Thrombosis is a global health issue and one of the leading factors of death.However,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective treatm...Thrombosis is a global health issue and one of the leading factors of death.However,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective treatment.In addition,clinical thrombolytics suffer from a short half-life,allergic reactions,inactivation,and unwanted tissue hemorrhage.Nano-medicines have gained extensive attention in diagnosis,drug delivery,and photo/sound/magnetic-theranostics due to their convertible properties.Furthermore,diagnosis and treatment of thrombosis using nano-medicines have also been widely studied.This review summarizes the recent advances in this area,which revealed six types of nanoparticle approaches:(1)in vitro diagnostic kits using“synthetic biomarkers”;(2)in vivo imaging using nano-contrast agents;(3)targeted drug delivery systems using artificial nanoparticles;(4)microenvironment responsive drug delivery systems;(5)drug delivery systems using biological nanostructures;and(6)treatments with external irradiation.The investigations of nano-medicines are believed to be of great significance,and some of the advanced drug delivery systems show potential applications in clinical theranotics.展开更多
In order to effectively control petroleum hydrocarbon pollution by immobilisation technology,it is necessary to understanding the degradation pathways of petroleum hydrocarbon in immobilised petroleum-degradation bact...In order to effectively control petroleum hydrocarbon pollution by immobilisation technology,it is necessary to understanding the degradation pathways of petroleum hydrocarbon in immobilised petroleum-degradation bacteria system.However,the adsorption in degradation process is rarely studied.In this study,adsorption process of petroleum hydrocarbon was synergistically studied by means of the surface properties,adsorption thermodynamics and molecular simulation.The results indicate that the immobilised petroleum-degradation bacteria have many holes for the bacteria to adsorb.The diesel adsorption by immobilised petroleum-degradation bacteria is a spontaneous,entropy-increasing and endothermic process.Diesel is first adsorbed to the surface of immobilised petroleum-degradation bacteria through hydrogen bonding,and then is biodegraded.This study provided substantial knowledge of immobilised technology in controlling petroleum hydrocarbon pollution.展开更多
The primary causes of satellite breakups are hypervelocity impact and explosion,the research on satellite breakup can be used not only to evaluate the influence of breakup event on the space environment,but also to tr...The primary causes of satellite breakups are hypervelocity impact and explosion,the research on satellite breakup can be used not only to evaluate the influence of breakup event on the space environment,but also to trace whether the satellite has been deliberately attacked.It is of great significance in both civil and military aspects.The study of satellite breakup behaviors and model is reviewed to summarize the research progress and insufficiency in recent decades,including the satellite breakup experiment,measurement and characterization of fragments,distribution characteristics of breakup fragments,satellite breakup model,etc.The classical studies are introduced in detail,and the limitations of the current research are pointed out.According to the current research results,the contemporary challenges and future directions for satellite breakup study are presented.The research on satellite breakup is developing in two directions:the miniaturization of satellite size and the complexity of satellite component.The study on satellite breakup needs to be explored and deepened on improving the experimental launch speed,expanding the model application range and breakup revealing the results under combined effect of impact and explosion.展开更多
基金supported by the Major State Basic Research Development Program of China(2017YFA0205201 and 2018YFA0107301)the National Natural Science Foundation of China(81901876,81925019,81603015,81871404,81801817,and U1705281)+2 种基金Xiamen science and technology program(3502Z20173012)the Fundamental Research Funds for the Central Universities(20720190088 and 20720200019)the Program for New Century Excellent Talents in University,China(NCET-13-0502).
文摘Thrombosis is a global health issue and one of the leading factors of death.However,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective treatment.In addition,clinical thrombolytics suffer from a short half-life,allergic reactions,inactivation,and unwanted tissue hemorrhage.Nano-medicines have gained extensive attention in diagnosis,drug delivery,and photo/sound/magnetic-theranostics due to their convertible properties.Furthermore,diagnosis and treatment of thrombosis using nano-medicines have also been widely studied.This review summarizes the recent advances in this area,which revealed six types of nanoparticle approaches:(1)in vitro diagnostic kits using“synthetic biomarkers”;(2)in vivo imaging using nano-contrast agents;(3)targeted drug delivery systems using artificial nanoparticles;(4)microenvironment responsive drug delivery systems;(5)drug delivery systems using biological nanostructures;and(6)treatments with external irradiation.The investigations of nano-medicines are believed to be of great significance,and some of the advanced drug delivery systems show potential applications in clinical theranotics.
基金supported by the scientific research fund project of the National Natural Science Foundation of China(grant numbers 52070123 and 51874193)the Natural Science Foundation of Shandong Province(grant numbers ZR2020ME224)+4 种基金the National Key Research and Development Project(grant number 2019YFC0408503)the Science and Technology Projects of Qingdao(grant number 19-6-2-25-cg)Young Science and Technology Innovation Program of Shandong Province(grant number 2020KJD001)the Open Research Fund Program of Shandong Key Laboratory of Eco-Environmental Science for Yellow River Delta(Binzhou University)(grant number 2019KFJJ02)Project of Shandong Province Higher Educational Young Innovative Talent Introduction and Cultivation Team[Hydrogen energy chemistry innovation team]。
文摘In order to effectively control petroleum hydrocarbon pollution by immobilisation technology,it is necessary to understanding the degradation pathways of petroleum hydrocarbon in immobilised petroleum-degradation bacteria system.However,the adsorption in degradation process is rarely studied.In this study,adsorption process of petroleum hydrocarbon was synergistically studied by means of the surface properties,adsorption thermodynamics and molecular simulation.The results indicate that the immobilised petroleum-degradation bacteria have many holes for the bacteria to adsorb.The diesel adsorption by immobilised petroleum-degradation bacteria is a spontaneous,entropy-increasing and endothermic process.Diesel is first adsorbed to the surface of immobilised petroleum-degradation bacteria through hydrogen bonding,and then is biodegraded.This study provided substantial knowledge of immobilised technology in controlling petroleum hydrocarbon pollution.
基金supported by National Defense Science and Technology Program(A14007)China National Space Administration Preliminary Research Project(KJSP2020020101,KJSP2020010304)。
文摘The primary causes of satellite breakups are hypervelocity impact and explosion,the research on satellite breakup can be used not only to evaluate the influence of breakup event on the space environment,but also to trace whether the satellite has been deliberately attacked.It is of great significance in both civil and military aspects.The study of satellite breakup behaviors and model is reviewed to summarize the research progress and insufficiency in recent decades,including the satellite breakup experiment,measurement and characterization of fragments,distribution characteristics of breakup fragments,satellite breakup model,etc.The classical studies are introduced in detail,and the limitations of the current research are pointed out.According to the current research results,the contemporary challenges and future directions for satellite breakup study are presented.The research on satellite breakup is developing in two directions:the miniaturization of satellite size and the complexity of satellite component.The study on satellite breakup needs to be explored and deepened on improving the experimental launch speed,expanding the model application range and breakup revealing the results under combined effect of impact and explosion.
