The auditory brainstern responses(ABR)and middle latency responses(MLR)were recorded in 24 normal mice with a 7S11A processor,and the normalparameters of ABR and MLR obtained.The results showed that the ABR of mice we...The auditory brainstern responses(ABR)and middle latency responses(MLR)were recorded in 24 normal mice with a 7S11A processor,and the normalparameters of ABR and MLR obtained.The results showed that the ABR of mice werecomposed of 6 waves,waves Ⅰ to Ⅵ.The mean threshold was 35.12±8.03 dB ,whichwas significantly different from the 22.63 dB of ABR found in guinea pigs.Thelatency of ABR waves Ⅰ to Ⅵizn the mice was found to be 1.30±8.03 ms ;2.02±0.24ms ;2.90±0.27 ms ;3.80±0.24 ms ;4.87±0.42 ms and 5.83±0.40 ms respectively.Nosex or strain differences were found.The MLR waveform of the mice were similar tothose of human and the latency was found to be P0 3.94±1.76 ms;P8.38±1.57ms;Na 14.98±2.54 ms;Pa 24.56±3.15 ms rcspectively.It is suggested that mice can beused for hearing research.Since the Na and Pa waves of MLR were unstable under anes-thesia,testing conditions for determining MLR in mice need further study.展开更多
The auditory brainstem response (ABR) was measured for 90 cars of norml gui-nea pigs,from which the mean latency,amplitude and recognition of waves were obtain-ded.The waves were classified into six types,with wave Ⅲ...The auditory brainstem response (ABR) was measured for 90 cars of norml gui-nea pigs,from which the mean latency,amplitude and recognition of waves were obtain-ded.The waves were classified into six types,with wave Ⅲ as the main wave which ac-counted for 77.1% of all the waves.The frequency domain of each type was analysed bymeans of digital filtering and auto-regressive (AR)estimation.The main frequency com-position of ABR in the guinea pigs was restricted within 1600 Hz,in which there werethree peaks at AR spectrum,the mean value of the peaks being 107.33 Hz,566.67 Hzand 1076 Hz respectively.The AR spectrograms of all types waves were very similar toeach other.展开更多
An mvestigation and analysis of 229 deal-mute children revealed that 54.2％ of ac-quired deafness were mused by ototoxic aminoglycoside drugs.There is an upward trend of the oc-cunence of the disease in the recent yea...An mvestigation and analysis of 229 deal-mute children revealed that 54.2％ of ac-quired deafness were mused by ototoxic aminoglycoside drugs.There is an upward trend of the oc-cunence of the disease in the recent years and more attention should be paid to it.The result ofpure tone audiometry showed that more than 90.4％ of deaf-mute children had some residualhearing.Twenty-six deal-mute children whose average hearing thresholds of speech frequency werebetter them 90dB(HL)had serviceable speech for daily use 3 after 3 to 18 months’ speech Warn-ing,and 4 of them were transferred to ordinary primary schools.The authors are of the opinionthat the deaf-mute children should use heating-aids as early as possible so as to promote theirspeech.展开更多
Objectics: To demonstrate the effects of NO synthase (NOS ) blockade on the OHCs. Methods: The Nnitro L-arginine (L-NNA) was used and the vibration velocity of basilar membrane (BMV ) was observed. Pigmented guinea pi...Objectics: To demonstrate the effects of NO synthase (NOS ) blockade on the OHCs. Methods: The Nnitro L-arginine (L-NNA) was used and the vibration velocity of basilar membrane (BMV ) was observed. Pigmented guinea pigs were anesthetized and surgically prepared to permit infusion of L- NNA into the scala tympani of basal turn of cochlea . The basilar membrane (BM ) vibration and compound action potential (cAP ), endocochlear potential (EP ) and cochlear mierophonic (CM ) were monitored. Eight μ1 of 1. 6 mmol/L- L- NNA was infused into the perilymph of scala tympani . The BM velocity responses elicited with direct current (DC ) pulses were recorded. Results: The BMV was increased by approximately 3 folds following infusion of L-NNA. The CM de creased by a small amount and there was no significant change in CP. This phenomenon occurs only in the cochlearsensitivity has been lost less than 40 dB . No improvement in BM velocity if the cochlear sensitivity was ’normal’ or was damaged too severely. Conclusion: The results imply that NO bas the excitotoxicity on OHCs, it can promote the injury of cochlea when noise is exposed. L-NNA may act as a guardian when facts of trauma act on cochlea.展开更多
