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超分子手性聚苯胺-金复合纳米酶的构建及其对映选择性催化 被引量:1
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作者 袁干印 奚政 +3 位作者 王楚 孙晓环 韩杰 郭荣 《物理化学学报》 SCIE CAS CSCD 北大核心 2023年第7期1-7,共7页
对映选择性催化是生物体内普遍存在的反应,与生命的产生代谢有着非常紧密的联系。设计研发具有高对映选择性催化效果的纳米酶在各类生物医药相关领域都至关重要。目前,关于纳米酶的研究大都集中在提高其催化活性,而涉及纳米酶对映选择... 对映选择性催化是生物体内普遍存在的反应,与生命的产生代谢有着非常紧密的联系。设计研发具有高对映选择性催化效果的纳米酶在各类生物医药相关领域都至关重要。目前,关于纳米酶的研究大都集中在提高其催化活性,而涉及纳米酶对映选择性的研究相对较少。已有对映选择性酶催化报道表明,手性纳米酶主要通过手性分子修饰纳米颗粒来构建。考虑到天然酶的选择性不仅仅取决于氨基酸等手性分子的手性,而且与蛋白质空间排列和折叠所产生的超分子手性微环境密切相关,因此构建具有超分子手性微环境的纳米酶也成为设计具有优异对映选择性纳米酶的有效途径。此外,为了进一步提高手性纳米酶的对映选择性,深入理解手性纳米酶选择性因子的影响因素也成为一个重要研究方向。基于此,本文构建了一种由不含任何手性分子的M-聚苯胺(M-PANI)扭曲纳米带和三种不同尺寸(3、10和16nm)的金纳米颗粒(AuNPs)组成的超分子纳米复合材料。扫描电子显微镜、透射电子显微镜、紫外-可见吸收光谱和X射线光电子能谱结果证实了M-PANI-Au超分子纳米复合材料的成功制备。同时,圆二色光谱显示M-PANI-Au超分子复合材料具有清晰的手性信号,表明它们在手性纳米催化方面具有潜在应用。以手性R-/S-3,4-二羟基苯丙氨酸(R-/S-DOPA)对映体的催化氧化为模型反应,该类纳米酶对R-DOPA的催化选择性均高于对S-DOPA。进一步研究表明,得益于超分子手性聚苯胺载体和3 nm AuNPs之间的强手性传递作用,3 nm AuNPs(2.59)负载的M-PANI比10 nm AuNPs(1.46)和16 nm NPs(1.58)负载的M-PANI具有更高的选择因子。这一发现阐明了手性转移是调控对映选择性催化的关键影响因素,为负载型超分子手性纳米酶的构建和设计提供了方向和指导。 展开更多
关键词 超分子手性 对映选择性催化 手性聚苯胺 金纳米颗粒 纳米酶
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B-doped and La_(4)NiLiO_(8)-coated Ni-rich cathode with enhanced structural and interfacial stability for lithium-ion batteries 被引量:19
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作者 Lingjun Li Lizhi Fu +9 位作者 Miao Li chu wang Zixiang Zhao Shangchen Xie Haichen Lin Xianwen Wu Haodong Liu Li Zhang Qiaobao Zhang Lei Tan 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2022年第8期588-594,I0016,共8页
Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni... Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced LIBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiLiO_(8)-coated LiNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiLiO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate Li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density LIBs. 展开更多
关键词 B-doped and La_(4)NiLiO_(8)-coated Nickel-rich layered cathode Cycle stability Lithium-ion battery
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Unsuspected Gallbladder Cancer During or After Laparoscopic Cholecystectomy 被引量:11
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作者 Xie-qun Xu Wei Liu +4 位作者 Bing-lu Li Tao Hong Chao-ji Zheng chu wang Yu-pei Zhao 《Chinese Medical Sciences Journal》 CAS CSCD 2013年第2期102-106,共5页
Objective To summarize the clinical features and outcomes of unsuspected gallbladder carcinoma (HGC) detected during or after laparoscopic cholecystectomy. Methods Medical records of 8005 patients, who underwent la... Objective To summarize the clinical features and outcomes of unsuspected gallbladder carcinoma (HGC) detected during or after laparoscopic cholecystectomy. Methods Medical records of 8005 patients, who underwent laparoscopic cholecystectomy in Peking Hnion Medical College Hospital between June 1993 and June 2011, were reviewed. Patients that pathologically diagnosed as HGC were retrospectively studied in terms of clinical features, preoperative and postoperative diagnosis, surviving period, and complications. Results In the 8005 patients who received laparoscopic cholecystectomy, 36 (0.45%) were diagnosed as LIGC during (25 patients) or after (11 patients) laparoscopic cholecystectomy. The gallbladder cancer was staged as T1 in 16 patients, T2 in 11 patients, and T3 in 9 patients. The 1-, 3-, and 5-year survival rates of all the patients were 88.9% (32/36), 63.9% (23/36), and 58.3% (21/36). The 5-year survival rates in T1 stage, T2 stage, and T3 stage patients were 100%, 75.0%, and 0.0%, respectively. Conclusions The survival rate of HGC is associated with tumor stage, not with operation approaches. Laparoscopic cholecystectomy is appropriate for T 1 patients. 展开更多
关键词 laparoscopic cholecystectomy gallbladder neoplasms CARCINOMA frozensections survival rate
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Blunt myocardial injury and gastrointestinal hemorrhage following Heimlich maneuver:A case report and literature review 被引量:1
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作者 chu wang Zhen-zhou wang Tian-bing wang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2022年第3期248-250,共3页
