Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as ind...Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture.Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method.The release of ADR from the nanosphere continued over 7 d.The drug-loaded micelles could effectively restrain the growth of cancer cell.These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.展开更多
A novel bioinspired phospholipid copolymer was synthesized by the free radical polymerization of poly-2-methacryloyloxyethylphosphorylcholine(MPC), stearyl methacrylate(SMA), hydroxypropyl methacrylate(HPMA) and trime...A novel bioinspired phospholipid copolymer was synthesized by the free radical polymerization of poly-2-methacryloyloxyethylphosphorylcholine(MPC), stearyl methacrylate(SMA), hydroxypropyl methacrylate(HPMA) and trimethoxysilylpropyl methacrylate(TSMA). A stable cross-linked coating was obtained via dip-coating, followed by curing at 70 ℃ for 9 h. Contact angle results indicate the coating surface rearrange to get a more hydrophilic surface on the polymer/water interface. The membrane mimic phosphorylcholine coating surface can resist the platelet adhesion and prolong plasma recalcification time significantly. Rhodamine S was used as model drugs to prepare drug-containing coating under the same conditions. Drug-releasing curves fall into Fickian release mechanism and there exists an efficient releasing-amount of the drug until 60 h.展开更多
文摘Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture.Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method.The release of ADR from the nanosphere continued over 7 d.The drug-loaded micelles could effectively restrain the growth of cancer cell.These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.
文摘A novel bioinspired phospholipid copolymer was synthesized by the free radical polymerization of poly-2-methacryloyloxyethylphosphorylcholine(MPC), stearyl methacrylate(SMA), hydroxypropyl methacrylate(HPMA) and trimethoxysilylpropyl methacrylate(TSMA). A stable cross-linked coating was obtained via dip-coating, followed by curing at 70 ℃ for 9 h. Contact angle results indicate the coating surface rearrange to get a more hydrophilic surface on the polymer/water interface. The membrane mimic phosphorylcholine coating surface can resist the platelet adhesion and prolong plasma recalcification time significantly. Rhodamine S was used as model drugs to prepare drug-containing coating under the same conditions. Drug-releasing curves fall into Fickian release mechanism and there exists an efficient releasing-amount of the drug until 60 h.
