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MicroRNA调控多不饱和脂肪酸合成关键酶研究进展 被引量:2
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作者 李飙 马海明 《猪业科学》 2020年第6期106-111,共6页
microRNA(miRNA)是生物体内自然存在的一种非编码小RNA,能够靶向调控众多基因的表达,进而参与多种生命活动的调节。脊椎动物体内长链多不饱和脂肪酸(LC-PUFA)的生物合成,如花生四烯酸(ARA;20∶4n-6)、二十碳五烯酸(EPA;20∶5n-3)和二十... microRNA(miRNA)是生物体内自然存在的一种非编码小RNA,能够靶向调控众多基因的表达,进而参与多种生命活动的调节。脊椎动物体内长链多不饱和脂肪酸(LC-PUFA)的生物合成,如花生四烯酸(ARA;20∶4n-6)、二十碳五烯酸(EPA;20∶5n-3)和二十二碳六烯酸(DHA;22∶6n-3)等脂肪酸合成需要脂肪酰基去饱和酶(Fads)的催化。早已有研究表明,中国地方猪种肉质优于瘦肉型猪种,究其原因是中国地方猪种肌肉和脂肪中含有大量不饱和脂肪酸等风味物质。然而LC-PUFA研究是一个蓬勃发展的领域,主要集中在人类健康方面,但对于猪肉中LCPUFA生物合成关键酶转录后水平调控机制还没有形成一个完整的观点。miRNA可能参与转录后水平的脂质代谢调控。然而,它们是否影响了LC-PUFA生物合成途径中的作用尚不清楚。文章综述了一些靶向关键去饱和酶和延长酶的miRNA在调控动物LC-PUFA合成的表达模式和调控机制。 展开更多
关键词 MIRNA 多不饱和脂肪酸 脂肪酸去饱和酶 脂肪酸延长酶
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Numerical and experimental study on the response characteristics of warhead in the fast cook-off process 被引量:6
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作者 Min Zhu Sheng-ao Wang +5 位作者 Huang Huang Gui Huang Fei Wu Shao-hua Sun biao li Zi-jian Xu 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2021年第4期1444-1452,共9页
The response characteristics of the warhead under thermal stimuli conditions are important to the safety improvement.The goal of this study is to obtain data on the warhead in the fast cook-off process.In this paper,a... The response characteristics of the warhead under thermal stimuli conditions are important to the safety improvement.The goal of this study is to obtain data on the warhead in the fast cook-off process.In this paper,a numerical calculation method is proposed,whose reliability is supported by comparison with experimental results.Through the numerical calculation,the temperature distribution,temperature change,and ignition time are acquired.The numerical results show that the ignition time is 76 s after the warhead started to burn and that the maximum temperature of the explosive’s outer surface is 238.3℃ at the ignition time.The fast cook-off experiment of the warhead is implemented so as to get the flame temperature and reaction grades that are not available through numerical calculation.The experimental results show that the overpressure fails to reach the preset minimumvalue which is equivalent to 6 kg of TNT and that the reaction grade is deflagration.The research results have reference value for the design of the warhead and the reduction of detonation risks. 展开更多
关键词 WARHEAD Explosives Fast cook-off Numerical calculations
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