The leader propagation is one of the most important stages in long air gap discharge.The mechanism behind leader re-illumination remains unclear.In high humidity conditions(20.0–30.1 g/m^(3)),we have conducted experi...The leader propagation is one of the most important stages in long air gap discharge.The mechanism behind leader re-illumination remains unclear.In high humidity conditions(20.0–30.1 g/m^(3)),we have conducted experiments of long sparks in a 10 m ultra-high voltage(UHV)transmission line gap under switching impulse voltages.The positive leaders predominantly propagate discontinuously,with almost no significantly continuous propagation occurring.The leader channels are intensely luminous and each elongation segment is straight,with streamers resembling the“branch type”which differs from the“diffuse type”streamers at the front of continuous propagation leaders.The distribution of the propagation velocities is highly random(3.7–18.4 cm/μs),and the average velocity(9.2 cm/μs)significantly exceeds that of continuous propagation(1.5–2.0 cm/μs).Analysis suggests that the current-velocity models suitable for continuous leader propagation do not align well with the experimental data in re-illumination mode.Based on the discharge current waveforms and optical images,it is speculated that the newly elongated leader in re-illumination mode does not evolve gradually from the stem(about 1 cm)but rather evolves overall from a thermal channel much longer than stem.展开更多
Intercalated transition metal dichalcogenides(TMDCs)attract much attention due to their rich properties and potential applications.In this article,we grew successfully high-quality V_(1/3)TaS_(2) crystals by a vapor t...Intercalated transition metal dichalcogenides(TMDCs)attract much attention due to their rich properties and potential applications.In this article,we grew successfully high-quality V_(1/3)TaS_(2) crystals by a vapor transport method.We measured the magnetization,longitudinal resistivityρxx(T,H),Hall resistivityρxy(T,H),as well as performed calculations of the electronic band structure.It was found that V_(1/3)TaS_(2) is an A-type antiferromagnet with the Neel temperature T_(N)=6.20 K,and exhibits a negative magnetoresistance(MR)near T_(N).Both band structure calculations and Hall resistivity measurements demonstrated it is a magnetic semimetal.展开更多
Combining the deviation between thin layers' adjacent surfaces with the confining potential method applied to the quantum curved systems,we derive the effective Schr?dinger equation describing the particle constra...Combining the deviation between thin layers' adjacent surfaces with the confining potential method applied to the quantum curved systems,we derive the effective Schr?dinger equation describing the particle constrained within a curved layer,accompanied by a general geometric potential V_(gq) composed of a compression-corrected geometric potential V_(gq)~*and a novel potential V_(gq)~(**) brought by the deviation.Applying this analysis to the cylindrical layer emerges two types of deviation-induced geometric potential,resulting from the the cases of slant deviation and tangent deviation,respectively,which strongly renormalizes the purely geometric potential and contribute to the energy spectrum based on a very substantial deepening of bound states they offer.展开更多
Liver fibrosis is a common pathological consequence of a variety of chronic stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic diseases. Fibrosis is driven by a dynamic process involving inc...Liver fibrosis is a common pathological consequence of a variety of chronic stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic diseases. Fibrosis is driven by a dynamic process involving increased synthesis of matrix components and a failure of physiological mechanisms of matrix turnover. Activation of hepatic stellate cells(HSCs) remains a central event in fibrosis. HSCs are the main source of extracellular matrix(ECM). Transforming growth factor-beta(TGF-β), which is the fibrogenic master cytokine, can induce the activation of HSCs to produce a large amount of ECM, and is capable of inducing apoptosis of liver cells. RNA interference(RNAi) is a novel gene disruption technology. Studies have shown that small interfering RNA(si RNA) targeting TGF-β1 may inhibit the activation and proliferation of HSCs, suppress ECM synthesis and block liver fibrosis. TGF-β1 si RNA-mediated gene silencing therapy provides a new avenue for liver fibrosis. This review summarizes recent progresses in research on HSCs, TGF-β1 and TGF-β1 si RNA in liver fibrosis.展开更多
