目的探讨苓桂抗纤方联合穴位贴敷对扩张型心肌病患者心肌纤维化及心功能的影响。方法将87例扩张型心肌病患者随机分为研究组44例和对照组43例。对照组脱落2例,剩余41例患者给予常规治疗。研究组脱落3例,剩余41例患者在对照组基础上,使...目的探讨苓桂抗纤方联合穴位贴敷对扩张型心肌病患者心肌纤维化及心功能的影响。方法将87例扩张型心肌病患者随机分为研究组44例和对照组43例。对照组脱落2例,剩余41例患者给予常规治疗。研究组脱落3例,剩余41例患者在对照组基础上,使用苓桂抗纤方联合穴位贴敷治疗。对比两组治疗4周的临床疗效。检测患者血清生长分化因子15(growth differentiation factor 15,GDF-15)、半乳糖凝集素-3(galactose agglutinin-3,Gal-3)、可溶性生长刺激表达基因2蛋白(growth stimulation expressed gene 2,ST2)的水平。对比两组左心房前后径(left atrial diameter,Lad)、左室舒张末期内径(left ventricular end diastolic diameter LVEDD)、左心射血分数(left ventricular ejection fraction,LVEF)的水平。使用6分钟步行试验评估患者的运动耐力。运用健康调查简表(the MOS item short from health survey,SF-36)评估患者的生活质量。结果研究组治疗后的总有效率为95.12%(39/41),对照组为80.49%(33/41),组间比较差异有统计学意义(P<0.05)。两组治疗后的GDF-15、Gal-3、ST2较治疗前降低,且研究组的GDF-15、Gal-3、ST2低于对照组,差异有统计学意义(P<0.05)。两组治疗后Lad、LVEDD较治疗前减小,LVEF较治疗前增大(P<0.05);研究组的Lad、LVEDD小于对照组,LVEF大于对照组,差异有统计学意义(P<0.05)。两组治疗后的6分钟行走最大距离较治疗前升高,且研究组较对照组升高更明显(P<0.05)。两组治疗后的SF-36各项评分较治疗前减小,且研究组的SF-36各项评分小于对照组(P<0.05)。结论苓桂抗纤方联合穴位贴敷可提高扩张型心肌病的疗效,有助于延缓心肌纤维化,改善心功能,提高生活质量。展开更多
We present a high-quality Ni/Ag/Pt Ohmic contact to p-type GaN. After the sample is annealed at 500℃ in 02 ambient for 3min, a specific contact resistance as low as 2.6 × 10^-5 Ωcm^2 and an optical reflectivity...We present a high-quality Ni/Ag/Pt Ohmic contact to p-type GaN. After the sample is annealed at 500℃ in 02 ambient for 3min, a specific contact resistance as low as 2.6 × 10^-5 Ωcm^2 and an optical reflectivity of 82% at 460 nm are obtained. The Auger electron spectroscopy analysis shows that the Pt layer can improve the surface morphology and thermal reliability of the annealed Ag-based electrode, Ag plays a key role in achieving good ohmic contact due to the outdiffusion of Ga into Ag forming Ga vacancies which increase the hole concentration, while the surface contamination of p-type GaN is reduced by Ni.展开更多
文摘目的探讨苓桂抗纤方联合穴位贴敷对扩张型心肌病患者心肌纤维化及心功能的影响。方法将87例扩张型心肌病患者随机分为研究组44例和对照组43例。对照组脱落2例,剩余41例患者给予常规治疗。研究组脱落3例,剩余41例患者在对照组基础上,使用苓桂抗纤方联合穴位贴敷治疗。对比两组治疗4周的临床疗效。检测患者血清生长分化因子15(growth differentiation factor 15,GDF-15)、半乳糖凝集素-3(galactose agglutinin-3,Gal-3)、可溶性生长刺激表达基因2蛋白(growth stimulation expressed gene 2,ST2)的水平。对比两组左心房前后径(left atrial diameter,Lad)、左室舒张末期内径(left ventricular end diastolic diameter LVEDD)、左心射血分数(left ventricular ejection fraction,LVEF)的水平。使用6分钟步行试验评估患者的运动耐力。运用健康调查简表(the MOS item short from health survey,SF-36)评估患者的生活质量。结果研究组治疗后的总有效率为95.12%(39/41),对照组为80.49%(33/41),组间比较差异有统计学意义(P<0.05)。两组治疗后的GDF-15、Gal-3、ST2较治疗前降低,且研究组的GDF-15、Gal-3、ST2低于对照组,差异有统计学意义(P<0.05)。两组治疗后Lad、LVEDD较治疗前减小,LVEF较治疗前增大(P<0.05);研究组的Lad、LVEDD小于对照组,LVEF大于对照组,差异有统计学意义(P<0.05)。两组治疗后的6分钟行走最大距离较治疗前升高,且研究组较对照组升高更明显(P<0.05)。两组治疗后的SF-36各项评分较治疗前减小,且研究组的SF-36各项评分小于对照组(P<0.05)。结论苓桂抗纤方联合穴位贴敷可提高扩张型心肌病的疗效,有助于延缓心肌纤维化,改善心功能,提高生活质量。
基金Supported by the National Natural Science Foundation of China under Grant Nos 60536020, 60390074, and 60536020, the Beijing Science and Technology Program （D0404003040321）, and the National High Technology Programme of China under Grant Nos 2001AA313130 and 2004AA31G060.
文摘We present a high-quality Ni/Ag/Pt Ohmic contact to p-type GaN. After the sample is annealed at 500℃ in 02 ambient for 3min, a specific contact resistance as low as 2.6 × 10^-5 Ωcm^2 and an optical reflectivity of 82% at 460 nm are obtained. The Auger electron spectroscopy analysis shows that the Pt layer can improve the surface morphology and thermal reliability of the annealed Ag-based electrode, Ag plays a key role in achieving good ohmic contact due to the outdiffusion of Ga into Ag forming Ga vacancies which increase the hole concentration, while the surface contamination of p-type GaN is reduced by Ni.
