This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome(PCOS).The meta-analysis was performed in ...This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome(PCOS).The meta-analysis was performed in accordance with the Cochrane Handbook guidelines and relevant the preferred reporting items for systematic reviews and meta-analyses(PRISMA)statement criteria.Of 825 identified reports,11 randomized clinical trials were included in the meta-analysis.An analysis of pooled extracted data revealed that supplementation with probiotics significantly decreased fasting blood glucose(FBG,n=7;standardized mean difference(SMD)=−0.40;95%confidence interval(CI):−2.02,−0.02;P=0.04)and insulin levels(n=6;SMD=−0.57;95%CI:−0.89,−0.25;P=0.0004)and the homeostatic model assessment of insulin resistance(n=7;SMD=−0.64;95%CI:−0.96,−0.31;P=0.0001)while increasing the quantitative insulin sensitivity check index(QUICKI,n=5;SMD=0.58;95%CI:0.08,1.09;P=0.02)in patients with PCOS.The FBG-reducing effect decreased as the baseline body mass index(BMI)and mean age of the participants increased.Indeed,a greater number of bacterial species and a higher bacterial dose were shown to reduce QUICKI effectively.The systematic review indicated that probiotic supplementation may help to control glucose homeostasis in adults with polycystic ovarian syndrome.展开更多
To solve the problem that the magnetic resonance(MR)image has weak boundaries,large amount of information,and low signal-to-noise ratio,we propose an image segmentation method based on the multi-resolution Markov rand...To solve the problem that the magnetic resonance(MR)image has weak boundaries,large amount of information,and low signal-to-noise ratio,we propose an image segmentation method based on the multi-resolution Markov random field(MRMRF)model.The algorithm uses undecimated dual-tree complex wavelet transformation to transform the image into multiple scales.The transformed low-frequency scale histogram is used to improve the initial clustering center of the K-means algorithm,and then other cluster centers are selected according to the maximum distance rule to obtain the coarse-scale segmentation.The results are then segmented by the improved MRMRF model.In order to solve the problem of fuzzy edge segmentation caused by the gray level inhomogeneity of MR image segmentation under the MRMRF model,it is proposed to introduce variable weight parameters in the segmentation process of each scale.Furthermore,the final segmentation results are optimized.We name this algorithm the variable-weight multi-resolution Markov random field(VWMRMRF).The simulation and clinical MR image segmentation verification show that the VWMRMRF algorithm has high segmentation accuracy and robustness,and can accurately and stably achieve low signal-to-noise ratio,weak boundary MR image segmentation.展开更多
A method for hub assembly sequence planning oriented to the fixed position layout is proposed.An assembly relationship model was constructed to describe the relationship between hub assembly components and workstation...A method for hub assembly sequence planning oriented to the fixed position layout is proposed.An assembly relationship model was constructed to describe the relationship between hub assembly components and workstations,considering the layout of the hub assembly line and process constraints,including the assembly precedence matrix,workstation assembly capability table and criticality table of components.The evaluation mechanism for the assembly sequence was established.Values from the evaluation functions with engineering significance were used to select the optimal assembly sequence from the perspective of assembly time,assembly index and assembly path distance.In function,the criticality of components was introduced into the traditional assemblability index,comparing the multi-objective dragonfly algorithm(MODA)with non-dominated sorting genetic algorithm-Ⅱ(NSGA-Ⅱ)to complete the assembly sequence planning and assignment for workstations.The optimized results show that the presented method is feasible and efficient for solving the hub assembly sequence planning problem.展开更多