To objectively classify and evaluate the strong aroma base liquors(SABLs)of different grades,solid-phase microextraction-mass spectrometry(SPME-MS)combined with chemometrics were used.Results showed that SPME-MS combi...To objectively classify and evaluate the strong aroma base liquors(SABLs)of different grades,solid-phase microextraction-mass spectrometry(SPME-MS)combined with chemometrics were used.Results showed that SPME-MS combined with a back-propagation artificial neural network(BPANN)method yielded almost the same recognition performance compared to linear discriminant analysis(LDA)in distinguishing different grades of SABL,with 84%recognition rate for the test set.Partial least squares(PLS),successive projection algorithm partial least squares(SPA-PLS)model,and competitive adaptive reweighed samplingpartial least squares(CARS-PLS)were established for the prediction of the four esters in the SABL.CARS-PLS model showed a greater advantage in the quantitative analysis of ethyl acetate,ethyl butyrate,ethyl caproate,and ethyl lactate.These results corroborated the hypothesis that SPME-MS combined with chemometrics can effectively achieve an accurate determination of different grades of SABL and prediction performance of esters.展开更多
We report a new minimally invasive technique utilizing interventional ultrasound for precise external intracerebral hemorrhage drain(EICHD) placement in pigs.
BACKGROUND The high-degree atrioventricular block(HAVB)in patients with bicuspid aortic valve(BAV)treated with transcatheter aortic valve implantation(TAVI)remains high.The study aims to explore this poorly understood...BACKGROUND The high-degree atrioventricular block(HAVB)in patients with bicuspid aortic valve(BAV)treated with transcatheter aortic valve implantation(TAVI)remains high.The study aims to explore this poorly understood subject of mech-anisms and predictors for HAVB in BAV self-expandable TAVI patients.METHODS We retrospectively included 181 BAV patients for analysis.Using computed tomography data,the curvature of ascending aorta(AAo)was quantified by the angle(AAo angle)between annulus and the cross-section at 35 mm above annulus(where the stent interacts with AAo the most).The valvular anatomy and leaflet calcification were also characterized.RESULTS The 30-day HAVB rate was 16.0%(median time to HAVB was three days).Type-1 morphology was found in 79 pat-ients(43.6%)(left-and right-coronary cusps fusion comprised 79.7%).Besides implantation below membrane septum,large AAo angle[odds ratio(OR)=1.08,P=0.016]and type-1 morphology(OR=4.97,P=0.001)were found as the independent predictors for HAVB.Together with baseline right bundle branch block,these predictors showed strong predictability for HAVB with area under the cure of 0.84(sensitivity=62.1%,specificity=92.8%).Bent AAo and calcified raphe had a synergistic effect in facilita-ting high implantation,though the former is associated with at-risk deployment(device implanted above annulus+prothesis pop-out,versus straight AAo:9.9%vs.2.2%,P=0.031).CONCLUSIONS AAo curvature and type-1 morphology are novel predictors for HAVB in BAV patients following self-expandable TAVI.For patients with bent AAo or calcified raphe,a progressive approach to implant the device above the lower edge of membrane septum is favored,though should be done cautiously to avoid pop-out.展开更多
Boreal forests commonly suff er from nitrogen defi ciency due to low rate of nitrogen mineralization.Biochar may promote soil organic matter decomposition and accelerate nitrogen mineralization.In this study,Illumina ...Boreal forests commonly suff er from nitrogen defi ciency due to low rate of nitrogen mineralization.Biochar may promote soil organic matter decomposition and accelerate nitrogen mineralization.In this study,Illumina NovaSeq sequencing combined with functional annotation of prokaryotic taxa(FAPROTAX)analysis was used to investigate the eff ect of biochar pyrolysis temperatures,the amount of applied biochar,and the period since the biochar application(2-and 3-year)on soil bacterial communities.The results show that biochar pyrolysis temperatures(500℃ and 650℃)and the amount of applied biochar(0.5 kg m^(−2)and 1.0 kg m^(−2))did not change soil properties.Nevertheless,the interaction of biochar pyrolysis temperature and the amount had signifi cant eff ects on bacterial species richness and evenness(P<0.05).The application of biochar produced at 500℃ had a lower abundance of Actinobacteria and Verrucomicrobia,while that produced at 650℃ had a higher abundance of Conexibacter and Phenylobacterium.When biochar produced at 650℃ was applied,applying 0.5 kg m^(−2)had a higher abundance of Cyanobacteria,Conexibacter,and Phenylobacterium than that of 1.0 kg m^(−2)(P<0.05).Functionally,the abundance of the aromatic compound degradation group increased with the extension of application time and increase of pyrolysis temperature.The time since application played an important role in the formation of soil bacterial communities and their functional structure.Long-term studies are necessary to understand the consequence of biochar on bacterial communities in boreal forests.展开更多
