Orthogonal design methocl,based on the formation of a yellow complex of lead(Ⅱ) with α、β、γ、δ Trtra(p sulfopheny 1) Porphine in the pH10.2 H 3BO 3 NaOH buffer selution,has been proposed.The maximum absorption w...Orthogonal design methocl,based on the formation of a yellow complex of lead(Ⅱ) with α、β、γ、δ Trtra(p sulfopheny 1) Porphine in the pH10.2 H 3BO 3 NaOH buffer selution,has been proposed.The maximum absorption wavelength (λ max ) is 464nm.The molar absorption coefficient(ε max ) is 2.5×10 5L·mol -1 ·cm -1 .The detection limit is 4μg·L -1 .Beer’s law is applicable in the rang of 0.1～10.4μg/25ml for lead.The method has been used for determination of trace lead in synthetic sample with satisfactory result.展开更多
恶性肿瘤的典型特点是增殖速度快、侵袭性强,肿瘤血供往往不能满足生长所需,由此使得肿瘤处于低氧、营养物质缺乏的应激微环境中。肿瘤细胞在应激微环境下通过激活未折叠蛋白反应、启动自噬和改变其代谢途径等一系列信号通路促进其存活...恶性肿瘤的典型特点是增殖速度快、侵袭性强,肿瘤血供往往不能满足生长所需,由此使得肿瘤处于低氧、营养物质缺乏的应激微环境中。肿瘤细胞在应激微环境下通过激活未折叠蛋白反应、启动自噬和改变其代谢途径等一系列信号通路促进其存活发展。未折叠蛋白反应(unfolded protein response,UPR)、自噬的启动及代谢方式的改变三者之间有着紧密的联系,本文将对三者之间的相互作用关系进行综述,将对理解肿瘤与其微环境之间的互动以及探索新的治疗策略提供新视角。展开更多
文摘Orthogonal design methocl,based on the formation of a yellow complex of lead(Ⅱ) with α、β、γ、δ Trtra(p sulfopheny 1) Porphine in the pH10.2 H 3BO 3 NaOH buffer selution,has been proposed.The maximum absorption wavelength (λ max ) is 464nm.The molar absorption coefficient(ε max ) is 2.5×10 5L·mol -1 ·cm -1 .The detection limit is 4μg·L -1 .Beer’s law is applicable in the rang of 0.1～10.4μg/25ml for lead.The method has been used for determination of trace lead in synthetic sample with satisfactory result.
文摘恶性肿瘤的典型特点是增殖速度快、侵袭性强,肿瘤血供往往不能满足生长所需,由此使得肿瘤处于低氧、营养物质缺乏的应激微环境中。肿瘤细胞在应激微环境下通过激活未折叠蛋白反应、启动自噬和改变其代谢途径等一系列信号通路促进其存活发展。未折叠蛋白反应(unfolded protein response,UPR)、自噬的启动及代谢方式的改变三者之间有着紧密的联系,本文将对三者之间的相互作用关系进行综述,将对理解肿瘤与其微环境之间的互动以及探索新的治疗策略提供新视角。