Magnetic topological states of matter provide a fertile playground for emerging topological physics and phenomena.The current main focus is on materials whose magnetism stems from 3d magnetic transition elements,e.g.,...Magnetic topological states of matter provide a fertile playground for emerging topological physics and phenomena.The current main focus is on materials whose magnetism stems from 3d magnetic transition elements,e.g.,MnBi_(2)Te_(4),Fe_(3)Sn_(2),and Co_(3)Sn_(2)S_(2).In contrast,topological materials with the magnetism from rare earth elements remain largely unexplored.Here we report rare earth antiferromagnet GdAuAl_(4)Ge_(2)as a candidate magnetic topological metal.Angle resolved photoemission spectroscopy(ARPES)and first-principles calculations have revealed multiple bulk bands crossing the Fermi level and pairs of low energy surface states.According to the parity and Wannier charge center analyses,these bulk bands possess nontrivial Z2 topology,establishing a strong topological insulator state in the nonmagnetic phase.Furthermore,the surface band pairs exhibit strong termination dependence which provides insight into their origin.Our results suggest GdAuAl_(4)Ge_(2)as a rare earth platform to explore the interplay between band topology,magnetism and f electron correlation,calling for further study targeting on its magnetic structure,magnetic topology state,transport behavior,and microscopic properties.展开更多
Akkermansia muciniphila, one of the most promising next-generation probiotics, was reported to exhibit beneficial modulatory effects on the gut barrier. However, the strain-specific and underlying regulatory mechanism...Akkermansia muciniphila, one of the most promising next-generation probiotics, was reported to exhibit beneficial modulatory effects on the gut barrier. However, the strain-specific and underlying regulatory mechanisms of this species on gut barrier function were not well studied. Therefore, this study evaluated the protective effect of A. muciniphila strains on the intestinal barrier and investigated the mode of action and material basis of this modulatory effect. We first confirmed the strain-specific effects of A. muciniphila on intestinal barrier regulation and found that this phenomenon may be explained by the different abilities of strains to affect tight junction protein expression in enterocytes. Comparative genomic analysis proved that the ability of A. muciniphila to regulate the intestinal barrier was exerted in part by the functional genes(such as COG0438, COG0463, and COG2244)related to the synthesis of cellular surface proteins. The role of these surface proteins in intestinal barrier regulation was further verified by strain-comparative experiments in animal and cell models and surface protein removal trials. This study confirmed the different effects of A. muciniphila strains on gut barrier modulation and provided molecular and genetic targets for the screening of A. muciniphila strains with superior protection against gut barrier dysfunction.展开更多
The simple kagome-lattice band structure possesses Dirac cones,flat band,and saddle point with van Hove singularities in the electronic density of states,facilitating the emergence of various electronic orders.Here we...The simple kagome-lattice band structure possesses Dirac cones,flat band,and saddle point with van Hove singularities in the electronic density of states,facilitating the emergence of various electronic orders.Here we report a titanium-based kagome metal CsTi_(3)Bi_(5)where titanium atoms form a kagome network,resembling its isostructural compound CsV_3Sb_5.Thermodynamic properties including the magnetization,resistance,and heat capacity reveal the conventional Fermi liquid behavior in the kagome metal CsTi_(3)Bi_(5)and no signature of superconducting or charge density wave(CDW)transition anomaly down to 85 m K.Systematic angle-resolved photoemission spectroscopy measurements reveal multiple bands crossing the Fermi level,consistent with the first-principles calculations.The flat band formed by the destructive interference of hopping in the kagome lattice is observed directly.Compared to Cs V_(3)Sb_(5),the van Hove singularities are pushed far away above the Fermi level in CsTi_(3)Bi_(5),in line with the absence of CDW.Furthermore,the first-principles calculations identify the nontrivial Z_(2)topological properties for those bands crossing the Fermi level,accompanied by several local band inversions.Our results suppose CsTi_(3)Bi_(5)as a complementary platform to explore the superconductivity and nontrivial band topology.展开更多
In our most recently published article,[1]an important reference[2]predicting CsTi_(3)Bi_(5) is missing and should be added,along with Ref.[3](originally Ref.[28]),to the introduction section.
基金supported by the National Natural Science Foundation of China Program(31871773 and 32001665)the Natural Science Foundation of Jiangsu Province(BK20200084)+3 种基金National First-Class Discipline Program of Food Science and Technology(JUFSTR20180102)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Provincethe Wuxi Health and Family Planning Commission(ZDRC039)High-level Health Talents in Jiangsu Province(LGY2018016).