Based on Landau–de Gennes theory and two-dimensional finite-difference iterative method, the spontaneous distortion in hybrid alignment nematic cells with M = ±1/2 disclination lines is investigated by establish...Based on Landau–de Gennes theory and two-dimensional finite-difference iterative method, the spontaneous distortion in hybrid alignment nematic cells with M = ±1/2 disclination lines is investigated by establishing two models. The fine structures of defect cores are described in the order space S^2/Z2. The joint action of elastic anisotropy（L2/L1） and biaxiality of defects induces the spontaneous twist distortion, accompanied by the movement of the defect center to the upper or lower plate. For each model, four mixed defect structures appear with the same energy, which are defined as energetically degenerated quadruple states.展开更多
Aramid fibers,due to their relatively high inter-yarn friction,high strength,high modulus,and other characteristics,have become a typical representative of flexible anti-ballistic materials in modern warfare.Current r...Aramid fibers,due to their relatively high inter-yarn friction,high strength,high modulus,and other characteristics,have become a typical representative of flexible anti-ballistic materials in modern warfare.Current research on the anti-penetration of aramid fabrics mostly focuses unilaterally on the structure and performance of aramid fabrics or the shape and size of projectiles,with fewer studies on the coupled effect of both on ballistic performance.This study analyzes how the coupling relationship(or size effect)between the projectile and fiber bundle dimensions affects the fabric ballistic performance from a mesoscopic scale perspective.Taking plain weave aramid fabric as the research object,considering different diameter projectiles,through a large number of ballistic impact tests and numerical simulations,parameters such as ballistic limit velocity,average energy absorption of fabric,and specific energy absorption ratio(average energy absorption of fabric divided by projectile cross-sectional area)are obtained for ballistic performance analysis.The influence law of projectile size on the ballistic performance of high-performance fabrics is as follows:The relative range of fitted ballistic limit velocity at different target positions gradually decreases and then stabilizes as the projectile diameter increases,indicating that the fabric structure effect gradually disappears at a projectile diameter of 12 mm;The average ballistic limit velocity at three impact positions,P1,P2,and P3,provides the corresponding ballistic limit velocity for 1000D aramid fabric,which increases with projectile diameter but the rate of increase slows down at an inflection point,which in this study occurs where the fabric structure effect nearly disappears at a projectile diameter of 12 mm;The energy absorption ratio increases and then decreases as the projectile diameter increases from 4 mm to 20 mm,reaching a peak at the diameter of 12 mm due to the gradual disappearance of the fabric structural effect.The projectile diameter of 12 mm corresponds to the coupling size of 11.159,which provides a size design reference for the macroscopic-based continuum models of aramid plain weave fabrics.展开更多
基金supported by National Key R&D Program of China(No.2022YFB3206800)Scientific Research Fund of Hunan Provincial Education Department(No.23A0240)+1 种基金Scientific Research Fund of Hunan Provincial Education Department(No.23C0128)CSUST Training Program of Innovation and Entrepreneurship for Undergraduates(No.202410536044)。
文摘The leader propagation is one of the most important stages in long air gap discharge.The mechanism behind leader re-illumination remains unclear.In high humidity conditions(20.0–30.1 g/m^(3)),we have conducted experiments of long sparks in a 10 m ultra-high voltage(UHV)transmission line gap under switching impulse voltages.The positive leaders predominantly propagate discontinuously,with almost no significantly continuous propagation occurring.The leader channels are intensely luminous and each elongation segment is straight,with streamers resembling the“branch type”which differs from the“diffuse type”streamers at the front of continuous propagation leaders.The distribution of the propagation velocities is highly random(3.7–18.4 cm/μs),and the average velocity(9.2 cm/μs)significantly exceeds that of continuous propagation(1.5–2.0 cm/μs).Analysis suggests that the current-velocity models suitable for continuous leader propagation do not align well with the experimental data in re-illumination mode.Based on the discharge current waveforms and optical images,it is speculated that the newly elongated leader in re-illumination mode does not evolve gradually from the stem(about 1 cm)but rather evolves overall from a thermal channel much longer than stem.
