Nine cases of congenital subaortic stenosis (SAS) associated with ventricular septal defect(VSD)were reported. The age ranged from 6 to 14 years. Under extracorporeal circulation, excision of the subaortic septum was ...Nine cases of congenital subaortic stenosis (SAS) associated with ventricular septal defect(VSD)were reported. The age ranged from 6 to 14 years. Under extracorporeal circulation, excision of the subaortic septum was performed in 8 cases, an extracardiac valve conduit from apex of left ventricle to aorta was established in another patient with tunnel-type of SAS. The VSD was repaired with patch in 7 cases. sutured in other 2. The operation was successful. The precardiac murmurs disappeared postoperatively and the symptoms relieved remarkably.Following up the patients for 3 to 97 months , the curative effect was satisfactory. The pathoanatomic characters of the congenital cardiac malformations of SAS associated with VSD were analysed, its diagnosis and surgical treatment were discussed briefly.展开更多
In the present experiment,fructose-1,6-diphosphate（FDP）and captopril（Cap）wereadded to the cold potassium cardioplegia solution and the levels of malondialdehyde（MDA）,cre-atine phosphokinase MB（CPK-MB）,thrombox...In the present experiment,fructose-1,6-diphosphate（FDP）and captopril（Cap）wereadded to the cold potassium cardioplegia solution and the levels of malondialdehyde（MDA）,cre-atine phosphokinase MB（CPK-MB）,thromboxane B（TXB<sub>2</sub>）and 6-keto-PGF<sub>1α</sub> in plasma weremeasured during open-heart surgery.Quantitative study of myocardial ultrastructure and obser-vation of cardiac resuscitation were also undertaken.The findings suggested that FDP,especiallywhen combined with Cap could significantly strengthen the protective effects of cold potassiumcardioplegia solution on ischemic myocardium.展开更多
Objective:The study aimed at looking into the effects of transmural revascularization with Nd:YAG laser for myocardial ischemia.Methods:Twelve healthy mongrel dogs were divided at random into 2 groups:experiment (EG) ...Objective:The study aimed at looking into the effects of transmural revascularization with Nd:YAG laser for myocardial ischemia.Methods:Twelve healthy mongrel dogs were divided at random into 2 groups:experiment (EG) and control (CG).The dogs of EG were followed up for 8 months to observe the morphological and functional changes of ischemic left ventricle which had been treated with laser transmural revascularization.Results:Left ventriculography showed EG exceeded CG in the total and area ejection fractions,and in the short diameter shortening of left ventricle (P<0.05).Two dogs in EG showed weak pulsation of anterior wall of left ventricle.All dogs in CG revealed aneurysm in anterior wall of left ventricle.The left ventricular end diastolic pressures were -0.06?.84 kpa (1 kpa=7.5 mmHg) in EG,and 0.36?.75 kpa in CG (P>0.05).Single photon emission computed tomography (SPECT) showed total myocardial infarction in all the dogs in CG while in EG there was subendocardial infarction in only one animal (P<0.01).Conclusion:Left ventriculography and SPECT could be used to monitor the effects of transmural revascularization and Nd:YAG laser might be an efficient technique for direct transmural revascularization.展开更多
Objective: To explore whether there existed prethrombotic state (PTS) in early severe myocardial contusion and its changes,so as to provide theoretical evidence for early clinical diagnosis and better treatment. Metho...Objective: To explore whether there existed prethrombotic state (PTS) in early severe myocardial contusion and its changes,so as to provide theoretical evidence for early clinical diagnosis and better treatment. Methods: The present study was carried out in the graded myocardial contusion model in rabbits,which had been previously established by the authors. Fourteen New Zealand rabbits were divided into 2 groups at random :Experimental group (severe myocardial contusion, n = 8) and control group (sham-impact, n = 6). The dynamic changes ofhemorrheology,tissue-type plasminogen activator (t-PA) activity,plasminogen activation inhibitor (PAI) activity,and pathologic changes were observed for 240 min after the impact or sham-impact. Results: ①In experimentalgroup,whole blood viscosity at low shear rate (ηb1) and erythrocyte aggregation index (EAI) increased significantly 30 min after contusion compared with those of pre-impact or control rabbits. There was a tendency of ηb1 andEAl descent 120 min after contusion,but they still remained high 240 min after contusion (P<0.05). The plasmat-PA activity showed a tendency to decrease,while the plasma PAI activity showed a tendency to increase 30 minafter contusion. The t-PA activity was significantly lower and PAI activity wad significantly higher 120 min aftercontusion than those in pre-impact or in control rabbits. Both t-PA and PAI activity showed more significantchanges 240 min after contusion. Pathologic changes were compatible with the changes of severe myocardial contusion. And the injury of coronary artery endothelial cells was found. ②In the control group,there were no significant changes in the aforementioned parameters. Conclusion: There is a PTS at the early stage of severe myocardialcontusion. PTS may be one of important factors in the development of severe myocardial contusion and its complications.展开更多
文摘Nine cases of congenital subaortic stenosis (SAS) associated with ventricular septal defect(VSD)were reported. The age ranged from 6 to 14 years. Under extracorporeal circulation, excision of the subaortic septum was performed in 8 cases, an extracardiac valve conduit from apex of left ventricle to aorta was established in another patient with tunnel-type of SAS. The VSD was repaired with patch in 7 cases. sutured in other 2. The operation was successful. The precardiac murmurs disappeared postoperatively and the symptoms relieved remarkably.Following up the patients for 3 to 97 months , the curative effect was satisfactory. The pathoanatomic characters of the congenital cardiac malformations of SAS associated with VSD were analysed, its diagnosis and surgical treatment were discussed briefly.
