Objective：To investigate serum levels of MMP-2,MMP-9, oxidized low-density lipoprotein （ox-LDL） in Alzheimer＇s disease （AD） patients and study the possible pathway and mechanism of AD with abnormal lipid metabol...Objective：To investigate serum levels of MMP-2,MMP-9, oxidized low-density lipoprotein （ox-LDL） in Alzheimer＇s disease （AD） patients and study the possible pathway and mechanism of AD with abnormal lipid metabolism. Methods： Subjects in this study were divided into 4 groups ： normal lipid group without AD （N）, hyperlipoidemia group without AD （H）, normal group with AD （A）, hyper- lipoidemia group with AD （AH）. There were 15 individuals in each group. MMP-2, MMP-9, ox-LDL was measured by enzyme linked immunosorbent assay （EL1SA）. Serum lipids levels were measured by biochemical methods. Results： The serum levels of MMP-2, MMP-9, ox-LDL were significantly higher in H, A and AH groups than those in N group. Those of ox-LDL in H, AH groups was higher than that of in A group. The serum level of MMP-2, MMP-9 in AH groups were higher than that of in H group. The score of mini-mental state examination （MMSE） in A and AD groups was negatively correlated with the serum level of ox-LDL. Relationship between the score of MMSE and the serum level of ox-LDL in AD groups and non-AD groups had statistical significance. Conclusion： MMP-2, MMP-9, ox-LDL and abnor- mal lipid metabolism may participate in pathogenesis of AD, in which abnormal lipid metabolism induces expressions of MMP-2,MMP-9 and ox-LDL. Oxidative stress and blood-brain barrier disruption might ac- celerate the process of AD.展开更多
Current hypotheses of pathogenesis of neuronal degeneration in Alzheimer's disease (AD) have been proposed, including formation of free radicals, oxidative stress, mitochondrial dysfunction, inflammatory processes...Current hypotheses of pathogenesis of neuronal degeneration in Alzheimer's disease (AD) have been proposed, including formation of free radicals, oxidative stress, mitochondrial dysfunction, inflammatory processes, genetic factors, environmental impact factors, apoptosis, and so on. Especially, oxidative stress plays an essential role in AD pathogenesis by the function of linking agent. Oxidative stress in AD mainly includes lipid peroxidation, protein oxidation and DNA oxidation. Lipid peroxidation plays a key role in the development and progression of AD. Protein oxidation is an important mechanism in AD. Oxidative damage to DNA may plays an important role in aging and AD.展开更多
基金the Doctoral Project of Chongqing Medical University(2006010068)
文摘Objective：To investigate serum levels of MMP-2,MMP-9, oxidized low-density lipoprotein （ox-LDL） in Alzheimer＇s disease （AD） patients and study the possible pathway and mechanism of AD with abnormal lipid metabolism. Methods： Subjects in this study were divided into 4 groups ： normal lipid group without AD （N）, hyperlipoidemia group without AD （H）, normal group with AD （A）, hyper- lipoidemia group with AD （AH）. There were 15 individuals in each group. MMP-2, MMP-9, ox-LDL was measured by enzyme linked immunosorbent assay （EL1SA）. Serum lipids levels were measured by biochemical methods. Results： The serum levels of MMP-2, MMP-9, ox-LDL were significantly higher in H, A and AH groups than those in N group. Those of ox-LDL in H, AH groups was higher than that of in A group. The serum level of MMP-2, MMP-9 in AH groups were higher than that of in H group. The score of mini-mental state examination （MMSE） in A and AD groups was negatively correlated with the serum level of ox-LDL. Relationship between the score of MMSE and the serum level of ox-LDL in AD groups and non-AD groups had statistical significance. Conclusion： MMP-2, MMP-9, ox-LDL and abnor- mal lipid metabolism may participate in pathogenesis of AD, in which abnormal lipid metabolism induces expressions of MMP-2,MMP-9 and ox-LDL. Oxidative stress and blood-brain barrier disruption might ac- celerate the process of AD.
文摘Current hypotheses of pathogenesis of neuronal degeneration in Alzheimer's disease (AD) have been proposed, including formation of free radicals, oxidative stress, mitochondrial dysfunction, inflammatory processes, genetic factors, environmental impact factors, apoptosis, and so on. Especially, oxidative stress plays an essential role in AD pathogenesis by the function of linking agent. Oxidative stress in AD mainly includes lipid peroxidation, protein oxidation and DNA oxidation. Lipid peroxidation plays a key role in the development and progression of AD. Protein oxidation is an important mechanism in AD. Oxidative damage to DNA may plays an important role in aging and AD.