基金Project supported by the National Key Research and Development Program of China(Grant No.2022YFA1403202)the National Natural Science Foundation of China(Grant Nos.NSFC-12074335,11974095,5177115,11974095,and 12188101)the Natural Science Foundation of Shaanxi Province of China(Grant No.2022JM-028).
文摘Intercalated transition metal dichalcogenides(TMDCs)attract much attention due to their rich properties and potential applications.In this article,we grew successfully high-quality V_(1/3)TaS_(2) crystals by a vapor transport method.We measured the magnetization,longitudinal resistivityρxx(T,H),Hall resistivityρxy(T,H),as well as performed calculations of the electronic band structure.It was found that V_(1/3)TaS_(2) is an A-type antiferromagnet with the Neel temperature T_(N)=6.20 K,and exhibits a negative magnetoresistance(MR)near T_(N).Both band structure calculations and Hall resistivity measurements demonstrated it is a magnetic semimetal.
基金Project jointly supported by the National Natural Science Foundation of China(Grant No.11934008)funded by the Fund from National Laboratory of Solid State Microstructure of Nanjing University(Grant Nos.M35040 and M35053)the Youth Independent Innovation Fund(Grant No.KYJBJKQTZQ23006)。
文摘Combining the deviation between thin layers' adjacent surfaces with the confining potential method applied to the quantum curved systems,we derive the effective Schr?dinger equation describing the particle constrained within a curved layer,accompanied by a general geometric potential V_(gq) composed of a compression-corrected geometric potential V_(gq)~*and a novel potential V_(gq)~(**) brought by the deviation.Applying this analysis to the cylindrical layer emerges two types of deviation-induced geometric potential,resulting from the the cases of slant deviation and tangent deviation,respectively,which strongly renormalizes the purely geometric potential and contribute to the energy spectrum based on a very substantial deepening of bound states they offer.
基金Supported by National Natural Science Foundation of China(81373465)
文摘Liver fibrosis is a common pathological consequence of a variety of chronic stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic diseases. Fibrosis is driven by a dynamic process involving increased synthesis of matrix components and a failure of physiological mechanisms of matrix turnover. Activation of hepatic stellate cells(HSCs) remains a central event in fibrosis. HSCs are the main source of extracellular matrix(ECM). Transforming growth factor-beta(TGF-β), which is the fibrogenic master cytokine, can induce the activation of HSCs to produce a large amount of ECM, and is capable of inducing apoptosis of liver cells. RNA interference(RNAi) is a novel gene disruption technology. Studies have shown that small interfering RNA(si RNA) targeting TGF-β1 may inhibit the activation and proliferation of HSCs, suppress ECM synthesis and block liver fibrosis. TGF-β1 si RNA-mediated gene silencing therapy provides a new avenue for liver fibrosis. This review summarizes recent progresses in research on HSCs, TGF-β1 and TGF-β1 si RNA in liver fibrosis.
