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汉防己甲素通过促进HIF-1α降解增强p53缺陷型非小细胞肺癌的放疗敏感性 被引量:5
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作者 金磊 郭洁 +2 位作者 刘昊 康云帆 吴翔 《中国肿瘤临床》 CAS CSCD 北大核心 2020年第20期1044-1050,共7页
目的:探讨汉防己甲素(tetrandrine,TET)增强非小细胞肺癌(non-small cell lung cancer,NSCLC)放疗敏感性的作用机制。方法:通过CCK-8法检测H1299和Calu-1细胞活力,并结合克隆形成实验检测在常规或缺氧条件下,TET对NSCLC放疗敏感性的影... 目的:探讨汉防己甲素(tetrandrine,TET)增强非小细胞肺癌(non-small cell lung cancer,NSCLC)放疗敏感性的作用机制。方法:通过CCK-8法检测H1299和Calu-1细胞活力,并结合克隆形成实验检测在常规或缺氧条件下,TET对NSCLC放疗敏感性的影响。研究TET对NSCLC中由辐射和缺氧诱导的缺氧诱导因子-1α(hypoxia inducible factor-1,HIF-1α)及血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的影响,并敲低HIF-1α基因进一步验证。通过逆转录聚合酶链反应(reverse tran⁃scription-polymerase chain reaction,RT-PCR)、环己酰亚胺(cycloheximide,CHX)追踪及免疫沉淀法检测TET对HIF-1α降解的影响,并探讨p53在TET放疗增敏中的作用。结果:TET可显著增强p53缺陷型NSCLC细胞的放疗敏感性,而对p53野生型的细胞作用不明显。辐射和缺氧暴露后,TET明显抑制HIF-1α及VEGF的表达。TET可通过蛋白泛素化降解系统加速HIF-1α的降解。野生型p53基因转染到H1299细胞中可减弱TET抑制HIF-1α表达的作用。结论:TET通过促进HIF-1α降解抑制HIF-1α通路,使p53缺陷型NSCLC细胞对辐射敏感,而p53在TET诱导的HIF-1α降解中发挥抑制作用。 展开更多
关键词 汉防己甲素放疗增敏HIF-1α P53 非小细胞肺癌
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Robust sliding mode control with ESO for dual-control missile 被引量:1
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作者 wei shang shengjing tang +2 位作者 jie guo yueyue ma yuhang yun 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第5期1073-1082,共10页
This paper proposes a novel composite dual-control bycombing the integral sliding mode control (ISMC) method basedon the finite time convergence theory with extended state observer(ESO) for a tracking problem of a... This paper proposes a novel composite dual-control bycombing the integral sliding mode control (ISMC) method basedon the finite time convergence theory with extended state observer(ESO) for a tracking problem of a missile with tail fins and reactionjetcontrol system (RCS). First, the ISMC method based on finitetime convergence is utilized to design the control law of tail fins andthe pulse control of RCS for the dual-control system, ensuring thesystem with rapid response and high accuracy of tracking. Then,ESO is employed for the estimation of aerodynamic disturbancesinfluenced by the airflow of thruster jets. With the characteristicof high accuracy estimation of ESO, the chattering free trackingperformance of the attack angle command and the robustnessof the control law are achieved. Meanwhile, the stability of thedual-control system is analyzed based on finite time convergencestability theorem and Lyapunov’s theorem. Finally, numerical simulationsdemonstrate the effectiveness of the proposed design. 展开更多
关键词 reaction-jet control system (RCS) tail fins system integral sliding mode control extended state observer (ESO).
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BTT autopilot design for agile missiles with aerodynamic uncertainty
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作者 Yueyue Ma jie guo Shengjing Tang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2015年第4期802-812,共11页
The approach to the synthesis of autopilot with aerody- namic uncertainty is investigated in order to achieve large maneu- verability of agile missiles. The dynamics of the agile missile with reaction-jet control syst... The approach to the synthesis of autopilot with aerody- namic uncertainty is investigated in order to achieve large maneu- verability of agile missiles. The dynamics of the agile missile with reaction-jet control system (RCS) are presented. Subsequently, the cascade control scheme based on the bank-to-turn (B-I-T) steering technique is described. To address the aerodynamic un- certainties encountered by the control system, the active distur- bance rejection control (ADRC) method is introduced in the autopi- lot design. Furthermore, a compound controller, using extended state observer (ESO) to online estimate system uncertainties and calculate derivative of command signals, is designed based on dynamic surface control (DSC). Nonlinear simulation results show the feasibility of the proposed approach and validate the robust- ness of the controller with severe unmodeled dynamics. 展开更多
关键词 agile missile AUTOPILOT high angle of attack active dis-turbance rejection control (ADRC) dynamic surface control (DSC) extended state observer (ESO).
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