Objective:To study the electromotility of the basilar membrane (BM) of guinea pigs in vivo. Methods :A pair of platinum-iridium wire electrodes were deposited into the holes drilled into the scala vestibuli and scala ...Objective:To study the electromotility of the basilar membrane (BM) of guinea pigs in vivo. Methods :A pair of platinum-iridium wire electrodes were deposited into the holes drilled into the scala vestibuli and scala tympani on the basal turn of cochlea. The organ of Corti was stimulated with rectangular, constant current pulses . The displacement and velocity of BM were measured with laser doppler velocimeter. Results: The electrically elicited displacement of BM moved toward the scala where the electrode was positively charged. The waveform of BM displacement generally corresponded to the shape of the rectangular pulse of electric current. Ringing responses could be seen at the onset and offset of current pulse reflecting transient responses of the organ of Corti. In the cochlea of hearing-impaired or dead animal, direct current (DC) could still elicit a BM displacement but the ringing response was attenuated or disappeared. This phenomenon was probably due to metabolic disturbance in the damaged outer hair cells. In the sensitive cochlea, the BM vibration induced with direct current was similar to that induced by acoustic stimulation, and the BM moves in a traveling wave pattern. Conclusion: The findings of this experiment implicated that the DC stimulation of the cochlea conduces the contraction or elongation of OHCs. The electromotility of OHCs provides sufficient force to displace the BM. In the electrically stimulated normal cochlea,transient response of OHCs can induce resonant vibration at the same frequency as that Of the characteristic frequency (CF) of a partition in the BM. The vibration should be an active process of energy depletion associated with the cochlear amplifier.The vibration of BM can propagate to other partition of BM according to the traveling wave theory. This characteristic has laid the foundation for the electromotile hearing and electrically evoked otoacoustic emission.展开更多
Facial electroneurographies(ENoG) of 46 normal persons and 180 patients with facial nerve diseases were analyzed. Normal persons showed a peak amplitude of ENoG of 1.65±0.63 mV,a peak latency of 5. 12±0.58 m...Facial electroneurographies(ENoG) of 46 normal persons and 180 patients with facial nerve diseases were analyzed. Normal persons showed a peak amplitude of ENoG of 1.65±0.63 mV,a peak latency of 5. 12±0.58 ms and a bilateral amplitude ratio of 0.80±0.11.In 134 cases of peripheral facial paralysis,however,the amplitude ratio was less than 0.1 in 29.1% and less than 0. 3 in 73.13%.In 46 cases of facial hemispasm,the amplitude ratio was less than 0.7 in 71.73%.among them 45.65% showed an amplitude ratio of 0.1 to 0.3,indicating that in some cases facial hemispasm might have originated from light or masked facial paralysis. The results showed that ENoG was quite effective in the quantitative analysis of, prescribing treatment to and determining prognosis of paralysis of facial nerve in its early stage.展开更多
The ear drums of 279 long-range gunners and 156 short-range gunners who hadparticipated in a battle for 4 months were inspected and 442 ears were subjected to acousticimpedance measurement.The results showed that retr...The ear drums of 279 long-range gunners and 156 short-range gunners who hadparticipated in a battle for 4 months were inspected and 442 ears were subjected to acousticimpedance measurement.The results showed that retraction was the main change of the ear drums,then,opacity and atrophy.The average static compliance was 1.06,tympanograms were 75.6% oftype A and 21.1% of AD.No obvious difference in acoustic reflex threshold at different frequencieswas found between the 2 sorts of gunners.But the short-range cannon gunners suffered a more seri-ous high frequency hearing loss.展开更多
文摘The auditory brainstern responses(ABR)and middle latency responses(MLR)were recorded in 24 normal mice with a 7S11A processor,and the normalparameters of ABR and MLR obtained.The results showed that the ABR of mice werecomposed of 6 waves,waves Ⅰ to Ⅵ.The mean threshold was 35.12±8.03 dB ,whichwas significantly different from the 22.63 dB of ABR found in guinea pigs.Thelatency of ABR waves Ⅰ to Ⅵizn the mice was found to be 1.30±8.03 ms ;2.02±0.24ms ;2.90±0.27 ms ;3.80±0.24 ms ;4.87±0.42 ms and 5.83±0.40 ms respectively.Nosex or strain differences were found.The MLR waveform of the mice were similar tothose of human and the latency was found to be P0 3.94±1.76 ms;P8.38±1.57ms;Na 14.98±2.54 ms;Pa 24.56±3.15 ms rcspectively.It is suggested that mice can beused for hearing research.Since the Na and Pa waves of MLR were unstable under anes-thesia,testing conditions for determining MLR in mice need further study.
文摘The auditory brainstem response (ABR) was measured for 90 cars of norml gui-nea pigs,from which the mean latency,amplitude and recognition of waves were obtain-ded.The waves were classified into six types,with wave Ⅲ as the main wave which ac-counted for 77.1% of all the waves.The frequency domain of each type was analysed bymeans of digital filtering and auto-regressive (AR)estimation.The main frequency com-position of ABR in the guinea pigs was restricted within 1600 Hz,in which there werethree peaks at AR spectrum,the mean value of the peaks being 107.33 Hz,566.67 Hzand 1076 Hz respectively.The AR spectrograms of all types waves were very similar toeach other.
