AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA scree...AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA screening indicators to detect concurrent DR at an early stage.METHODS:A total of 200 patients who treated in the ophthalmology department of the Seventh Affiliated Hospital,Sun Yat-sen University from 2022 to 2023 were included,including 95 first-diagnosed DR patients and 105 patients without DR,and all patients underwent OCTA examination and a collection of demographics and renal function parameters.After a quality check,automated measurements of the foveal avascular zone area,vessel density(VD),and perfusion density(PD)of both 3 mm×3 mm and 6 mm×6 mm windows were obtained.RESULTS:Using random forest and multivariate Logistic regression methods,we developed a diagnostic model for DR based on 12 variables(age,FBG,SBP,DBP,HbA1c,ALT,ALP,urea/Scr,DM duration,HUA,DN,and CMT).Adding specific OCTA parameters enhanced the efficacy of the existing diagnostic model for DR(outer vessel density in 6 mm×6 mm window,AUC=0.837 vs 0.819,P=0.03).In the study of DN patients,the parameters in the 6 mm×6 mm window improved the diagnostic efficacy of DR(inner VD;outer VD;full VD;outer PD;full PD).CONCLUSION:The outer VD in the 6 mm×6 mm window can enhance the efficacy of the traditional DR diagnostic model.Meanwhile,compared with the 3 mm×3 mm window,the microvascular parameters in the 6 mm×6 mm window focusing on DN patients can be more sensitive to diagnosing the occurrence of DR.展开更多
基于鱼礁概念,提出一种新型四棱台透水框架结构,并开展系列水槽试验,利用剖面流速仪ADCP(acoustic doppler current profilers)测量四棱台透水框架防护区周围流场结构,分析架空率对透水框架周围水流结构的影响,研究四棱台透水框架对防...基于鱼礁概念,提出一种新型四棱台透水框架结构,并开展系列水槽试验,利用剖面流速仪ADCP(acoustic doppler current profilers)测量四棱台透水框架防护区周围流场结构,分析架空率对透水框架周围水流结构的影响,研究四棱台透水框架对防护区周围的水动力特性影响。试验结果表明:四棱台透水框架防护后水流上下速度分布差异更为明显,框架层流速显著减小,且流速减小幅度随架空率的减小而增大;紊动强度分布出现拐点,拐点位置与架空率具有明显的相关性,紊动强度随架空率的减小而增大;防护区内部近底处存在紊动收敛区域,其紊动强度随架空率减小而减小。展开更多
文摘AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA screening indicators to detect concurrent DR at an early stage.METHODS:A total of 200 patients who treated in the ophthalmology department of the Seventh Affiliated Hospital,Sun Yat-sen University from 2022 to 2023 were included,including 95 first-diagnosed DR patients and 105 patients without DR,and all patients underwent OCTA examination and a collection of demographics and renal function parameters.After a quality check,automated measurements of the foveal avascular zone area,vessel density(VD),and perfusion density(PD)of both 3 mm×3 mm and 6 mm×6 mm windows were obtained.RESULTS:Using random forest and multivariate Logistic regression methods,we developed a diagnostic model for DR based on 12 variables(age,FBG,SBP,DBP,HbA1c,ALT,ALP,urea/Scr,DM duration,HUA,DN,and CMT).Adding specific OCTA parameters enhanced the efficacy of the existing diagnostic model for DR(outer vessel density in 6 mm×6 mm window,AUC=0.837 vs 0.819,P=0.03).In the study of DN patients,the parameters in the 6 mm×6 mm window improved the diagnostic efficacy of DR(inner VD;outer VD;full VD;outer PD;full PD).CONCLUSION:The outer VD in the 6 mm×6 mm window can enhance the efficacy of the traditional DR diagnostic model.Meanwhile,compared with the 3 mm×3 mm window,the microvascular parameters in the 6 mm×6 mm window focusing on DN patients can be more sensitive to diagnosing the occurrence of DR.
文摘基于鱼礁概念,提出一种新型四棱台透水框架结构,并开展系列水槽试验,利用剖面流速仪ADCP(acoustic doppler current profilers)测量四棱台透水框架防护区周围流场结构,分析架空率对透水框架周围水流结构的影响,研究四棱台透水框架对防护区周围的水动力特性影响。试验结果表明:四棱台透水框架防护后水流上下速度分布差异更为明显,框架层流速显著减小,且流速减小幅度随架空率的减小而增大;紊动强度分布出现拐点,拐点位置与架空率具有明显的相关性,紊动强度随架空率的减小而增大;防护区内部近底处存在紊动收敛区域,其紊动强度随架空率减小而减小。
