BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin resistance.This study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence...BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin resistance.This study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence after radiofrequency catheter ablation(RFCA).METHODS A total of 576 patients with AF who underwent RFCA at the Second Affiliated Hospital of Xi'an Jiaotong University were included in this study.The participants were grouped based on cumulative TyG index values tertiles within 3 months after ablation.Cox regression and restricted cubic spline analyses were used to determine the relationship between cumulative TyG index values and AF recurrence.The predictive value of all risk factors was assessed by receiver operating curve analysis.RESULTS There were 375 patients completed the study(age:63.23±10.73 years,64.27%male).The risk of AF recurrence increased with increasing cumulative TyG index values tertiles.After adjusting for potential confounders,patients in the medium cumulative TyG index group[hazard ratio(HR)=4.949,95%CI:1.778–13.778,P=0.002]and the high cumulative TyG index group(HR=8.716,95%CI:3.371–22.536,P<0.001)had a higher risk of AF recurrence than those in the low cumulative TyG index group.The restricted cubic spline regression model also showed an increased risk of AF recurrence with increasing cumulative TyG index values.When considering cumulative TyG index values,left atrial diameter,and lactate dehydrogenase levels as a comprehensive factor,the model could effectively predict AF recurrence after RFCA[area under the curve(AUC)=0.847,95%CI:0.797–0.897,P<0.001].CONCLUSIONS Cumulative TyG index values were a risk factor for AF recurrence after RFCA.Monitoring longitudinal TyG index values may assist with optimized for risk stratification and outcome prediction for AF recurrence.展开更多
目的:建立鱼腥草中黄酮类成分的含量测定方法,对不同来源鱼腥草进行检测,为鱼腥草的质量标准提升提供理论依据。方法:采用HPLC法,建立同时测定金丝桃苷和槲皮苷的含量测定方法,并测定不同来源鱼腥草中金丝桃苷和槲皮苷的含量。结果:建立...目的:建立鱼腥草中黄酮类成分的含量测定方法,对不同来源鱼腥草进行检测,为鱼腥草的质量标准提升提供理论依据。方法:采用HPLC法,建立同时测定金丝桃苷和槲皮苷的含量测定方法,并测定不同来源鱼腥草中金丝桃苷和槲皮苷的含量。结果:建立的HPLC方法为乙腈-0.1%磷酸水溶液(18∶82)等度洗脱,流速为1 m L·min-1,检测波长为205 nm。收集的51批次鱼腥草道地产区和主产区样品、31批次市场样品中金丝桃苷含量0.04%~0.86%;平均值为0.28%;槲皮苷含量0.10%~2.58%,平均值为0.59%。其中道地产区和主产区样品中金丝桃苷的含量0.04%~0.86%,平均值为0.35%;槲皮苷含量0.10%~2.58%,平均值为0.76%。市场样品中金丝桃苷的含量0.08%~0.56%,平均值为0.21%;槲皮苷含量0.18%~0.79%,平均值为0.44%。结论:建立的含量测定方法简单,快速,保留时间短,实用性强,可用于客观评价并控制鱼腥草的质量;不同来源的鱼腥草之间金丝桃苷和槲皮苷的含量均存在差异,以它们的总和计,道地产区和主产区样品高于市场样品,野生品高于栽培品。展开更多
High-performance flexible one-dimensional(1D)electrochemical energy storage devices are crucial for the applications of wearable electronics.Although much progress on various 1D energy storage devices has been made,ch...High-performance flexible one-dimensional(1D)electrochemical energy storage devices are crucial for the applications of wearable electronics.Although much progress on various 1D energy storage devices has been made,challenges involving fabrication cost,scalability,and efficiency remain.Herein,a highperformance flexible all-fiber zinc-ion battery(ZIB)is fabricated using a low-cost,scalable,and efficient continuous wet-spinning method.Viscous composite inks containing cellulose nanofibers/carbon nanotubes(CNFs/CNTs)binary composite network and either manganese dioxide nanowires(MnO_(2) NWs)or commercial Zn powders are utilized to spinning fiber cathodes and anodes,respectively.MnO_(2) NWs and Zn powders are uniformly dispersed in the interpenetrated CNFs/CNTs fibrous network,leading to homogenous composite inks with an ideal shear-thinning property.The obtained fiber electrodes demonstrate favorable uniformity and flexibility.Benefiting from the well-designed electrodes,the assembled flexible fiber-shaped ZIB delivers a high specific capacity of 281.5 m Ah g^(-1) at 0.25 A g^(-1) and displays excellent cycling stability over 400 cycles.Moreover,the wet-spun fiber-shaped ZIBs achieve ultrahigh gravimetric and volumetric energy densities of 47.3 Wh kg^(-1) and 131.3 m Wh cm^(-3),respectively,based on both cathode and anode and maintain favorable stability even after 4000 bending cycles.This work offers a new concept design of 1D flexible ZIBs that can be potentially incorporated into commercial textiles for wearable and portable electronics.展开更多
