目的探索低浓度碘对比剂威视派克270 mg/m L、低管电压扫描技术在肾动脉CTA应用中的价值,建立适合不同人群的个性化扫描方案。方法将55例临床怀疑肾动脉血管病变的患者(32名男性,23名女性,体质量指数≤30 kg/m^2)使用西门子64排螺旋CT机...目的探索低浓度碘对比剂威视派克270 mg/m L、低管电压扫描技术在肾动脉CTA应用中的价值,建立适合不同人群的个性化扫描方案。方法将55例临床怀疑肾动脉血管病变的患者(32名男性,23名女性,体质量指数≤30 kg/m^2)使用西门子64排螺旋CT机(SOMATOM Definition AS)的100 k V或120 k V进行肾动脉CTA扫描。55名入组随机分成两组,A组(27例)CTA扫描使用100 k V及威视派克270 mg/m L,B组(28例)使用120 k V及欧乃派克350 mg/m L,每位患者对比剂使用剂量为0.9 m L/kg,注射流速5 m L/s,使用智能跟踪进行估算循环时间及触发扫描(检测腹主动脉,阈值设定为100 HU)。使用五级评分法对所有CTA图像进行图像质量评估,并对照两组的碘摄入量、对比噪声比(CNR)以及有效辐射剂量(ED)。结果 9名患者被确诊肾动脉狭窄(A组4名,B组5名),所有患者的肾动脉及其分支均可清晰显示,两组患者肾动脉强化程度及对比噪声比无统计学差异;A组患者的有效辐射剂量及碘摄入量低于B组(1.45±0.09 vs 1.96±0.17,P<0.05;16.12±3.20 vs 20.45±5.35,P<0.05)。结论使用100 k V和威视派克270进行肾动脉动脉CTA可获得与120 k V、高浓度碘对比剂CTA同样的血管造影图像质量,并能较大幅度降低碘摄入量及辐射剂量,具有较高的临床应用价值。展开更多
The inhibition of Piperol B on rabbit platelet aggregation induced by PAF and its mechanism were studied.Piperol B and ginkgolid B (BN52021) dose dependently inhibited rabbit platelet aggregation induced by PAF, IC50s...The inhibition of Piperol B on rabbit platelet aggregation induced by PAF and its mechanism were studied.Piperol B and ginkgolid B (BN52021) dose dependently inhibited rabbit platelet aggregation induced by PAF, IC50s were 14. 2, 4. 78μmol· L-1. But Piperol B (100, 200μmol· L-1) had no significant effect on aggregation of rabbit platelet induced by AA and ADP. Either increase of cytoplasmic free calcium[Ca2+]i or calcium influx induced by PAF was dose dependently inhibited by Piperol B (10, 100μmol· L-1). The maximum inhibition was 50. 8% and 37. 2%,respectively. But Piperol B had no effect on the increase of [Ca2+]i induced by A23187. Our results suggest that Piperol B selectively inhibits aggregation of rabbit platelet induced by PAF, and this effect is concerned with its inhibition on increase of [Ca2+]i and Ca2+ influx induced by PAF.展开更多
文摘目的探索低浓度碘对比剂威视派克270 mg/m L、低管电压扫描技术在肾动脉CTA应用中的价值,建立适合不同人群的个性化扫描方案。方法将55例临床怀疑肾动脉血管病变的患者(32名男性,23名女性,体质量指数≤30 kg/m^2)使用西门子64排螺旋CT机(SOMATOM Definition AS)的100 k V或120 k V进行肾动脉CTA扫描。55名入组随机分成两组,A组(27例)CTA扫描使用100 k V及威视派克270 mg/m L,B组(28例)使用120 k V及欧乃派克350 mg/m L,每位患者对比剂使用剂量为0.9 m L/kg,注射流速5 m L/s,使用智能跟踪进行估算循环时间及触发扫描(检测腹主动脉,阈值设定为100 HU)。使用五级评分法对所有CTA图像进行图像质量评估,并对照两组的碘摄入量、对比噪声比(CNR)以及有效辐射剂量(ED)。结果 9名患者被确诊肾动脉狭窄(A组4名,B组5名),所有患者的肾动脉及其分支均可清晰显示,两组患者肾动脉强化程度及对比噪声比无统计学差异;A组患者的有效辐射剂量及碘摄入量低于B组(1.45±0.09 vs 1.96±0.17,P<0.05;16.12±3.20 vs 20.45±5.35,P<0.05)。结论使用100 k V和威视派克270进行肾动脉动脉CTA可获得与120 k V、高浓度碘对比剂CTA同样的血管造影图像质量,并能较大幅度降低碘摄入量及辐射剂量,具有较高的临床应用价值。
文摘The inhibition of Piperol B on rabbit platelet aggregation induced by PAF and its mechanism were studied.Piperol B and ginkgolid B (BN52021) dose dependently inhibited rabbit platelet aggregation induced by PAF, IC50s were 14. 2, 4. 78μmol· L-1. But Piperol B (100, 200μmol· L-1) had no significant effect on aggregation of rabbit platelet induced by AA and ADP. Either increase of cytoplasmic free calcium[Ca2+]i or calcium influx induced by PAF was dose dependently inhibited by Piperol B (10, 100μmol· L-1). The maximum inhibition was 50. 8% and 37. 2%,respectively. But Piperol B had no effect on the increase of [Ca2+]i induced by A23187. Our results suggest that Piperol B selectively inhibits aggregation of rabbit platelet induced by PAF, and this effect is concerned with its inhibition on increase of [Ca2+]i and Ca2+ influx induced by PAF.
