The optical active fork glycerinol （2,2-dimethyl-1,3-dioxolane- 4-methanol）（1） was synthesized with L-serine（2） as the starting material. L-glyceric acid（3） was synthesized via the nitrosation of （2）. With T...The optical active fork glycerinol （2,2-dimethyl-1,3-dioxolane- 4-methanol）（1） was synthesized with L-serine（2） as the starting material. L-glyceric acid（3） was synthesized via the nitrosation of （2）. With TsOH as the catalyst and 4A molecular sieve as the dehydration agent, L-2,3-O-isopropylidene-glycerate（5） was （directly） prepared from （3）, 2,2′-dimethoxypropane and methanol without isolating the intermediate. Instead of （LiAlH4）, NaBH4 was used to reduce （5） to the final compound （1）. The total yield of was 47%.展开更多
文摘The optical active fork glycerinol （2,2-dimethyl-1,3-dioxolane- 4-methanol）（1） was synthesized with L-serine（2） as the starting material. L-glyceric acid（3） was synthesized via the nitrosation of （2）. With TsOH as the catalyst and 4A molecular sieve as the dehydration agent, L-2,3-O-isopropylidene-glycerate（5） was （directly） prepared from （3）, 2,2′-dimethoxypropane and methanol without isolating the intermediate. Instead of （LiAlH4）, NaBH4 was used to reduce （5） to the final compound （1）. The total yield of was 47%.