基金The study was supported by the Key Research and Development Program of Jiangsu Province(BE2020312)National Natural Science Foundation of China(31671844)+2 种基金Open Project of National Engineering Laboratory for Agri-product Quality Traceability(AQT-2019-YB7)Science Foundation for Postdoctoral in Jiangsu Province(1501100C)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘To objectively classify and evaluate the strong aroma base liquors(SABLs)of different grades,solid-phase microextraction-mass spectrometry(SPME-MS)combined with chemometrics were used.Results showed that SPME-MS combined with a back-propagation artificial neural network(BPANN)method yielded almost the same recognition performance compared to linear discriminant analysis(LDA)in distinguishing different grades of SABL,with 84%recognition rate for the test set.Partial least squares(PLS),successive projection algorithm partial least squares(SPA-PLS)model,and competitive adaptive reweighed samplingpartial least squares(CARS-PLS)were established for the prediction of the four esters in the SABL.CARS-PLS model showed a greater advantage in the quantitative analysis of ethyl acetate,ethyl butyrate,ethyl caproate,and ethyl lactate.These results corroborated the hypothesis that SPME-MS combined with chemometrics can effectively achieve an accurate determination of different grades of SABL and prediction performance of esters.
基金supported by grants from the Beijing Science and Technology New Star Project (XX2018019/Z181100006218028)the National Natural Science Fund (81701961)+3 种基金the PLA Logistic Major Science and Technology Project (16QNP135)the PLA General Hospital Science and Technology Project (2018XXFC-20, 16KMM56, 2017FC-WJFWZX-30)the Winter Olympics of Science and Technology (2019YFF0302300)the Construction Project of Key Disciplines in the 13th Five-Year Plan of the PLA (Traumatic Surgery in the Battlefield, 2019–126, 2019–513)。
文摘We report a new minimally invasive technique utilizing interventional ultrasound for precise external intracerebral hemorrhage drain(EICHD) placement in pigs.
基金This study was supported by the National Natural Science Foundation of China(No.81970325&No.81900348&No.81901825)the Science and Technology Support Plan of Sichuan Province(2019YFS0299&2019YFS0433)。
文摘BACKGROUND The high-degree atrioventricular block(HAVB)in patients with bicuspid aortic valve(BAV)treated with transcatheter aortic valve implantation(TAVI)remains high.The study aims to explore this poorly understood subject of mech-anisms and predictors for HAVB in BAV self-expandable TAVI patients.METHODS We retrospectively included 181 BAV patients for analysis.Using computed tomography data,the curvature of ascending aorta(AAo)was quantified by the angle(AAo angle)between annulus and the cross-section at 35 mm above annulus(where the stent interacts with AAo the most).The valvular anatomy and leaflet calcification were also characterized.RESULTS The 30-day HAVB rate was 16.0%(median time to HAVB was three days).Type-1 morphology was found in 79 pat-ients(43.6%)(left-and right-coronary cusps fusion comprised 79.7%).Besides implantation below membrane septum,large AAo angle[odds ratio(OR)=1.08,P=0.016]and type-1 morphology(OR=4.97,P=0.001)were found as the independent predictors for HAVB.Together with baseline right bundle branch block,these predictors showed strong predictability for HAVB with area under the cure of 0.84(sensitivity=62.1%,specificity=92.8%).Bent AAo and calcified raphe had a synergistic effect in facilita-ting high implantation,though the former is associated with at-risk deployment(device implanted above annulus+prothesis pop-out,versus straight AAo:9.9%vs.2.2%,P=0.031).CONCLUSIONS AAo curvature and type-1 morphology are novel predictors for HAVB in BAV patients following self-expandable TAVI.For patients with bent AAo or calcified raphe,a progressive approach to implant the device above the lower edge of membrane septum is favored,though should be done cautiously to avoid pop-out.
基金funded by The Foundation for Research of Natural Resources in Finland(2016085)supported by the Academy of Finland(286685,294600,307222,277623)the FCoE of atmospheric sciences(Center of Excellence(1118615)).
