Starting from 2,6-dimethyl phenol,antiviral agent pleconaril was synthesized via bromination,cyanidation and etherification followed by reaction with acetaldehyde oxime,hydroxylamine hydrochloride and trifluoroacetic ...Starting from 2,6-dimethyl phenol,antiviral agent pleconaril was synthesized via bromination,cyanidation and etherification followed by reaction with acetaldehyde oxime,hydroxylamine hydrochloride and trifluoroacetic anhydride respectively.Its structure was confirmed by IR,MS, 1 HNMR and elemental analysis.展开更多
AIM:To study the crystals form of tegaserod maleate. METHOD:The DSC,TGA and X -ray powder diffraction were used in this observation. RESULT and CONCLUSION: Twe crystals of tegaserod maleate,S-form and W-form,were obta...AIM:To study the crystals form of tegaserod maleate. METHOD:The DSC,TGA and X -ray powder diffraction were used in this observation. RESULT and CONCLUSION: Twe crystals of tegaserod maleate,S-form and W-form,were obtained and it was confirmed that the S-crystal form is a monohydrate crystal. Preliminary pharmacokinetic test shows that the S-crystal form bioavailability is 46% in mice and the W-crystal form is only 19%.展开更多
文摘Starting from 2,6-dimethyl phenol,antiviral agent pleconaril was synthesized via bromination,cyanidation and etherification followed by reaction with acetaldehyde oxime,hydroxylamine hydrochloride and trifluoroacetic anhydride respectively.Its structure was confirmed by IR,MS, 1 HNMR and elemental analysis.
文摘AIM:To study the crystals form of tegaserod maleate. METHOD:The DSC,TGA and X -ray powder diffraction were used in this observation. RESULT and CONCLUSION: Twe crystals of tegaserod maleate,S-form and W-form,were obtained and it was confirmed that the S-crystal form is a monohydrate crystal. Preliminary pharmacokinetic test shows that the S-crystal form bioavailability is 46% in mice and the W-crystal form is only 19%.