基金The project was supported by the National Natural Science Foundation of China No.3880772
文摘In the present experiment,fructose-1,6-diphosphate（FDP）and captopril（Cap）wereadded to the cold potassium cardioplegia solution and the levels of malondialdehyde（MDA）,cre-atine phosphokinase MB（CPK-MB）,thromboxane B（TXB<sub>2</sub>）and 6-keto-PGF<sub>1α</sub> in plasma weremeasured during open-heart surgery.Quantitative study of myocardial ultrastructure and obser-vation of cardiac resuscitation were also undertaken.The findings suggested that FDP,especiallywhen combined with Cap could significantly strengthen the protective effects of cold potassiumcardioplegia solution on ischemic myocardium.
文摘Objective:The study aimed at looking into the effects of transmural revascularization with Nd:YAG laser for myocardial ischemia.Methods:Twelve healthy mongrel dogs were divided at random into 2 groups:experiment (EG) and control (CG).The dogs of EG were followed up for 8 months to observe the morphological and functional changes of ischemic left ventricle which had been treated with laser transmural revascularization.Results:Left ventriculography showed EG exceeded CG in the total and area ejection fractions,and in the short diameter shortening of left ventricle (P<0.05).Two dogs in EG showed weak pulsation of anterior wall of left ventricle.All dogs in CG revealed aneurysm in anterior wall of left ventricle.The left ventricular end diastolic pressures were -0.06?.84 kpa (1 kpa=7.5 mmHg) in EG,and 0.36?.75 kpa in CG (P>0.05).Single photon emission computed tomography (SPECT) showed total myocardial infarction in all the dogs in CG while in EG there was subendocardial infarction in only one animal (P<0.01).Conclusion:Left ventriculography and SPECT could be used to monitor the effects of transmural revascularization and Nd:YAG laser might be an efficient technique for direct transmural revascularization.
文摘Objective: To explore whether there existed prethrombotic state (PTS) in early severe myocardial contusion and its changes,so as to provide theoretical evidence for early clinical diagnosis and better treatment. Methods: The present study was carried out in the graded myocardial contusion model in rabbits,which had been previously established by the authors. Fourteen New Zealand rabbits were divided into 2 groups at random :Experimental group (severe myocardial contusion, n = 8) and control group (sham-impact, n = 6). The dynamic changes ofhemorrheology,tissue-type plasminogen activator (t-PA) activity,plasminogen activation inhibitor (PAI) activity,and pathologic changes were observed for 240 min after the impact or sham-impact. Results: ①In experimentalgroup,whole blood viscosity at low shear rate (ηb1) and erythrocyte aggregation index (EAI) increased significantly 30 min after contusion compared with those of pre-impact or control rabbits. There was a tendency of ηb1 andEAl descent 120 min after contusion,but they still remained high 240 min after contusion (P<0.05). The plasmat-PA activity showed a tendency to decrease,while the plasma PAI activity showed a tendency to increase 30 minafter contusion. The t-PA activity was significantly lower and PAI activity wad significantly higher 120 min aftercontusion than those in pre-impact or in control rabbits. Both t-PA and PAI activity showed more significantchanges 240 min after contusion. Pathologic changes were compatible with the changes of severe myocardial contusion. And the injury of coronary artery endothelial cells was found. ②In the control group,there were no significant changes in the aforementioned parameters. Conclusion: There is a PTS at the early stage of severe myocardialcontusion. PTS may be one of important factors in the development of severe myocardial contusion and its complications.