文摘Boreal forests commonly suff er from nitrogen defi ciency due to low rate of nitrogen mineralization.Biochar may promote soil organic matter decomposition and accelerate nitrogen mineralization.In this study,Illumina NovaSeq sequencing combined with functional annotation of prokaryotic taxa(FAPROTAX)analysis was used to investigate the eff ect of biochar pyrolysis temperatures,the amount of applied biochar,and the period since the biochar application(2-and 3-year)on soil bacterial communities.The results show that biochar pyrolysis temperatures(500℃ and 650℃)and the amount of applied biochar(0.5 kg m^(−2)and 1.0 kg m^(−2))did not change soil properties.Nevertheless,the interaction of biochar pyrolysis temperature and the amount had signifi cant eff ects on bacterial species richness and evenness(P<0.05).The application of biochar produced at 500℃ had a lower abundance of Actinobacteria and Verrucomicrobia,while that produced at 650℃ had a higher abundance of Conexibacter and Phenylobacterium.When biochar produced at 650℃ was applied,applying 0.5 kg m^(−2)had a higher abundance of Cyanobacteria,Conexibacter,and Phenylobacterium than that of 1.0 kg m^(−2)(P<0.05).Functionally,the abundance of the aromatic compound degradation group increased with the extension of application time and increase of pyrolysis temperature.The time since application played an important role in the formation of soil bacterial communities and their functional structure.Long-term studies are necessary to understand the consequence of biochar on bacterial communities in boreal forests.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11374087 and 11447179)the Key Subject Construction Project of Hebei Province University,China
文摘Based on Landau–de Gennes theory and two-dimensional finite-difference iterative method, the spontaneous distortion in hybrid alignment nematic cells with M = ±1/2 disclination lines is investigated by establishing two models. The fine structures of defect cores are described in the order space S^2/Z2. The joint action of elastic anisotropy（L2/L1） and biaxiality of defects induces the spontaneous twist distortion, accompanied by the movement of the defect center to the upper or lower plate. For each model, four mixed defect structures appear with the same energy, which are defined as energetically degenerated quadruple states.
基金National Natural Science Foundation of China(Grant Nos.12172179,11802141 and U2341244)National Natural Science Foundation for Young Scientists of China(Grant No.12202207)+3 种基金China Postdoctoral Science Foundation(Grant No.2022M711623)Natural Science Foundation of Jiangsu Province(Grant No.BK20220968)Open Funds for Key Laboratory of Impact and Safety Engineering(Ningbo University),Ministry of Education(Grant No.CJ202201)Open Funds for Shock and Vibration of Engineering Materials and Structures Key Laboratory of Sichuan Province(Grant No.22kfgk03)。
文摘Aramid fibers,due to their relatively high inter-yarn friction,high strength,high modulus,and other characteristics,have become a typical representative of flexible anti-ballistic materials in modern warfare.Current research on the anti-penetration of aramid fabrics mostly focuses unilaterally on the structure and performance of aramid fabrics or the shape and size of projectiles,with fewer studies on the coupled effect of both on ballistic performance.This study analyzes how the coupling relationship(or size effect)between the projectile and fiber bundle dimensions affects the fabric ballistic performance from a mesoscopic scale perspective.Taking plain weave aramid fabric as the research object,considering different diameter projectiles,through a large number of ballistic impact tests and numerical simulations,parameters such as ballistic limit velocity,average energy absorption of fabric,and specific energy absorption ratio(average energy absorption of fabric divided by projectile cross-sectional area)are obtained for ballistic performance analysis.The influence law of projectile size on the ballistic performance of high-performance fabrics is as follows:The relative range of fitted ballistic limit velocity at different target positions gradually decreases and then stabilizes as the projectile diameter increases,indicating that the fabric structure effect gradually disappears at a projectile diameter of 12 mm;The average ballistic limit velocity at three impact positions,P1,P2,and P3,provides the corresponding ballistic limit velocity for 1000D aramid fabric,which increases with projectile diameter but the rate of increase slows down at an inflection point,which in this study occurs where the fabric structure effect nearly disappears at a projectile diameter of 12 mm;The energy absorption ratio increases and then decreases as the projectile diameter increases from 4 mm to 20 mm,reaching a peak at the diameter of 12 mm due to the gradual disappearance of the fabric structural effect.The projectile diameter of 12 mm corresponds to the coupling size of 11.159,which provides a size design reference for the macroscopic-based continuum models of aramid plain weave fabrics.
