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基于微流控芯片的复方木鸡颗粒抗肝肿瘤的“谱-物-效”关系 被引量:2
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作者 秦妍 包永睿 +4 位作者 王帅 李天娇 张秀君 孟宪生 潘海鸥 《中国药理学通报》 CAS CSCD 北大核心 2023年第1期185-192,共8页
目的探讨复方木鸡颗粒抗肝肿瘤作用的物质基础。方法采用微流控芯片技术对复方木鸡颗粒进行体外抗肝肿瘤药效学研究;采用HPLC法建立复方木鸡颗粒指纹图谱;采用灰色关联度分析、偏最小二乘回归以及网络药理学方法,对复方木鸡颗粒进行“谱... 目的探讨复方木鸡颗粒抗肝肿瘤作用的物质基础。方法采用微流控芯片技术对复方木鸡颗粒进行体外抗肝肿瘤药效学研究;采用HPLC法建立复方木鸡颗粒指纹图谱;采用灰色关联度分析、偏最小二乘回归以及网络药理学方法,对复方木鸡颗粒进行“谱-物-效”分析;采用UPLC-Q-TOF-MS技术对药效成分进行解析;结果成功建立7批不同提取方式的复方木鸡颗粒指纹图谱,灰色关联分析结果显示复方木鸡颗粒与药效关联系数>0.80的14个成分中有7个呈正相关;对抗肝肿瘤具有促进作用的贡献依次为峰号48(木犀草素)>6(没食子酸)>19(绿原酸)>59(槲皮素)>67(山柰酚)>65(柚皮素)>38(鞣花酸)。结论本实验通过建立“谱-物-效”研究方法,明确以上7种活性单体很可能为复方木鸡颗粒的抗肝肿瘤物质基础。 展开更多
关键词 复方木鸡颗粒 肝肿瘤 指纹图谱 微流控芯片 谱效分析 物质基础
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Analysis of the Main Body the Object and their Relationship Concerning Research of Traditional Chinese Medicine
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作者 SU Yan-bin meng xian-sheng +1 位作者 SU Yan-wen SI Ying-kui 《中华中医药学刊》 CAS 2007年第2期344-347,共4页
This paper is the analysis of the main body, the object and their relationship concerning research of traditional Chinese medicine. The result proved that the main body of research of traditional Chinese medicine is r... This paper is the analysis of the main body, the object and their relationship concerning research of traditional Chinese medicine. The result proved that the main body of research of traditional Chinese medicine is researchers who possessed the fundamentals of traditional Chinese medicine. It is the objects of research of traditional Chinese medicine that origin of a class of traditional Chinese medical literature consisting of herbals which focus on descriptions of individual drugs; the relationship of the technological process of preparing Chinese medicine, as by parching, roasting, baking, steaming, soaking, and simmering, etc.;and technology of separating, extracting and purifying for composition; traditional Chinese medicine dynamics of one of the 12 two-hour periods into which the day was formerly divided before the introduction of western chronology; compatibility of medicines in active compositions; patent, effectiveness for a given period of time and constantly changing of traditional Chinese medicine.The relationship between the main body and the objects was that the former depends on the latter ones and the main body has subjective initiative as fully as possible. 展开更多
关键词 Research of traditional Chinese medicine main body OBJECTS RELATIONSHIP
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