Quantum computers are in hot-spot with the potential to handle more complex problems than classical computers can.Realizing the quantum computation requires the universal quantum gate set {T,H,CNOT} so as to perform a...Quantum computers are in hot-spot with the potential to handle more complex problems than classical computers can.Realizing the quantum computation requires the universal quantum gate set {T,H,CNOT} so as to perform any unitary transformation with arbitrary accuracy.Here we first briefly review the Majorana fermions and then propose the realization of arbitrary two-qubit quantum gates based on chiral Majorana fermions.Elementary cells consist of a quantum anomalous Hall insulator surrounded by a topological superconductor with electric gates and quantum-dot structures,which enable the braiding operation and the partial exchange operation.After defining a qubit by four chiral Majorana fermions,the singlequbit T and H quantum gates are realized via one partial exchange operation and three braiding operations,respectively.The entangled CNOT quantum gate is performed by braiding six chiral Majorana fermions.Besides,we design a powerful device with which arbitrary two-qubit quantum gates can be realized and take the quantum Fourier transform as an example to show that several quantum operations can be performed with this space-limited device.Thus,our proposal could inspire further utilization of mobile chiral Majorana edge states for faster quantum computation.展开更多
We theoretically study the Josephson effect in a quantum anomalous Hall insulator(QAHI)nanoribbon with a domain wall structure and covered by the superconductor.The anomalous Josephson current,the nonzero supercurrent...We theoretically study the Josephson effect in a quantum anomalous Hall insulator(QAHI)nanoribbon with a domain wall structure and covered by the superconductor.The anomalous Josephson current,the nonzero supercurrent at the zero superconducting phase difference,appears with the nonzero magnetization and the suitable azimuth angle of the domain wall.Dependent on the configuration of the domain wall,the anomalous current peaks in the Bloch type but disappears in the Néel type because the y-component of magnetization is necessary to break symmetry to arouse the anomalous current.The phase shift of the anomalous current is tunable by the magnetization,the azimuth angle,or the thickness of the domain wall.By introducing a bare QAHI region in the middle of the junction which is not covered by the superconductor,the anomalous Josephson effect is enhanced such that the phase shift can exceedπ.Thus,a continuous change between 0 andπjunctions is realized via regulating the configuration of the domain wall or the magnetization strength.As long as an s-wave superconductor is placed on the top of the QAHI with a domain wall structure,this proposal can be experimentally fabricated and useful for the phase battery or superconducting quantum bit.展开更多
We propose a new method to construct low-dimensional quantum devices consisting of the magnetic topological insulators.Unlike previous systems based on locally depleting two-dimensional electron gas in semiconductor h...We propose a new method to construct low-dimensional quantum devices consisting of the magnetic topological insulators.Unlike previous systems based on locally depleting two-dimensional electron gas in semiconductor heterojunctions,magnetization provides a simpler and rewriteable fabrication way.The motion of electrons can be manipulated through the domain wall formed by the boundary between different magnetic domains.Here,three devices designed by local magnetization are presented.For the quantum point contact,conductance exhibits quantized plateaus with the increasing silt width between two magnetic domains.For the quantum dot,conductance shows pronounced peaks as the change of gate voltage.Finally,for the Aharonov–Bohm ring,conductance oscillates periodically with the external magnetic field.Numerical results show that the transport of these local magnetization systems is identical to that of the previous systems based on depleting two-dimensional electron gas,and the only difference is the approach of construction.These findings may pave the way for realization of low-power-consumption devices based on magnetic domain walls.展开更多
Objective of this investigation is to further analyze the cardiac function status change by phonocar-diogram during mixed anesthesia which is conducted by midazolam,skelaxin,fentanyi and propofol.The results show that...Objective of this investigation is to further analyze the cardiac function status change by phonocar-diogram during mixed anesthesia which is conducted by midazolam,skelaxin,fentanyi and propofol.The results show that blood pressure,heart rate,amplitude of R wave and T wave,amplitude of first heart sound（S1）and second heart sound（S2）about 37 subjects after anesthesia decrease compared with baseline,while the ratio of first heart sound and second heart sound（S1/S2）and the ratio of diastole duration and systole duration（D/S）increase.Our study demonstrates that phonocardiogram as a noninvasive,high benefit/cost ratio,objective,repeatable and portable method can be used for the monitoring and evaluation of cardiac function status during anesthesia and operations.展开更多
