Nociceptin, or orphanin FQ, is a 17 amino-acid peptide which is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORLI, and suggested to participate in modulating nociceptive transmi...Nociceptin, or orphanin FQ, is a 17 amino-acid peptide which is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORLI, and suggested to participate in modulating nociceptive transmission. We examined the actions of nociceptin on excitatory and inhibitory transmission in substantia gelatinosa (SG) neurons in the dorsal horn of adult rat spinal cord slices by use of the blind whole-cell patch-clamp technique. Nociceptin induced an outward current at-70 mV in a dose-dependent manner (EC_(50)=0.23μM);展开更多
Although intrathecal administration of adenosine analogues or A_1 adenosine receptor agonists is known to result in antinociception, this has not been examined yet at the cellular level. In the present study, we exami...Although intrathecal administration of adenosine analogues or A_1 adenosine receptor agonists is known to result in antinociception, this has not been examined yet at the cellular level. In the present study, we examined pharmacologically the actions of adenosine on spontaneous sensory transmission in substantia gelatinosa (SG) neurons of an adult rat spinal cord slice under the condition where a postsynaptic action of adenosine展开更多
文摘Nociceptin, or orphanin FQ, is a 17 amino-acid peptide which is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORLI, and suggested to participate in modulating nociceptive transmission. We examined the actions of nociceptin on excitatory and inhibitory transmission in substantia gelatinosa (SG) neurons in the dorsal horn of adult rat spinal cord slices by use of the blind whole-cell patch-clamp technique. Nociceptin induced an outward current at-70 mV in a dose-dependent manner (EC_(50)=0.23μM);
文摘Although intrathecal administration of adenosine analogues or A_1 adenosine receptor agonists is known to result in antinociception, this has not been examined yet at the cellular level. In the present study, we examined pharmacologically the actions of adenosine on spontaneous sensory transmission in substantia gelatinosa (SG) neurons of an adult rat spinal cord slice under the condition where a postsynaptic action of adenosine
