Two diterpene lactones, sarcophinone(1) and iso sarcophinone(2), which are biogenetically related to the sarcophine, were isolated from the soft coral Sarcophyton molle Tix. Dur. iso Sarcophinone 2 is a new compound. ...Two diterpene lactones, sarcophinone(1) and iso sarcophinone(2), which are biogenetically related to the sarcophine, were isolated from the soft coral Sarcophyton molle Tix. Dur. iso Sarcophinone 2 is a new compound. Its structure was determined to be C 1 epimer of sarcophinone by spectroscopic methods. Bioassay showed that both sarcophinone(1) and iso sarcophinone(2) had potent cytotoxicity toward Ehrlich and S180 tumor cell lines.展开更多
In our continuing search of discovering bioactive substances from marine organisms, a sample of soft coral Sarcophyton crassocaule Mosre collected off the Sanya bay, China, was investigated. Two polyhydroxylated stero...In our continuing search of discovering bioactive substances from marine organisms, a sample of soft coral Sarcophyton crassocaule Mosre collected off the Sanya bay, China, was investigated. Two polyhydroxylated sterols 1 and 2 were isolated from the 95% ethanol extract of the sample by chromatography over silica gel. Compound 1, named sarcrasterol, was a new compound, its structure was established as(22R*,24ξ)-methyl-cholest-5-en-3β,22α,25,28-tetraol by spectroscopic methods. Compound 2, a known compound, was first obtained by Kobayashi, however, the relative configuration of C24 has not been determined yet. This paper reports the stereochemistry of compound 2 established as (24S*)-methyl cholest-3β,5β,6α,25-tetraol by means of X-ray single crystal diffraction analysis. Bioassay results show that compound 2 has a moderate activity against human tumor cell lines MGC-803 with an IC50 value of 23.0 μg/mL.展开更多
A new glycoside, cervicoside, was isolated from the soft coral Sinularia cervicornis Tix Dur ., collected from the bay of Sanya, Hainan Island. Its chemical structure was determined by spectroscopic methods as hexadec...A new glycoside, cervicoside, was isolated from the soft coral Sinularia cervicornis Tix Dur ., collected from the bay of Sanya, Hainan Island. Its chemical structure was determined by spectroscopic methods as hexadecanyl 1 O β D arabinopyranosyloxy (1→4) [ β D arabinopyranosyloxy(1→4)] β D arabinopyranoside. Cervicoside(1) exhibited cytotoxicity against human SKMG 4, Hep G2 and CNE2 cell in vitro.展开更多
Two new steroidal glycosides and one polyhydroxylated sterol were isolated from the soft coral Cladiella sp. by HPLC fractionation. The animal material was collected from Sanya bay, Hainan province, China. On the basi...Two new steroidal glycosides and one polyhydroxylated sterol were isolated from the soft coral Cladiella sp. by HPLC fractionation. The animal material was collected from Sanya bay, Hainan province, China. On the basis of spectroscopic analysis and chemical conversion, their chemical structures were elucidated as pregn-5,20-dien-3β-ol-3-O-α-L-fucopyranoside(1), pregn-5,20-dien-3β-ol-3-O-β-D-xylopyranoside(2) and (22E,24R)-ergost-7,22-dien-3β,5α,6β-triol(3). Compounds 1 and 2 are new compounds.展开更多
文摘Two diterpene lactones, sarcophinone(1) and iso sarcophinone(2), which are biogenetically related to the sarcophine, were isolated from the soft coral Sarcophyton molle Tix. Dur. iso Sarcophinone 2 is a new compound. Its structure was determined to be C 1 epimer of sarcophinone by spectroscopic methods. Bioassay showed that both sarcophinone(1) and iso sarcophinone(2) had potent cytotoxicity toward Ehrlich and S180 tumor cell lines.
文摘In our continuing search of discovering bioactive substances from marine organisms, a sample of soft coral Sarcophyton crassocaule Mosre collected off the Sanya bay, China, was investigated. Two polyhydroxylated sterols 1 and 2 were isolated from the 95% ethanol extract of the sample by chromatography over silica gel. Compound 1, named sarcrasterol, was a new compound, its structure was established as(22R*,24ξ)-methyl-cholest-5-en-3β,22α,25,28-tetraol by spectroscopic methods. Compound 2, a known compound, was first obtained by Kobayashi, however, the relative configuration of C24 has not been determined yet. This paper reports the stereochemistry of compound 2 established as (24S*)-methyl cholest-3β,5β,6α,25-tetraol by means of X-ray single crystal diffraction analysis. Bioassay results show that compound 2 has a moderate activity against human tumor cell lines MGC-803 with an IC50 value of 23.0 μg/mL.
文摘A new glycoside, cervicoside, was isolated from the soft coral Sinularia cervicornis Tix Dur ., collected from the bay of Sanya, Hainan Island. Its chemical structure was determined by spectroscopic methods as hexadecanyl 1 O β D arabinopyranosyloxy (1→4) [ β D arabinopyranosyloxy(1→4)] β D arabinopyranoside. Cervicoside(1) exhibited cytotoxicity against human SKMG 4, Hep G2 and CNE2 cell in vitro.
文摘Two new steroidal glycosides and one polyhydroxylated sterol were isolated from the soft coral Cladiella sp. by HPLC fractionation. The animal material was collected from Sanya bay, Hainan province, China. On the basis of spectroscopic analysis and chemical conversion, their chemical structures were elucidated as pregn-5,20-dien-3β-ol-3-O-α-L-fucopyranoside(1), pregn-5,20-dien-3β-ol-3-O-β-D-xylopyranoside(2) and (22E,24R)-ergost-7,22-dien-3β,5α,6β-triol(3). Compounds 1 and 2 are new compounds.
