A Pickering emulsion based on sodium starch octenyl succinate(SSOS)was prepared and its effects on the physicochemical properties of hairtail myofibrillar protein gels(MPGs)subjected to multiple freeze-thaw(F-T)cycles...A Pickering emulsion based on sodium starch octenyl succinate(SSOS)was prepared and its effects on the physicochemical properties of hairtail myofibrillar protein gels(MPGs)subjected to multiple freeze-thaw(F-T)cycles were investigated.The whiteness,water-holding capacity,storage modulus(G')and texture properties of the MPGs were significantly improved by adding 1%-2%Pickering emulsion(P<0.05).Meanwhile,Raman spectral analysis demonstrated that Pickering emulsion promoted the transformation of secondary structure,enhanced hydrogen bonds and hydrophobic interactions,and promoted the transition of disulfide bond conformation from g-g-g to g-g-t and t-g-t.At an emulsion concentration of 2%,theα-helix content decreased by 10.37%,while theβ-sheet content increased by 7.94%,compared to the control.After F-T cycles,the structure of the MPGs was destroyed,with an increase in hardness and a decrease in whiteness and water-holding capacity,however,the quality degradation of MPGs was reduced with 1%-2%Pickering emulsion.These findings demonstrated that SSOS-Pickering emulsions,as potential fat substitutes,can enhance the gel properties and the F-T stability of MPGs.展开更多
Oxidative stress is one of the main ways to cause alcohol-induced liver injury,and alcoholic liver disease(ALD)has been a common health problem worldwide.Lactic acid bacteria(LAB)is also considered as a potential trea...Oxidative stress is one of the main ways to cause alcohol-induced liver injury,and alcoholic liver disease(ALD)has been a common health problem worldwide.Lactic acid bacteria(LAB)is also considered as a potential treatment to alleviate alcohol-induced liver injury.Lactobacillus plantarum J26 is a LAB isolated from Chinese traditional fermented dairy products with excellent probiotic effects.This study aimed to establish a mice model of alcoholic liver injury through acute-on-chronic alcohol feeding and to study the alleviating effect of pre-intake of L.plantarum J26 on alcohol-induced oxidative liver injury and focus on its potential mechanism of alleviating effect.The results showed that pre-intake of L.plantarum J26 could improve liver pathological changes,reduce lipid accumulation,increase mitochondrial ATP and mitochondrial(mtDNA)levels,and alleviate liver injury.In addition,pre-intake L.plantarum J26 can improve the level of short-chain fatty acids(SCFAs)in the intestines in mice,short chain fatty acids can be used as a signaling molecule activation of nuclear factor E2-related factor 2(Nrf2)signaling pathway to alleviate liver oxidative stress,and maintain mitochondrial homeostasis by regulating the expression of genes related to mitochondrial dynamics and autophagy,thereby reducing cell apoptosis to alleviate alcohol-induced oxidative liver injury.展开更多
Branched-chain fatty acids(BCFAs)are new bioactive fatty acids with anti-inflammatory properties.However,the role of BCFAs in alleviating ulcerative colitis has not been clarified.Herein,we evaluated the protective ef...Branched-chain fatty acids(BCFAs)are new bioactive fatty acids with anti-inflammatory properties.However,the role of BCFAs in alleviating ulcerative colitis has not been clarified.Herein,we evaluated the protective effect of BCFAs from goat milk in mice with colitis induced using dextran sodium sulfate(DSS)and explored the corresponding mechanism.These results show that BCFAs extracted from goat milk can significantly alleviate weight loss in mice,and reduce the disease activity index and the activity of myeloperoxidase while increasing the content of antioxidant enzymes in colon tissue and reducing the oxidation stress response.These data also show that BCFAs can down-regulate the gene and protein expression of the toll-like receptor 4(TLR4)/nuclear factorκB p65(NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathway,and at the same time significantly reduce the expression of pro-inflammatory factors tumor necrosis factorα(TNF-α),interleukin 1β(IL-1β),and IL-18 in colon tissue,and significantly increase the expression of the anti-inflammatory factor IL-10.In conclusion,these results demonstrated that BCFAs in goat milk exerted effects on colitis-related inflammatory cytokines and inhibited inflammation by inducing the TLR4/NF-κB/NLRP3 pathway to alleviate DSS-induced ulcerative colitis.This study provides evidence for the potential of BCFAs as bioactive fatty acids in food products and to ameliorate ulcerative colitis development in mice.展开更多