Dear editor,In 1975,Dr.Henry Heimlich introduced the Heimlich maneuver[2],which has become the initial treatment for emergency foreign-body airway obstruction.It is recommended by American Heart Association Guidelines... Dear editor,In 1975,Dr.Henry Heimlich introduced the Heimlich maneuver[2],which has become the initial treatment for emergency foreign-body airway obstruction.It is recommended by American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.[2]During thrusts,airway pressure increases,thereby expelling foreign bodies. 展开更多
关键词 AIRWAY OBSTRUCTION GASTROINTESTINAL
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Selection of elite lines of BpGH3.5-transgenic Betula platyphylla using growth adaptability analysis
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作者 chu wang Yang wang +4 位作者 Jianjun Zou Rusheng Peng Qibin Yu Guifeng Liu Jing Jiang 《Journal of Forestry Research》 SCIE CAS CSCD 2022年第6期1891-1901,共11页
White birch(Betula platyphylla)is precious material for pulpwood and widely distributed in 14 provinces of China.Previous study indicated that inhibited expression of a gene encoding an auxin amide synthase,BpGH3.5,in... White birch(Betula platyphylla)is precious material for pulpwood and widely distributed in 14 provinces of China.Previous study indicated that inhibited expression of a gene encoding an auxin amide synthase,BpGH3.5,in transgenic plants reduced the level of IAA–amino acid conjugation,resulting in more free IAA,thereby better growth of birch.Utilizing transgenic-B pGH3.5 lines to increase wood production in a wide range of environments is the goal for breeders.In three field trials here,we measured tree height,diameter at breast height,and volume of 16 BpGH3.5-transgenic 7-year-old white birch lines(including 12 antisense strand lines and 4 overexpression lines)and a wild-type white birch line from three sites that varied greatly in their environmental conditions.To select elite BpGH3.5-transgenic lines for each target environment,we used an additive main effects and multiplicative interaction model to analyze genotype by environment interaction,growth adaptability and stability.The selection criteria for elite transgenic lines were set as the average volume plus 0.75 times the standard deviation for the tested lines at each test site.Results showed that the effect of line and site for height was highly significant(P<0.01),and the effect of line×site was significant(P<0.05);selected as the elite lines were FG12,FG13 and FG27 at the Maoershan Experimental Forest Farm,FG13 and FG32 at the Shidaohe Forest Farm,and FG3 and FG31 at the Ecological Experiment Forest Farm.These seven high-yield,stable lines can now be tested in production trials or adjacent trial areas with similar environmental conditions,while the high-yield,unstable lines should be tested in production trials in areas deemed suitable for their growth.These results provide guidance on which released transgenic elite lines will grow best in a wide range of conditions. 展开更多
关键词 Betula platyphylla BpGH3.5 Afforestation test Growth adaptability
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Correcting on-chip distortion of control pulses with silicon spin qubits
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作者 Ming Ni Rong-Long Ma +10 位作者 Zhen-Zhen Kong Ning chu Wei-Zhu Liao Sheng-Kai Zhu chu wang Gang Luo Di Liu Gang Cao Gui-Lei wang Hai-Ou Li Guo-Ping Guo 《Chinese Physics B》 2025年第1期265-271,共7页
In semiconductor quantum dot systems,pulse distortion is a significant source of coherent errors,which impedes qubit characterization and control.Here,we demonstrate two calibration methods using a two-qubit system as... In semiconductor quantum dot systems,pulse distortion is a significant source of coherent errors,which impedes qubit characterization and control.Here,we demonstrate two calibration methods using a two-qubit system as the detector to correct distortion and calibrate the transfer function of the control line.Both methods are straightforward to implement,robust against noise,and applicable to a wide range of qubit types.The two methods differ in correction accuracy and complexity.The first,coarse predistortion(CPD)method,partially mitigates distortion.The second,all predistortion(APD)method,measures the transfer function and significantly enhances exchange oscillation uniformity.Both methods use exchange oscillation homogeneity as the metric and are suitable for any qubit driven by a diabatic pulse.We believe these methods will enhance qubit characterization accuracy and operation quality in future applications. 展开更多
关键词 quantum computation quantum dot pulse distortion
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