目的:系统评价康柏西普和雷珠单抗治疗视网膜静脉阻塞(RVO)继发黄斑水肿(ME)的疗效、安全性、经济性。方法:分别在万方数据库、中国生物医学文献服务系统、中国知网、Pubmed、The Cochrane Library Central Register of Controlled Tria...目的:系统评价康柏西普和雷珠单抗治疗视网膜静脉阻塞(RVO)继发黄斑水肿(ME)的疗效、安全性、经济性。方法:分别在万方数据库、中国生物医学文献服务系统、中国知网、Pubmed、The Cochrane Library Central Register of Controlled Trials(CENTRAL)、Google scholar等数据库收集自建库至2020-02-20关于康柏西普和雷珠单抗治疗RVO继发ME的对照研究,提取最佳矫正视力、黄斑中心凹视网膜厚度、不良反应发生情况、注射次数等主要结局指标进行系统评价,比较二者的效果。采用RevMan 5.3统计软件进行数据的分析。结果:共纳入16项研究,合计患者1337例。Meta分析结果提示,与雷珠单抗相比,康柏西普在采用1+PRN注射方案和治疗视网膜分支静脉阻塞(BRVO)继发ME患者时,对黄斑水肿的消退效果更明显,但二者注射次数无明显差异;与雷珠单抗相比,康柏西普在采用3+PRN注射方案和治疗视网膜中央静脉阻塞(CRVO)继发ME患者时,注射次数更少;康柏西普和雷珠单抗在视力改善和不良反应的发生方面无明显差异。结论:与雷珠单抗相比,康柏西普在不同的注射方案和不同的静脉阻塞类型治疗中体现出更优的效果,即更少的注射次数或更好的黄斑水肿消退效果。展开更多
There are few population-based data in investigating the impact of diabetes on chemotherapy adverse effects and treatment outcomes of non-metastatic breast cancer. The purpose of this study is to evaluate whether diab...There are few population-based data in investigating the impact of diabetes on chemotherapy adverse effects and treatment outcomes of non-metastatic breast cancer. The purpose of this study is to evaluate whether diabetes affects the patterns of use in chemotherapy, toxic effects of chemotherapy, and treatment outcomes for non-metastatic breast cancer in Taiwan. The study results can provide physicians for making a decision whether or not to use chemotherapy based on the individual patients＇ condition.展开更多
文摘目的:系统评价康柏西普和雷珠单抗治疗视网膜静脉阻塞(RVO)继发黄斑水肿(ME)的疗效、安全性、经济性。方法:分别在万方数据库、中国生物医学文献服务系统、中国知网、Pubmed、The Cochrane Library Central Register of Controlled Trials(CENTRAL)、Google scholar等数据库收集自建库至2020-02-20关于康柏西普和雷珠单抗治疗RVO继发ME的对照研究,提取最佳矫正视力、黄斑中心凹视网膜厚度、不良反应发生情况、注射次数等主要结局指标进行系统评价,比较二者的效果。采用RevMan 5.3统计软件进行数据的分析。结果:共纳入16项研究,合计患者1337例。Meta分析结果提示,与雷珠单抗相比,康柏西普在采用1+PRN注射方案和治疗视网膜分支静脉阻塞(BRVO)继发ME患者时,对黄斑水肿的消退效果更明显,但二者注射次数无明显差异;与雷珠单抗相比,康柏西普在采用3+PRN注射方案和治疗视网膜中央静脉阻塞(CRVO)继发ME患者时,注射次数更少;康柏西普和雷珠单抗在视力改善和不良反应的发生方面无明显差异。结论:与雷珠单抗相比,康柏西普在不同的注射方案和不同的静脉阻塞类型治疗中体现出更优的效果,即更少的注射次数或更好的黄斑水肿消退效果。
基金supported by the MST of Taiwan under Grant No.101-2221-E-008-125-MY3
文摘There are few population-based data in investigating the impact of diabetes on chemotherapy adverse effects and treatment outcomes of non-metastatic breast cancer. The purpose of this study is to evaluate whether diabetes affects the patterns of use in chemotherapy, toxic effects of chemotherapy, and treatment outcomes for non-metastatic breast cancer in Taiwan. The study results can provide physicians for making a decision whether or not to use chemotherapy based on the individual patients＇ condition.
