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低磷血症对去势难治性前列腺癌患者预后的预测价值 被引量:1
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作者 陈海燕 蒋宁 +2 位作者 李刚 孟甲 姜埃利 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第24期1263-1267,共5页
目的:探讨低磷血症对去势难治性前列腺癌(castration-resistant prostate cancer,CRPC)预后的预测价值。方法:回顾性分析2009年1月至2012年1月56例天津医科大学第二医院收治的CRPC患者的临床资料,分为低磷组(血磷水平<0.8 mmol/L)、... 目的:探讨低磷血症对去势难治性前列腺癌(castration-resistant prostate cancer,CRPC)预后的预测价值。方法:回顾性分析2009年1月至2012年1月56例天津医科大学第二医院收治的CRPC患者的临床资料,分为低磷组(血磷水平<0.8 mmol/L)、血磷正常组(血磷水平为0.8~1.5 mmol/L)和高磷组(血磷水平>1.5 mmol/L),比较三组患者的临床病理特征,分析血磷水平对患者预后的影响。结果:56例CRPC患者中低磷组13例(23.2%)、血磷正常组39例(69.6%)、高磷组4例(7.2%),三组中位生存时间分别为18、27和24个月,低磷组与血磷正常组以及高磷组比较,差异均具有统计学意义(P<0.05)。单因素分析显示,患者临床分期(χ~2=3.940,P=0.047)、远处转移(χ~2=5.369,P=0.020)及低磷血症(χ~2=6.695,P=0.010)影响患者的生存时间,差异具有统计学意义。Cox模型多因素分析显示,患者低磷血症、高钙血症及远处转移是影响患者预后的相关危险因素,其HR分别为5.448、5.868及3.708,95%CI分别为1.532~19.379、1.897~18.147及1.300~10.578。结论:诊断为CRPC时血磷水平低的患者预后差,低磷血症、高钙血症和远处转移是CRPC患者预后的相关危险因素,血磷水平可以在一定程度上预测患者的预后。 展开更多
关键词 去势难治性前列腺癌 低磷血症 预后 生存时间
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Improved genetic algorithm for nonlinear programming problems 被引量:8
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作者 Kezong Tang Jingyu Yang +1 位作者 haiyan chen Shang Gao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第3期540-546,共7页
An improved genetic algorithm(IGA) based on a novel selection strategy to handle nonlinear programming problems is proposed.Each individual in selection process is represented as a three-dimensional feature vector w... An improved genetic algorithm(IGA) based on a novel selection strategy to handle nonlinear programming problems is proposed.Each individual in selection process is represented as a three-dimensional feature vector which is composed of objective function value,the degree of constraints violations and the number of constraints violations.It is easy to distinguish excellent individuals from general individuals by using an individuals' feature vector.Additionally,a local search(LS) process is incorporated into selection operation so as to find feasible solutions located in the neighboring areas of some infeasible solutions.The combination of IGA and LS should offer the advantage of both the quality of solutions and diversity of solutions.Experimental results over a set of benchmark problems demonstrate that IGA has better performance than other algorithms. 展开更多
关键词 genetic algorithm(GA) nonlinear programming problem constraint handling non-dominated solution optimization problem.
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幼儿园新手教师区域活动指导存在的问题与解决策略 被引量:12
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作者 舒秀珍 陈海燕 +1 位作者 张倩 林雅婷 《学前教育研究》 CSSCI 北大核心 2020年第11期85-88,共4页
区域活动是幼儿园重要的教育组织形式,提升新手教师的区域活动指导能力既是新手教师专业发展的必然要求,也是提升幼儿园教育质量的重要途径。新手教师在区域环境创设、材料提供以及幼儿观察和指导等方面都存在不足。幼儿园应为新手教师... 区域活动是幼儿园重要的教育组织形式,提升新手教师的区域活动指导能力既是新手教师专业发展的必然要求,也是提升幼儿园教育质量的重要途径。新手教师在区域环境创设、材料提供以及幼儿观察和指导等方面都存在不足。幼儿园应为新手教师建立有效的区域活动学习平台和机制,提升新手教师的自我学习能力;应建立健全教学科研制度,以教学研究、课题研究等方式促进新手教师对区域活动本质和规律的认识;应建设专业发展共同体,让新手教师在老教师的传帮带下,在与其他教师共同学习与反思的促进下,更好地提升自身的区域活动指导能力。 展开更多
关键词 新手教师 区域活动 专业能力
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Unsupervised feature selection based on Markov blanket and particle swarm optimization 被引量:2
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作者 Yintong Wang Jiandong Wang +1 位作者 Hao Liao haiyan chen 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第1期151-161,共11页
Feature selection plays an important role in data mining and recognition, especially in the large scale text, image and biological data. Specifically, the class label information is unavailable to guide the selection ... Feature selection plays an important role in data mining and recognition, especially in the large scale text, image and biological data. Specifically, the class label information is unavailable to guide the selection of minimal feature subset in unsupervised feature selection, which is challenging and interesting. An unsupervised feature selection based on Markov blanket and particle swarm optimization is proposed named as UFSMB-PSO. The proposed method seeks to find the high-quality feature subset through multi-particles' cooperation of particle swarm optimization without using any learning algorithms. Moreover, the features' relevance will be computed based on an information metric of relevance gain, which provides an information theoretical foundation for finding the minimization of the redundancy between features. Our results on several benchmark datasets demonstrate that UFSMB-PSO can achieve significant improvement over state of the art unsupervised methods. © 1990-2011 Beijing Institute of Aerospace Information. 展开更多
关键词 Character recognition Data mining Feature extraction Information theory
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