目的贝尔麻痹是一种常见的特发性面神经病变,导致病变侧的面部肌肉运动功能丧失。作者探讨了贝尔麻痹对大脑默认模式网络(DMN)功能连接的影响。材料与方法使用1.5 T MR成像仪获取静息态f MRI数据,包括健康志愿者35名及不同病理状态下的...目的贝尔麻痹是一种常见的特发性面神经病变,导致病变侧的面部肌肉运动功能丧失。作者探讨了贝尔麻痹对大脑默认模式网络(DMN)功能连接的影响。材料与方法使用1.5 T MR成像仪获取静息态f MRI数据,包括健康志愿者35名及不同病理状态下的面瘫患者52例次。使用双重回归独立成分分析方法处理数据。结果发现面瘫不同病理状态下DMN的功能连接发生了不同的变化。在面瘫疾病早期,DMN功能连接在右侧初级感觉皮层、初级运动皮层、背外侧前额叶显著增强;在面瘫后期,DMN功能连接在双侧中扣带回、楔前叶、右侧富内侧前额叶、后扣带回显著增强;在面瘫康复后,DMN功能连接在左侧舌回、小脑显著增强。结论在面瘫不同病理阶段,DMN的功能连接存在着明显的不同,涉及到感觉运动,运动映射,情感以及认知等不同功能脑区。展开更多
Although compressed sensing inverse synthetic aperture radar(ISAR) imaging methods are widely used in radar signal processing, its reconstructing time and memory storage space requirements are very high. The main reas...Although compressed sensing inverse synthetic aperture radar(ISAR) imaging methods are widely used in radar signal processing, its reconstructing time and memory storage space requirements are very high. The main reason is that large scene reconstruction needs a higher dimension of the sensing matrix. To reduce this limitation, a fast high resolution ISAR imaging method,which is based on scene segmentation for random chirp frequencystepped signals, is proposed. The idea of scene segmentation is used to solve the problems aforementioned. In the method,firstly, the observed scene is divided into multiple sub-scenes and then the sub-scenes are reconstructed respectively. Secondly, the whole image scene can be obtained through the stitching of the sub-scenes. Due to the reduction of the dimension of the sensing matrix, the requirement of the memory storage space is reduced substantially. In addition, due to the nonlinear superposition of the reconstructed time of the segmented sub-scenes, the reconstruction time is reduced, and the purpose of fast imaging is achieved.Meanwhile, the feasibility and the related factors which affect the performance of the proposed method are also analyzed, and the selection criterion of the scene segmentation is afforded. Finally,theoretical analysis and simulation results demonstrate the feasibility and effectiveness of the proposed method.展开更多
Point-of-care(POC)testing offers rapid results of diagnostics near the site of patient care,which can significantly improve health care and management of infectious diseases.POC testing now plays a crucial role in hea...Point-of-care(POC)testing offers rapid results of diagnostics near the site of patient care,which can significantly improve health care and management of infectious diseases.POC testing now plays a crucial role in healthcare delivery of both developed and developing countries,particularly in developing countries where medical resources are limited.Challenges remain for the biomedical engineering community to develop truly portable,automatic,low-cost and easyto-use POC tools.Blood tests are the most commonly-used diagnostic methods nowadays because blood analyses provide definitive information of medical conditions of patients.Traditional blood tests,including sample collection,preparation and detection,are conducted using large-scale blood an-展开更多
文摘目的贝尔麻痹是一种常见的特发性面神经病变,导致病变侧的面部肌肉运动功能丧失。作者探讨了贝尔麻痹对大脑默认模式网络(DMN)功能连接的影响。材料与方法使用1.5 T MR成像仪获取静息态f MRI数据,包括健康志愿者35名及不同病理状态下的面瘫患者52例次。使用双重回归独立成分分析方法处理数据。结果发现面瘫不同病理状态下DMN的功能连接发生了不同的变化。在面瘫疾病早期,DMN功能连接在右侧初级感觉皮层、初级运动皮层、背外侧前额叶显著增强;在面瘫后期,DMN功能连接在双侧中扣带回、楔前叶、右侧富内侧前额叶、后扣带回显著增强;在面瘫康复后,DMN功能连接在左侧舌回、小脑显著增强。结论在面瘫不同病理阶段,DMN的功能连接存在着明显的不同,涉及到感觉运动,运动映射,情感以及认知等不同功能脑区。
基金supported by the National Natural Science Foundation of China(61671469)
文摘Although compressed sensing inverse synthetic aperture radar(ISAR) imaging methods are widely used in radar signal processing, its reconstructing time and memory storage space requirements are very high. The main reason is that large scene reconstruction needs a higher dimension of the sensing matrix. To reduce this limitation, a fast high resolution ISAR imaging method,which is based on scene segmentation for random chirp frequencystepped signals, is proposed. The idea of scene segmentation is used to solve the problems aforementioned. In the method,firstly, the observed scene is divided into multiple sub-scenes and then the sub-scenes are reconstructed respectively. Secondly, the whole image scene can be obtained through the stitching of the sub-scenes. Due to the reduction of the dimension of the sensing matrix, the requirement of the memory storage space is reduced substantially. In addition, due to the nonlinear superposition of the reconstructed time of the segmented sub-scenes, the reconstruction time is reduced, and the purpose of fast imaging is achieved.Meanwhile, the feasibility and the related factors which affect the performance of the proposed method are also analyzed, and the selection criterion of the scene segmentation is afforded. Finally,theoretical analysis and simulation results demonstrate the feasibility and effectiveness of the proposed method.
基金the financial support from Natural Science and Engineering Research Council of Canada(NSERC)
文摘Point-of-care(POC)testing offers rapid results of diagnostics near the site of patient care,which can significantly improve health care and management of infectious diseases.POC testing now plays a crucial role in healthcare delivery of both developed and developing countries,particularly in developing countries where medical resources are limited.Challenges remain for the biomedical engineering community to develop truly portable,automatic,low-cost and easyto-use POC tools.Blood tests are the most commonly-used diagnostic methods nowadays because blood analyses provide definitive information of medical conditions of patients.Traditional blood tests,including sample collection,preparation and detection,are conducted using large-scale blood an-