基金supported by the National Natural Science Foundation of China(No.82360608)the Free Exploration Project of the Second Affiliated Hospital of Xi’an Jiaotong University(2020YJ153)。
文摘BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin resistance.This study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence after radiofrequency catheter ablation(RFCA).METHODS A total of 576 patients with AF who underwent RFCA at the Second Affiliated Hospital of Xi'an Jiaotong University were included in this study.The participants were grouped based on cumulative TyG index values tertiles within 3 months after ablation.Cox regression and restricted cubic spline analyses were used to determine the relationship between cumulative TyG index values and AF recurrence.The predictive value of all risk factors was assessed by receiver operating curve analysis.RESULTS There were 375 patients completed the study(age:63.23±10.73 years,64.27%male).The risk of AF recurrence increased with increasing cumulative TyG index values tertiles.After adjusting for potential confounders,patients in the medium cumulative TyG index group[hazard ratio(HR)=4.949,95%CI:1.778–13.778,P=0.002]and the high cumulative TyG index group(HR=8.716,95%CI:3.371–22.536,P<0.001)had a higher risk of AF recurrence than those in the low cumulative TyG index group.The restricted cubic spline regression model also showed an increased risk of AF recurrence with increasing cumulative TyG index values.When considering cumulative TyG index values,left atrial diameter,and lactate dehydrogenase levels as a comprehensive factor,the model could effectively predict AF recurrence after RFCA[area under the curve(AUC)=0.847,95%CI:0.797–0.897,P<0.001].CONCLUSIONS Cumulative TyG index values were a risk factor for AF recurrence after RFCA.Monitoring longitudinal TyG index values may assist with optimized for risk stratification and outcome prediction for AF recurrence.
文摘目的:建立鱼腥草中黄酮类成分的含量测定方法,对不同来源鱼腥草进行检测,为鱼腥草的质量标准提升提供理论依据。方法:采用HPLC法,建立同时测定金丝桃苷和槲皮苷的含量测定方法,并测定不同来源鱼腥草中金丝桃苷和槲皮苷的含量。结果:建立的HPLC方法为乙腈-0.1%磷酸水溶液(18∶82)等度洗脱,流速为1 m L·min-1,检测波长为205 nm。收集的51批次鱼腥草道地产区和主产区样品、31批次市场样品中金丝桃苷含量0.04%~0.86%;平均值为0.28%;槲皮苷含量0.10%~2.58%,平均值为0.59%。其中道地产区和主产区样品中金丝桃苷的含量0.04%~0.86%,平均值为0.35%;槲皮苷含量0.10%~2.58%,平均值为0.76%。市场样品中金丝桃苷的含量0.08%~0.56%,平均值为0.21%;槲皮苷含量0.18%~0.79%,平均值为0.44%。结论:建立的含量测定方法简单,快速,保留时间短,实用性强,可用于客观评价并控制鱼腥草的质量;不同来源的鱼腥草之间金丝桃苷和槲皮苷的含量均存在差异,以它们的总和计,道地产区和主产区样品高于市场样品,野生品高于栽培品。
基金financially supported by the National Science Fund for Distinguished Young Scholars(52025133)the Beijing Natural Science Foundation(JQ18005)+7 种基金the Tencent Foundation through the XPLORER PRIZE,the National Key R&D Program of China(2017YFA0206701)the BIC-ESAT fundingthe financial support of the Central Universities(2232020D-13)the Shanghai Sailing Program(20YF1400700)the National Natural Science Foundation of China(52003045)the financial support from the Young Elite Scientist Sponsorship Program by CAST(2019QNRC001)the“1000-Plan program”of Shaanxi Provincethe“Young Talent Support Plan”of Xi’an Jiaotong University。
文摘High-performance flexible one-dimensional(1D)electrochemical energy storage devices are crucial for the applications of wearable electronics.Although much progress on various 1D energy storage devices has been made,challenges involving fabrication cost,scalability,and efficiency remain.Herein,a highperformance flexible all-fiber zinc-ion battery(ZIB)is fabricated using a low-cost,scalable,and efficient continuous wet-spinning method.Viscous composite inks containing cellulose nanofibers/carbon nanotubes(CNFs/CNTs)binary composite network and either manganese dioxide nanowires(MnO_(2) NWs)or commercial Zn powders are utilized to spinning fiber cathodes and anodes,respectively.MnO_(2) NWs and Zn powders are uniformly dispersed in the interpenetrated CNFs/CNTs fibrous network,leading to homogenous composite inks with an ideal shear-thinning property.The obtained fiber electrodes demonstrate favorable uniformity and flexibility.Benefiting from the well-designed electrodes,the assembled flexible fiber-shaped ZIB delivers a high specific capacity of 281.5 m Ah g^(-1) at 0.25 A g^(-1) and displays excellent cycling stability over 400 cycles.Moreover,the wet-spun fiber-shaped ZIBs achieve ultrahigh gravimetric and volumetric energy densities of 47.3 Wh kg^(-1) and 131.3 m Wh cm^(-3),respectively,based on both cathode and anode and maintain favorable stability even after 4000 bending cycles.This work offers a new concept design of 1D flexible ZIBs that can be potentially incorporated into commercial textiles for wearable and portable electronics.