The efficient integration of satellite and terrestrial networks has become an important component for 6 G wireless architectures to provide highly reliable and secure connectivity over a wide geographical area.As the ...The efficient integration of satellite and terrestrial networks has become an important component for 6 G wireless architectures to provide highly reliable and secure connectivity over a wide geographical area.As the satellite and cellular networks are developed separately these years,the integrated network should synergize the communication,storage,computation capabilities of both sides towards an intelligent system more than mere consideration of coexistence.This has motivated us to develop double-edge intelligent integrated satellite and terrestrial networks(DILIGENT).Leveraging the boost development of multi-access edge computing(MEC)technology and artificial intelligence(AI),the framework is entitled with the systematic learning and adaptive network management of satellite and cellular networks.In this article,we provide a brief review of the state-of-art contributions from the perspective of academic research and standardization.Then we present the overall design of the proposed DILIGENT architecture,where the advantages are discussed and summarized.Strategies of task offloading,content caching and distribution are presented.Numerical results show that the proposed network architecture outperforms the existing integrated networks.展开更多
As a viable component of 6G wireless communication architecture,satellite-terrestrial networks support efficient file delivery by leveraging the innate broadcast ability of satellite and the enhanced powerful file tra...As a viable component of 6G wireless communication architecture,satellite-terrestrial networks support efficient file delivery by leveraging the innate broadcast ability of satellite and the enhanced powerful file transmission approaches of multi-tier terrestrial networks.In the paper,we introduce edge computing technology into the satellite-terrestrial network and propose a partition-based cache and delivery strategy to make full use of the integrated resources and reducing the backhaul load.Focusing on the interference effect from varied nodes in different geographical distances,we derive the file successful transmission probability of the typical user and by utilizing the tool of stochastic geometry.Considering the constraint of nodes cache space and file sets parameters,we propose a near-optimal partition-based cache and delivery strategy by optimizing the asymptotic successful transmission probability of the typical user.The complex nonlinear programming problem is settled by jointly utilizing standard particle-based swarm optimization(PSO)method and greedy based multiple knapsack choice problem(MKCP)optimization method.Numerical results show that compared with the terrestrial only cache strategy,Ground Popular Strategy,Satellite Popular Strategy,and Independent and identically distributed popularity strategy,the performance of the proposed scheme improve by 30.5%,9.3%,12.5%and 13.7%.展开更多
In the semiconductor-based photocatalysts for overall water splitting, loading proper cocatalysts play a crucial role in enhancing the photocatalytic activity. In this work, we have chosen Ni_n/α-Ga_2O_3 as a model a...In the semiconductor-based photocatalysts for overall water splitting, loading proper cocatalysts play a crucial role in enhancing the photocatalytic activity. In this work, we have chosen Ni_n/α-Ga_2O_3 as a model and provided detailed density functional theory calculations to investigate the function of cocatalysts in hydrogen evolution reaction(HER). We have studied the formation and stability of Ni_n(n = 1–4) cluster on two stable surfaces of α-Ga_2O_3(001) and(012). In a Ni_n/α-Ga_2O_3 system, as the Ni 3d states well overlap with O and Ga states, the excited electrons transferred from Ga to Ni may participate in HER. We theoretically predict that introduction of Nincluster on(012) surface can elevate the Fermi level toward the conduction band, which is favorable for the occurrence of HER. Electrochemical computations are used to explore the mechanism of HER. It is found that, in most of Ni_n/α-Ga_2O_3 systems, the active sites of HER are on Ni_n clusters. Loading Ni_n clusters not only importantly reduces the Gibbs free energy of HER but also improves the reaction activity of surface O and Ga sites in HER. Our calculations reasonably explain the experimental observation on significant enhancement of activity for generating hydrogen after loading nickel oxide cocatalysts.展开更多
We examine quantum anomalous Hall(QAH)insulators with intrinsic magnetism displaying quantized Hall conductance at zero magnetic fields.The spin-momentum locking of the topological edge stats promises QAH insulators w...We examine quantum anomalous Hall(QAH)insulators with intrinsic magnetism displaying quantized Hall conductance at zero magnetic fields.The spin-momentum locking of the topological edge stats promises QAH insulators with great potential in device applications in the field of spintronics.Here,we generalize Haldane’s model on the honeycomb lattice to a more realistic two-orbital case without the artificial real-space complex hopping.Instead,we introduce an intraorbital coupling,stemming directly from the local spin-orbit coupling(SOC).Our dxy/dx2-y2 model