文摘This meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplementation on glucose homeostasis in patients with polycystic ovary syndrome(PCOS).The meta-analysis was performed in accordance with the Cochrane Handbook guidelines and relevant the preferred reporting items for systematic reviews and meta-analyses(PRISMA)statement criteria.Of 825 identified reports,11 randomized clinical trials were included in the meta-analysis.An analysis of pooled extracted data revealed that supplementation with probiotics significantly decreased fasting blood glucose(FBG,n=7;standardized mean difference(SMD)=−0.40;95%confidence interval(CI):−2.02,−0.02;P=0.04)and insulin levels(n=6;SMD=−0.57;95%CI:−0.89,−0.25;P=0.0004)and the homeostatic model assessment of insulin resistance(n=7;SMD=−0.64;95%CI:−0.96,−0.31;P=0.0001)while increasing the quantitative insulin sensitivity check index(QUICKI,n=5;SMD=0.58;95%CI:0.08,1.09;P=0.02)in patients with PCOS.The FBG-reducing effect decreased as the baseline body mass index(BMI)and mean age of the participants increased.Indeed,a greater number of bacterial species and a higher bacterial dose were shown to reduce QUICKI effectively.The systematic review indicated that probiotic supplementation may help to control glucose homeostasis in adults with polycystic ovarian syndrome.
基金the National Natural Science Foundation of China(Grant No.11471004)the Key Research and Development Program of Shaanxi Province,China(Grant No.2018SF-251)。
文摘To solve the problem that the magnetic resonance(MR)image has weak boundaries,large amount of information,and low signal-to-noise ratio,we propose an image segmentation method based on the multi-resolution Markov random field(MRMRF)model.The algorithm uses undecimated dual-tree complex wavelet transformation to transform the image into multiple scales.The transformed low-frequency scale histogram is used to improve the initial clustering center of the K-means algorithm,and then other cluster centers are selected according to the maximum distance rule to obtain the coarse-scale segmentation.The results are then segmented by the improved MRMRF model.In order to solve the problem of fuzzy edge segmentation caused by the gray level inhomogeneity of MR image segmentation under the MRMRF model,it is proposed to introduce variable weight parameters in the segmentation process of each scale.Furthermore,the final segmentation results are optimized.We name this algorithm the variable-weight multi-resolution Markov random field(VWMRMRF).The simulation and clinical MR image segmentation verification show that the VWMRMRF algorithm has high segmentation accuracy and robustness,and can accurately and stably achieve low signal-to-noise ratio,weak boundary MR image segmentation.
基金Supported by the National Natural Science Foundation of China(51965034,51565028)the Fundamental Research Funds for the Lanzhou City Innovation and Entrepreneurship Project(2018-RC-25)。
文摘A method for hub assembly sequence planning oriented to the fixed position layout is proposed.An assembly relationship model was constructed to describe the relationship between hub assembly components and workstations,considering the layout of the hub assembly line and process constraints,including the assembly precedence matrix,workstation assembly capability table and criticality table of components.The evaluation mechanism for the assembly sequence was established.Values from the evaluation functions with engineering significance were used to select the optimal assembly sequence from the perspective of assembly time,assembly index and assembly path distance.In function,the criticality of components was introduced into the traditional assemblability index,comparing the multi-objective dragonfly algorithm(MODA)with non-dominated sorting genetic algorithm-Ⅱ(NSGA-Ⅱ)to complete the assembly sequence planning and assignment for workstations.The optimized results show that the presented method is feasible and efficient for solving the hub assembly sequence planning problem.
基金Project supported by the National Key Research and Development Program of China (Grant No. 2022YFA1403700)the National Natural Science Foundation of China (Grant No. 12074163)+2 种基金the Basic and Applied Basic Research Foundation of Guangdong Province, China (Grants Nos. 2022B1515020046, 2022B1515130005, and 2021B1515130007)the Innovative and Entrepreneurial Research Team Program of Guangdong Province, China (Grant Nos. 2019ZT08C044)Shenzhen Science and Technology Program (Grant No. KQTD20190929173815000)
文摘Magnetic topological states of matter provide a fertile playground for emerging topological physics and phenomena.The current main focus is on materials whose magnetism stems from 3d magnetic transition elements,e.g.,MnBi_(2)Te_(4),Fe_(3)Sn_(2),and Co_(3)Sn_(2)S_(2).In contrast,topological materials with the magnetism from rare earth elements remain largely unexplored.Here we report rare earth antiferromagnet GdAuAl_(4)Ge_(2)as a candidate magnetic topological metal.Angle resolved photoemission spectroscopy(ARPES)and first-principles calculations have revealed multiple bulk bands crossing the Fermi level and pairs of low energy surface states.According to the parity and Wannier charge center analyses,these bulk bands possess nontrivial Z2 topology,establishing a strong topological insulator state in the nonmagnetic phase.Furthermore,the surface band pairs exhibit strong termination dependence which provides insight into their origin.Our results suggest GdAuAl_(4)Ge_(2)as a rare earth platform to explore the interplay between band topology,magnetism and f electron correlation,calling for further study targeting on its magnetic structure,magnetic topology state,transport behavior,and microscopic properties.
