The hydrogenation of avermectin catalyzed by [RhCl(COD)]2-BISBIS [COD:1,5-cyclooctadiene,BISBIS:sulfonated 1,1’-bis(diphenylphosphino methyl)-2,2’-biphenyl] in situ in aquenous/organic two-phase system was studied.T...The hydrogenation of avermectin catalyzed by [RhCl(COD)]2-BISBIS [COD:1,5-cyclooctadiene,BISBIS:sulfonated 1,1’-bis(diphenylphosphino methyl)-2,2’-biphenyl] in situ in aquenous/organic two-phase system was studied.The influence of various parameters,such as the surfactant concentration,the molar ratio of rhodium to phosphine,the reaction temperature and pressure on this hydrogenation were investigated.The results showed that the hydrogenation activities of diphosphine was higher that of monophosphine.展开更多
目的:探究驱动蛋白超家族23(Kinesin family member 23,KIF23)、蛋白质精氨酸甲基转移酶5(Protein arginine methyltransferase 5,PRMT5)的表达与结直肠癌患者临床病理特征关联性。方法:选取我院92例结直肠癌患者(2018年1月至2020年12...目的:探究驱动蛋白超家族23(Kinesin family member 23,KIF23)、蛋白质精氨酸甲基转移酶5(Protein arginine methyltransferase 5,PRMT5)的表达与结直肠癌患者临床病理特征关联性。方法:选取我院92例结直肠癌患者(2018年1月至2020年12月),比较癌组织、癌旁正常组织的不同临床病理特征和PRMT5、KIF23阳性表达率,并分析其与临床病理特征的关联性。结果:结直肠癌癌组织中PRMT5、KIF23阳性表达率高于癌旁正常组织(P<0.05);分期为Ⅲ期~Ⅳ期、低分化、淋巴结有转移患者PRMT5、KIF23阳性率较高,浸润深度为T3+T4患者KIF23阳性率较高(P<0.05);PRMT5、KIF23与分期、淋巴结转移呈正相关,与肿瘤分化程度呈负相关,KIF23与浸润深度呈正相关(P<0.05)。结论:PRMT5、KIF23在结直肠癌患者癌组织中呈高表达状态,且与临床病理学特征密切相关,通过检测其水平可对结直肠癌患者的情况进行辅助评估。展开更多
文摘The hydrogenation of avermectin catalyzed by [RhCl(COD)]2-BISBIS [COD:1,5-cyclooctadiene,BISBIS:sulfonated 1,1’-bis(diphenylphosphino methyl)-2,2’-biphenyl] in situ in aquenous/organic two-phase system was studied.The influence of various parameters,such as the surfactant concentration,the molar ratio of rhodium to phosphine,the reaction temperature and pressure on this hydrogenation were investigated.The results showed that the hydrogenation activities of diphosphine was higher that of monophosphine.
文摘目的:探究驱动蛋白超家族23(Kinesin family member 23,KIF23)、蛋白质精氨酸甲基转移酶5(Protein arginine methyltransferase 5,PRMT5)的表达与结直肠癌患者临床病理特征关联性。方法:选取我院92例结直肠癌患者(2018年1月至2020年12月),比较癌组织、癌旁正常组织的不同临床病理特征和PRMT5、KIF23阳性表达率,并分析其与临床病理特征的关联性。结果:结直肠癌癌组织中PRMT5、KIF23阳性表达率高于癌旁正常组织(P<0.05);分期为Ⅲ期~Ⅳ期、低分化、淋巴结有转移患者PRMT5、KIF23阳性率较高,浸润深度为T3+T4患者KIF23阳性率较高(P<0.05);PRMT5、KIF23与分期、淋巴结转移呈正相关,与肿瘤分化程度呈负相关,KIF23与浸润深度呈正相关(P<0.05)。结论:PRMT5、KIF23在结直肠癌患者癌组织中呈高表达状态,且与临床病理学特征密切相关,通过检测其水平可对结直肠癌患者的情况进行辅助评估。
