目的:探讨诱导型一氧化氮合酶(iNOS)在糖尿病大鼠视网膜组织中的表达及其对细胞凋亡的影响。方法:建立糖尿病大鼠动物模型,分别在成模后第1,3,6mo时测定大鼠视网膜组织细胞凋亡指数(AI)和iNOS表达水平。结果:(1)与正常对照组(NC)相比,i...目的:探讨诱导型一氧化氮合酶(iNOS)在糖尿病大鼠视网膜组织中的表达及其对细胞凋亡的影响。方法:建立糖尿病大鼠动物模型,分别在成模后第1,3,6mo时测定大鼠视网膜组织细胞凋亡指数(AI)和iNOS表达水平。结果:(1)与正常对照组(NC)相比,iNOS表达在糖尿病各组均升高,6mo时明显增强(P<0.05);(2)视网膜细胞凋亡情况:与正常对照组(NC)相比,糖尿病模型1mo时细胞凋亡指数差异无统计学意义,3,6mo时则明显升高(P<0.05)。结论:iNOS在糖尿病大鼠视网膜组织中的表达增强,推断iNOS在糖尿病视网膜病变(retinopathy of diabetes,DR)的发病机制中起一定作用。展开更多
The hard X-ray micro-focusing beamline(BL15U1) of SSRF is dedicated to hard X-ray micro/nanospectrochemical analysis consisting of X-ray fluorescence(XRF), X-ray absorption spectroscopy(XAS) and X-ray diffraction(XRD)...The hard X-ray micro-focusing beamline(BL15U1) of SSRF is dedicated to hard X-ray micro/nanospectrochemical analysis consisting of X-ray fluorescence(XRF), X-ray absorption spectroscopy(XAS) and X-ray diffraction(XRD) techniques. It is one of the most versatile instruments in hard X-ray microscopy science. Since its commission in 2009, BL15U1 has allocated over 25000 h beamtime for users, and about 700 proposals have been executed. The beamline and the experimental end-station were upgraded for several times to facilitate the users' experimental needs and make it more convenient to operate. In this paper, we give a review on the beamline, describing its characteristics, recent technical developments, and a few examples of scientific progresses achieved in recent years on BL15U1.展开更多
文摘目的:探讨诱导型一氧化氮合酶(iNOS)在糖尿病大鼠视网膜组织中的表达及其对细胞凋亡的影响。方法:建立糖尿病大鼠动物模型,分别在成模后第1,3,6mo时测定大鼠视网膜组织细胞凋亡指数(AI)和iNOS表达水平。结果:(1)与正常对照组(NC)相比,iNOS表达在糖尿病各组均升高,6mo时明显增强(P<0.05);(2)视网膜细胞凋亡情况:与正常对照组(NC)相比,糖尿病模型1mo时细胞凋亡指数差异无统计学意义,3,6mo时则明显升高(P<0.05)。结论:iNOS在糖尿病大鼠视网膜组织中的表达增强,推断iNOS在糖尿病视网膜病变(retinopathy of diabetes,DR)的发病机制中起一定作用。
基金Supported by the National Natural Science Foundation of China(Nos.U1332117 and U1332120)Natural Science Foundation of Shanghai(No.14ZR1448200)
文摘The hard X-ray micro-focusing beamline(BL15U1) of SSRF is dedicated to hard X-ray micro/nanospectrochemical analysis consisting of X-ray fluorescence(XRF), X-ray absorption spectroscopy(XAS) and X-ray diffraction(XRD) techniques. It is one of the most versatile instruments in hard X-ray microscopy science. Since its commission in 2009, BL15U1 has allocated over 25000 h beamtime for users, and about 700 proposals have been executed. The beamline and the experimental end-station were upgraded for several times to facilitate the users' experimental needs and make it more convenient to operate. In this paper, we give a review on the beamline, describing its characteristics, recent technical developments, and a few examples of scientific progresses achieved in recent years on BL15U1.