基金supported by the Natural Science Foundation of Jiangsu Province (BK20200084)The National Natural Science Foundation of China (32021005 and 31871773)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
文摘Akkermansia muciniphila, one of the most promising next-generation probiotics, was reported to exhibit beneficial modulatory effects on the gut barrier. However, the strain-specific and underlying regulatory mechanisms of this species on gut barrier function were not well studied. Therefore, this study evaluated the protective effect of A. muciniphila strains on the intestinal barrier and investigated the mode of action and material basis of this modulatory effect. We first confirmed the strain-specific effects of A. muciniphila on intestinal barrier regulation and found that this phenomenon may be explained by the different abilities of strains to affect tight junction protein expression in enterocytes. Comparative genomic analysis proved that the ability of A. muciniphila to regulate the intestinal barrier was exerted in part by the functional genes(such as COG0438, COG0463, and COG2244)related to the synthesis of cellular surface proteins. The role of these surface proteins in intestinal barrier regulation was further verified by strain-comparative experiments in animal and cell models and surface protein removal trials. This study confirmed the different effects of A. muciniphila strains on gut barrier modulation and provided molecular and genetic targets for the screening of A. muciniphila strains with superior protection against gut barrier dysfunction.
基金the National Key R&D Program of China(Grant No.2022YFA1403700)the National Natural Science Foundation of China(Grant Nos.12074163 and 12004030)+5 种基金the Guangdong Basic and Applied Basic Research Foundation(Grant Nos.2022B1515020046,2022B1515130005,2021B1515130007,and 2020B1515120100)the Guangdong Innovative and Entrepreneurial Research Team Program(Grant Nos.2017ZT07C062 and 2019ZT08C044)the Shenzhen Science and Technology Program(Grant No.KQTD20190929173815000)Shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices(Grant No.ZDSYS20190902092905285)the Shenzhen Fundamental Research Program(Grant No.JCYJ20220818100405013)China Postdoctoral Science Foundation(Grant No.2020M682780 and 2022M711495)。
文摘The simple kagome-lattice band structure possesses Dirac cones,flat band,and saddle point with van Hove singularities in the electronic density of states,facilitating the emergence of various electronic orders.Here we report a titanium-based kagome metal CsTi_(3)Bi_(5)where titanium atoms form a kagome network,resembling its isostructural compound CsV_3Sb_5.Thermodynamic properties including the magnetization,resistance,and heat capacity reveal the conventional Fermi liquid behavior in the kagome metal CsTi_(3)Bi_(5)and no signature of superconducting or charge density wave(CDW)transition anomaly down to 85 m K.Systematic angle-resolved photoemission spectroscopy measurements reveal multiple bands crossing the Fermi level,consistent with the first-principles calculations.The flat band formed by the destructive interference of hopping in the kagome lattice is observed directly.Compared to Cs V_(3)Sb_(5),the van Hove singularities are pushed far away above the Fermi level in CsTi_(3)Bi_(5),in line with the absence of CDW.Furthermore,the first-principles calculations identify the nontrivial Z_(2)topological properties for those bands crossing the Fermi level,accompanied by several local band inversions.Our results suppose CsTi_(3)Bi_(5)as a complementary platform to explore the superconductivity and nontrivial band topology.
文摘In our most recently published article,[1]an important reference[2]predicting CsTi_(3)Bi_(5) is missing and should be added,along with Ref.[3](originally Ref.[28]),to the introduction section.
