phenols,8 carbohydrates,7 alkaloids,6 coumarins and 43 other constituents.NP results showed that caspase-1 was the most dysregulated of the core genes associated with UC.A PR dose of 0.136 mg/g administered to DSS treated mice reversed weight loss and decreased colon lengths found in UC mice.PR also alleviated intestinal mucosal shedding,inflammatory cell infiltration and mucin loss.PR treatment suppressed upregulation of NOD-like receptor protein 3(NLRP3),cysteinyl aspartate-specific proteases-1(caspase-1),apoptosis-associated speck-like(ASC)and gasdermin D(GSDMD)at both the protein and m RNA expression levels.The addition of a small molecule dual-specificity phosphatase inhibitor NSC 95397 inhibited the positive effects of PR.These results indicated that PR exerts a protective effect on DSS-induced colitis by inhibiting NLRP3 inflammasome activation in mice.展开更多
The measurements on temperature dependences of magnetic susceptibility χ（T）, specific heat C（T）, and electrical resistivity ρ（T） were carried out for the antiferromagnetic（AFM）（Ce（1-x）Lax）2Ir3Ge5（0 ≤ x...The measurements on temperature dependences of magnetic susceptibility χ（T）, specific heat C（T）, and electrical resistivity ρ（T） were carried out for the antiferromagnetic（AFM）（Ce（1-x）Lax）2Ir3Ge5（0 ≤ x ≤ 0.66） system. It was found that the Neel temperature TNdecreases with increasing La content x, and reaches 0 K near a critical content xcr =0.6. A new phase diagram was constructed based on these measurements. A non-Fermi liquid behavior in ρ（T） and a log T relationship in C（T） were found in the samples near xcr, indicating them to be near an AFM quantum critical point（QCP） with strong spin fluctuation. Our finding indicates that（Ce（1-x）Lax）2Ir3Ge5 may be a new platform to search for unconventional superconductivity.展开更多
In blind quantum computation(BQC),a client with weak quantum computation capabilities is allowed to delegate its quantum computation tasks to a server with powerful quantum computation capabilities,and the inputs,algo...In blind quantum computation(BQC),a client with weak quantum computation capabilities is allowed to delegate its quantum computation tasks to a server with powerful quantum computation capabilities,and the inputs,algorithms and outputs of the quantum computation are confidential to the server.Verifiability refers to the ability of the client to verify with a certain probability whether the server has executed the protocol correctly and can be realized by introducing trap qubits into the computation graph state to detect server deception.The existing verifiable universal BQC protocols are analyzed and compared in detail.The XTH protocol(proposed by Xu Q S,Tan X Q,Huang R in 2020),a recent improvement protocol of verifiable universal BQC,uses a sandglass-like graph state to further decrease resource expenditure and enhance verification capability.However,the XTH protocol has two shortcomings:limitations in the coloring scheme and a high probability of accepting an incorrect computation result.In this paper,we present an improved version of the XTH protocol,which revises the limitations of the original coloring scheme and further improves the verification ability.The analysis demonstrates that the resource expenditure is the same as for the XTH protocol,while the probability of accepting the wrong computation result is reduced from the original minimum(0.866)^(d*)to(0.819)^(d^(*)),where d;is the number of repeated executions of the protocol.展开更多
基金financially supported by the National Natural Science Foundation of China(32172897)Central Significant Changes in the Project at the Corresponding Level(Valuable Resources Capacity-Building for Sustainable Utilization of Traditional Chinese Medicine Program)(2060302)Chinese Herbal Medicine Industry Innovation Team of Shandong Province Agricultural Technology System(SDAIT-20-06)。
文摘Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal tract.Traditional Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrheal therapy.The aims of this study were to investigate the protective effect of PR using the dextran sulfate sodium salt(DSS)-induced UC model in mice and identify molecular mechanisms of PR action.The chemical constituents of PR via ultra-performance liquid chromatography/tandem mass spectrometry and identified potential PR and UC targets using a network pharmacology(NP)approach were obtained to guide mouse experiments.A total of 180 peaks were identified from PR including 48 flavonoids,46 organic acids,14 amino acids,8 phenols,8 carbohydrates,7 alkaloids,6 coumarins and 43 other constituents.NP results showed that caspase-1 was the most dysregulated of the core genes associated with UC.A PR dose of 0.136 mg/g administered to DSS treated mice reversed weight loss and decreased colon lengths found in UC mice.PR also alleviated intestinal mucosal shedding,inflammatory cell infiltration and mucin loss.PR treatment suppressed upregulation of NOD-like receptor protein 3(NLRP3),cysteinyl aspartate-specific proteases-1(caspase-1),apoptosis-associated speck-like(ASC)and gasdermin D(GSDMD)at both the protein and m RNA expression levels.The addition of a small molecule dual-specificity phosphatase inhibitor NSC 95397 inhibited the positive effects of PR.These results indicated that PR exerts a protective effect on DSS-induced colitis by inhibiting NLRP3 inflammasome activation in mice.
基金supported by the National Basic Research Program of China(Grant Nos.2016FYA0300402,2015CB921004,and 2012CB821404)the National Natural Science Foundation of China(Grant Nos.11374261 and 11204059)
文摘The measurements on temperature dependences of magnetic susceptibility χ（T）, specific heat C（T）, and electrical resistivity ρ（T） were carried out for the antiferromagnetic（AFM）（Ce（1-x）Lax）2Ir3Ge5（0 ≤ x ≤ 0.66） system. It was found that the Neel temperature TNdecreases with increasing La content x, and reaches 0 K near a critical content xcr =0.6. A new phase diagram was constructed based on these measurements. A non-Fermi liquid behavior in ρ（T） and a log T relationship in C（T） were found in the samples near xcr, indicating them to be near an AFM quantum critical point（QCP） with strong spin fluctuation. Our finding indicates that（Ce（1-x）Lax）2Ir3Ge5 may be a new platform to search for unconventional superconductivity.
文摘In blind quantum computation(BQC),a client with weak quantum computation capabilities is allowed to delegate its quantum computation tasks to a server with powerful quantum computation capabilities,and the inputs,algorithms and outputs of the quantum computation are confidential to the server.Verifiability refers to the ability of the client to verify with a certain probability whether the server has executed the protocol correctly and can be realized by introducing trap qubits into the computation graph state to detect server deception.The existing verifiable universal BQC protocols are analyzed and compared in detail.The XTH protocol(proposed by Xu Q S,Tan X Q,Huang R in 2020),a recent improvement protocol of verifiable universal BQC,uses a sandglass-like graph state to further decrease resource expenditure and enhance verification capability.However,the XTH protocol has two shortcomings:limitations in the coloring scheme and a high probability of accepting an incorrect computation result.In this paper,we present an improved version of the XTH protocol,which revises the limitations of the original coloring scheme and further improves the verification ability.The analysis demonstrates that the resource expenditure is the same as for the XTH protocol,while the probability of accepting the wrong computation result is reduced from the original minimum(0.866)^(d*)to(0.819)^(d^(*)),where d;is the number of repeated executions of the protocol.