may be viewed as a generalization of the bismuthene px/py-model for correlated d-orbitals.It promises a large SOC gap,featuring a high operating temperature.This two-orbital model nicely explains the low-energy excitation and the topology of two-dimensional ferromagnetic iron-halogenides.Furthermore,we find that electronic correlations can drive the QAH states to a c=0 phase,in which every band carries a nonzero Chern number.Our work not only provides a realistic QAH model,but also generalizes the nontrivial band topology to correlated orbitals,which demonstrates an exciting topological phase transition driven by Coulomb repulsions.Both the model and the material candidates provide excellent platforms for future study of the interplay between electronic correlations and nontrivial band topology.展开更多
基金supported by the National Natural Science Foundation of China(U20A2067,32272360)。
文摘A Pickering emulsion based on sodium starch octenyl succinate(SSOS)was prepared and its effects on the physicochemical properties of hairtail myofibrillar protein gels(MPGs)subjected to multiple freeze-thaw(F-T)cycles were investigated.The whiteness,water-holding capacity,storage modulus(G')and texture properties of the MPGs were significantly improved by adding 1%-2%Pickering emulsion(P<0.05).Meanwhile,Raman spectral analysis demonstrated that Pickering emulsion promoted the transformation of secondary structure,enhanced hydrogen bonds and hydrophobic interactions,and promoted the transition of disulfide bond conformation from g-g-g to g-g-t and t-g-t.At an emulsion concentration of 2%,theα-helix content decreased by 10.37%,while theβ-sheet content increased by 7.94%,compared to the control.After F-T cycles,the structure of the MPGs was destroyed,with an increase in hardness and a decrease in whiteness and water-holding capacity,however,the quality degradation of MPGs was reduced with 1%-2%Pickering emulsion.These findings demonstrated that SSOS-Pickering emulsions,as potential fat substitutes,can enhance the gel properties and the F-T stability of MPGs.
基金supported by the National Key R&D Program of China(2021YFD2100701).
文摘Oxidative stress is one of the main ways to cause alcohol-induced liver injury,and alcoholic liver disease(ALD)has been a common health problem worldwide.Lactic acid bacteria(LAB)is also considered as a potential treatment to alleviate alcohol-induced liver injury.Lactobacillus plantarum J26 is a LAB isolated from Chinese traditional fermented dairy products with excellent probiotic effects.This study aimed to establish a mice model of alcoholic liver injury through acute-on-chronic alcohol feeding and to study the alleviating effect of pre-intake of L.plantarum J26 on alcohol-induced oxidative liver injury and focus on its potential mechanism of alleviating effect.The results showed that pre-intake of L.plantarum J26 could improve liver pathological changes,reduce lipid accumulation,increase mitochondrial ATP and mitochondrial(mtDNA)levels,and alleviate liver injury.In addition,pre-intake L.plantarum J26 can improve the level of short-chain fatty acids(SCFAs)in the intestines in mice,short chain fatty acids can be used as a signaling molecule activation of nuclear factor E2-related factor 2(Nrf2)signaling pathway to alleviate liver oxidative stress,and maintain mitochondrial homeostasis by regulating the expression of genes related to mitochondrial dynamics and autophagy,thereby reducing cell apoptosis to alleviate alcohol-induced oxidative liver injury.
基金financially supported by the 2021 Kabrita Nutrition Grant.
文摘Branched-chain fatty acids(BCFAs)are new bioactive fatty acids with anti-inflammatory properties.However,the role of BCFAs in alleviating ulcerative colitis has not been clarified.Herein,we evaluated the protective effect of BCFAs from goat milk in mice with colitis induced using dextran sodium sulfate(DSS)and explored the corresponding mechanism.These results show that BCFAs extracted from goat milk can significantly alleviate weight loss in mice,and reduce the disease activity index and the activity of myeloperoxidase while increasing the content of antioxidant enzymes in colon tissue and reducing the oxidation stress response.These data also show that BCFAs can down-regulate the gene and protein expression of the toll-like receptor 4(TLR4)/nuclear factorκB p65(NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathway,and at the same time significantly reduce the expression of pro-inflammatory factors tumor necrosis factorα(TNF-α),interleukin 1β(IL-1β),and IL-18 in colon tissue,and significantly increase the expression of the anti-inflammatory factor IL-10.In conclusion,these results demonstrated that BCFAs in goat milk exerted effects on colitis-related inflammatory cytokines and inhibited inflammation by inducing the TLR4/NF-κB/NLRP3 pathway to alleviate DSS-induced ulcerative colitis.This study provides evidence for the potential of BCFAs as bioactive fatty acids in food products and to ameliorate ulcerative colitis development in mice.
