目的对我国癌因性疲乏患者居家照护进行范围审查,为我国建立全面、规范化的癌因性疲乏患者居家照护提供参考。方法以JBI范围综述指南为方法学框架,检索PubMed、Embase、CINAHL、PsycINFO、Web of Science、Cochrane Library、EMCARE、...目的对我国癌因性疲乏患者居家照护进行范围审查,为我国建立全面、规范化的癌因性疲乏患者居家照护提供参考。方法以JBI范围综述指南为方法学框架,检索PubMed、Embase、CINAHL、PsycINFO、Web of Science、Cochrane Library、EMCARE、中国生物医学文献服务系统、中国知网、万方、维普数据库。检索时间为自建库起至2022年9月1日止。对纳入文献进行汇总分析。结果共纳入113篇文献,其中华东地区发表最多、随机对照试验占比最高、居家照护的实施者以多专业团队为主;通过对干预流程进行主题分析,归纳出开发远程干预平台/App、组建远程干预团队等11个主题;干预内容被归纳为日常生活、疾病相关、社会心理支持3个主题,21个亚主题;结局指标以癌因性疲乏、生命质量、焦虑抑郁、不良反应发生率为主。结论我国癌因性疲乏患者居家照护逐渐得到研究者重视、居家照护的方法较为完善、结局指标较为充分,但地域发展不均衡、多专业团队配比不足、文献报告不全,未来需要更多高质量、报告规范的研究,为进一步优化癌因性疲乏患者居家照护提供参考。展开更多
The adenine, 8-hypoxanthine, 6-thioguanine and 8-azaguanine were separated and determined with the method of micellar electrokinetic capillary chromatography. The optimal conditions of electrophoresis were studied. At...The adenine, 8-hypoxanthine, 6-thioguanine and 8-azaguanine were separated and determined with the method of micellar electrokinetic capillary chromatography. The optimal conditions of electrophoresis were studied. At 25 ℃ and 20 kV applied voltage, the four components were baseline separated within 16 min in 25 mmol/L phosphate-borate buffer（pH=7.0） including 30 mmol/L SDS at the detection wavelength of 210 nm. The peek area versus concentration was linear over the concentration range of （12200）×10{-6} mol/L for 8-hypoxanthine and 8-azaguanine, and （6.5100）×10{-6} mol/L for adenine and 6-thioguanine. The detection limits of all analytes mentioned above attained to 10{-6} mol/L grade. And the correlationg coefficients of four analytes were over 0.998 5. In the real sample of the mean absolute recoveries of 8-hypoxanthine, adenine, 6-thioguanine and 8-azaguanine were 97.2%{102.1%}, and the relative standard deviations for the four components were less than 3.41%（n=5）. The method is rapid, simple with a good solution for the analysis of 8-hypoxanthine, adenine, 6-thioguanine and 8-azaguanine, and satisfactory results were obtained.展开更多
文摘目的对我国癌因性疲乏患者居家照护进行范围审查,为我国建立全面、规范化的癌因性疲乏患者居家照护提供参考。方法以JBI范围综述指南为方法学框架,检索PubMed、Embase、CINAHL、PsycINFO、Web of Science、Cochrane Library、EMCARE、中国生物医学文献服务系统、中国知网、万方、维普数据库。检索时间为自建库起至2022年9月1日止。对纳入文献进行汇总分析。结果共纳入113篇文献,其中华东地区发表最多、随机对照试验占比最高、居家照护的实施者以多专业团队为主;通过对干预流程进行主题分析,归纳出开发远程干预平台/App、组建远程干预团队等11个主题;干预内容被归纳为日常生活、疾病相关、社会心理支持3个主题,21个亚主题;结局指标以癌因性疲乏、生命质量、焦虑抑郁、不良反应发生率为主。结论我国癌因性疲乏患者居家照护逐渐得到研究者重视、居家照护的方法较为完善、结局指标较为充分,但地域发展不均衡、多专业团队配比不足、文献报告不全,未来需要更多高质量、报告规范的研究,为进一步优化癌因性疲乏患者居家照护提供参考。
文摘The adenine, 8-hypoxanthine, 6-thioguanine and 8-azaguanine were separated and determined with the method of micellar electrokinetic capillary chromatography. The optimal conditions of electrophoresis were studied. At 25 ℃ and 20 kV applied voltage, the four components were baseline separated within 16 min in 25 mmol/L phosphate-borate buffer（pH=7.0） including 30 mmol/L SDS at the detection wavelength of 210 nm. The peek area versus concentration was linear over the concentration range of （12200）×10{-6} mol/L for 8-hypoxanthine and 8-azaguanine, and （6.5100）×10{-6} mol/L for adenine and 6-thioguanine. The detection limits of all analytes mentioned above attained to 10{-6} mol/L grade. And the correlationg coefficients of four analytes were over 0.998 5. In the real sample of the mean absolute recoveries of 8-hypoxanthine, adenine, 6-thioguanine and 8-azaguanine were 97.2%{102.1%}, and the relative standard deviations for the four components were less than 3.41%（n=5）. The method is rapid, simple with a good solution for the analysis of 8-hypoxanthine, adenine, 6-thioguanine and 8-azaguanine, and satisfactory results were obtained.
