Objective: To assess the effects of hormone replacement therapy (HRT) on plasma lipid levels and hormone levels in postmenopausal women. Methods: A total of 108 Chinese postmenopausal women with hyperlipodemia (mean a...Objective: To assess the effects of hormone replacement therapy (HRT) on plasma lipid levels and hormone levels in postmenopausal women. Methods: A total of 108 Chinese postmenopausal women with hyperlipodemia (mean age (65.3±0.7) years) were randomly divided into 3 groups (group Ⅰ , Ⅱ and Ⅲ). Patients in group Ⅰ received exclusive estrogen therapy (Premarin), those in group Ⅱ received combined therapy with estrogen and progestrone (Livial), and those in group Ⅲ were treated with placebo. At the end of 3 and 6 months of the therapy, the serum sex hormone and lipid levels were determined and compared with the baseline levels. Results: After 6 months’ therapy, in group Ⅰ, a statistically significant (P < 0.01) decrease or increase vs the baseline was observed in serum lipid levels: the tatal cholesteror (TC) dropped by 12.8%, triglyceride (TG) by 17%, low-density lipoprotein cholesterol (LDL-ch) by 29%, and high-density lipoprotein cholesterol (HDL-ch) was elevated by 14.6%. In group Ⅱ, TC levels was decreased by 8.7%, TG by 15.6%, LDL-ch by 33% and HDL-ch by 28.3%. The serum estradiol (E2) levels in both group Ⅰ and Ⅱ was increased significantly (P < 0.01). Conclusion: Estrogen replacement therapy (ERT) benefits the lipoprotein metabolism in postmenopausal women with hyperlipodemia but when progestational is added to the ERT, the beneficial effect of estrogen on blood lipids was reduced.展开更多
Objective: The purpose of this study was to investigate the effect of estrogen estrogen treatment on arterial neointimal pro liferation induced by balloon injury of bled vessels in rabbit. Methods: Fifty female rabbit...Objective: The purpose of this study was to investigate the effect of estrogen estrogen treatment on arterial neointimal pro liferation induced by balloon injury of bled vessels in rabbit. Methods: Fifty female rabbits were were divided into 5 groups (groups A, B, C, D and E, 10 in each group). Rabbits in group A, B, C and D underwent ovariectomy and 1 month later, the abdominal arteries of the rabbits in all the groups underwent balloon injury Rabbits in groups B, C, D re ceived intramusular injection of 17 β-estradiol cypionate 2, 20, l00 μg’ kg-1’ d-1 respectively, beginning 1 d before till 3 d after balloon injury (5 in each group) or till 3 weeks ther balloon injury (the other 5 in each group). Those in group A and E received no estrogen. Inhibition of cell proliferation by estrogen was evaluated by incorporation of tritiated thymidine in vitro into the rabbit abdominal aorta 3 d for balloon injury. Morphological sodes were performed to detendne the inti mal tiickness 21 d ther injury. Results: Estradiol treatment significantly inhibited the myointimal thickening in vivo and thymidine incorporation (P < 0.01) in mied vessels vessels in the rabbits undergoing balloon balloon injury in the abdominal ar teries. Conclusion: Inhibitory effect of estradiol on balloon injury-induced arterial neointimal hyperolasia may be mediated by inhibition of vascular smooth muscle cell proliferation, and estrogen replacement therapy may be a new approach to pre vent restenosis.展开更多
基金Natural Science Foundation of China No. 39600169, Guangdong Natural Science Foundation No. 950845 and Key Item ofGuangdong Nat
文摘Objective: To assess the effects of hormone replacement therapy (HRT) on plasma lipid levels and hormone levels in postmenopausal women. Methods: A total of 108 Chinese postmenopausal women with hyperlipodemia (mean age (65.3±0.7) years) were randomly divided into 3 groups (group Ⅰ , Ⅱ and Ⅲ). Patients in group Ⅰ received exclusive estrogen therapy (Premarin), those in group Ⅱ received combined therapy with estrogen and progestrone (Livial), and those in group Ⅲ were treated with placebo. At the end of 3 and 6 months of the therapy, the serum sex hormone and lipid levels were determined and compared with the baseline levels. Results: After 6 months’ therapy, in group Ⅰ, a statistically significant (P < 0.01) decrease or increase vs the baseline was observed in serum lipid levels: the tatal cholesteror (TC) dropped by 12.8%, triglyceride (TG) by 17%, low-density lipoprotein cholesterol (LDL-ch) by 29%, and high-density lipoprotein cholesterol (HDL-ch) was elevated by 14.6%. In group Ⅱ, TC levels was decreased by 8.7%, TG by 15.6%, LDL-ch by 33% and HDL-ch by 28.3%. The serum estradiol (E2) levels in both group Ⅰ and Ⅱ was increased significantly (P < 0.01). Conclusion: Estrogen replacement therapy (ERT) benefits the lipoprotein metabolism in postmenopausal women with hyperlipodemia but when progestational is added to the ERT, the beneficial effect of estrogen on blood lipids was reduced.
文摘Objective: The purpose of this study was to investigate the effect of estrogen estrogen treatment on arterial neointimal pro liferation induced by balloon injury of bled vessels in rabbit. Methods: Fifty female rabbits were were divided into 5 groups (groups A, B, C, D and E, 10 in each group). Rabbits in group A, B, C and D underwent ovariectomy and 1 month later, the abdominal arteries of the rabbits in all the groups underwent balloon injury Rabbits in groups B, C, D re ceived intramusular injection of 17 β-estradiol cypionate 2, 20, l00 μg’ kg-1’ d-1 respectively, beginning 1 d before till 3 d after balloon injury (5 in each group) or till 3 weeks ther balloon injury (the other 5 in each group). Those in group A and E received no estrogen. Inhibition of cell proliferation by estrogen was evaluated by incorporation of tritiated thymidine in vitro into the rabbit abdominal aorta 3 d for balloon injury. Morphological sodes were performed to detendne the inti mal tiickness 21 d ther injury. Results: Estradiol treatment significantly inhibited the myointimal thickening in vivo and thymidine incorporation (P < 0.01) in mied vessels vessels in the rabbits undergoing balloon balloon injury in the abdominal ar teries. Conclusion: Inhibitory effect of estradiol on balloon injury-induced arterial neointimal hyperolasia may be mediated by inhibition of vascular smooth muscle cell proliferation, and estrogen replacement therapy may be a new approach to pre vent restenosis.