基金Project supported by the National Key R&D Program of China(Grant No.2017YFA0303301)the National Natural Science Foundation of China(Grant No.11921005)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB28000000)Beijing Municipal Science&Technology Commission,China(Grant No.Z191100007219013)。
文摘Quantum computers are in hot-spot with the potential to handle more complex problems than classical computers can.Realizing the quantum computation requires the universal quantum gate set {T,H,CNOT} so as to perform any unitary transformation with arbitrary accuracy.Here we first briefly review the Majorana fermions and then propose the realization of arbitrary two-qubit quantum gates based on chiral Majorana fermions.Elementary cells consist of a quantum anomalous Hall insulator surrounded by a topological superconductor with electric gates and quantum-dot structures,which enable the braiding operation and the partial exchange operation.After defining a qubit by four chiral Majorana fermions,the singlequbit T and H quantum gates are realized via one partial exchange operation and three braiding operations,respectively.The entangled CNOT quantum gate is performed by braiding six chiral Majorana fermions.Besides,we design a powerful device with which arbitrary two-qubit quantum gates can be realized and take the quantum Fourier transform as an example to show that several quantum operations can be performed with this space-limited device.Thus,our proposal could inspire further utilization of mobile chiral Majorana edge states for faster quantum computation.
基金Project supported by the National Key R&D Program of China(Grant No.2017YFA0303301)the National Natural Science Foundation of China(Grant Nos.11921005 and 11574007)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB28000000)Beijing Municipal Science&Technology Commission,China(Grant No.Z191100007219013).
文摘We theoretically study the Josephson effect in a quantum anomalous Hall insulator(QAHI)nanoribbon with a domain wall structure and covered by the superconductor.The anomalous Josephson current,the nonzero supercurrent at the zero superconducting phase difference,appears with the nonzero magnetization and the suitable azimuth angle of the domain wall.Dependent on the configuration of the domain wall,the anomalous current peaks in the Bloch type but disappears in the Néel type because the y-component of magnetization is necessary to break symmetry to arouse the anomalous current.The phase shift of the anomalous current is tunable by the magnetization,the azimuth angle,or the thickness of the domain wall.By introducing a bare QAHI region in the middle of the junction which is not covered by the superconductor,the anomalous Josephson effect is enhanced such that the phase shift can exceedπ.Thus,a continuous change between 0 andπjunctions is realized via regulating the configuration of the domain wall or the magnetization strength.As long as an s-wave superconductor is placed on the top of the QAHI with a domain wall structure,this proposal can be experimentally fabricated and useful for the phase battery or superconducting quantum bit.
基金Supported by the National Key R&D Program of China(Grant No.2017YFA0303301)the National Natural Science Foundation of China(Grant Nos.11921005 and 11574007)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB28000000)Beijing Municipal Science and Technology Commission,China(Grant No.Z191100007219013).
文摘We propose a new method to construct low-dimensional quantum devices consisting of the magnetic topological insulators.Unlike previous systems based on locally depleting two-dimensional electron gas in semiconductor heterojunctions,magnetization provides a simpler and rewriteable fabrication way.The motion of electrons can be manipulated through the domain wall formed by the boundary between different magnetic domains.Here,three devices designed by local magnetization are presented.For the quantum point contact,conductance exhibits quantized plateaus with the increasing silt width between two magnetic domains.For the quantum dot,conductance shows pronounced peaks as the change of gate voltage.Finally,for the Aharonov–Bohm ring,conductance oscillates periodically with the external magnetic field.Numerical results show that the transport of these local magnetization systems is identical to that of the previous systems based on depleting two-dimensional electron gas,and the only difference is the approach of construction.These findings may pave the way for realization of low-power-consumption devices based on magnetic domain walls.
基金supported by the National Nature Science Foundation of China under Grant No. 30400105973 Project under Grant No. 2003CB716106Outstanding Youth Fund of China under Grant No. 30525030
文摘Objective of this investigation is to further analyze the cardiac function status change by phonocar-diogram during mixed anesthesia which is conducted by midazolam,skelaxin,fentanyi and propofol.The results show that blood pressure,heart rate,amplitude of R wave and T wave,amplitude of first heart sound（S1）and second heart sound（S2）about 37 subjects after anesthesia decrease compared with baseline,while the ratio of first heart sound and second heart sound（S1/S2）and the ratio of diastole duration and systole duration（D/S）increase.Our study demonstrates that phonocardiogram as a noninvasive,high benefit/cost ratio,objective,repeatable and portable method can be used for the monitoring and evaluation of cardiac function status during anesthesia and operations.
