Smooth muscle cells can work properly over a large length range,drastic reorganization of the cytoskeletal structure has to occur,but the mechanism behind the process of cytoskeleton reorganization of smooth muscle is...Smooth muscle cells can work properly over a large length range,drastic reorganization of the cytoskeletal structure has to occur,but the mechanism behind the process of cytoskeleton reorganization of smooth muscle is still poorly understood,especially with respect to unique problem of maintaining force generation and transmission within the confine of an ever-changing cytoskeleton in smooth muscle.Using a cytoskeletal preparation derived from skinned airway smooth muscle,we aimed at separating the contribution of actomyosin interaction and elucidating the cytoskeletal stiffness in smooth muscle.The results indicate that there is a Ca++de-展开更多
基金supported by National Natural Science Foundation of China(11172340)Training Program for Hundreds of Distinguished Leading Scientists of ChongqingSpecialized Research Fund for the Doctoral Program of Higher Education of China(20120191120032)
文摘Smooth muscle cells can work properly over a large length range,drastic reorganization of the cytoskeletal structure has to occur,but the mechanism behind the process of cytoskeleton reorganization of smooth muscle is still poorly understood,especially with respect to unique problem of maintaining force generation and transmission within the confine of an ever-changing cytoskeleton in smooth muscle.Using a cytoskeletal preparation derived from skinned airway smooth muscle,we aimed at separating the contribution of actomyosin interaction and elucidating the cytoskeletal stiffness in smooth muscle.The results indicate that there is a Ca++de-
