Wie present a 29-year-old woman with pT2N0M0 breast cancer,histological diagnosis of invasive ductal carcinoma,ER and PR low positive,and HER-2(3+).The patient developed trastuzumab-induced thrombocytopenia in 6 hours...Wie present a 29-year-old woman with pT2N0M0 breast cancer,histological diagnosis of invasive ductal carcinoma,ER and PR low positive,and HER-2(3+).The patient developed trastuzumab-induced thrombocytopenia in 6 hours after an intravenous infusion of trastuzumab at the second cycle of trastuzumab treatment with the symptom of abnormal uterine bleeding.Laboratory exam revealed a sharp drop of platelet count down to 3X109/L.With the treatment of single-donor platelet transfusions,glucocorticoids,oxytocin and thrombopoietic drugs,the platelet count recovered completely in 11 days.This case was confirmed to be severe thrombocytopenia induced by trastuzumab,and retreatment with trastuzumab was not attempted.With increasing clinical utilization of trastuzumab,clinicians are likely to encounter more life-threatening trastuzumab induced severe thrombocytopenia.By this case report and literature review we hope to increase the awareness,attach the attentions to this condition,and help with the effective treatment.展开更多
Emulation of synaptic function by ionic/electronic hybrid device is crucial for brain-like computing and neuromorphic systems.Electric-double-layer(EDL)transistors with proton conducting electrolytes as the gate diele...Emulation of synaptic function by ionic/electronic hybrid device is crucial for brain-like computing and neuromorphic systems.Electric-double-layer(EDL)transistors with proton conducting electrolytes as the gate dielectrics provide a prospective approach for such application.Here,artificial synapses based on indium-tungsten-oxide(IWO)-based EDL transistors are proposed,and some important synaptic functions(excitatory post-synaptic current,paired-pulse facilitation,filtering)are emulated.Two types of spike-timing-dependent plasticity(Hebbian STDP and anti-Hebbian STDP)learning rules and multistore memory(sensory memory,short-term memory,and long-term memory)are also mimicked.At last,classical conditioning is successfully demonstrated.Our results indicate that IWO-based neuromorphic transistors are interesting for neuromorphic applications.展开更多
Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecularimaging technique at the protein level in tissue. Neurodegenerative diseases have a highlikelihood of causing abnormal protein accu...Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecularimaging technique at the protein level in tissue. Neurodegenerative diseases have a highlikelihood of causing abnormal protein accumulation in the brain, which can be detectedby APT MRI. This article briefly introduces the principles and image processing technologyof APT MRI, and reviews the current state of research on Alzheimer's disease and Parkinson's disease using this technique. Early applications of this approach in these twoneurodegenerative diseases are encouraging, which also suggests continued technicaldevelopment and larger clinical trials to gauge the value of this technique.展开更多
基金Fund supported by the President Foundation of Nanfang Hospital,Southern Medical University(2016L007).
文摘Wie present a 29-year-old woman with pT2N0M0 breast cancer,histological diagnosis of invasive ductal carcinoma,ER and PR low positive,and HER-2(3+).The patient developed trastuzumab-induced thrombocytopenia in 6 hours after an intravenous infusion of trastuzumab at the second cycle of trastuzumab treatment with the symptom of abnormal uterine bleeding.Laboratory exam revealed a sharp drop of platelet count down to 3X109/L.With the treatment of single-donor platelet transfusions,glucocorticoids,oxytocin and thrombopoietic drugs,the platelet count recovered completely in 11 days.This case was confirmed to be severe thrombocytopenia induced by trastuzumab,and retreatment with trastuzumab was not attempted.With increasing clinical utilization of trastuzumab,clinicians are likely to encounter more life-threatening trastuzumab induced severe thrombocytopenia.By this case report and literature review we hope to increase the awareness,attach the attentions to this condition,and help with the effective treatment.
基金the National Natural Science Foundation of China(Grant Nos.11674162 and 61834001)the National Key R&D Program of China(Grant Nos.2018YFA0305800 and 2019YFB2205400).
文摘Emulation of synaptic function by ionic/electronic hybrid device is crucial for brain-like computing and neuromorphic systems.Electric-double-layer(EDL)transistors with proton conducting electrolytes as the gate dielectrics provide a prospective approach for such application.Here,artificial synapses based on indium-tungsten-oxide(IWO)-based EDL transistors are proposed,and some important synaptic functions(excitatory post-synaptic current,paired-pulse facilitation,filtering)are emulated.Two types of spike-timing-dependent plasticity(Hebbian STDP and anti-Hebbian STDP)learning rules and multistore memory(sensory memory,short-term memory,and long-term memory)are also mimicked.At last,classical conditioning is successfully demonstrated.Our results indicate that IWO-based neuromorphic transistors are interesting for neuromorphic applications.
文摘Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecularimaging technique at the protein level in tissue. Neurodegenerative diseases have a highlikelihood of causing abnormal protein accumulation in the brain, which can be detectedby APT MRI. This article briefly introduces the principles and image processing technologyof APT MRI, and reviews the current state of research on Alzheimer's disease and Parkinson's disease using this technique. Early applications of this approach in these twoneurodegenerative diseases are encouraging, which also suggests continued technicaldevelopment and larger clinical trials to gauge the value of this technique.
