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Suppression and mitigation of inter-ELM high-frequency Alfvén-like mode by resonant magnetic perturbation in EAST
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作者 Jiquan ZHAO Youwen SUN +6 位作者 Nan CHU Tonghui SHI Qun MA Yumin WANG Kaiyang HE Youjun HU EAST Team 《Plasma Science and Technology》 SCIE EI CAS CSCD 2021年第9期7-12,共6页
Suppression and mitigation of a high-frequency Alfvén-like mode(HFAM)between type-I edge localized modes(ELMs)during ELM mitigation by resonant magnetic perturbation(RMP)is observed for the first time in the EAST... Suppression and mitigation of a high-frequency Alfvén-like mode(HFAM)between type-I edge localized modes(ELMs)during ELM mitigation by resonant magnetic perturbation(RMP)is observed for the first time in the EAST tokamak.This mode is located near the edge pedestal region.The modeling result of the Alfvén continuum shows that the HFAM is located near the elipical Alfvén eigenmode(EAE)gap.During the application of n=1 RMP for ELM mitigation,the HFAM can be fully suppressed when the RMP amplitude exceeds a threshold,below which the HFAM is mitigated.The suppression is caused by a reduction of pedestal height induced by RMP.In the case using n=3 RMP,the mode is localized toroidally at specific phase depending on the phase of applied RMP,i.e.locked in the three-dimensional equilibrium formed by RMP.The dominant toroidal mode number of HFAM is around n=-6 and it reduces to-3 during the application of n=3 RMP,which indicates the existence of possible nonlinear coupling between the HFAM and RMP.Here the negative mode number denotes that the mode rotates in electron diamagnetic drift direction.The observation reported here improves the understanding of pedestal dynamics and its stability in RMP ELM control. 展开更多
关键词 Alfvén-like mode RMP HFAM mode inter-ELM
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Exendin-4对hIAPP转基因鼠胰岛功能的改善作用
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作者 刘辰 邹庆宝 赵济全 《中国医药科学》 2022年第11期27-30,共4页
目的探究Exendin-4对hIAPP转基因鼠的保护作用及其可能的作用机制。方法正常小鼠和hIAPP转基因鼠分别注射PBS和Exdendin-4,共分为四组:正常小鼠对照组(WT+PBS)、正常小鼠注射Exendin-4组(WT+Ex-4)、hIAPP小鼠对照组(homo+PBS)、hIAPP小... 目的探究Exendin-4对hIAPP转基因鼠的保护作用及其可能的作用机制。方法正常小鼠和hIAPP转基因鼠分别注射PBS和Exdendin-4,共分为四组:正常小鼠对照组(WT+PBS)、正常小鼠注射Exendin-4组(WT+Ex-4)、hIAPP小鼠对照组(homo+PBS)、hIAPP小鼠注射Exendin-4组(homo+Ex-4),每组6只。对四组小鼠进行2个月每天一次的腹腔注射,给药结束后进行葡萄糖耐受实验;体外培养Min6胰岛β细胞,取对数生长期细胞分别加入2.5、5、10、20μM的hIAPP完全培养基,检测细胞周期相关蛋白的表达;分离小鼠原代胰岛细胞,Annexin V-FITC检测细胞凋亡;提取小鼠胰腺组织蛋白,检测周期相关蛋白表达水平变化。结果homo+PBS组小鼠葡萄糖耐受能力显著降低,差异有统计学意义(P<0.05),hIAPP体外处理Min6细胞会剂量依赖式下调ABC蛋白及周期相关蛋白CCND2和CCND3的蛋白表达。相反,homo+Ex-4组的小鼠葡萄糖耐受能力显著增强,差异有统计学意义(P<0.05),原代胰岛细胞的凋亡比例明显降低,细胞周期蛋白CCND2和CCND3的表达水平增加。结论Exendin-4对hIAPP转基因鼠造成的胰岛损伤具有保护作用,其机制与调控胰岛细胞增殖和凋亡有关。 展开更多
关键词 EXENDIN-4 胰岛淀粉样多肽 细胞增殖 细胞凋亡
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