基金supportedin part by the National Science Foundation of China(NSFC)under Grant 61631005,Grant 61771065,Grant 61901048in part by the Zhijiang Laboratory Open Project Fund 2020LCOAB01in part by the Beijing Municipal Science and Technology Commission Research under Project Z181100003218015。
文摘The efficient integration of satellite and terrestrial networks has become an important component for 6 G wireless architectures to provide highly reliable and secure connectivity over a wide geographical area.As the satellite and cellular networks are developed separately these years,the integrated network should synergize the communication,storage,computation capabilities of both sides towards an intelligent system more than mere consideration of coexistence.This has motivated us to develop double-edge intelligent integrated satellite and terrestrial networks(DILIGENT).Leveraging the boost development of multi-access edge computing(MEC)technology and artificial intelligence(AI),the framework is entitled with the systematic learning and adaptive network management of satellite and cellular networks.In this article,we provide a brief review of the state-of-art contributions from the perspective of academic research and standardization.Then we present the overall design of the proposed DILIGENT architecture,where the advantages are discussed and summarized.Strategies of task offloading,content caching and distribution are presented.Numerical results show that the proposed network architecture outperforms the existing integrated networks.
基金supported by the National Key Research and Development Program of China 2021YFB2900504,2020YFB1807900 and 2020YFB1807903by the National Science Foundation of China under Grant 62271062,62071063。
文摘As a viable component of 6G wireless communication architecture,satellite-terrestrial networks support efficient file delivery by leveraging the innate broadcast ability of satellite and the enhanced powerful file transmission approaches of multi-tier terrestrial networks.In the paper,we introduce edge computing technology into the satellite-terrestrial network and propose a partition-based cache and delivery strategy to make full use of the integrated resources and reducing the backhaul load.Focusing on the interference effect from varied nodes in different geographical distances,we derive the file successful transmission probability of the typical user and by utilizing the tool of stochastic geometry.Considering the constraint of nodes cache space and file sets parameters,we propose a near-optimal partition-based cache and delivery strategy by optimizing the asymptotic successful transmission probability of the typical user.The complex nonlinear programming problem is settled by jointly utilizing standard particle-based swarm optimization(PSO)method and greedy based multiple knapsack choice problem(MKCP)optimization method.Numerical results show that compared with the terrestrial only cache strategy,Ground Popular Strategy,Satellite Popular Strategy,and Independent and identically distributed popularity strategy,the performance of the proposed scheme improve by 30.5%,9.3%,12.5%and 13.7%.
基金financially supported by the National Natural Science Foundation of China under Grants 21473183 and 21303079
文摘In the semiconductor-based photocatalysts for overall water splitting, loading proper cocatalysts play a crucial role in enhancing the photocatalytic activity. In this work, we have chosen Ni_n/α-Ga_2O_3 as a model and provided detailed density functional theory calculations to investigate the function of cocatalysts in hydrogen evolution reaction(HER). We have studied the formation and stability of Ni_n(n = 1–4) cluster on two stable surfaces of α-Ga_2O_3(001) and(012). In a Ni_n/α-Ga_2O_3 system, as the Ni 3d states well overlap with O and Ga states, the excited electrons transferred from Ga to Ni may participate in HER. We theoretically predict that introduction of Nincluster on(012) surface can elevate the Fermi level toward the conduction band, which is favorable for the occurrence of HER. Electrochemical computations are used to explore the mechanism of HER. It is found that, in most of Ni_n/α-Ga_2O_3 systems, the active sites of HER are on Ni_n clusters. Loading Ni_n clusters not only importantly reduces the Gibbs free energy of HER but also improves the reaction activity of surface O and Ga sites in HER. Our calculations reasonably explain the experimental observation on significant enhancement of activity for generating hydrogen after loading nickel oxide cocatalysts.
基金Supported by the National Key R&D Program of China(Grant No.2017YFE0131300)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDA18010000)+1 种基金the Starting Grant of Shanghai Tech Universitythe Program for Professor of Special Appointment(Shanghai Eastern Scholar)。
文摘We examine quantum anomalous Hall(QAH)insulators with intrinsic magnetism displaying quantized Hall conductance at zero magnetic fields.The spin-momentum locking of the topological edge stats promises QAH insulators with great potential in device applications in the field of spintronics.Here,we generalize Haldane’s model on the honeycomb lattice to a more realistic two-orbital case without the artificial real-space complex hopping.Instead,we introduce an intraorbital coupling,stemming directly from the local spin-orbit coupling(SOC).Our dxy/dx2-y2 model may be viewed as a generalization of the bismuthene px/py-model for correlated d-orbitals.It promises a large SOC gap,featuring a high operating temperature.This two-orbital model nicely explains the low-energy excitation and the topology of two-dimensional ferromagnetic iron-halogenides.Furthermore,we find that electronic correlations can drive the QAH states to a c=0 phase,in which every band carries a nonzero Chern number.Our work not only provides a realistic QAH model,but also generalizes the nontrivial band topology to correlated orbitals,which demonstrates an exciting topological phase transition driven by Coulomb repulsions.Both the model and the material candidates provide excellent platforms for future study of the interplay between electronic correlations and nontrivial band topology.