文摘An mvestigation and analysis of 229 deal-mute children revealed that 54.2％ of ac-quired deafness were mused by ototoxic aminoglycoside drugs.There is an upward trend of the oc-cunence of the disease in the recent years and more attention should be paid to it.The result ofpure tone audiometry showed that more than 90.4％ of deaf-mute children had some residualhearing.Twenty-six deal-mute children whose average hearing thresholds of speech frequency werebetter them 90dB(HL)had serviceable speech for daily use 3 after 3 to 18 months’ speech Warn-ing,and 4 of them were transferred to ordinary primary schools.The authors are of the opinionthat the deaf-mute children should use heating-aids as early as possible so as to promote theirspeech.
文摘Objectics: To demonstrate the effects of NO synthase (NOS ) blockade on the OHCs. Methods: The Nnitro L-arginine (L-NNA) was used and the vibration velocity of basilar membrane (BMV ) was observed. Pigmented guinea pigs were anesthetized and surgically prepared to permit infusion of L- NNA into the scala tympani of basal turn of cochlea . The basilar membrane (BM ) vibration and compound action potential (cAP ), endocochlear potential (EP ) and cochlear mierophonic (CM ) were monitored. Eight μ1 of 1. 6 mmol/L- L- NNA was infused into the perilymph of scala tympani . The BM velocity responses elicited with direct current (DC ) pulses were recorded. Results: The BMV was increased by approximately 3 folds following infusion of L-NNA. The CM de creased by a small amount and there was no significant change in CP. This phenomenon occurs only in the cochlearsensitivity has been lost less than 40 dB . No improvement in BM velocity if the cochlear sensitivity was ’normal’ or was damaged too severely. Conclusion: The results imply that NO bas the excitotoxicity on OHCs, it can promote the injury of cochlea when noise is exposed. L-NNA may act as a guardian when facts of trauma act on cochlea.
文摘Objective:To study the electromotility of the basilar membrane (BM) of guinea pigs in vivo. Methods :A pair of platinum-iridium wire electrodes were deposited into the holes drilled into the scala vestibuli and scala tympani on the basal turn of cochlea. The organ of Corti was stimulated with rectangular, constant current pulses . The displacement and velocity of BM were measured with laser doppler velocimeter. Results: The electrically elicited displacement of BM moved toward the scala where the electrode was positively charged. The waveform of BM displacement generally corresponded to the shape of the rectangular pulse of electric current. Ringing responses could be seen at the onset and offset of current pulse reflecting transient responses of the organ of Corti. In the cochlea of hearing-impaired or dead animal, direct current (DC) could still elicit a BM displacement but the ringing response was attenuated or disappeared. This phenomenon was probably due to metabolic disturbance in the damaged outer hair cells. In the sensitive cochlea, the BM vibration induced with direct current was similar to that induced by acoustic stimulation, and the BM moves in a traveling wave pattern. Conclusion: The findings of this experiment implicated that the DC stimulation of the cochlea conduces the contraction or elongation of OHCs. The electromotility of OHCs provides sufficient force to displace the BM. In the electrically stimulated normal cochlea,transient response of OHCs can induce resonant vibration at the same frequency as that Of the characteristic frequency (CF) of a partition in the BM. The vibration should be an active process of energy depletion associated with the cochlear amplifier.The vibration of BM can propagate to other partition of BM according to the traveling wave theory. This characteristic has laid the foundation for the electromotile hearing and electrically evoked otoacoustic emission.
文摘Facial electroneurographies(ENoG) of 46 normal persons and 180 patients with facial nerve diseases were analyzed. Normal persons showed a peak amplitude of ENoG of 1.65±0.63 mV,a peak latency of 5. 12±0.58 ms and a bilateral amplitude ratio of 0.80±0.11.In 134 cases of peripheral facial paralysis,however,the amplitude ratio was less than 0.1 in 29.1% and less than 0. 3 in 73.13%.In 46 cases of facial hemispasm,the amplitude ratio was less than 0.7 in 71.73%.among them 45.65% showed an amplitude ratio of 0.1 to 0.3,indicating that in some cases facial hemispasm might have originated from light or masked facial paralysis. The results showed that ENoG was quite effective in the quantitative analysis of, prescribing treatment to and determining prognosis of paralysis of facial nerve in its early stage.
文摘The ear drums of 279 long-range gunners and 156 short-range gunners who hadparticipated in a battle for 4 months were inspected and 442 ears were subjected to acousticimpedance measurement.The results showed that retraction was the main change of the ear drums,then,opacity and atrophy.The average static compliance was 1.06,tympanograms were 75.6% oftype A and 21.1% of AD.No obvious difference in acoustic reflex threshold at different frequencieswas found between the 2 sorts of gunners.But the short-range cannon gunners suffered a more seri-ous high frequency hearing loss.
